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scn 4 M 89.504 103.4 16.276 8.138 re B* 10 M 89.504 103.343 16.276 8.139 re S BT 0.137 0.123 0.126 scn /TT0 1 Tf 6.2327 0 0 6.2327 107.8135 103.4023 Tm (Central intermediary metabolism )Tj ET 0 0.534 0.806 scn 4 M 89.504 113.347 16.276 8.14 re B* 10 M 89.52 113.286 16.272 8.138 re S BT 0.137 0.123 0.126 scn /TT0 1 Tf 6.2327 0 0 6.2327 107.8135 113.3477 Tm (Fatty acid & phospholipid metabolism )Tj ET 89.504 93.395 16.278 8.135 re S 0.25 0.396 0.688 scn 4 M 89.504 93.453 16.276 8.139 re B* BT 0.137 0.123 0.126 scn /TT0 1 Tf 6.2327 0 0 6.2327 107.8135 93.4531 Tm (Purines, pyrimidines, nucleosides, & nucleotides )Tj ET 0.716 0.434 0.681 scn 89.504 123.29 16.276 8.14 re B* 10 M 89.504 123.229 16.276 8.137 re S BT 0.137 0.123 0.126 scn /TT0 1 Tf 6.2327 0 0 6.2327 107.8135 123.291 Tm (Transport & binding proteins )Tj ET 0.501 0.764 0.267 scn 4 M 309.845 92.097 16.274 8.14 re B* 10 M 309.845 92.04 16.277 8.136 re S BT 0.137 0.123 0.126 scn /TT0 1 Tf 6.2327 0 0 6.2327 328.1533 92.0967 Tm 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375.702 131.883 16.273 8.135 re B* 10 M 375.716 131.824 16.278 8.138 re S BT 0.137 0.123 0.126 scn /TT0 1 Tf 6.2327 0 0 6.2327 394.0117 131.8838 Tm (Cellular processes )Tj ET 0.99 0.914 0.17 scn 4 M 375.702 112.29 16.273 8.138 re B* 10 M 375.716 112.232 16.278 8.141 re S BT 0.137 0.123 0.126 scn /TT0 1 Tf 6.2327 0 0 6.2327 394.0117 112.292 Tm (DNA metabolism )Tj ET 0 0.677 0.647 scn 4 M 375.702 102.495 16.273 8.138 re B* 10 M 375.702 102.435 16.276 8.138 re S BT 0.137 0.123 0.126 scn /TT0 1 Tf 6.2327 0 0 6.2327 394.0117 102.4961 Tm (Protein synthesis )Tj 0 -1.523 TD (Watermarks )Tj ET 0.932 0.418 0.31 scn 0.55 w 375.935 93.414 15.811 7.188 re B BT 1 1 1 scn /TT0 1 Tf 6.7172 0 0 5.2962 377.7031 95.3203 Tm (WM#)Tj 0.137 0.123 0.126 scn 6.2327 0 0 6.2327 456.0654 124.3945 Tm (10 Kb segment border )Tj ET 0 0.698 0.941 scn q 1 0 0 1 450.4863 127.1152 cm 0 0 m -2.898 -4.35 l -5.8 0 l -2.898 4.347 l h f Q 4 M q 1 0 0 1 450.4863 127.1152 cm 0 0 m -2.898 -4.35 l -5.8 0 l -2.898 4.347 l 0 0 l h 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l S Q q 1 0 0 1 479.6143 686.395 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 491.1016 686.395 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 490.2451 685.6577 cm 0 0 m 11.483 0 l S Q q 1 0 0 1 490.2451 686.395 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 501.7285 686.395 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 500.874 685.6577 cm 0 0 m 10.687 0 l S Q q 1 0 0 1 500.874 686.395 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 510.9121 685.6577 cm 0 0 m 0.648 0 l S Q q 1 0 0 1 510.9121 686.395 cm 0 0 m 0 -1.476 l S Q BT 0.137 0.123 0.126 scn /TT0 1 Tf 5.2485 0 0 5.2485 515.0791 690.0869 Tm (40 kb)Tj 4.4285 0 0 4.4285 525.6094 690.0869 Tm ( )Tj 3.9365 0 0 3.9365 89.709 697.0908 Tm (0001 )Tj 3.724 0 Td (0002 )Tj 0 3.9365 -3.9365 0 118.7939 697.0908 Tm (0003 )Tj 0 -1.596 TD (0004 )Tj 3.9365 0 0 3.9365 131.123 697.0908 Tm (0005 )Tj 4.997 0 Td (0006 )Tj 6.26 0 Td (0007 )Tj 5.047 0 Td (0008 )Tj 4.364 0 Td (0009 )Tj 5.404 0 Td (0010 )Tj 4.786 0 Td (0011 )Tj 4.769 0 Td (0012 )Tj 4.639 0 Td (0013 )Tj 4.258 0 Td (0014 )Tj 4.089 0 Td (0015 )Tj 4.376 0 Td (0016 )Tj 2.3805 2.3805 -2.7833 2.7833 353.3638 697.0803 Tm (ncRNA )Tj 3.9365 0 0 3.9365 358.2676 697.0908 Tm (0914 )Tj 2.65 0 Td (0917 )Tj 0 3.067 -3.9365 0 384.6172 697.0908 Tm (0918 )Tj 3.9365 0 0 3.9365 404.1172 697.0908 Tm (0913 )Tj 7.755 0 Td (0915 )Tj 0 3.9365 -3.9365 0 464.6455 697.0908 Tm (0921 )Tj 0 -2.035 TD (0922 )Tj 3.9365 0 0 3.9365 478.8594 697.0908 Tm (0019 )Tj 2.37 0 Td (0020 )Tj 0 3.9365 -3.9365 0 499.6562 697.0908 Tm (0021 )Tj 0 -1.503 TD (0022 )Tj 0 -1.447 TD (0023 )Tj 3.9365 0 0 3.9365 87.8779 686.2495 Tm (811a )Tj 2.684 0 Td (812a )Tj 2.7 0 Td (813 )Tj 2.7 0 Td (814 )Tj 2.7 0 Td (815 )Tj 2.7 0 Td (816 )Tj 2.7 0 Td (817 )Tj 2.7 0 Td (818 )Tj 2.7 0 Td (819 )Tj 2.7 0 Td (820 )Tj 2.7 0 Td (821 )Tj 2.7 0 Td (822 )Tj 2.7 0 Td (823 )Tj 2.7 0 Td (824 )Tj 2.7 0 Td (825 )Tj 2.7 0 Td (826 )Tj 2.7 0 Td (827 )Tj 2.7 0 Td (828 )Tj 2.7 0 Td (829 )Tj 2.699 0 Td (830 )Tj 2.701 0 Td (831 )Tj 2.7 0 Td (832 )Tj 2.699 0 Td (833 )Tj 2.701 0 Td (834 )Tj 2.699 0 Td (835a )Tj 2.7 0 Td (836a )Tj 2.7 0 Td (837a )Tj 2.7 0 Td (838a )Tj 2.7 0 Td (839a )Tj 2.7 0 Td (840a )Tj 2.699 0 Td (841a )Tj 2.701 0 Td (842a )Tj 2.7 0 Td (843a )Tj 2.701 0 Td (844a )Tj 2.699 0 Td (845a )Tj 2.699 0 Td (846a )Tj 2.701 0 Td (847a )Tj 2.699 0 Td (848a )Tj 2.701 0 Td (849a )Tj 2.699 0 Td (850a )Tj /TT2 1 Tf 3.2804 0 0 3.2804 90.0791 693.3389 Tm [(d)-25(n)-25(a)-25(A)]TJ 82.103 0 Td [(b)-50(l)-50(a)]TJ -55.97 0.058 Td (gyrA)Tj -21.666 -0.067 Td [(d)-25(n)-25(a)-25(N)]TJ 14.2 0.067 Td [(g)-25(y)-25(r)-25(B)]TJ 1 1 1 scn /TT3 1 Tf 1.9682 0 0 1.9682 115.0107 693.7461 Tm (rnmV)Tj /TT2 1 Tf 3.2804 0 0 3.2804 121.123 693.3672 Tm (ksgA)Tj ET 0.328 w 4 M 265.111 701.957 -73.043 1.64 re S 243.791 701.246 -30.401 3.062 re f BT 0.137 0.123 0.126 scn /TT2 1 Tf 3.2804 0 0 3.2804 216.3896 702.104 Tm (ribose galactose)Tj 1 1 1 scn 16.719 -2.647 Td [(m)-25(e)-25(t)-25(G)]TJ /TT1 1 Tf 5.621 -0.017 Td [(L)-25(p)-25(p)-25(A)]TJ 5.1 0 Td [(L)-25(p)-25(p)-25(A)]TJ 5.032 0 Td [(L)-25(p)-25(p)-25(A)]TJ 5.2 0 Td [(L)-50(p)-50(p)-50(A)]TJ 0.137 0.123 0.126 scn /TT0 1 Tf 2.6243 0 0 2.6243 367.0801 693.5571 Tm (transposase)Tj /TT2 1 Tf 3.2804 0 0 3.2804 381.0811 693.3379 Tm [(h)50(i)50(s)50(3)]TJ 7.32 -0.021 Td [(t)-25(e)-25(t)-25(M)]TJ 9.354 0.04 Td [(l)-25(a)-25(c)-25(Z)]TJ 2.0634 0 0 3.2804 468.5674 693.3086 Tm (tnpB_1)Tj ET 0.262 w 10 M q 1 0 0 1 86.3999 627.5547 cm 0 0 m 425.161 0 l S Q 0.73 0.805 0.919 scn 4 M q 1 0 0 1 86.3999 630.291 cm 0 0 m 6.555 0 l 6.555 3.396 l 0 3.396 l B* Q 10 M q 1 0 0 1 86.3999 630.2856 cm 0 0 m 6.555 0 l 6.555 3.395 l 0 3.395 l S Q 0 0.65 0.316 scn q 1 0 0 1 113.6792 633.6865 cm 0 0 m -17.092 0 l -17.092 1.698 l -17.979 -1.697 l -17.092 -5.093 l -17.092 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 113.6792 633.6865 cm 0 0 m -17.092 0 l -17.092 1.698 l -17.979 -1.697 l -17.092 -5.093 l -17.092 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 113.6821 633.6807 cm 0 0 m -17.095 0 l -17.095 1.698 l -17.98 -1.697 l -17.095 -5.093 l -17.095 -3.395 l 0 -3.395 l 0 0 l h S Q q 1 0 0 1 121.7993 633.6865 cm 0 0 m -5.786 0 l -5.786 1.698 l -6.406 -1.697 l -5.786 -5.093 l -5.786 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 121.7993 633.6865 cm 0 0 m -5.786 0 l -5.786 1.698 l -6.406 -1.697 l -5.786 -5.093 l -5.786 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 121.8022 633.6807 cm 0 0 m -5.788 0 l -5.788 1.698 l -6.407 -1.697 l -5.788 -5.093 l -5.788 -3.395 l 0 -3.395 l 0 0 l h S Q q 1 0 0 1 150.6733 633.6865 cm 0 0 m -25.567 0 l -25.567 1.698 l -26.454 -1.697 l -25.567 -5.093 l -25.567 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 150.6733 633.6865 cm 0 0 m -25.567 0 l -25.567 1.698 l -26.454 -1.697 l -25.567 -5.093 l -25.567 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 150.6787 633.6807 cm 0 0 m -25.571 0 l -25.571 1.698 l -26.456 -1.697 l -25.571 -5.093 l -25.571 -3.395 l 0 -3.395 l 0 0 l h S Q q 1 0 0 1 160.6816 633.6865 cm 0 0 m -7.38 0 l -7.38 1.698 l -8.178 -1.697 l -7.38 -5.093 l -7.38 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 160.6816 633.6865 cm 0 0 m -7.38 0 l -7.38 1.698 l -8.178 -1.697 l -7.38 -5.093 l -7.38 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 160.6865 633.6807 cm 0 0 m -7.382 0 l -7.382 1.698 l -8.178 -1.697 l -7.382 -5.093 l -7.382 -3.395 l 0 -3.395 l 0 0 l h S Q q 1 0 0 1 168.1221 633.6865 cm 0 0 m -6.879 0 l -6.879 1.698 l -7.618 -1.697 l -6.879 -5.093 l -6.879 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 168.1221 633.6865 cm 0 0 m -6.879 0 l -6.879 1.698 l -7.618 -1.697 l -6.879 -5.093 l -6.879 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 168.1265 633.6807 cm 0 0 m -6.879 0 l -6.879 1.698 l -7.617 -1.697 l -6.879 -5.093 l -6.879 -3.395 l 0 -3.395 l 0 0 l h S Q 0.501 0.764 0.267 scn q 1 0 0 1 199.4751 633.6865 cm 0 0 m -29.256 0 l -29.256 1.698 l -30.144 -1.697 l -29.256 -5.093 l -29.256 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 199.4751 633.6865 cm 0 0 m -29.256 0 l -29.256 1.698 l -30.144 -1.697 l -29.256 -5.093 l -29.256 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 199.4814 633.6807 cm 0 0 m -29.259 0 l -29.259 1.698 l -30.145 -1.697 l -29.259 -5.093 l -29.259 -3.395 l 0 -3.395 l 0 0 l h S Q q 1 0 0 1 200.4214 633.6865 cm 0 0 m 5.52 0 l 5.52 1.698 l 6.11 -1.697 l 5.52 -5.093 l 5.52 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 200.4214 633.6865 cm 0 0 m 5.52 0 l 5.52 1.698 l 6.11 -1.697 l 5.52 -5.093 l 5.52 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 200.4277 633.6807 cm 0 0 m 5.521 0 l 5.521 1.698 l 6.112 -1.697 l 5.521 -5.093 l 5.521 -3.395 l 0 -3.395 l 0 0 l h S Q 0.99 0.914 0.17 scn q 1 0 0 1 207.3286 633.6865 cm 0 0 m 8.796 0 l 8.796 1.698 l 9.684 -1.697 l 8.796 -5.093 l 8.796 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 207.3286 633.6865 cm 0 0 m 8.796 0 l 8.796 1.698 l 9.684 -1.697 l 8.796 -5.093 l 8.796 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 207.335 633.6807 cm 0 0 m 8.8 0 l 8.8 1.698 l 9.686 -1.697 l 8.8 -5.093 l 8.8 -3.395 l 0 -3.395 l 0 0 l h S Q q 1 0 0 1 219.1968 633.6865 cm 0 0 m 9.892 0 l 9.892 1.698 l 10.776 -1.697 l 9.892 -5.093 l 9.892 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 219.1968 633.6865 cm 0 0 m 9.892 0 l 9.892 1.698 l 10.776 -1.697 l 9.892 -5.093 l 9.892 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 219.2041 633.6807 cm 0 0 m 9.892 0 l 9.892 1.698 l 10.778 -1.697 l 9.892 -5.093 l 9.892 -3.395 l 0 -3.395 l 0 0 l h S Q q 1 0 0 1 229.8848 633.6865 cm 0 0 m 8.857 0 l 8.857 1.698 l 9.741 -1.697 l 8.857 -5.093 l 8.857 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 229.8848 633.6865 cm 0 0 m 8.857 0 l 8.857 1.698 l 9.741 -1.697 l 8.857 -5.093 l 8.857 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 229.8945 633.6807 cm 0 0 m 8.855 0 l 8.855 1.698 l 9.743 -1.697 l 8.855 -5.093 l 8.855 -3.395 l 0 -3.395 l 0 0 l h S Q q 1 0 0 1 239.3911 633.6865 cm 0 0 m 15.943 0 l 15.943 1.698 l 16.828 -1.697 l 15.943 -5.093 l 15.943 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 239.3911 633.6865 cm 0 0 m 15.943 0 l 15.943 1.698 l 16.828 -1.697 l 15.943 -5.093 l 15.943 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 239.4009 633.6807 cm 0 0 m 15.943 0 l 15.943 1.698 l 16.828 -1.697 l 15.943 -5.093 l 15.943 -3.395 l 0 -3.395 l 0 0 l h S Q 1 1 1 scn q 1 0 0 1 260.8848 633.6865 cm 0 0 m 12.901 0 l 12.901 1.698 l 13.788 -1.697 l 12.901 -5.093 l 12.901 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 260.8848 633.6865 cm 0 0 m 12.901 0 l 12.901 1.698 l 13.788 -1.697 l 12.901 -5.093 l 12.901 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 260.8945 633.6807 cm 0 0 m 12.902 0 l 12.902 1.698 l 13.788 -1.697 l 12.902 -5.093 l 12.902 -3.395 l 0 -3.395 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 281.6689 633.6865 cm 0 0 m 2.657 0 l 2.657 1.698 l 2.923 -1.697 l 2.657 -5.093 l 2.657 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 281.6689 633.6865 cm 0 0 m 2.657 0 l 2.657 1.698 l 2.923 -1.697 l 2.657 -5.093 l 2.657 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 281.6807 633.6807 cm 0 0 m 2.658 0 l 2.658 1.698 l 2.921 -1.697 l 2.658 -5.093 l 2.658 -3.395 l 0 -3.395 l 0 0 l h S Q 0.137 0.123 0.126 scn q 1 0 0 1 284.6211 633.6865 cm 0 0 m 5.313 0 l 5.313 1.698 l 5.904 -1.697 l 5.313 -5.093 l 5.313 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 284.6211 633.6865 cm 0 0 m 5.313 0 l 5.313 1.698 l 5.904 -1.697 l 5.313 -5.093 l 5.313 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 284.6328 633.6807 cm 0 0 m 5.315 0 l 5.315 1.698 l 5.903 -1.697 l 5.315 -5.093 l 5.315 -3.395 l 0 -3.395 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 299.1167 633.6865 cm 0 0 m -7.706 0 l -7.706 1.698 l -8.561 -1.697 l -7.706 -5.093 l -7.706 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 299.1167 633.6865 cm 0 0 m -7.706 0 l -7.706 1.698 l -8.561 -1.697 l -7.706 -5.093 l -7.706 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 299.1284 633.6807 cm 0 0 m -7.705 0 l -7.705 1.698 l -8.561 -1.697 l -7.705 -5.093 l -7.705 -3.395 l 0 -3.395 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 301.417 633.6865 cm 0 0 m -2.093 0 l -2.093 1.698 l -2.3 -1.697 l -2.093 -5.093 l -2.093 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 301.417 633.6865 cm 0 0 m -2.093 0 l -2.093 1.698 l -2.3 -1.697 l -2.093 -5.093 l -2.093 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 301.4326 633.6807 cm 0 0 m 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-7.173 0 l -7.173 1.698 l -7.971 -1.697 l -7.173 -5.093 l -7.173 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 349.9131 633.6807 cm 0 0 m -7.177 0 l -7.177 1.698 l -7.974 -1.697 l -7.177 -5.093 l -7.177 -3.395 l 0 -3.395 l 0 0 l h S Q 0.969 0.719 0.828 scn q 1 0 0 1 350.6931 631.8198 cm 0 0 m 0.061 -3.227 l 0.061 -1.529 l 0.8 -2.038 l 0.8 2.038 l 0.8 1.867 l 0.061 1.867 l 0.061 4.074 l h f Q 4 M q 1 0 0 1 351.4932 633.6865 cm 0 0 m -0.739 0 l -0.739 2.208 l -0.8 -1.867 l -0.739 -5.093 l -0.739 -3.396 l 0 -3.905 l 0 0.171 l S Q q 1 0 0 1 350.7093 631.8144 cm 0 0 m 0.059 -3.227 l 0.059 -1.529 l 0.798 -2.039 l 0.798 2.035 l 0.059 1.867 l 0.059 4.073 l h f Q 10 M q 1 0 0 1 351.5078 633.8496 cm 0 0 m -0.739 -0.169 l -0.739 2.038 l -0.799 -2.035 l -0.739 -5.262 l -0.739 -3.564 l 0 -4.074 l 0 0 l h S Q 0.501 0.764 0.267 scn q 1 0 0 1 376.4072 633.6865 cm 0 0 m -23.353 0 l -23.353 1.698 l -24.236 -1.697 l -23.353 -5.093 l -23.353 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 376.4072 633.6865 cm 0 0 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0 1 117.6392 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 129.0942 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 128.2676 623.1265 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 128.2676 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 139.7231 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 138.8975 623.1265 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 138.8975 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 150.3535 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 149.5244 623.1265 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 149.5244 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 160.9805 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 160.1548 623.1265 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 160.1548 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 171.6104 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 170.7837 623.1265 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 170.7837 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 182.2397 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 181.4131 623.1265 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 181.4131 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 192.8687 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 192.042 623.1265 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 192.042 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 203.4971 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 202.6709 623.1265 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 202.6709 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 214.127 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 213.3003 623.1265 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 213.3003 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 224.7559 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 223.9292 623.1265 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 223.9292 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 235.3853 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 234.5586 623.1265 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 234.5586 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 246.0132 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 245.1865 623.1265 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 245.1865 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 256.6436 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 255.8154 623.1265 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 255.8154 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 267.2725 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 266.4458 623.1265 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 266.4458 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 277.9004 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 277.0747 623.1265 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 277.0747 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 288.5308 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 287.7017 623.1265 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 287.7017 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 299.1597 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 298.332 623.1265 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 298.332 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 309.7881 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 308.9609 623.1265 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 308.9609 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 320.417 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 319.5898 623.1265 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 319.5898 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 331.0459 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 330.2197 623.1265 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 330.2197 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 341.6738 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 340.8486 623.1265 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 340.8486 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 352.3027 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 351.4775 623.1265 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 351.4775 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 362.9336 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 362.1055 623.1265 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 362.1055 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 373.5605 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 372.7354 623.1265 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 372.7354 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 384.1914 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 383.3623 623.1265 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 383.3623 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 394.8203 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 393.9951 623.1265 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 393.9951 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 405.4502 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 404.623 623.1265 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 404.623 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 416.0801 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 415.249 623.1265 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 415.249 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 426.7061 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 425.8799 623.1265 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 425.8799 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 437.3359 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 436.5088 623.1265 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 436.5088 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 447.9658 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 447.1387 623.1265 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 447.1387 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 458.5947 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 457.7686 623.1265 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 457.7686 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 469.2227 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 468.3965 623.1265 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 468.3965 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 479.8516 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 479.0254 623.1265 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 479.0254 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 490.4814 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 489.6543 623.1265 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 489.6543 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 501.1104 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 500.2852 623.1265 cm 0 0 m 11.275 0 l S Q q 1 0 0 1 500.2852 623.8638 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 510.9131 623.1265 cm 0 0 m 0.647 0 l S Q q 1 0 0 1 510.9131 623.8638 cm 0 0 m 0 -1.476 l S Q BT 0.137 0.123 0.126 scn /TT0 1 Tf 5.2485 0 0 5.2485 515.0791 627.5605 Tm (160 kb)Tj 4.4285 0 0 4.4285 528.0029 627.5605 Tm ( )Tj 3.9365 0 0 3.9365 101.2529 634.1855 Tm (0089 )Tj 0 3.9365 -3.9365 0 120.1709 634.1855 Tm (0923 )Tj 3.9365 0 0 3.9365 135.8252 634.1855 Tm (0092 )Tj 0 3.9365 -3.9365 0 158.9707 634.1855 Tm (0093 )Tj 0 -1.681 Td (0094 )Tj 3.9365 0 0 3.9365 181.0371 634.1855 Tm (0095 )Tj 0 3.9365 -3.9365 0 204.79 634.5635 Tm (0096 )Tj 3.9365 0 0 3.9365 208.2734 634.1855 Tm (0097 )Tj 3.237 0 Td (0098 )Tj 2.356 0 Td (0099 )Tj 3.46 0 Td (0100 )Tj 5.185 0 Td (0101 )Tj 0 3.9365 -3.9365 0 283.8242 634.1855 Tm (0102 )Tj 0 -1.216 TD (0103 )Tj 0 -1.959 TD (0104 )Tj 0 -1.434 TD (0105 )Tj 3.9365 0 0 3.9365 305.0439 634.1855 Tm (0106 )Tj 0 3.9365 -3.9365 0 320.1143 634.1855 Tm (0107 )Tj 3.9365 0 0 3.9365 323.5498 634.1855 Tm (0108 )Tj 2.712 0 Td (0109 )Tj 0 3.9365 -3.9365 0 347.0703 634.1855 Tm (0110 )Tj 2.3195 2.3195 -2.3195 2.3195 350.7681 634.1734 Tm (tRNA-lys )Tj 3.9365 0 0 3.9365 361.5918 634.1855 Tm (0112 )Tj 5.348 0 Td (0113 )Tj 3.28 0 Td (0114 )Tj 3.723 0 Td (0115 )Tj 0 3.9365 -3.9365 0 424.0107 634.1855 Tm (0116 )Tj 3.9365 0 0 3.9365 425.4512 634.1855 Tm (0117 )Tj 3.062 0 Td (0118 )Tj 3.643 0 Td (0119 )Tj 2.853 0 Td (0120 )Tj 4.359 0 Td (0121 )Tj 3.438 0 Td (0122 )Tj 2.912 0 Td (0123 )Tj -103.487 -2.658 Td (934 )Tj 2.7 0 Td (935 )Tj 2.7 0 Td (940f )Tj 2.7 0 Td (941 )Tj 2.7 0 Td (942 )Tj 2.7 0 Td (943 )Tj 2.7 0 Td (944 )Tj 2.701 0 Td (945 )Tj 2.7 0 Td (946 )Tj 2.7 0 Td (947 )Tj 2.699 0 Td (948 )Tj 2.7 0 Td (949 )Tj 2.7 0 Td (950 )Tj 2.7 0 Td (951 )Tj 2.7 0 Td (952 )Tj 2.7 0 Td (953 )Tj 2.7 0 Td (954 )Tj 2.699 0 Td (955 )Tj 2.7 0 Td (956 )Tj 2.7 0 Td (957 )Tj 2.7 0 Td (958 )Tj 2.7 0 Td (959 )Tj 2.7 0 Td (960 )Tj 2.7 0 Td (961 )Tj 2.7 0 Td (962 )Tj 2.7 0 Td (963 )Tj 2.7 0 Td (964 )Tj 2.7 0 Td (965 )Tj 2.7 0 Td (966 )Tj 2.7 0 Td (967 )Tj 2.7 0 Td (968 )Tj 2.7 0 Td (969 )Tj 2.7 0 Td (970 )Tj 2.7 0 Td (971 )Tj 2.7 0 Td (972 )Tj 2.7 0 Td (973 )Tj 2.7 0 Td (974 )Tj 2.7 0 Td (975 )Tj 2.7 0 Td (976 )Tj -105.308 0 Td (933 )Tj 2.282 0 0 2.6243 219.6738 631.2354 Tm (mmyCVIM1)Tj 4.6 -0.061 Td [(m)50(m)50(y)50(C)50(V)50(I)50(M)50(2)]TJ /TT2 1 Tf 2.8525 0 0 3.2804 241.0059 630.8579 Tm (mmyCVIR)Tj ET 0.23 w 4 M 218.232 638.713 37.397 1.64 re S 1 1 1 scn 250.693 637.484 -27.527 4.1 re f BT 0.137 0.123 0.126 scn /TT2 1 Tf 2.8525 0 0 3.2804 224.7344 638.4272 Tm [(T)50(y)50(p)50(e)50( )50(I)50(I)50( )50(R)50(/)50(M)50( )50(-)50( )50(C)50(C)50(A)50(T)50(C)]TJ 1 1 1 scn 20.868 -2.321 Td [(c)50(o)50(a)50(E)]TJ 2.791 0.058 Td [(r)-25(r)-25(m)-25(J)]TJ 0.137 0.123 0.126 scn 4.742 -0.017 Td [(x)-25(s)-25(e)-25(A)-25( )]TJ /TT0 1 Tf 2.282 0 0 2.6243 316.5742 631.1699 Tm [(n)25(u)25(s)25(B)]TJ 1 1 1 scn /TT2 1 Tf 2.8525 0 0 3.2804 426.3574 630.9507 Tm (plsY)Tj 13.518 -0.076 Td [(i)-25(l)-25(v)-25(A)-25( )]TJ ET 0.262 w 10 M q 1 0 0 1 86.3999 623.8623 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 86.3999 607.9565 cm 0 0 m 425.161 0 l S Q 0 0.65 0.316 scn 4 M q 1 0 0 1 86.3999 614.0889 cm 0 0 m 1.447 0 l 1.447 1.698 l 1.595 -1.698 l 1.447 -5.093 l 1.447 -3.394 l 0 -3.394 l B* Q 10 M q 1 0 0 1 86.3999 614.0825 cm 0 0 m 1.449 0 l 1.449 1.697 l 1.595 -1.697 l 1.449 -5.093 l 1.449 -3.396 l 0 -3.396 l S Q 0.716 0.434 0.681 scn q 1 0 0 1 92.2461 614.0889 cm 0 0 m 13.256 0 l 13.256 1.698 l 14.142 -1.698 l 13.256 -5.093 l 13.256 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 92.2461 614.0889 cm 0 0 m 13.256 0 l 13.256 1.698 l 14.142 -1.698 l 13.256 -5.093 l 13.256 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 92.2471 614.0825 cm 0 0 m 13.257 0 l 13.257 1.697 l 14.143 -1.697 l 13.257 -5.093 l 13.257 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 110.1074 614.0889 cm 0 0 m 17.212 0 l 17.212 1.698 l 18.099 -1.698 l 17.212 -5.093 l 17.212 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 110.1074 614.0889 cm 0 0 m 17.212 0 l 17.212 1.698 l 18.099 -1.698 l 17.212 -5.093 l 17.212 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 110.1099 614.0825 cm 0 0 m 17.214 0 l 17.214 1.697 l 18.098 -1.697 l 17.214 -5.093 l 17.214 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 129.6245 614.0889 cm 0 0 m 14.525 0 l 14.525 1.698 l 15.41 -1.698 l 14.525 -5.093 l 14.525 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 129.6245 614.0889 cm 0 0 m 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l 8.592 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 194.1899 614.0889 cm 0 0 m 8.592 0 l 8.592 1.698 l 9.477 -1.698 l 8.592 -5.093 l 8.592 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 194.1963 614.0825 cm 0 0 m 8.593 0 l 8.593 1.697 l 9.479 -1.697 l 8.593 -5.093 l 8.593 -3.396 l 0 -3.396 l 0 0 l h S Q 1 1 1 scn q 1 0 0 1 205.2617 614.0889 cm 0 0 m 10.392 0 l 10.392 1.698 l 11.277 -1.698 l 10.392 -5.093 l 10.392 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 205.2617 614.0889 cm 0 0 m 10.392 0 l 10.392 1.698 l 11.277 -1.698 l 10.392 -5.093 l 10.392 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 205.2681 614.0825 cm 0 0 m 10.394 0 l 10.394 1.697 l 11.281 -1.697 l 10.394 -5.093 l 10.394 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 216.4814 614.0889 cm 0 0 m 23.264 0 l 23.264 1.698 l 24.151 -1.698 l 23.264 -5.093 l 23.264 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 216.4814 614.0889 cm 0 0 m 23.264 0 l 23.264 1.698 l 24.151 -1.698 l 23.264 -5.093 l 23.264 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 216.4888 614.0825 cm 0 0 m 23.266 0 l 23.266 1.697 l 24.151 -1.697 l 23.266 -5.093 l 23.266 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 257.5771 614.0889 cm 0 0 m -14.938 0 l -14.938 1.698 l -15.824 -1.698 l -14.938 -5.093 l -14.938 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 257.5771 614.0889 cm 0 0 m -14.938 0 l -14.938 1.698 l -15.824 -1.698 l -14.938 -5.093 l -14.938 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 257.5879 614.0825 cm 0 0 m -14.941 0 l -14.941 1.697 l -15.826 -1.697 l -14.941 -5.093 l -14.941 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 262.4199 614.0889 cm 0 0 m -1.093 0 l -1.093 1.698 l -1.211 -1.698 l -1.093 -5.093 l -1.093 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 262.4199 614.0889 cm 0 0 m -1.093 0 l -1.093 1.698 l -1.211 -1.698 l -1.093 -5.093 l -1.093 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 262.4307 614.0825 cm 0 0 m -1.094 0 l -1.094 1.697 l -1.211 -1.697 l -1.094 -5.093 l -1.094 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.534 0.806 scn q 1 0 0 1 263.895 614.0889 cm 0 0 m 6.761 0 l 6.761 1.698 l 7.5 -1.698 l 6.761 -5.093 l 6.761 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 263.895 614.0889 cm 0 0 m 6.761 0 l 6.761 1.698 l 7.5 -1.698 l 6.761 -5.093 l 6.761 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 263.9058 614.0825 cm 0 0 m 6.761 0 l 6.761 1.697 l 7.499 -1.697 l 6.761 -5.093 l 6.761 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 273.0776 614.0889 cm 0 0 m 2.656 0 l 2.656 1.698 l 2.951 -1.698 l 2.656 -5.093 l 2.656 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 273.0776 614.0889 cm 0 0 m 2.656 0 l 2.656 1.698 l 2.951 -1.698 l 2.656 -5.093 l 2.656 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 273.0889 614.0825 cm 0 0 m 2.657 0 l 2.657 1.697 l 2.952 -1.697 l 2.657 -5.093 l 2.657 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 276.8267 614.0889 cm 0 0 m 19.277 0 l 19.277 1.698 l 20.165 -1.698 l 19.277 -5.093 l 19.277 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 276.8267 614.0889 cm 0 0 m 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6.053 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 313.9355 614.0889 cm 0 0 m 10.748 0 l 10.748 1.698 l 11.633 -1.698 l 10.748 -5.093 l 10.748 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 313.9355 614.0889 cm 0 0 m 10.748 0 l 10.748 1.698 l 11.633 -1.698 l 10.748 -5.093 l 10.748 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 313.9502 614.0825 cm 0 0 m 10.746 0 l 10.746 1.697 l 11.633 -1.697 l 10.746 -5.093 l 10.746 -3.396 l 0 -3.396 l 0 0 l h S Q 0.501 0.764 0.267 scn q 1 0 0 1 325.4795 614.0889 cm 0 0 m 8.121 0 l 8.121 1.698 l 9.007 -1.698 l 8.121 -5.093 l 8.121 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 325.4795 614.0889 cm 0 0 m 8.121 0 l 8.121 1.698 l 9.007 -1.698 l 8.121 -5.093 l 8.121 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 325.4941 614.0825 cm 0 0 m 8.12 0 l 8.12 1.697 l 9.007 -1.697 l 8.12 -5.093 l 8.12 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 334.6016 614.0889 cm 0 0 m 14.763 0 l 14.763 1.698 l 15.65 -1.698 l 14.763 -5.093 l 14.763 -3.394 l 0 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0 0 m 11.456 0 l S Q q 1 0 0 1 170.7837 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 182.2397 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 181.4131 603.5269 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 181.4131 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 192.8687 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 192.042 603.5269 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 192.042 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 203.4971 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 202.6709 603.5269 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 202.6709 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 214.127 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 213.3003 603.5269 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 213.3003 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 224.7559 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 223.9292 603.5269 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 223.9292 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 235.3853 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 234.5586 603.5269 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 234.5586 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 246.0132 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 245.1865 603.5269 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 245.1865 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 256.6436 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 255.8154 603.5269 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 255.8154 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 267.2725 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 266.4458 603.5269 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 266.4458 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 277.9004 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 277.0747 603.5269 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 277.0747 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 288.5308 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 287.7017 603.5269 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 287.7017 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 299.1597 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 298.332 603.5269 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 298.332 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 309.7881 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 308.9609 603.5269 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 308.9609 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 320.417 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 319.5898 603.5269 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 319.5898 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 331.0459 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 330.2197 603.5269 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 330.2197 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 341.6738 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 340.8486 603.5269 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 340.8486 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 352.3027 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 351.4775 603.5269 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 351.4775 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 362.9336 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 362.1055 603.5269 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 362.1055 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 373.5605 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 372.7354 603.5269 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 372.7354 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 384.1914 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 383.3623 603.5269 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 383.3623 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 394.8203 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 393.9951 603.5269 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 393.9951 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 405.4502 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 404.623 603.5269 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 404.623 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 416.0801 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 415.249 603.5269 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 415.249 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 426.7061 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 425.8799 603.5269 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 425.8799 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 437.3359 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 436.5088 603.5269 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 436.5088 604.2646 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 447.9658 604.2646 cm 0 0 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S Q BT 0.137 0.123 0.126 scn /TT0 1 Tf 5.2485 0 0 5.2485 515.0791 607.9634 Tm (200 kb )Tj 3.9365 0 0 3.9365 93.9072 614.5044 Tm (0124 )Tj 5.611 0 Td (0125 )Tj 4.421 0 Td (0126 )Tj 3.535 0.069 Td (0127 )Tj 0 3.9365 -3.9365 0 161.6982 614.7759 Tm (0128 )Tj 3.9365 0 0 3.9365 167.8623 614.7759 Tm (0129 )Tj 3.891 0 Td (0130 )Tj 3.038 0 Td (0131 )Tj 2.857 0 Td (0132 )Tj 4.757 0 Td (0133 )Tj 5.49 0 Td (0134 )Tj 0 3.9365 -3.9365 0 263.2158 614.7759 Tm (0135 )Tj 0 -1.465 TD (0136 )Tj 0 -1.787 TD (0137 )Tj 3.9365 0 0 3.9365 282.4238 614.7759 Tm (0138 )Tj 3.985 0 Td (0139 )Tj 0 3.9365 -3.9365 0 311.6348 614.7759 Tm (0140 )Tj 3.9365 0 0 3.9365 315.6572 614.7759 Tm (0141 )Tj 2.624 0 Td (0142 )Tj 2.923 0 Td (0143 )Tj 0 3.9365 -3.9365 0 353.7051 614.7759 Tm (0144 )Tj 3.9365 0 0 3.9365 357.4297 614.7759 Tm (0145 )Tj 2.798 0 Td (0146 )Tj 3.042 0 Td (0147 )Tj 0 3.9365 -3.9365 0 397.7461 614.5894 Tm (0148 )Tj 0 -1.325 TD (0149 )Tj 3.9365 0 0 3.9365 412.5732 614.7759 Tm (0150 )Tj 4.62 0 Td (0151 )Tj 4.47 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l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 175.5669 552.2671 cm 0 0 m 13.611 0 l 13.611 1.697 l 14.497 -1.699 l 13.611 -5.094 l 13.611 -3.397 l 0 -3.397 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 190.0889 552.2783 cm 0 0 m 9.77 0 l 9.77 1.696 l 10.656 -1.698 l 9.77 -5.093 l 9.77 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 190.0889 552.2783 cm 0 0 m 9.77 0 l 9.77 1.696 l 10.656 -1.698 l 9.77 -5.093 l 9.77 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 190.0933 552.2671 cm 0 0 m 9.774 0 l 9.774 1.697 l 10.659 -1.699 l 9.774 -5.094 l 9.774 -3.397 l 0 -3.397 l 0 0 l h S Q 0.503 0.51 0.52 scn q 1 0 0 1 201.2178 552.2783 cm 0 0 m 10.954 0 l 10.954 1.696 l 11.838 -1.698 l 10.954 -5.093 l 10.954 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 201.2178 552.2783 cm 0 0 m 10.954 0 l 10.954 1.696 l 11.838 -1.698 l 10.954 -5.093 l 10.954 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 201.2241 552.2671 cm 0 0 m 10.955 0 l 10.955 1.697 l 11.839 -1.699 l 10.955 -5.094 l 10.955 -3.397 l 0 -3.397 l 0 0 l h S Q q 1 0 0 1 213.0562 552.2783 cm 0 0 m 9.625 0 l 9.625 1.696 l 10.51 -1.698 l 9.625 -5.093 l 9.625 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 213.0562 552.2783 cm 0 0 m 9.625 0 l 9.625 1.696 l 10.51 -1.698 l 9.625 -5.093 l 9.625 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 213.0635 552.2671 cm 0 0 m 9.626 0 l 9.626 1.697 l 10.512 -1.699 l 9.626 -5.094 l 9.626 -3.397 l 0 -3.397 l 0 0 l h S Q q 1 0 0 1 223.8618 552.2783 cm 0 0 m 13.195 0 l 13.195 1.696 l 14.083 -1.698 l 13.195 -5.093 l 13.195 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 223.8618 552.2783 cm 0 0 m 13.195 0 l 13.195 1.696 l 14.083 -1.698 l 13.195 -5.093 l 13.195 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 223.8701 552.2671 cm 0 0 m 13.196 0 l 13.196 1.697 l 14.083 -1.699 l 13.196 -5.094 l 13.196 -3.397 l 0 -3.397 l 0 0 l h S Q q 1 0 0 1 238.1504 552.2783 cm 0 0 m 19.19 0 l 19.19 1.696 l 20.078 -1.698 l 19.19 -5.093 l 19.19 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 238.1504 552.2783 cm 0 0 m 19.19 0 l 19.19 1.696 l 20.078 -1.698 l 19.19 -5.093 l 19.19 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 238.1602 552.2671 cm 0 0 m 19.191 0 l 19.191 1.697 l 20.077 -1.699 l 19.191 -5.094 l 19.191 -3.397 l 0 -3.397 l 0 0 l h S Q 0.919 0.152 0.567 scn q 1 0 0 1 258.4634 552.2783 cm 0 0 m 9.389 0 l 9.389 1.696 l 10.273 -1.698 l 9.389 -5.093 l 9.389 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 258.4634 552.2783 cm 0 0 m 9.389 0 l 9.389 1.696 l 10.273 -1.698 l 9.389 -5.093 l 9.389 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 258.4741 552.2671 cm 0 0 m 9.389 0 l 9.389 1.697 l 10.274 -1.699 l 9.389 -5.094 l 9.389 -3.397 l 0 -3.397 l 0 0 l h S Q 0.503 0.51 0.52 scn q 1 0 0 1 268.8848 552.2783 cm 0 0 m 11.662 0 l 11.662 1.696 l 12.548 -1.698 l 11.662 -5.093 l 11.662 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 268.8848 552.2783 cm 0 0 m 11.662 0 l 11.662 1.696 l 12.548 -1.698 l 11.662 -5.093 l 11.662 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 268.896 552.2671 cm 0 0 m 11.663 0 l 11.663 1.697 l 12.548 -1.699 l 11.663 -5.094 l 11.663 -3.397 l 0 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0 Td (26 )Tj 2.7 0 Td (27 )Tj 2.7 0 Td (28 )Tj 2.7 0 Td (29 )Tj 2.7 0 Td (30 )Tj 2.7 0 Td (31 )Tj 2.7 0 Td (32 )Tj 2.7 0 Td (33 )Tj 2.701 0 Td (34 )Tj 2.7 0 Td (35 )Tj -105.689 0 Td (1097 )Tj 0 3.9365 -3.9365 0 306.5215 552.7954 Tm (0232 )Tj 0 -8.755 TD (0236 )Tj 0 -1.39 TD (0237 )Tj 1 1 1 scn /TT2 1 Tf 3.2804 0 0 3.2804 93.2363 549.7056 Tm [(g)-25(l)-25(p)-25(K)]TJ 8.667 -0.067 Td (pfkA)Tj 4.383 0.017 Td (pyk)Tj 6.284 -0.117 Td [(t)-25(h)-25(r)-25(S)]TJ 13.908 0.058 Td [(p)-25(d)-25(h)-25(A)]TJ 3.425 0 Td [(p)-25(d)-25(h)-25(B)]TJ 3.825 0.05 Td [(p)-25(d)-25(h)-25(C)]TJ 5.275 0 Td [(l)-25(p)-25(d)-25(A)]TJ 5.376 0.1 Td [(p)-25(t)-25(a)]TJ 3.15 -0.1 Td [(a)-25(c)-25(k)-25(A)]TJ /TT0 1 Tf 2.6243 0 0 2.6243 302.8242 549.6782 Tm [(c)25(o)25(a)25(D)]TJ 3.2804 0 0 3.2804 314.7148 549.5952 Tm [(p)-50(t)-50(s)-50(P)]TJ 6.7 -0.049 Td (dhaL)Tj 3.575 0 Td (rpsD)Tj /TT2 1 Tf 9.6 0 Td [(t)-25(h)-25(i)-25(L)]TJ ET q 1 0 0 1 86.3999 525.6719 cm 0 0 m 425.163 0 l S Q 0.716 0.434 0.681 scn 4 M 86.4 528.639 26.986 2.951 re B* 10 M q 1 0 0 1 86.3999 528.625 cm 0 0 m 26.988 0 l 26.988 2.953 l 0 2.953 l S Q 0 0.677 0.647 scn q 1 0 0 1 119.7324 531.813 cm 0 0 m -5.64 0 l -5.64 1.697 l -6.259 -1.699 l -5.64 -5.094 l -5.64 -3.396 l 0 -3.396 l h f* Q 0.281 w 4 M q 1 0 0 1 119.7324 531.813 cm 0 0 m -5.64 0 l -5.64 1.697 l -6.259 -1.699 l -5.64 -5.094 l -5.64 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 119.7349 531.7993 cm 0 0 m -5.639 0 l -5.639 1.697 l -6.259 -1.699 l -5.639 -5.094 l -5.639 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 125.6362 531.813 cm 0 0 m -5.373 0 l -5.373 1.697 l -5.962 -1.699 l -5.373 -5.094 l -5.373 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 125.6362 531.813 cm 0 0 m -5.373 0 l -5.373 1.697 l -5.962 -1.699 l -5.373 -5.094 l -5.373 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 125.6396 531.7993 cm 0 0 m -5.373 0 l -5.373 1.697 l -5.963 -1.699 l -5.373 -5.094 l -5.373 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 131.7788 531.813 cm 0 0 m -5.55 0 l 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M q 1 0 0 1 140.019 531.7993 cm 0 0 m 6.642 0 l 6.642 1.697 l 7.35 -1.699 l 6.642 -5.094 l 6.642 -3.396 l 0 -3.396 l 0 0 l h S Q 0.919 0.152 0.567 scn q 1 0 0 1 155.043 531.813 cm 0 0 m -6.909 0 l -6.909 1.697 l -7.646 -1.699 l -6.909 -5.094 l -6.909 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 155.043 531.813 cm 0 0 m -6.909 0 l -6.909 1.697 l -7.646 -1.699 l -6.909 -5.094 l -6.909 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 155.0469 531.7993 cm 0 0 m -6.909 0 l -6.909 1.697 l -7.646 -1.699 l -6.909 -5.094 l -6.909 -3.396 l 0 -3.396 l 0 0 l h S Q 0.524 0.135 0.083 scn q 1 0 0 1 160.5645 531.813 cm 0 0 m -4.517 0 l -4.517 1.697 l -5.019 -1.699 l -4.517 -5.094 l -4.517 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 160.5645 531.813 cm 0 0 m -4.517 0 l -4.517 1.697 l -5.019 -1.699 l -4.517 -5.094 l -4.517 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 160.5674 531.7993 cm 0 0 m -4.516 0 l -4.516 1.697 l -5.019 -1.699 l -4.516 -5.094 l -4.516 -3.396 l 0 -3.396 l 0 0 l h S Q 0.99 0.914 0.17 scn q 1 0 0 1 180.5205 531.813 cm 0 0 m -17.772 0 l -17.772 1.697 l -18.657 -1.699 l -17.772 -5.094 l -17.772 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 180.5205 531.813 cm 0 0 m -17.772 0 l -17.772 1.697 l -18.657 -1.699 l -17.772 -5.094 l -17.772 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 180.5278 531.7993 cm 0 0 m -17.775 0 l -17.775 1.697 l -18.659 -1.699 l -17.775 -5.094 l -17.775 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 191.8877 531.813 cm 0 0 m -10.392 0 l -10.392 1.697 l -11.277 -1.699 l -10.392 -5.094 l -10.392 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 191.8877 531.813 cm 0 0 m -10.392 0 l -10.392 1.697 l -11.277 -1.699 l -10.392 -5.094 l -10.392 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 191.896 531.7993 cm 0 0 m -10.395 0 l -10.395 1.697 l -11.28 -1.699 l -10.395 -5.094 l -10.395 -3.396 l 0 -3.396 l 0 0 l h S Q 0.716 0.434 0.681 scn q 1 0 0 1 209.8379 531.813 cm 0 0 m -16.356 0 l -16.356 1.697 l -17.24 -1.699 l -16.356 -5.094 l -16.356 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 209.8379 531.813 cm 0 0 m -16.356 0 l -16.356 1.697 l -17.24 -1.699 l -16.356 -5.094 l -16.356 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 209.8457 531.7993 cm 0 0 m -16.358 0 l -16.358 1.697 l -17.243 -1.699 l -16.358 -5.094 l -16.358 -3.396 l 0 -3.396 l 0 0 l h S Q 0.919 0.152 0.567 scn q 1 0 0 1 229.5596 531.813 cm 0 0 m -17.714 0 l -17.714 1.697 l -18.599 -1.699 l -17.714 -5.094 l -17.714 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 229.5596 531.813 cm 0 0 m -17.714 0 l -17.714 1.697 l -18.599 -1.699 l -17.714 -5.094 l -17.714 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 229.5679 531.7993 cm 0 0 m -17.713 0 l -17.713 1.697 l -18.601 -1.699 l -17.713 -5.094 l -17.713 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 238.5645 531.813 cm 0 0 m -6.908 0 l -6.908 1.697 l -7.648 -1.699 l -6.908 -5.094 l -6.908 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 238.5645 531.813 cm 0 0 m -6.908 0 l -6.908 1.697 l -7.648 -1.699 l -6.908 -5.094 l -6.908 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 238.5737 531.7993 cm 0 0 m -6.908 0 l -6.908 1.697 l -7.647 -1.699 l -6.908 -5.094 l -6.908 -3.396 l 0 -3.396 l 0 0 l h S Q 0.137 0.123 0.126 scn q 1 0 0 1 247.1558 531.813 cm 0 0 m -7.647 0 l -7.647 1.697 l -8.474 -1.699 l -7.647 -5.094 l -7.647 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 247.1558 531.813 cm 0 0 m -7.647 0 l -7.647 1.697 l -8.474 -1.699 l -7.647 -5.094 l -7.647 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 247.1665 531.7993 cm 0 0 m -7.648 0 l -7.648 1.697 l -8.476 -1.699 l -7.648 -5.094 l -7.648 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 276.1484 531.813 cm 0 0 m -26.926 0 l -26.926 1.697 l -27.812 -1.699 l -26.926 -5.094 l -26.926 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 276.1484 531.813 cm 0 0 m -26.926 0 l -26.926 1.697 l -27.812 -1.699 l -26.926 -5.094 l -26.926 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 276.1616 531.7993 cm 0 0 m -26.93 0 l -26.93 1.697 l -27.814 -1.699 l -26.93 -5.094 l -26.93 -3.396 l 0 -3.396 l 0 0 l h S Q 0.137 0.123 0.126 scn q 1 0 0 1 283.7349 531.813 cm 0 0 m -5.992 0 l -5.992 1.697 l -6.642 -1.699 l -5.992 -5.094 l -5.992 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 283.7349 531.813 cm 0 0 m -5.992 0 l -5.992 1.697 l -6.642 -1.699 l -5.992 -5.094 l -5.992 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 283.7485 531.7993 cm 0 0 m -5.996 0 l -5.996 1.697 l -6.645 -1.699 l -5.996 -5.094 l -5.996 -3.396 l 0 -3.396 l 0 0 l h S Q 0.503 0.51 0.52 scn q 1 0 0 1 290.8218 531.813 cm 0 0 m -6.495 0 l -6.495 1.697 l -7.204 -1.699 l -6.495 -5.094 l -6.495 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 290.8218 531.813 cm 0 0 m -6.495 0 l -6.495 1.697 l -7.204 -1.699 l -6.495 -5.094 l -6.495 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 290.8335 531.7993 cm 0 0 m -6.495 0 l -6.495 1.697 l -7.204 -1.699 l -6.495 -5.094 l -6.495 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 300.4473 531.813 cm 0 0 m -8.711 0 l -8.711 1.697 l -9.597 -1.699 l -8.711 -5.094 l -8.711 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 300.4473 531.813 cm 0 0 m -8.711 0 l -8.711 1.697 l -9.597 -1.699 l -8.711 -5.094 l -8.711 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 300.459 531.7993 cm 0 0 m -8.709 0 l -8.709 1.697 l -9.595 -1.699 l -8.709 -5.094 l -8.709 -3.396 l 0 -3.396 l 0 0 l h S Q 1 1 1 scn q 1 0 0 1 312.4023 531.813 cm 0 0 m -10.983 0 l -10.983 1.697 l -11.869 -1.699 l -10.983 -5.094 l -10.983 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 312.4023 531.813 cm 0 0 m -10.983 0 l -10.983 1.697 l -11.869 -1.699 l -10.983 -5.094 l -10.983 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 312.415 531.7993 cm 0 0 m -10.982 0 l -10.982 1.697 l -11.868 -1.699 l -10.982 -5.094 l -10.982 -3.396 l 0 -3.396 l 0 0 l h S Q 0.555 0.846 0.972 scn q 1 0 0 1 320.4336 531.813 cm 0 0 m -7.233 0 l -7.233 1.697 l -8.031 -1.699 l -7.233 -5.094 l -7.233 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 320.4336 531.813 cm 0 0 m -7.233 0 l -7.233 1.697 l -8.031 -1.699 l -7.233 -5.094 l -7.233 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 320.4473 531.7993 cm 0 0 m 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521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 129.3306 521.2432 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 129.3306 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 140.7866 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 139.959 521.2432 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 139.959 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 151.4146 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 150.5889 521.2432 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 150.5889 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 162.0439 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 161.2178 521.2432 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 161.2178 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 172.6729 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 171.8472 521.2432 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 171.8472 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 183.3037 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 182.4761 521.2432 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 182.4761 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 193.9316 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 193.1045 521.2432 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 193.1045 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 204.5591 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 203.7334 521.2432 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 203.7334 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 215.1909 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 214.3623 521.2432 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 214.3623 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 225.8188 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 224.9927 521.2432 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 224.9927 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 236.4478 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 235.6206 521.2432 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 235.6206 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 247.0762 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 246.25 521.2432 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 246.25 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 257.7051 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 256.8779 521.2432 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 256.8779 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 268.3345 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 267.5078 521.2432 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 267.5078 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 278.9653 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 278.1387 521.2432 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 278.1387 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 289.5947 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 288.7686 521.2432 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 288.7686 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 300.2236 522.0552 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 345.042 521.2432 cm 0 0 m 10.6 0 l S Q q 1 0 0 1 354.7861 521.2432 cm 0 0 m 7.172 0 l S Q q 1 0 0 1 315.46 521.2432 cm 0 0 m 11.45 0 l S Q q 1 0 0 1 315.46 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 326.9102 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 326.0869 521.2432 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 326.0869 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 337.541 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 336.7148 521.2432 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 336.7148 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 348.1719 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 347.3457 521.2432 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 347.3457 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 358.8018 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 357.9727 521.2432 cm 0 0 m 11.459 0 l S Q q 1 0 0 1 357.9727 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 369.4316 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 368.6045 521.2432 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 368.6045 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 380.0596 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 379.2314 521.2432 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 379.2314 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 390.6875 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 389.8594 521.2432 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 389.8594 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 401.3154 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 400.4893 521.2432 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 400.4893 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 411.9453 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 411.1182 521.2432 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 411.1182 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 422.5742 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 421.748 521.2432 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 421.748 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 433.2041 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 432.377 521.2432 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 432.377 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 443.832 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 443.0059 521.2432 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 443.0059 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 454.4619 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 453.6357 521.2432 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 453.6357 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 465.0898 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 464.2637 521.2432 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 464.2637 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 475.7197 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 474.8936 521.2432 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 474.8936 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 486.3496 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 485.5234 521.2432 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 485.5234 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 496.9785 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 496.1494 521.2432 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 496.1494 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 507.6064 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 506.7803 521.2432 cm 0 0 m 4.782 0 l S Q q 1 0 0 1 506.7803 521.981 cm 0 0 m 0 -1.475 l S Q BT 0.137 0.123 0.126 scn /TT0 1 Tf 5.2485 0 0 5.2485 515.0811 525.6851 Tm (360 kb)Tj 4.4285 0 0 4.4285 528.0049 525.6851 Tm ( )Tj 0 3.9365 -3.9365 0 118.5225 532.0825 Tm (0247 )Tj 0 -1.547 TD (0248 )Tj 0 -1.514 TD (0249 )Tj 0 -1.813 TD (0250 )Tj 0 -1.848 TD (0251 )Tj 0 -2.049 TD (0252 )Tj 0 -1.76 TD (0253 )Tj 3.9365 0 0 3.9365 167.8223 532.4097 Tm (0254 )Tj 3.866 -0.021 Td (0255 )Tj 3.82 0 Td (0256 )Tj 4.89 0.021 Td (0257 )Tj 0 3.9365 -3.9365 0 236.166 532.2456 Tm (0258 )Tj -0.021 -2.161 Td (0259 )Tj 3.9365 0 0 3.9365 258.9023 532.3286 Tm (0260 )Tj 0 3.9365 -3.9365 0 282.252 532.3286 Tm (0261 )Tj -0.042 -1.735 Td (0262 )Tj 3.9365 0 0 3.9365 292.7783 532.4917 Tm (0263 )Tj 2.624 -0.021 Td (0264 )Tj 0 3.9365 -3.9365 0 318.1182 532.2466 Tm (0268 )Tj 3.9365 0 0 3.9365 324.7734 532.4097 Tm (0269 )Tj 0 3.9365 -3.9365 0 340.1416 532.3286 Tm (0270 )Tj 0 -1.329 Td (0271 )Tj 3.9365 0 0 3.9365 369.4326 532.2466 Tm (0272 )Tj 12.479 0.021 Td (0273 )Tj 0 3.9365 -3.9365 0 444.4072 532.2466 Tm (0274 )Tj 0 -2.03 TD (0275 )Tj 0 -2.2 TD (0276 )Tj 0 -1.953 TD (0277 )Tj 3.9365 0 0 3.9365 479.8301 532.4097 Tm (0278 )Tj 0 3.9365 -3.9365 0 501.3936 532.0825 Tm (0279 )Tj 2.3196 2.3196 -2.3196 2.3196 504.5457 532.3154 Tm (tRNA-ser )Tj 3.9365 0 0 3.9365 507.2637 532.4917 Tm (0281 )Tj -106.434 -2.704 Td (36 )Tj 2.7 0 Td (37 )Tj 2.7 0 Td (38 )Tj 2.7 0 Td (39 )Tj 2.7 0 Td (40 )Tj 2.7 0 Td (41 )Tj 2.7 0 Td (42 )Tj 2.7 0 Td (43 )Tj 2.7 0 Td (44 )Tj 2.701 0 Td (45 )Tj 2.7 0 Td (46 )Tj 2.7 0 Td (47 )Tj 2.7 0 Td (48 )Tj 2.7 0 Td (49 )Tj 2.7 0 Td (50 )Tj 2.7 0 Td (51 )Tj 2.7 0 Td (52 )Tj 2.7 0 Td (53 )Tj 2.7 0 Td (54 )Tj 2.7 0 Td (55 )Tj 2.676 0 Td (56a )Tj 3.4471 0 0 3.9365 310.9541 521.8481 Tm [(5)50(8)50(a)50( )]TJ 3.9365 0 0 3.9365 316.9189 521.8481 Tm (59 )Tj 2.7 0 Td (60 )Tj 2.7 0 Td (61 )Tj 2.908 0.041 Td (62 )Tj 2.381 0 Td (63 )Tj 2.811 -0.041 Td (64 )Tj 2.7 0 Td (65 )Tj 2.7 0 Td (66 )Tj 2.7 0 Td (67 )Tj 2.7 0 Td (68 )Tj 2.7 0 Td (69 )Tj 2.7 0.103 Td (70 )Tj 2.7 -0.103 Td (71 )Tj 2.699 0 Td (72 )Tj 2.701 0 Td (73 )Tj 2.7 0 Td (74 )Tj 2.7 0 Td (75 )Tj 2.7 0 Td (76 )Tj 2.7 0 Td (77 )Tj -104.958 2.6 Td (0246 )Tj 1 1 1 scn 3.2804 0 0 3.2804 114.0381 529.1304 Tm [(y)25(s)25(x)25(C)]TJ 2.6243 0 0 2.6243 155.9453 529.3765 Tm [(g)25(r)25(e)25(A)]TJ 0.137 0.123 0.126 scn /TT2 1 Tf 3.2804 0 0 3.2804 167.7539 528.8843 Tm [(u)-25(v)-25(r)-25(C)]TJ 1 1 1 scn 27.924 0.025 Td [(v)-25(a)-25(l)-25(S)]TJ 10.051 0.05 Td [(r)-25(s)-25(g)-25(A)]TJ ET q 1 0 0 1 86.3999 499.6323 cm 0 0 m 6.673 0 l S Q q 1 0 0 1 93.0728 500.3696 cm 0 0 m 0 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0 0 1 156.0229 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 167.4766 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 166.6499 499.6323 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 166.6499 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 178.106 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 177.2788 499.6323 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 177.2788 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 188.7354 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 187.9092 499.6323 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 187.9092 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 199.3643 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 198.5371 499.6323 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 198.5371 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 209.9946 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 209.167 499.6323 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 209.167 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 220.6226 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 219.7944 499.6323 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 219.7944 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 231.2505 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 230.4243 499.6323 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 230.4243 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 241.8818 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 241.0537 499.6323 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 241.0537 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 252.5098 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 251.6851 499.6323 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 251.6851 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 263.1392 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 262.3115 499.6323 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 262.3115 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 273.7671 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 272.9399 499.6323 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 272.9399 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 284.397 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 283.5703 499.6323 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 283.5703 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 295.0254 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 294.1997 499.6323 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 294.1997 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 305.6543 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 304.8286 499.6323 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 304.8286 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 316.2832 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 315.457 499.6323 cm 0 0 m 11.453 0 l S Q q 1 0 0 1 315.457 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 326.9102 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 326.085 499.6323 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 326.085 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 337.541 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 336.7139 499.6323 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 336.7139 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 348.1689 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 347.3438 499.6323 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 347.3438 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 358.8008 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 357.9717 499.6323 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 357.9717 500.3696 cm 0 0 m 0 -1.476 l S 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432.5254 499.6323 cm 0 0 m 11.453 0 l S Q q 1 0 0 1 432.5254 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 443.9785 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 443.1514 499.6323 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 443.1514 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 454.6074 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 453.7822 499.6323 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 453.7822 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 465.2393 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 464.4102 499.6323 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 464.4102 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 475.8652 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 475.0371 499.6323 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 475.0371 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 486.4951 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 485.6689 499.6323 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 485.6689 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 497.123 500.3696 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 496.2969 499.6323 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 496.2969 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0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 507.4922 510.2007 cm 0 0 m 1.476 0 l 1.476 1.699 l 1.624 -1.697 l 1.476 -5.092 l 1.476 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 507.4922 510.2007 cm 0 0 m 1.476 0 l 1.476 1.699 l 1.624 -1.697 l 1.476 -5.092 l 1.476 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 507.5176 510.1855 cm 0 0 m 1.477 0 l 1.477 1.698 l 1.623 -1.698 l 1.477 -5.094 l 1.477 -3.395 l 0 -3.395 l 0 0 l h S Q 0.503 0.51 0.52 scn 4 M 509.735 506.805 1.801 3.396 re B* 10 M q 1 0 0 1 511.5605 506.7905 cm 0 0 m -1.799 0 l -1.799 3.395 l 0 3.395 l S Q BT 0.137 0.123 0.126 scn /TT0 1 Tf 5.2485 0 0 5.2485 515.0791 504.0757 Tm (400 kb)Tj 4.4285 0 0 4.4285 528.0029 504.0757 Tm ( )Tj 3.9365 0 0 3.9365 92.3467 510.7163 Tm (0282 )Tj 0 3.9365 -3.9365 0 108.5898 510.5532 Tm (0283 )Tj 3.9365 0 0 3.9365 111.2559 510.7983 Tm (0284 )Tj 3.658 -0.021 Td (0285 )Tj 3.61 0 Td (0286 )Tj 3.683 0 Td (0287 )Tj 4.003 0 Td (0288 )Tj 0 3.9365 -3.9365 0 185.0107 510.5532 Tm (0289 )Tj 3.9365 0 0 3.9365 186.7363 510.7163 Tm (0290 )Tj 0 3.9365 -3.9365 0 199.4502 510.6333 Tm (0291 )Tj 3.9365 0 0 3.9365 209.3672 510.7983 Tm (0292 )Tj 5.531 0.021 Td (0293 )Tj 0 3.9365 -3.9365 0 248.4141 510.6333 Tm (0294 )Tj 2.3196 2.3196 -2.3196 2.3196 250.0675 511.6049 Tm (tRNA-gly )Tj 3.9365 0 0 3.9365 251.6514 510.5532 Tm [(0)50(2)50(9)50(6)50( )]TJ 3.664 0.041 Td (0297 )Tj 0 3.9365 -3.9365 0 282.4414 510.4722 Tm (0298 )Tj 0.021 -0.815 Td (0299 )Tj 3.9365 0 0 3.9365 290.8066 510.7983 Tm (0300 )Tj 0 3.9365 -3.9365 0 308.3594 510.6333 Tm (0301 )Tj 0 -1.833 TD (0302 )Tj 3.9365 0 0 3.9365 337.6367 510.7163 Tm (0303 )Tj 7.511 -0.021 Td (0304 )Tj 3.281 0.021 Td (0305 )Tj 0 3.9365 -3.9365 0 404.9805 510.4722 Tm (0307 )Tj 3.9365 0 0 3.9365 408.1201 510.7163 Tm (0308 )Tj 2.871 0 Td (0309 )Tj 2.216 0 Td (0310 )Tj 2.989 0.021 Td (0311 )Tj 5.243 0.021 Td (0312 )Tj 6.642 -0.042 Td (0313 )Tj 2.835 0 Td (0314 )Tj 0 3.9365 -3.9365 0 509.0342 510.4722 Tm (0315 )Tj 3.9365 0 0 3.9365 93.7217 500.2368 Tm (78 )Tj 2.7 0 Td (79 )Tj 2.7 0 Td (80 )Tj 2.7 0 Td (81 )Tj 2.7 0 Td (82 )Tj 2.7 0 Td (83 )Tj 2.7 0 Td (84 )Tj 2.7 0 Td (85 )Tj 2.7 0 Td (86 )Tj 2.7 0 Td (87 )Tj 2.7 0 Td (88 )Tj 2.7 0 Td (89 )Tj 2.7 0 Td (90 )Tj 2.7 0 Td (91 )Tj 2.7 0 Td (92 )Tj 2.7 0 Td (93 )Tj 2.7 0 Td (94 )Tj 2.7 0 Td (95 )Tj 2.7 0 Td (96 )Tj 2.699 0 Td (97 )Tj 2.7 0 Td (98 )Tj 2.7 0 Td (99 )Tj 2.7 0 Td (100 )Tj 2.7 0 Td (101 )Tj 2.7 0 Td (102 )Tj 2.7 0 Td (103 )Tj 2.7 0 Td (104 )Tj 2.7 0 Td (105 )Tj 2.7 0 Td (WM3 )Tj 2.74 0 Td (107 )Tj 2.7 0 Td (108 )Tj 2.7 0 Td (109 )Tj 2.7 0 Td (110 )Tj 2.7 0 Td (111 )Tj 2.7 0 Td (112 )Tj 2.7 0 Td (113 )Tj 2.7 0 Td (114 )Tj 2.7 0 Td (115 )Tj 2.7 0 Td (116 )Tj 2.7 0 Td (117 )Tj 1 1 1 scn /TT2 1 Tf 3.2804 0 0 3.2804 92.6338 507.6011 Tm [(p)-25(r)-25(o)-25(S)]TJ 0.137 0.123 0.126 scn /TT0 1 Tf 3.55 -0.075 Td (rnhA)Tj /TT2 1 Tf 6.75 0.05 Td [(l)-25(e)-25(p)-25(A)]TJ 1 1 1 scn 8.425 -0.05 Td [(a)-25(s)-25(p)-25(S)]TJ 5.1 0 Td [(h)-25(i)-25(s)-25(S)]TJ 0.137 0.123 0.126 scn /TT0 1 Tf 2.2963 0 0 2.2963 182.1055 507.8462 Tm (rbfA)Tj 1 1 1 scn /TT2 1 Tf 3.2804 0 0 3.2804 187.5166 507.2729 Tm [(t)-25(r)-25(u)-25(B)]TJ /TT0 1 Tf 0 1.7714 -1.7714 0 248.8057 506.9712 Tm [(r)25(p)25(s)25(O)]TJ /TT2 1 Tf 3.2804 0 0 3.2804 267.04 507.2446 Tm [(i)-25(n)-25(f)-25(B)]TJ 0.137 0.123 0.126 scn 7.233 0.017 Td [(n)-25(u)-25(s)-25(A)]TJ 14.375 0.042 Td [(p)-25(o)-25(l)-25(C)]TJ 1 1 1 scn 8.826 -0.025 Td [(c)-25(d)-25(s)-25(A)]TJ 12.8 0 Td [(t)-25(r)-25(p)-25(S)]TJ 23.1 0.025 Td [(t)-25(r)-25(m)-25(F)-25(O)-25(2)]TJ ET 0.262 w q 1 0 0 1 86.3999 484.1665 cm 0 0 m 425.161 0 l S Q 0.503 0.51 0.52 scn 0.281 w 4 M q 1 0 0 1 86.3999 490.3086 cm 0 0 m 18.247 0 l 18.247 1.698 l 19.132 -1.696 l 18.247 -5.091 l 18.247 -3.395 l 0 -3.395 l B* Q 10 M q 1 0 0 1 86.3999 490.293 cm 0 0 m 18.248 0 l 18.248 1.698 l 19.134 -1.698 l 18.248 -5.094 l 18.248 -3.396 l 0 -3.396 l S Q 0.73 0.805 0.919 scn q 1 0 0 1 105.709 490.3086 cm 0 0 m 2.361 0 l 2.361 1.698 l 2.598 -1.696 l 2.361 -5.091 l 2.361 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 105.709 490.3086 cm 0 0 m 2.361 0 l 2.361 1.698 l 2.598 -1.696 l 2.361 -5.091 l 2.361 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 105.7109 490.293 cm 0 0 m 2.36 0 l 2.36 1.698 l 2.597 -1.698 l 2.36 -5.094 l 2.36 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 109.0454 490.3086 cm 0 0 m 15.528 0 l 15.528 1.698 l 16.416 -1.696 l 15.528 -5.091 l 15.528 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 109.0454 490.3086 cm 0 0 m 15.528 0 l 15.528 1.698 l 16.416 -1.696 l 15.528 -5.091 l 15.528 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 109.0474 490.293 cm 0 0 m 15.531 0 l 15.531 1.698 l 16.416 -1.698 l 15.531 -5.094 l 15.531 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 126.4053 490.3086 cm 0 0 m 29.908 0 l 29.908 1.698 l 30.793 -1.696 l 29.908 -5.091 l 29.908 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 126.4053 490.3086 cm 0 0 m 29.908 0 l 29.908 1.698 l 30.793 -1.696 l 29.908 -5.091 l 29.908 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 126.4063 490.293 cm 0 0 m 29.911 0 l 29.911 1.698 l 30.795 -1.698 l 29.911 -5.094 l 29.911 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.534 0.806 scn q 1 0 0 1 157.2871 490.3086 cm 0 0 m 7.645 0 l 7.645 1.698 l 8.474 -1.696 l 7.645 -5.091 l 7.645 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 157.2871 490.3086 cm 0 0 m 7.645 0 l 7.645 1.698 l 8.474 -1.696 l 7.645 -5.091 l 7.645 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 157.2915 490.293 cm 0 0 m 7.647 0 l 7.647 1.698 l 8.473 -1.698 l 7.647 -5.094 l 7.647 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 167.3838 490.3086 cm 0 0 m 4.104 0 l 4.104 1.698 l 4.546 -1.696 l 4.104 -5.091 l 4.104 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 167.3838 490.3086 cm 0 0 m 4.104 0 l 4.104 1.698 l 4.546 -1.696 l 4.104 -5.091 l 4.104 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 167.3882 490.293 cm 0 0 m 4.104 0 l 4.104 1.698 l 4.546 -1.698 l 4.104 -5.094 l 4.104 -3.396 l 0 -3.396 l 0 0 l h S Q 1 1 1 scn q 1 0 0 1 175.3853 490.3086 cm 0 0 m 14.583 0 l 14.583 1.698 l 15.468 -1.696 l 14.583 -5.091 l 14.583 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 175.3853 490.3086 cm 0 0 m 14.583 0 l 14.583 1.698 l 15.468 -1.696 l 14.583 -5.091 l 14.583 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 175.3892 490.293 cm 0 0 m 14.587 0 l 14.587 1.698 l 15.471 -1.698 l 14.587 -5.094 l 14.587 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 206.9146 490.3086 cm 0 0 m -14.968 0 l -14.968 1.698 l -15.855 -1.696 l -14.968 -5.091 l -14.968 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 206.9146 490.3086 cm 0 0 m -14.968 0 l -14.968 1.698 l -15.855 -1.696 l -14.968 -5.091 l -14.968 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 206.9219 490.293 cm 0 0 m -14.968 0 l -14.968 1.698 l -15.853 -1.698 l -14.968 -5.094 l -14.968 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 214.2959 490.3086 cm 0 0 m -5.048 0 l -5.048 1.698 l -5.581 -1.696 l -5.048 -5.091 l -5.048 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 214.2959 490.3086 cm 0 0 m -5.048 0 l -5.048 1.698 l -5.581 -1.696 l -5.048 -5.091 l -5.048 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 214.3037 490.293 cm 0 0 m -5.049 0 l -5.049 1.698 l -5.58 -1.698 l -5.049 -5.094 l -5.049 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 228.793 490.3086 cm 0 0 m 14.967 0 l 14.967 1.698 l 15.854 -1.696 l 14.967 -5.091 l 14.967 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 228.793 490.3086 cm 0 0 m 14.967 0 l 14.967 1.698 l 15.854 -1.696 l 14.967 -5.091 l 14.967 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 228.8013 490.293 cm 0 0 m 14.969 0 l 14.969 1.698 l 15.855 -1.698 l 14.969 -5.094 l 14.969 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 244.8242 490.3086 cm 0 0 m 7.291 0 l 7.291 1.698 l 8.089 -1.696 l 7.291 -5.091 l 7.291 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 244.8242 490.3086 cm 0 0 m 7.291 0 l 7.291 1.698 l 8.089 -1.696 l 7.291 -5.091 l 7.291 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 244.8325 490.293 cm 0 0 m 7.293 0 l 7.293 1.698 l 8.089 -1.698 l 7.293 -5.094 l 7.293 -3.396 l 0 -3.396 l 0 0 l h S Q 0.555 0.846 0.972 scn q 1 0 0 1 253.0293 490.3086 cm 0 0 m 8 0 l 8 1.698 l 8.888 -1.696 l 8 -5.091 l 8 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 253.0293 490.3086 cm 0 0 m 8 0 l 8 1.698 l 8.888 -1.696 l 8 -5.091 l 8 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 253.041 490.293 cm 0 0 m 8.001 0 l 8.001 1.698 l 8.888 -1.698 l 8.001 -5.094 l 8.001 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 261.7402 490.3086 cm 0 0 m 6.02 0 l 6.02 1.698 l 6.672 -1.696 l 6.02 -5.091 l 6.02 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 261.7402 490.3086 cm 0 0 m 6.02 0 l 6.02 1.698 l 6.672 -1.696 l 6.02 -5.091 l 6.02 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 261.75 490.293 cm 0 0 m 6.025 0 l 6.025 1.698 l 6.673 -1.698 l 6.025 -5.094 l 6.025 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 269.1504 490.3086 cm 0 0 m 7.264 0 l 7.264 1.698 l 8.06 -1.696 l 7.264 -5.091 l 7.264 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 269.1504 490.3086 cm 0 0 m 7.264 0 l 7.264 1.698 l 8.06 -1.696 l 7.264 -5.091 l 7.264 -3.395 l 0 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292.6211 490.3086 cm 0 0 m 7.94 0 l 7.94 1.698 l 8.796 -1.696 l 7.94 -5.091 l 7.94 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 292.6211 490.3086 cm 0 0 m 7.94 0 l 7.94 1.698 l 8.796 -1.696 l 7.94 -5.091 l 7.94 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 292.6338 490.293 cm 0 0 m 7.942 0 l 7.942 1.698 l 8.799 -1.698 l 7.942 -5.094 l 7.942 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 306.645 490.3086 cm 0 0 m 4.016 0 l 4.016 1.698 l 4.458 -1.696 l 4.016 -5.091 l 4.016 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 306.645 490.3086 cm 0 0 m 4.016 0 l 4.016 1.698 l 4.458 -1.696 l 4.016 -5.091 l 4.016 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 306.6587 490.293 cm 0 0 m 4.016 0 l 4.016 1.698 l 4.457 -1.698 l 4.016 -5.094 l 4.016 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 315.7686 490.3086 cm 0 0 m 4.604 0 l 4.604 1.698 l 5.106 -1.696 l 4.604 -5.091 l 4.604 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 315.7686 490.3086 cm 0 0 m 4.604 0 l 4.604 1.698 l 5.106 -1.696 l 4.604 -5.091 l 4.604 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18.334 1.698 l 19.221 -1.696 l 18.334 -5.091 l 18.334 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 336.5508 490.3086 cm 0 0 m 18.334 0 l 18.334 1.698 l 19.221 -1.696 l 18.334 -5.091 l 18.334 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 336.5664 490.293 cm 0 0 m 18.337 0 l 18.337 1.698 l 19.222 -1.698 l 18.337 -5.094 l 18.337 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 357.6025 490.3086 cm 0 0 m 6.879 0 l 6.879 1.698 l 7.615 -1.696 l 6.879 -5.091 l 6.879 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 357.6025 490.3086 cm 0 0 m 6.879 0 l 6.879 1.698 l 7.615 -1.696 l 6.879 -5.091 l 6.879 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 357.6182 490.293 cm 0 0 m 6.879 0 l 6.879 1.698 l 7.616 -1.698 l 6.879 -5.094 l 6.879 -3.396 l 0 -3.396 l 0 0 l h S Q 0.716 0.434 0.681 scn q 1 0 0 1 369.5313 490.3086 cm 0 0 m 18.451 0 l 18.451 1.698 l 19.335 -1.696 l 18.451 -5.091 l 18.451 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 369.5313 490.3086 cm 0 0 m 18.451 0 l 18.451 1.698 l 19.335 -1.696 l 18.451 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0.65 0.316 scn q 1 0 0 1 424.5898 490.3086 cm 0 0 m 22.351 0 l 22.351 1.698 l 23.237 -1.696 l 22.351 -5.091 l 22.351 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 424.5898 490.3086 cm 0 0 m 22.351 0 l 22.351 1.698 l 23.237 -1.696 l 22.351 -5.091 l 22.351 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 424.6104 490.293 cm 0 0 m 22.351 0 l 22.351 1.698 l 23.236 -1.698 l 22.351 -5.094 l 22.351 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 449.2725 490.3086 cm 0 0 m 6.643 0 l 6.643 1.698 l 7.381 -1.696 l 6.643 -5.091 l 6.643 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 449.2725 490.3086 cm 0 0 m 6.643 0 l 6.643 1.698 l 7.381 -1.696 l 6.643 -5.091 l 6.643 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 449.2949 490.293 cm 0 0 m 6.643 0 l 6.643 1.698 l 7.382 -1.698 l 6.643 -5.094 l 6.643 -3.396 l 0 -3.396 l 0 0 l h S Q 0.919 0.152 0.567 scn q 1 0 0 1 463.2061 490.3086 cm 0 0 m -5.374 0 l -5.374 1.698 l -5.964 -1.696 l -5.374 -5.091 l -5.374 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 463.2061 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S Q 0.262 w q 1 0 0 1 86.3999 479.7383 cm 0 0 m 6.821 0 l S Q q 1 0 0 1 93.2207 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 92.395 479.7383 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 92.395 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 103.8501 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 103.0239 479.7383 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 103.0239 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 114.479 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 113.6543 479.7383 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 113.6543 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 125.1079 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 124.2813 479.7383 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 124.2813 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 135.7383 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 134.9116 479.7383 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 134.9116 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 146.3662 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 145.5386 479.7383 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 145.5386 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 156.9946 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 156.1685 479.7383 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 156.1685 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 167.6235 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 166.7969 479.7383 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 166.7969 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 178.2534 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 177.4277 479.7383 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 177.4277 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 188.8828 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 188.0562 479.7383 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 188.0562 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 199.5117 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 198.686 479.7383 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 198.686 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 210.1411 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 209.314 479.7383 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 209.314 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 220.769 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 219.9434 479.7383 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 219.9434 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 231.3989 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 230.5723 479.7383 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 230.5723 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 242.0273 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 241.2017 479.7383 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 241.2017 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 252.6567 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 251.8286 479.7383 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 251.8286 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 263.2861 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 262.4585 479.7383 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 262.4585 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 273.915 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 273.0889 479.7383 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 273.0889 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 284.5449 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 283.7178 479.7383 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 283.7178 480.4761 cm 0 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l S Q q 1 0 0 1 358.1182 479.7383 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 358.1182 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 369.5762 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 368.75 479.7383 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 368.75 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 380.2061 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 379.3779 479.7383 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 379.3779 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 390.834 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 390.0078 479.7383 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 390.0078 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 401.4639 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 400.6367 479.7383 cm 0 0 m 11.452 0 l S Q q 1 0 0 1 400.6367 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 412.0889 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 411.2656 479.7383 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 411.2656 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 422.7227 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 421.8955 479.7383 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 421.8955 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 433.3516 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 432.5254 479.7383 cm 0 0 m 11.453 0 l S Q q 1 0 0 1 432.5254 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 443.9785 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 443.1514 479.7383 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 443.1514 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 454.6074 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 453.7822 479.7383 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 453.7822 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 465.2393 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 464.4102 479.7383 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 464.4102 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 475.8652 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 475.0371 479.7383 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 475.0371 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 486.4951 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 485.6689 479.7383 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 485.6689 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 497.123 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 496.2969 479.7383 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 496.2969 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 507.7529 480.4761 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 506.9268 479.7383 cm 0 0 m 4.634 0 l S Q q 1 0 0 1 506.9268 480.4761 cm 0 0 m 0 -1.476 l S Q BT 0.137 0.123 0.126 scn /TT0 1 Tf 5.2485 0 0 5.2485 515.0791 484.1821 Tm (440 kb )Tj 0 3.9365 -3.9365 0 107.915 490.7437 Tm (0317 )Tj 3.9365 0 0 3.9365 113.373 490.9077 Tm (0318 )Tj 6.875 -0.042 Td (0319 )Tj 4.302 0.042 Td (0320 )Tj 0 3.9365 -3.9365 0 170.7773 490.7437 Tm (0321 )Tj 3.9365 0 0 3.9365 179.1328 490.9077 Tm (0322 )Tj 4.24 -0.021 Td (0323 )Tj 0 3.9365 -3.9365 0 213.3477 490.7437 Tm (0324 )Tj 3.9365 0 0 3.9365 233.1455 490.8257 Tm (0325 )Tj 0 3.9365 -3.9365 0 249.6367 490.6616 Tm (0326 )Tj 3.9365 0 0 3.9365 253.6709 490.8257 Tm (0327 )Tj 0 3.9365 -3.9365 0 266.1611 490.6616 Tm (0328 )Tj 0 -2.066 TD (0329 )Tj 0.021 -1.824 Td (0330 )Tj 0.021 -1.808 Td (0331 )Tj 3.9365 0 0 3.9365 292.9023 490.9077 Tm (0332 )Tj 0 3.9365 -3.9365 0 309.875 490.7437 Tm (0333 )Tj 0 -2.437 TD (0334 )Tj -0.021 -2.347 Td (0335 )Tj 0 -1.639 TD (0336 )Tj 3.9365 0 0 3.9365 342.4863 490.9077 Tm (0337 )Tj 3.715 -0.021 Td (0338 )Tj 4.642 -0.021 Td (0339 )Tj 4.909 0.021 Td (0340 )Tj 4.487 0 Td (0341 )Tj 5.044 0.063 Td (0342 )Tj 0 3.9365 -3.9365 0 453.9453 490.7437 Tm (0343 )Tj 0 -2.05 TD (0344 )Tj 3.9365 0 0 3.9365 465.2988 490.9077 Tm (0345 )Tj 0 3.9365 -3.9365 0 479.5117 490.7437 Tm (0346 )Tj 0 -1.828 TD (0347 )Tj 3.9365 0 0 3.9365 492.041 490.9897 Tm (0348 )Tj 3.077 0.021 Td (0349 )Tj -104.226 -2.725 Td (118 )Tj 2.7 0 Td (119 )Tj 2.7 0 Td (120 )Tj 2.7 0 Td (121 )Tj 2.7 0 Td (122 )Tj 2.7 0 Td (123 )Tj 2.7 0 Td (124 )Tj 2.7 0 Td (125 )Tj 2.7 0 Td (126 )Tj 2.7 0 Td (127 )Tj 2.7 0 Td (128 )Tj 2.7 0 Td (129 )Tj 2.7 0 Td (130 )Tj 2.7 0 Td (131 )Tj 2.7 0 Td (132 )Tj 2.7 0 Td (133 )Tj 2.7 0 Td (134 )Tj 2.7 0 Td (135 )Tj 2.7 0 Td (136 )Tj 2.7 0 Td (137 )Tj 2.7 0 Td (138 )Tj 2.7 0 Td (139 )Tj 2.7 0 Td (140 )Tj 2.7 0 Td (141 )Tj 2.7 0 Td (142 )Tj 2.7 0 Td (143 )Tj 2.7 0 Td (144 )Tj 2.7 0 Td (145 )Tj 2.7 0 Td (146 )Tj 2.7 0 Td (147 )Tj 2.7 0 Td (148 )Tj 2.7 0 Td (149 )Tj 2.7 0 Td (150 )Tj 2.7 0 Td (151 )Tj 2.7 0 Td (152 )Tj 2.7 0 Td (153 )Tj 2.7 0 Td (154 )Tj 2.7 0 Td (155 )Tj 2.7 0 Td (156 )Tj 2.7 0 Td (157 )Tj 1 1 1 scn /TT2 1 Tf 3.2804 0 0 3.2804 93.373 487.4634 Tm [(t)-25(k)-25(t)]TJ 0.137 0.123 0.126 scn /TT0 1 Tf 3.9365 0 0 3.9365 91.1504 490.9077 Tm (0316 )Tj 3.2804 0 0 3.2804 254.0273 487.6274 Tm [(s)-25(c)-25(p)-25(A)]TJ 2.4 -0.025 Td [(s)-25(c)-25(p)-25(B)]TJ 1 1 1 scn 2.6243 0 0 2.6243 306.6768 487.8745 Tm [(v)-25(l)-25(c)-25(A)]TJ 3.594 -0.063 Td [(v)-25(l)-25(c)-25(B)]TJ 3.562 0 Td [(v)-25(l)-25(c)-25(C)]TJ /TT2 1 Tf 3.2804 0 0 3.2804 457.4893 487.8745 Tm [(p)-25(p)-25(a)]TJ 7.701 -0.075 Td [(c)-25(m)-25(k)]TJ 2.975 0 Td [(e)-25(n)-25(g)-25(A)]TJ 3.4 0.025 Td [(g)-25(p)-25(s)-25(A)]TJ ET q 1 0 0 1 86.3999 461.6045 cm 0 0 m 425.161 0 l S Q 0 0.534 0.806 scn 0.281 w 4 M q 1 0 0 1 86.3999 467.749 cm 0 0 m 2.125 0 l 2.125 1.697 l 2.334 -1.698 l 2.125 -5.092 l 2.125 -3.396 l 0 -3.396 l B* Q 10 M q 1 0 0 1 86.3999 467.7305 cm 0 0 m 2.125 0 l 2.125 1.697 l 2.334 -1.699 l 2.125 -5.094 l 2.125 -3.397 l 0 -3.397 l S Q 0.99 0.914 0.17 scn q 1 0 0 1 89.0586 467.749 cm 0 0 m 2.626 0 l 2.626 1.697 l 2.893 -1.698 l 2.626 -5.092 l 2.626 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 89.0586 467.749 cm 0 0 m 2.626 0 l 2.626 1.697 l 2.893 -1.698 l 2.626 -5.092 l 2.626 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 89.0586 467.7305 cm 0 0 m 2.626 0 l 2.626 1.697 l 2.894 -1.699 l 2.626 -5.094 l 2.626 -3.397 l 0 -3.397 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 92.543 467.749 cm 0 0 m 5.254 0 l 5.254 1.697 l 5.816 -1.698 l 5.254 -5.092 l 5.254 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 92.543 467.749 cm 0 0 m 5.254 0 l 5.254 1.697 l 5.816 -1.698 l 5.254 -5.092 l 5.254 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 92.543 467.7305 cm 0 0 m 5.254 0 l 5.254 1.697 l 5.816 -1.699 l 5.254 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-3.396 l h f* Q 4 M q 1 0 0 1 109.7539 467.749 cm 0 0 m 14.171 0 l 14.171 1.697 l 15.057 -1.698 l 14.171 -5.092 l 14.171 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 109.7549 467.7305 cm 0 0 m 14.173 0 l 14.173 1.697 l 15.059 -1.699 l 14.173 -5.094 l 14.173 -3.397 l 0 -3.397 l 0 0 l h S Q q 1 0 0 1 126.6421 467.749 cm 0 0 m 12.104 0 l 12.104 1.697 l 12.991 -1.698 l 12.104 -5.092 l 12.104 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 126.6421 467.749 cm 0 0 m 12.104 0 l 12.104 1.697 l 12.991 -1.698 l 12.104 -5.092 l 12.104 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 126.644 467.7305 cm 0 0 m 12.105 0 l 12.105 1.697 l 12.991 -1.699 l 12.105 -5.094 l 12.105 -3.397 l 0 -3.397 l 0 0 l h S Q 0.986 0.823 0.154 scn q 1 0 0 1 140.5469 467.749 cm 0 0 m 3.306 0 l 3.306 1.697 l 3.661 -1.698 l 3.306 -5.092 l 3.306 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 140.5469 467.749 cm 0 0 m 3.306 0 l 3.306 1.697 l 3.661 -1.698 l 3.306 -5.092 l 3.306 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 140.5503 467.7305 cm 0 0 m 3.306 0 l 3.306 1.697 l 3.661 -1.699 l 3.306 -5.094 l 3.306 -3.397 l 0 -3.397 l 0 0 l h S Q 0.555 0.846 0.972 scn q 1 0 0 1 144.5908 467.749 cm 0 0 m 4.517 0 l 4.517 1.697 l 4.991 -1.698 l 4.517 -5.092 l 4.517 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 144.5908 467.749 cm 0 0 m 4.517 0 l 4.517 1.697 l 4.991 -1.698 l 4.517 -5.092 l 4.517 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 144.5957 467.7305 cm 0 0 m 4.517 0 l 4.517 1.697 l 4.989 -1.699 l 4.517 -5.094 l 4.517 -3.397 l 0 -3.397 l 0 0 l h S Q 0.99 0.914 0.17 scn q 1 0 0 1 150.0532 467.749 cm 0 0 m 10.126 0 l 10.126 1.697 l 11.012 -1.698 l 10.126 -5.092 l 10.126 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 150.0532 467.749 cm 0 0 m 10.126 0 l 10.126 1.697 l 11.012 -1.698 l 10.126 -5.092 l 10.126 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 150.0566 467.7305 cm 0 0 m 10.127 0 l 10.127 1.697 l 11.013 -1.699 l 10.127 -5.094 l 10.127 -3.397 l 0 -3.397 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 162.5117 467.749 cm 0 0 m 15.383 0 l 15.383 1.697 l 16.268 -1.698 l 15.383 -5.092 l 15.383 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 162.5117 467.749 cm 0 0 m 15.383 0 l 15.383 1.697 l 16.268 -1.698 l 15.383 -5.092 l 15.383 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 162.5161 467.7305 cm 0 0 m 15.384 0 l 15.384 1.697 l 16.27 -1.699 l 15.384 -5.094 l 15.384 -3.397 l 0 -3.397 l 0 0 l h S Q 0.501 0.764 0.267 scn q 1 0 0 1 179.1348 467.749 cm 0 0 m 13.373 0 l 13.373 1.697 l 14.259 -1.698 l 13.373 -5.092 l 13.373 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 179.1348 467.749 cm 0 0 m 13.373 0 l 13.373 1.697 l 14.259 -1.698 l 13.373 -5.092 l 13.373 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 179.1396 467.7305 cm 0 0 m 13.375 0 l 13.375 1.697 l 14.259 -1.699 l 13.375 -5.094 l 13.375 -3.397 l 0 -3.397 l 0 0 l h S Q 1 1 1 scn q 1 0 0 1 193.4531 467.749 cm 0 0 m 4.487 0 l 4.487 1.697 l 4.959 -1.698 l 4.487 -5.092 l 4.487 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 193.4531 467.749 cm 0 0 m 4.487 0 l 4.487 1.697 l 4.959 -1.698 l 4.487 -5.092 l 4.487 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 193.46 467.7305 cm 0 0 m 4.488 0 l 4.488 1.697 l 4.959 -1.699 l 4.488 -5.094 l 4.488 -3.397 l 0 -3.397 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 199.3862 467.749 cm 0 0 m 2.657 0 l 2.657 1.697 l 2.953 -1.698 l 2.657 -5.092 l 2.657 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 199.3862 467.749 cm 0 0 m 2.657 0 l 2.657 1.697 l 2.953 -1.698 l 2.657 -5.092 l 2.657 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 199.3936 467.7305 cm 0 0 m 2.658 0 l 2.658 1.697 l 2.954 -1.699 l 2.658 -5.094 l 2.658 -3.397 l 0 -3.397 l 0 0 l h S Q 0.97 0.579 0.116 scn q 1 0 0 1 202.666 467.749 cm 0 0 m 4.751 0 l 4.751 1.697 l 5.254 -1.698 l 4.751 -5.092 l 4.751 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 202.666 467.749 cm 0 0 m 4.751 0 l 4.751 1.697 l 5.254 -1.698 l 4.751 -5.092 l 4.751 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 202.6709 467.7305 cm 0 0 m 4.752 0 l 4.752 1.697 l 5.255 -1.699 l 4.752 -5.094 l 4.752 -3.397 l 0 -3.397 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 207.9478 467.749 cm 0 0 m 6.909 0 l 6.909 1.697 l 7.677 -1.698 l 6.909 -5.092 l 6.909 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 207.9478 467.749 cm 0 0 m 6.909 0 l 6.909 1.697 l 7.677 -1.698 l 6.909 -5.092 l 6.909 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 207.9561 467.7305 cm 0 0 m 6.909 0 l 6.909 1.697 l 7.675 -1.699 l 6.909 -5.094 l 6.909 -3.397 l 0 -3.397 l 0 0 l h S Q q 1 0 0 1 215.625 467.749 cm 0 0 m 3.69 0 l 3.69 1.697 l 4.075 -1.698 l 3.69 -5.092 l 3.69 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 215.625 467.749 cm 0 0 m 3.69 0 l 3.69 1.697 l 4.075 -1.698 l 3.69 -5.092 l 3.69 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 215.6309 467.7305 cm 0 0 m 3.692 0 l 3.692 1.697 l 4.077 -1.699 l 3.692 -5.094 l 3.692 -3.397 l 0 -3.397 l 0 0 l h S Q q 1 0 0 1 220.7627 467.749 cm 0 0 m 9.21 0 l 9.21 1.697 l 10.096 -1.698 l 9.21 -5.092 l 9.21 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 220.7627 467.749 cm 0 0 m 9.21 0 l 9.21 1.697 l 10.096 -1.698 l 9.21 -5.092 l 9.21 -3.396 l 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4 M q 1 0 0 1 400.2607 467.749 cm 0 0 m 6.91 0 l 6.91 1.697 l 7.649 -1.698 l 6.91 -5.092 l 6.91 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 400.2822 467.7305 cm 0 0 m 6.91 0 l 6.91 1.697 l 7.646 -1.699 l 6.91 -5.094 l 6.91 -3.397 l 0 -3.397 l 0 0 l h S Q q 1 0 0 1 408.7354 467.749 cm 0 0 m 7.058 0 l 7.058 1.697 l 7.823 -1.698 l 7.058 -5.092 l 7.058 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 408.7354 467.749 cm 0 0 m 7.058 0 l 7.058 1.697 l 7.823 -1.698 l 7.058 -5.092 l 7.058 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 408.7549 467.7305 cm 0 0 m 7.058 0 l 7.058 1.697 l 7.825 -1.699 l 7.058 -5.094 l 7.058 -3.397 l 0 -3.397 l 0 0 l h S Q q 1 0 0 1 416.6797 467.749 cm 0 0 m 6.493 0 l 6.493 1.697 l 7.203 -1.698 l 6.493 -5.092 l 6.493 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 416.6797 467.749 cm 0 0 m 6.493 0 l 6.493 1.697 l 7.203 -1.698 l 6.493 -5.092 l 6.493 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 416.6973 467.7305 cm 0 0 m 6.497 0 l 6.497 1.697 l 7.206 -1.699 l 6.497 -5.094 l 6.497 -3.397 l 0 -3.397 l 0 0 l h S Q q 1 0 0 1 424.2959 467.749 cm 0 0 m 8.117 0 l 8.117 1.697 l 9 -1.698 l 8.117 -5.092 l 8.117 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 424.2959 467.749 cm 0 0 m 8.117 0 l 8.117 1.697 l 9 -1.698 l 8.117 -5.092 l 8.117 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 424.3164 467.7305 cm 0 0 m 8.119 0 l 8.119 1.697 l 9.003 -1.699 l 8.119 -5.094 l 8.119 -3.397 l 0 -3.397 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 434.4219 467.749 cm 0 0 m 11.1 0 l 11.1 1.697 l 11.986 -1.698 l 11.1 -5.092 l 11.1 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 434.4219 467.749 cm 0 0 m 11.1 0 l 11.1 1.697 l 11.986 -1.698 l 11.1 -5.092 l 11.1 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 434.4434 467.7305 cm 0 0 m 11.104 0 l 11.104 1.697 l 11.985 -1.699 l 11.104 -5.094 l 11.104 -3.397 l 0 -3.397 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 446.9092 467.749 cm 0 0 m 5.903 0 l 5.903 1.697 l 6.555 -1.698 l 5.903 -5.092 l 5.903 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 446.9092 467.749 cm 0 0 m 5.903 0 l 5.903 1.697 l 6.555 -1.698 l 5.903 -5.092 l 5.903 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 446.9326 467.7305 cm 0 0 m 5.904 0 l 5.904 1.697 l 6.552 -1.699 l 5.904 -5.094 l 5.904 -3.397 l 0 -3.397 l 0 0 l h S Q q 1 0 0 1 454.292 467.749 cm 0 0 m 21.874 0 l 21.874 1.697 l 22.762 -1.698 l 21.874 -5.092 l 21.874 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 454.292 467.749 cm 0 0 m 21.874 0 l 21.874 1.697 l 22.762 -1.698 l 21.874 -5.092 l 21.874 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 454.3125 467.7305 cm 0 0 m 21.88 0 l 21.88 1.697 l 22.765 -1.699 l 21.88 -5.094 l 21.88 -3.397 l 0 -3.397 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 476.9629 467.749 cm 0 0 m 9.243 0 l 9.243 1.697 l 10.127 -1.698 l 9.243 -5.092 l 9.243 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 476.9629 467.749 cm 0 0 m 9.243 0 l 9.243 1.697 l 10.127 -1.698 l 9.243 -5.092 l 9.243 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 476.9912 467.7305 cm 0 0 m 9.238 0 l 9.238 1.697 l 10.122 -1.699 l 9.238 -5.094 l 9.238 -3.397 l 0 -3.397 l 0 0 l h S Q q 1 0 0 1 488.0049 467.749 cm 0 0 m 5.316 0 l 5.316 1.697 l 5.906 -1.698 l 5.316 -5.092 l 5.316 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 488.0049 467.749 cm 0 0 m 5.316 0 l 5.316 1.697 l 5.906 -1.698 l 5.316 -5.092 l 5.316 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 488.0293 467.7305 cm 0 0 m 5.316 0 l 5.316 1.697 l 5.907 -1.699 l 5.316 -5.094 l 5.316 -3.397 l 0 -3.397 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 494.0898 467.749 cm 0 0 m 2.922 0 l 2.922 1.697 l 3.215 -1.698 l 2.922 -5.092 l 2.922 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 494.0898 467.749 cm 0 0 m 2.922 0 l 2.922 1.697 l 3.215 -1.698 l 2.922 -5.092 l 2.922 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 494.1113 467.7305 cm 0 0 m 2.925 0 l 2.925 1.697 l 3.22 -1.699 l 2.925 -5.094 l 2.925 -3.397 l 0 -3.397 l 0 0 l h S Q 0.501 0.764 0.267 scn q 1 0 0 1 497.4834 467.749 cm 0 0 m 12.785 0 l 12.785 1.697 l 13.669 -1.698 l 12.785 -5.092 l 12.785 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 497.4834 467.749 cm 0 0 m 12.785 0 l 12.785 1.697 l 13.669 -1.698 l 12.785 -5.092 l 12.785 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 497.5088 467.7305 cm 0 0 m 12.783 0 l 12.783 1.697 l 13.67 -1.699 l 12.783 -5.094 l 12.783 -3.397 l 0 -3.397 l 0 0 l h S Q 0.262 w q 1 0 0 1 86.3999 457.1753 cm 0 0 m 6.821 0 l S Q q 1 0 0 1 93.2207 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 92.395 457.1753 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 92.395 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 103.8501 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 103.0239 457.1753 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 103.0239 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 114.479 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 113.6543 457.1753 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 113.6543 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 125.1079 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 124.2813 457.1753 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 124.2813 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 135.7383 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 134.9116 457.1753 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 134.9116 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 146.3662 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 145.5386 457.1753 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 145.5386 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 156.9946 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 156.1685 457.1753 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 156.1685 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 167.6235 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 166.7969 457.1753 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 166.7969 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 178.2534 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 177.4277 457.1753 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 177.4277 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 188.8828 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 188.0562 457.1753 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 188.0562 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 199.5117 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 198.686 457.1753 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 198.686 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 210.1411 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 209.314 457.1753 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 209.314 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 220.769 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 219.9434 457.1753 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 219.9434 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 231.3989 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 230.5723 457.1753 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 230.5723 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 242.0273 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 241.2017 457.1753 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 241.2017 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 252.6567 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 251.8286 457.1753 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 251.8286 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 263.2861 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 262.4585 457.1753 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 262.4585 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 273.915 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 273.0889 457.1753 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 273.0889 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 284.5449 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 283.7178 457.1753 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 283.7178 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 295.1724 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 294.3457 457.1753 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 294.3457 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 305.8032 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 304.9741 457.1753 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 304.9741 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 316.4307 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 315.6055 457.1753 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 315.6055 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 327.0605 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 326.2324 457.1753 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 326.2324 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 337.6895 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 336.8623 457.1753 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 336.8623 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 348.3193 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 347.4893 457.1753 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 347.4893 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 358.9453 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 358.1182 457.1753 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 358.1182 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 369.5762 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 368.75 457.1753 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 368.75 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 380.2061 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 379.3779 457.1753 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 379.3779 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 390.834 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 390.0078 457.1753 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 390.0078 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 401.4639 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 400.6367 457.1753 cm 0 0 m 11.452 0 l S Q q 1 0 0 1 400.6367 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 412.0889 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 411.2656 457.1753 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 411.2656 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 422.7227 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 421.8955 457.1753 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 421.8955 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 433.3516 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 432.5254 457.1753 cm 0 0 m 11.453 0 l S Q q 1 0 0 1 432.5254 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 443.9785 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 443.1514 457.1753 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 443.1514 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 454.6074 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 453.7822 457.1753 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 453.7822 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 465.2393 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 464.4102 457.1753 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 464.4102 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 475.8652 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 475.0371 457.1753 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 475.0371 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 486.4951 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 485.6689 457.1753 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 485.6689 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 497.123 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 496.2969 457.1753 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 496.2969 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 507.7529 457.9136 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 506.9268 457.1753 cm 0 0 m 4.634 0 l S Q q 1 0 0 1 506.9268 457.9136 cm 0 0 m 0 -1.476 l S Q BT 0.137 0.123 0.126 scn /TT0 1 Tf 5.2485 0 0 5.2485 515.0791 461.6216 Tm (480 kb )Tj 0 3.9365 -3.9365 0 91.7012 468.3462 Tm (0350 )Tj -0.021 -1.21 Td (0352 )Tj 0 -1.456 TD (0351 )Tj 0.021 -1.236 Td (0353 )Tj 3.9365 0 0 3.9365 113.2266 468.1821 Tm (0354 )Tj 3.987 0 Td (0355 )Tj 2.7835 2.7835 -2.7835 2.7835 140.0938 469.2346 Tm (ncRNA )Tj 0 3.9365 -3.9365 0 148.2627 468.1021 Tm (0357 )Tj 3.9365 0 0 3.9365 151.6377 468.3462 Tm (0358 )Tj 3.779 -0.021 Td (0359 )Tj 3.94 0.021 Td (0360 )Tj 0 3.9365 -3.9365 0 197.123 468.1821 Tm (0361 )Tj 0.083 -1.129 Td (0362 )Tj -0.062 -1.26 Td (0363 )Tj -0.021 -1.597 Td (0364 )Tj -0.021 -1.478 Td (0365 )Tj 3.9365 0 0 3.9365 221.9287 468.2651 Tm (0366 )Tj 0 3.9365 -3.9365 0 235.0566 468.1831 Tm (0367 )Tj 3.9365 0 0 3.9365 244.1299 468.2651 Tm (0368 )Tj 4.168 0.021 Td (0369 )Tj 0 3.9365 -3.9365 0 274.168 468.2651 Tm (0370 )Tj 3.9365 0 0 3.9365 283.5361 468.3462 Tm (0371 )Tj 4.938 0 Td (0372 )Tj 4.866 0 Td (0373 )Tj 2.3196 2.3196 -2.3196 2.3196 334.6512 469.4785 Tm (tRNA-arg )Tj 3.9365 0 0 3.9365 336.3223 468.2651 Tm [(0)25(3)25(7)25(5)25( )]TJ 0 3.9365 -3.9365 0 346.8779 468.1021 Tm (0376 )Tj 3.9365 0 0 3.9365 351.7686 468.3462 Tm (0377 )Tj 2.534 0.021 Td (0378 )Tj 0 3.9365 -3.9365 0 372.5527 468.02 Tm (0379 )Tj 3.9365 0 0 3.9365 374.7637 468.3462 Tm (0380 )Tj 0 3.9365 -3.9365 0 389.6211 468.1831 Tm (0381 )Tj 0.021 -1.779 Td (0382 )Tj 0 -2.174 TD (0383 )Tj 0.042 -2.139 Td (0384 )Tj -0.042 -1.941 Td (0385 )Tj 3.9365 0 0 3.9365 424.5215 468.3462 Tm (0386 )Tj 3.127 0 Td (0387 )Tj 0 3.9365 -3.9365 0 451.25 468.1021 Tm (0388 )Tj 3.9365 0 0 3.9365 461.5674 468.4292 Tm (0389 )Tj 4.187 -0.042 Td (0390 )Tj 0 3.9365 -3.9365 0 492.123 468.1821 Tm (0391 )Tj -0.041 -1.178 Td (0392 )Tj 3.9365 0 0 3.9365 500.2354 468.3462 Tm (0393 )Tj -103.231 -2.683 Td (158 )Tj 2.7 0 Td (159 )Tj 2.7 0 Td (160 )Tj 2.7 0 Td (161 )Tj 2.7 0 Td (162 )Tj 2.7 0 Td (163 )Tj 2.7 0 Td (164 )Tj 2.7 0 Td (165 )Tj 2.7 0 Td (166 )Tj 2.7 0 Td (167 )Tj 2.7 0 Td (168 )Tj 2.7 0 Td (169 )Tj 2.7 0 Td (170 )Tj 2.7 0 Td (171 )Tj 2.7 0 Td (172 )Tj 2.7 0 Td (173 )Tj 2.7 0 Td (174 )Tj 2.7 0 Td (175 )Tj 2.7 0 Td (176 )Tj 2.7 0 Td (177 )Tj 2.7 0 Td (178 )Tj 2.7 0 Td (179 )Tj 2.7 0 Td (180 )Tj 2.7 0 Td (181 )Tj 2.7 0 Td (182 )Tj 2.7 0 Td (183 )Tj 2.7 0 Td (184 )Tj 2.7 0 Td (185 )Tj 2.7 0 Td (186 )Tj 2.7 0 Td (187 )Tj 2.7 0 Td (188 )Tj 2.7 0 Td (189 )Tj 2.7 0 Td (190 )Tj 2.7 0 Td (191 )Tj 2.7 0 Td (192 )Tj 2.7 0 Td (193 )Tj 2.7 0 Td (194 )Tj 2.7 0 Td (195 )Tj 2.7 0 Td (196 )Tj 2.7 0 Td (197 )Tj 0 2.1651 -2.1651 0 90.9932 464.7222 Tm [(h)25(u)25(p)]TJ 2.6243 0 0 2.6243 98.6201 465.2144 Tm [(r)25(e)25(c)25(U)]TJ /TT2 1 Tf 3.2804 0 0 3.2804 151.9258 464.8872 Tm [(r)-25(e)-25(c)-25(A)]TJ 1 1 1 scn 9.7 0 Td [(f)-50(f)-50(h)]TJ /TT0 1 Tf 0 1.9682 -1.9682 0 201.376 464.394 Tm [(r)25(p)25(s)25(P)]TJ 0.137 0.123 0.126 scn 2.6243 0 0 2.6243 202.9346 465.1323 Tm [(r)25(i)25(m)25(M)]TJ 1 1 1 scn /TT2 1 Tf 3.2804 0 0 3.2804 208.1846 464.9683 Tm [(t)10(r)10(m)10(D)]TJ 2.2963 0 0 2.2963 215.5654 465.2964 Tm [(r)25(p)25(l)25(S)]TJ 3.2804 0 0 3.2804 222.7822 465.1323 Tm [(y)-25(l)-25(g)-25(F)]TJ 0.137 0.123 0.126 scn /TT0 1 Tf 2.575 -0.05 Td [(r)25(n)25(h)25(B)]TJ 1 1 1 scn /TT2 1 Tf 36.824 0.075 Td [(c)-25(g)-25(t)-25(A)]TJ 3.026 -0.1 Td (nadE)Tj /TT0 1 Tf 7.074 0 Td [(m)10(t)10(n)10(N)]TJ /TT2 1 Tf 15.801 -0.025 Td [(t)-25(r)-25(m)-25(U)]TJ 13.05 0.025 Td [(f)-25(m)-25(t)]TJ 2.625 0.025 Td [(e)-25(f)-25(p)]TJ 4.15 0.05 Td [(t)-25(i)-25(g)]TJ ET q 1 0 0 1 86.3999 441.7598 cm 0 0 m 425.161 0 l S Q 0.501 0.764 0.267 scn q 1 0 0 1 87.3169 447.9053 cm 0 0 m 24.208 0 l 24.208 1.696 l 25.095 -1.697 l 24.208 -5.094 l 24.208 -3.395 l 0 -3.395 l h f* Q 0.281 w 4 M q 1 0 0 1 87.3169 447.9053 cm 0 0 m 24.208 0 l 24.208 1.696 l 25.095 -1.697 l 24.208 -5.094 l 24.208 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 87.3169 447.8853 cm 0 0 m 24.21 0 l 24.21 1.697 l 25.095 -1.698 l 24.21 -5.094 l 24.21 -3.396 l 0 -3.396 l 0 0 l h S Q 0.99 0.914 0.17 scn q 1 0 0 1 113.4438 447.9053 cm 0 0 m 12.252 0 l 12.252 1.696 l 13.138 -1.697 l 12.252 -5.094 l 12.252 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 113.4438 447.9053 cm 0 0 m 12.252 0 l 12.252 1.696 l 13.138 -1.697 l 12.252 -5.094 l 12.252 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 113.4473 447.8853 cm 0 0 m 12.251 0 l 12.251 1.697 l 13.137 -1.698 l 12.251 -5.094 l 12.251 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 150.5244 447.9053 cm 0 0 m -22.761 0 l -22.761 1.696 l -23.646 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l -25.271 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 202.0205 447.8853 cm 0 0 m -25.272 0 l -25.272 1.697 l -26.159 -1.698 l -25.272 -5.094 l -25.272 -3.396 l 0 -3.396 l 0 0 l h S Q 0.716 0.434 0.681 scn q 1 0 0 1 203.6079 447.9053 cm 0 0 m 55.033 0 l 55.033 1.696 l 55.919 -1.697 l 55.033 -5.094 l 55.033 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 203.6079 447.9053 cm 0 0 m 55.033 0 l 55.033 1.696 l 55.919 -1.697 l 55.033 -5.094 l 55.033 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 203.6162 447.8853 cm 0 0 m 55.034 0 l 55.034 1.697 l 55.92 -1.698 l 55.034 -5.094 l 55.034 -3.396 l 0 -3.396 l 0 0 l h S Q 1 1 1 scn q 1 0 0 1 260.0571 447.9053 cm 0 0 m 5.285 0 l 5.285 1.696 l 5.847 -1.697 l 5.285 -5.094 l 5.285 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 260.0571 447.9053 cm 0 0 m 5.285 0 l 5.285 1.696 l 5.847 -1.697 l 5.285 -5.094 l 5.285 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 260.0679 447.8853 cm 0 0 m 5.286 0 l 5.286 1.697 l 5.844 -1.698 l 5.286 -5.094 l 5.286 -3.396 l 0 -3.396 l 0 0 l h S Q 0.501 0.764 0.267 scn q 1 0 0 1 266.9355 447.9053 cm 0 0 m 18.07 0 l 18.07 1.696 l 18.954 -1.697 l 18.07 -5.094 l 18.07 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 266.9355 447.9053 cm 0 0 m 18.07 0 l 18.07 1.696 l 18.954 -1.697 l 18.07 -5.094 l 18.07 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 266.9473 447.8853 cm 0 0 m 18.069 0 l 18.069 1.697 l 18.956 -1.698 l 18.069 -5.094 l 18.069 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 285.9482 447.9053 cm 0 0 m 4.755 0 l 4.755 1.696 l 5.257 -1.697 l 4.755 -5.094 l 4.755 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 285.9482 447.9053 cm 0 0 m 4.755 0 l 4.755 1.696 l 5.257 -1.697 l 4.755 -5.094 l 4.755 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 285.9614 447.8853 cm 0 0 m 4.753 0 l 4.753 1.697 l 5.255 -1.698 l 4.753 -5.094 l 4.753 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 291.2632 447.9053 cm 0 0 m 8.709 0 l 8.709 1.696 l 9.594 -1.697 l 8.709 -5.094 l 8.709 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 291.2632 447.9053 cm 0 0 m 8.709 0 l 8.709 1.696 l 9.594 -1.697 l 8.709 -5.094 l 8.709 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 291.2749 447.8853 cm 0 0 m 8.711 0 l 8.711 1.697 l 9.597 -1.698 l 8.711 -5.094 l 8.711 -3.396 l 0 -3.396 l 0 0 l h S Q 0.99 0.914 0.17 scn q 1 0 0 1 300.8574 447.9053 cm 0 0 m 7.175 0 l 7.175 1.696 l 7.971 -1.697 l 7.175 -5.094 l 7.175 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 300.8574 447.9053 cm 0 0 m 7.175 0 l 7.175 1.696 l 7.971 -1.697 l 7.175 -5.094 l 7.175 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 300.8721 447.8853 cm 0 0 m 7.176 0 l 7.176 1.697 l 7.971 -1.698 l 7.176 -5.094 l 7.176 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 309.5078 447.9053 cm 0 0 m 13.671 0 l 13.671 1.696 l 14.555 -1.697 l 13.671 -5.094 l 13.671 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 309.5078 447.9053 cm 0 0 m 13.671 0 l 13.671 1.696 l 14.555 -1.697 l 13.671 -5.094 l 13.671 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 309.5225 447.8853 cm 0 0 m 13.672 0 l 13.672 1.697 l 14.556 -1.698 l 13.672 -5.094 l 13.672 -3.396 l 0 -3.396 l 0 0 l h S Q 0.99 0.914 0.17 scn q 1 0 0 1 324.4473 447.9053 cm 0 0 m 18.63 0 l 18.63 1.696 l 19.516 -1.697 l 18.63 -5.094 l 18.63 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 324.4473 447.9053 cm 0 0 m 18.63 0 l 18.63 1.696 l 19.516 -1.697 l 18.63 -5.094 l 18.63 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 324.4609 447.8853 cm 0 0 m 18.629 0 l 18.629 1.697 l 19.515 -1.698 l 18.629 -5.094 l 18.629 -3.396 l 0 -3.396 l 0 0 l h S Q 0.97 0.579 0.116 scn q 1 0 0 1 344.0205 447.9053 cm 0 0 m 15.265 0 l 15.265 1.696 l 16.148 -1.697 l 15.265 -5.094 l 15.265 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 344.0205 447.9053 cm 0 0 m 15.265 0 l 15.265 1.696 l 16.148 -1.697 l 15.265 -5.094 l 15.265 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 344.0391 447.8853 cm 0 0 m 15.262 0 l 15.262 1.697 l 16.147 -1.698 l 15.262 -5.094 l 15.262 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 360.1689 447.9053 cm 0 0 m 6.467 0 l 6.467 1.696 l 7.176 -1.697 l 6.467 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1 0 0 1 375.5713 447.8853 cm 0 0 m 13.582 0 l 13.582 1.697 l 14.465 -1.698 l 13.582 -5.094 l 13.582 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 390.4629 447.9053 cm 0 0 m 15.202 0 l 15.202 1.696 l 16.089 -1.697 l 15.202 -5.094 l 15.202 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 390.4629 447.9053 cm 0 0 m 15.202 0 l 15.202 1.696 l 16.089 -1.697 l 15.202 -5.094 l 15.202 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 390.4795 447.8853 cm 0 0 m 15.205 0 l 15.205 1.697 l 16.091 -1.698 l 15.205 -5.094 l 15.205 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 407.792 447.9053 cm 0 0 m 43.25 0 l 43.25 1.696 l 44.136 -1.697 l 43.25 -5.094 l 43.25 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 407.792 447.9053 cm 0 0 m 43.25 0 l 43.25 1.696 l 44.136 -1.697 l 43.25 -5.094 l 43.25 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 407.8105 447.8853 cm 0 0 m 43.254 0 l 43.254 1.697 l 44.142 -1.698 l 43.254 -5.094 l 43.254 -3.396 l 0 -3.396 l 0 0 l h S Q 0.25 0.396 0.688 scn q 1 0 0 1 452.0479 447.9053 cm 0 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0.137 0.123 0.126 scn 5.875 0 Td [(r)-25(a)-25(r)-25(A)]TJ 1 1 1 scn 53.75 0.05 Td [(e)-25(r)-25(a)]TJ 0.137 0.123 0.126 scn 2.375 -0.025 Td [(r)-25(e)-25(c)-25(O)]TJ 1 1 1 scn 3.7 0.05 Td [(g)-25(l)-25(y)-25(S)]TJ 0.137 0.123 0.126 scn 5.1 -0.075 Td [(d)-25(n)-25(a)-25(G)]TJ 5.6 0.025 Td [(r)-25(p)-25(o)-25(D)]TJ 1 1 1 scn 31.725 0.05 Td [(a)-25(p)-25(t)]TJ 13.025 -0.05 Td [(s)-25(m)-25(c)]TJ ET q 1 0 0 1 86.3999 400.8384 cm 0 0 m 425.161 0 l S Q 0.99 0.914 0.17 scn 0.281 w 4 M q 1 0 0 1 86.3999 406.9844 cm 0 0 m 5.611 0 l 5.611 1.7 l 6.231 -1.696 l 5.611 -5.091 l 5.611 -3.394 l 0 -3.394 l B* Q 10 M q 1 0 0 1 86.3999 406.9639 cm 0 0 m 5.611 0 l 5.611 1.697 l 6.231 -1.699 l 5.611 -5.094 l 5.611 -3.395 l 0 -3.395 l S Q 0.73 0.805 0.919 scn q 1 0 0 1 93.7817 406.9844 cm 0 0 m 22.32 0 l 22.32 1.7 l 23.206 -1.696 l 22.32 -5.091 l 22.32 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 93.7817 406.9844 cm 0 0 m 22.32 0 l 22.32 1.7 l 23.206 -1.696 l 22.32 -5.091 l 22.32 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 93.7817 406.9639 cm 0 0 m 22.322 0 l 22.322 1.697 l 23.208 -1.699 l 22.322 -5.094 l 22.322 -3.395 l 0 -3.395 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 133.5503 406.9844 cm 0 0 m -15.235 0 l -15.235 1.7 l -16.121 -1.696 l -15.235 -5.091 l -15.235 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 133.5503 406.9844 cm 0 0 m -15.235 0 l -15.235 1.7 l -16.121 -1.696 l -15.235 -5.091 l -15.235 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 133.5522 406.9639 cm 0 0 m -15.235 0 l -15.235 1.697 l -16.12 -1.699 l -15.235 -5.094 l -15.235 -3.395 l 0 -3.395 l 0 0 l h S Q 0.756 0.48 0.179 scn q 1 0 0 1 147.8101 406.9844 cm 0 0 m 34.837 0 l 34.837 1.7 l 35.723 -1.696 l 34.837 -5.091 l 34.837 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 147.8101 406.9844 cm 0 0 m 34.837 0 l 34.837 1.7 l 35.723 -1.696 l 34.837 -5.091 l 34.837 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 147.8135 406.9639 cm 0 0 m 34.839 0 l 34.839 1.697 l 35.726 -1.699 l 34.839 -5.094 l 34.839 -3.395 l 0 -3.395 l 0 0 l h S Q 0.739 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cm 0 0 m -11.632 0 l -11.632 1.7 l -12.519 -1.696 l -11.632 -5.091 l -11.632 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 212.2949 406.9639 cm 0 0 m -11.632 0 l -11.632 1.697 l -12.518 -1.699 l -11.632 -5.094 l -11.632 -3.395 l 0 -3.395 l 0 0 l h S Q 0.501 0.764 0.267 scn q 1 0 0 1 223.3008 406.9844 cm 0 0 m -10.126 0 l -10.126 1.7 l -11.012 -1.696 l -10.126 -5.091 l -10.126 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 223.3008 406.9844 cm 0 0 m -10.126 0 l -10.126 1.7 l -11.012 -1.696 l -10.126 -5.091 l -10.126 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 223.3091 406.9639 cm 0 0 m -10.127 0 l -10.127 1.697 l -11.014 -1.699 l -10.127 -5.094 l -10.127 -3.395 l 0 -3.395 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 232.1875 406.9844 cm 0 0 m -8.237 0 l -8.237 1.7 l -9.124 -1.696 l -8.237 -5.091 l -8.237 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 232.1875 406.9844 cm 0 0 m -8.237 0 l -8.237 1.7 l -9.124 -1.696 l -8.237 -5.091 l -8.237 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 232.1958 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0 0 m 20.37 0 l 20.37 1.7 l 21.258 -1.696 l 20.37 -5.091 l 20.37 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 369.9307 406.9639 cm 0 0 m 20.371 0 l 20.371 1.697 l 21.26 -1.699 l 20.371 -5.094 l 20.371 -3.395 l 0 -3.395 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 396.5713 406.9844 cm 0 0 m -4.192 0 l -4.192 1.7 l -4.634 -1.696 l -4.192 -5.091 l -4.192 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 396.5713 406.9844 cm 0 0 m -4.192 0 l -4.192 1.7 l -4.634 -1.696 l -4.192 -5.091 l -4.192 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 396.5918 406.9639 cm 0 0 m -4.194 0 l -4.194 1.697 l -4.636 -1.699 l -4.194 -5.094 l -4.194 -3.395 l 0 -3.395 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 399.9385 406.9844 cm 0 0 m 1.595 0 l 1.595 1.7 l 1.738 -1.696 l 1.595 -5.091 l 1.595 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 399.9385 406.9844 cm 0 0 m 1.595 0 l 1.595 1.7 l 1.738 -1.696 l 1.595 -5.091 l 1.595 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 399.957 406.9639 cm 0 0 m 1.596 0 l 1.596 1.697 l 1.741 -1.699 l 1.596 -5.094 l 1.596 -3.395 l 0 -3.395 l 0 0 l h S Q 0.99 0.914 0.17 scn q 1 0 0 1 402.8594 406.9844 cm 0 0 m 5.347 0 l 5.347 1.7 l 5.937 -1.696 l 5.347 -5.091 l 5.347 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 402.8594 406.9844 cm 0 0 m 5.347 0 l 5.347 1.7 l 5.937 -1.696 l 5.347 -5.091 l 5.347 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 402.8809 406.9639 cm 0 0 m 5.345 0 l 5.345 1.697 l 5.932 -1.699 l 5.345 -5.094 l 5.345 -3.395 l 0 -3.395 l 0 0 l h S Q q 1 0 0 1 408.9717 406.9844 cm 0 0 m 8.945 0 l 8.945 1.7 l 9.833 -1.696 l 8.945 -5.091 l 8.945 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 408.9717 406.9844 cm 0 0 m 8.945 0 l 8.945 1.7 l 9.833 -1.696 l 8.945 -5.091 l 8.945 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 408.9912 406.9639 cm 0 0 m 8.946 0 l 8.946 1.697 l 9.833 -1.699 l 8.946 -5.094 l 8.946 -3.395 l 0 -3.395 l 0 0 l h S Q 0.503 0.51 0.52 scn q 1 0 0 1 419.6318 406.9844 cm 0 0 m 13.521 0 l 13.521 1.7 l 14.403 -1.696 l 13.521 -5.091 l 13.521 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 419.6318 406.9844 cm 0 0 m 13.521 0 l 13.521 1.7 l 14.403 -1.696 l 13.521 -5.091 l 13.521 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 419.6514 406.9639 cm 0 0 m 13.522 0 l 13.522 1.697 l 14.405 -1.699 l 13.522 -5.094 l 13.522 -3.395 l 0 -3.395 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 442.8076 406.9844 cm 0 0 m -7.736 0 l -7.736 1.7 l -8.593 -1.696 l -7.736 -5.091 l -7.736 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 442.8076 406.9844 cm 0 0 m -7.736 0 l -7.736 1.7 l -8.593 -1.696 l -7.736 -5.091 l -7.736 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 442.8291 406.9639 cm 0 0 m -7.737 0 l -7.737 1.697 l -8.594 -1.699 l -7.737 -5.094 l -7.737 -3.395 l 0 -3.395 l 0 0 l h S Q q 1 0 0 1 443.6338 406.9844 cm 0 0 m 8.885 0 l 8.885 1.7 l 9.769 -1.696 l 8.885 -5.091 l 8.885 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 443.6338 406.9844 cm 0 0 m 8.885 0 l 8.885 1.7 l 9.769 -1.696 l 8.885 -5.091 l 8.885 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 443.6543 406.9639 cm 0 0 m 8.889 0 l 8.889 1.697 l 9.773 -1.699 l 8.889 -5.094 l 8.889 -3.395 l 0 -3.395 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 453.4941 406.9844 cm 0 0 m 10.835 0 l 10.835 1.7 l 11.719 -1.696 l 10.835 -5.091 l 10.835 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 453.4941 406.9844 cm 0 0 m 10.835 0 l 10.835 1.7 l 11.719 -1.696 l 10.835 -5.091 l 10.835 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 453.5156 406.9639 cm 0 0 m 10.835 0 l 10.835 1.697 l 11.724 -1.699 l 10.835 -5.094 l 10.835 -3.395 l 0 -3.395 l 0 0 l h S Q 0.99 0.914 0.17 scn q 1 0 0 1 478.3223 406.9844 cm 0 0 m -12.104 0 l -12.104 1.7 l -12.988 -1.696 l -12.104 -5.091 l -12.104 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 478.3223 406.9844 cm 0 0 m -12.104 0 l -12.104 1.7 l -12.988 -1.696 l -12.104 -5.091 l -12.104 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 478.3467 406.9639 cm 0 0 m -12.105 0 l -12.105 1.697 l -12.99 -1.699 l -12.105 -5.094 l -12.105 -3.395 l 0 -3.395 l 0 0 l h S Q 0.501 0.764 0.267 scn q 1 0 0 1 479.8584 406.9844 cm 0 0 m 28.195 0 l 28.195 1.7 l 29.08 -1.696 l 28.195 -5.091 l 28.195 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 479.8584 406.9844 cm 0 0 m 28.195 0 l 28.195 1.7 l 29.08 -1.696 l 28.195 -5.091 l 28.195 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 479.8818 406.9639 cm 0 0 m 28.197 0 l 28.197 1.697 l 29.083 -1.699 l 28.197 -5.094 l 28.197 -3.395 l 0 -3.395 l 0 0 l h S Q 0.25 0.396 0.688 scn 4 M q 1 0 0 1 511.5361 406.9844 cm 0 0 m -1.595 0 l -1.595 1.7 l -1.771 -1.696 l -1.595 -5.091 l -1.595 -3.394 l 0 -3.394 l B* Q 10 M q 1 0 0 1 511.5605 406.9639 cm 0 0 m -1.594 0 l -1.594 1.697 l -1.769 -1.699 l -1.594 -5.094 l -1.594 -3.395 l 0 -3.395 l S Q 0.262 w q 1 0 0 1 86.3999 396.4111 cm 0 0 m 6.821 0 l S Q q 1 0 0 1 93.2207 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 92.395 396.4111 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 92.395 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 103.8501 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 103.0239 396.4111 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 103.0239 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 114.479 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 113.6543 396.4111 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 113.6543 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 125.1079 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 124.2813 396.4111 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 124.2813 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 135.7383 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 134.9116 396.4111 cm 0 0 m 13.049 0 l S Q q 1 0 0 1 134.9116 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 147.9609 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 147.1333 396.4111 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 147.1333 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 158.5894 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 157.7622 396.4111 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 157.7622 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 169.2192 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 168.3926 396.4111 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 168.3926 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 179.8481 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 179.0215 396.4111 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 179.0215 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 190.4766 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 189.6509 396.4111 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 189.6509 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 201.1055 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 200.2798 396.4111 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 200.2798 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 211.7334 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 210.9067 396.4111 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 210.9067 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 222.3643 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 221.5381 396.4111 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 221.5381 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 232.9932 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 232.167 396.4111 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 232.167 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 243.6235 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 242.7974 396.4111 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 242.7974 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 254.2515 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 253.4233 396.4111 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 253.4233 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 264.8794 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 264.0532 396.4111 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 264.0532 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 275.5088 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 274.6826 396.4111 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 274.6826 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 286.1387 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 285.3105 396.4111 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 285.3105 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 296.7671 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 295.9395 396.4111 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 295.9395 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 307.3955 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 306.5688 396.4111 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 306.5688 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 318.0225 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 317.1992 396.4111 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 317.1992 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 328.6533 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 327.8281 396.4111 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 327.8281 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 339.2822 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 338.458 396.4111 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 338.458 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 349.9131 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 349.0869 396.4111 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 349.0869 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 360.542 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 359.7168 396.4111 cm 0 0 m 11.453 0 l S Q q 1 0 0 1 359.7168 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 371.1699 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 370.3418 396.4111 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 370.3418 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 381.7998 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 380.9717 396.4111 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 380.9717 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 392.4277 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 391.6016 396.4111 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 391.6016 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 403.0586 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 402.2305 396.4111 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 402.2305 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 413.6855 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 412.8604 396.4111 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 412.8604 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 424.3164 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 423.4883 396.4111 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 423.4883 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 434.9443 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 434.1172 396.4111 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 434.1172 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 445.5742 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 444.7471 396.4111 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 444.7471 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 456.2041 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 455.377 396.4111 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 455.377 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 466.832 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 466.0059 396.4111 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 466.0059 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 477.46 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 476.6348 396.4111 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 476.6348 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 488.0898 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 487.2607 396.4111 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 487.2607 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 498.7178 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 497.8926 396.4111 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 497.8926 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 509.3486 397.1484 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 508.5215 396.4111 cm 0 0 m 3.039 0 l S Q q 1 0 0 1 508.5215 397.1484 cm 0 0 m 0 -1.476 l S Q BT 0.137 0.123 0.126 scn /TT0 1 Tf 5.2485 0 0 5.2485 515.0791 400.8579 Tm (600 kb )Tj 3.9365 0 0 3.9365 101.0059 407.5015 Tm (0454 )Tj 5.286 0.042 Td (0455 )Tj 10.137 -0.063 Td (0460 )Tj 0 3.9365 -3.9365 0 189.6982 407.3384 Tm (0461 )Tj 0.021 -2.08 Td (0462 )Tj 3.9365 0 0 3.9365 202.9775 407.5835 Tm (0463 )Tj 3.059 0.042 Td (0464 )Tj 2.414 -0.042 Td (0465 )Tj 0 3.9365 -3.9365 0 235.8486 407.4194 Tm (0466 )Tj 3.9365 0 0 3.9365 238.1074 407.5835 Tm (0467 )Tj 2.02 0 Td (0468 )Tj 2.179 0.021 Td (0469 )Tj 2.942 -0.021 Td (0470 )Tj 0 3.9365 -3.9365 0 280.1494 407.3384 Tm (0471 )Tj 3.9365 0 0 3.9365 281.9404 407.5835 Tm (0472 )Tj 0 3.9365 -3.9365 0 299.4492 407.4194 Tm (0473 )Tj 0.021 -1.978 Td (0474 )Tj 3.9365 0 0 3.9365 313.5508 407.6655 Tm (0475 )Tj 2.983 -0.021 Td (0476 )Tj 2.861 0 Td (0477 )Tj 0 3.9365 -3.9365 0 349.3525 407.5015 Tm (0478 )Tj 3.9365 0 0 3.9365 356.4883 407.5015 Tm (0479 )Tj 4.929 -0.021 Td (0480 )Tj 0 3.9365 -3.9365 0 395.9854 407.3384 Tm (0481 )Tj 0.021 -1.292 Td (0482 )Tj 0.021 -1.459 Td (0483 )Tj 3.9365 0 0 3.9365 409.6992 407.6655 Tm (0484 )Tj 3.487 0 Td (0485 )Tj 3.167 -0.021 Td (0486 )Tj 2.255 0 Td (0487 )Tj 2.675 -0.021 Td (0488 )Tj 3.358 0.021 Td (0489 )Tj 5.428 0 Td (0490 )Tj 5.199 -0.021 Td (0491 )Tj -105.801 -2.662 Td (278 )Tj 2.7 0 Td (279 )Tj 2.7 0 Td (280 )Tj 2.7 0 Td (281 )Tj 2.7 0 Td (WM1 )Tj 3.108 0 Td (288 )Tj 2.7 0 Td (289 )Tj 2.7 0 Td (290 )Tj 2.7 0 Td (291 )Tj 2.7 0 Td (292 )Tj 2.7 0 Td (293 )Tj 2.7 0 Td (294 )Tj 2.7 0 Td (295 )Tj 2.7 0 Td (296 )Tj 2.7 0 Td (297 )Tj 2.7 0 Td (298 )Tj 2.7 0 Td (299 )Tj 2.7 0 Td (300 )Tj 2.7 0 Td (301 )Tj 2.7 0 Td (302 )Tj 2.7 0 Td (303 )Tj 2.699 0 Td (304 )Tj 2.7 0 Td (305 )Tj 2.7 0 Td (306 )Tj 2.7 0 Td (307 )Tj 2.7 0 Td (308 )Tj 2.7 0 Td (309 )Tj 2.7 0 Td (310 )Tj 2.701 0 Td (311 )Tj 2.699 0 Td (312 )Tj 2.701 0 Td (313 )Tj 2.7 0 Td (314 )Tj 2.7 0 Td (315 )Tj 2.7 0 Td (316 )Tj 2.7 0 Td (317 )Tj 2.701 0 Td (318 )Tj 2.7 0 Td (319 )Tj 2.7 0 Td (320 )Tj 2.7 0 Td (321 )Tj /TT2 1 Tf 1.9704 0 0 3.2804 184.7295 404.2241 Tm [(t)-25(n)-25(p)-25(B)-25(_)-25(3)]TJ 1.6023 0 0 2.6243 193.668 404.4692 Tm (tnpA_3)Tj 1 1 1 scn 3.2902 0 0 3.2804 314.7139 404.0601 Tm [(l)-25(d)-25(h)]TJ 3.14 0.125 Td [(n)-25(a)-25(g)-25(A)]TJ /TT0 1 Tf 2.9612 0 0 2.9523 391.9648 404.1421 Tm (vlcE)Tj /TT2 1 Tf 0 1.3161 -1.3121 0 401.2324 403.895 Tm (rpsU)Tj 0.137 0.123 0.126 scn /TT0 1 Tf 3.2902 0 0 3.2804 403.0381 404.2241 Tm [(r)25(u)25(v)25(A)]TJ /TT2 1 Tf 2.119 0 Td [(r)-25(u)-25(v)-25(B)]TJ 1 1 1 scn 13.734 0.05 Td [(y)-25(q)-25(e)-25(H)-25( )]TJ 0.137 0.123 0.126 scn 4.112 -0.1 Td [(d)-25(i)-25(n)-25(B)]TJ ET q 1 0 0 1 86.3999 359.3975 cm 0 0 m 425.161 0 l S Q 0.969 0.719 0.828 scn 4 M q 1 0 0 1 86.3999 361.8984 cm 0 0 m 13.434 0 l 13.434 3.904 l 0 3.904 l B* Q 10 M q 1 0 0 1 86.3999 361.8682 cm 0 0 m 13.436 0 l 13.436 3.905 l 0 3.905 l S Q 0 0.677 0.647 scn q 1 0 0 1 119.7617 365.5479 cm 0 0 m -16.798 0 l -16.798 1.698 l -17.683 -1.7 l -16.798 -5.092 l -16.798 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 119.7617 365.5479 cm 0 0 m -16.798 0 l -16.798 1.698 l -17.683 -1.7 l -16.798 -5.092 l 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-8.443 1.698 l -9.331 -1.7 l -8.443 -5.092 l -8.443 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 160.0664 365.5215 cm 0 0 m -8.444 0 l -8.444 1.698 l -9.331 -1.7 l -8.444 -5.096 l -8.444 -3.394 l 0 -3.394 l 0 0 l h S Q 0.501 0.764 0.267 scn q 1 0 0 1 174.145 365.5479 cm 0 0 m -10.984 0 l -10.984 1.698 l -11.868 -1.7 l -10.984 -5.092 l -10.984 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 174.145 365.5479 cm 0 0 m -10.984 0 l -10.984 1.698 l -11.868 -1.7 l -10.984 -5.092 l -10.984 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 174.1509 365.5215 cm 0 0 m -10.984 0 l -10.984 1.698 l -11.872 -1.7 l -10.984 -5.096 l -10.984 -3.394 l 0 -3.394 l 0 0 l h S Q q 1 0 0 1 193.6885 365.5479 cm 0 0 m -17.98 0 l -17.98 1.698 l -18.865 -1.7 l -17.98 -5.092 l -17.98 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 193.6885 365.5479 cm 0 0 m -17.98 0 l -17.98 1.698 l -18.865 -1.7 l -17.98 -5.092 l -17.98 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 193.6943 365.5215 cm 0 0 m -17.979 0 l -17.979 1.698 l -18.866 -1.7 l 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-3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 234.4014 365.5479 cm 0 0 m -21.876 0 l -21.876 1.698 l -22.763 -1.7 l -21.876 -5.092 l -21.876 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 234.4116 365.5215 cm 0 0 m -21.88 0 l -21.88 1.698 l -22.765 -1.7 l -21.88 -5.096 l -21.88 -3.394 l 0 -3.394 l 0 0 l h S Q q 1 0 0 1 238.6528 365.5479 cm 0 0 m -2.273 0 l -2.273 1.698 l -2.51 -1.7 l -2.273 -5.092 l -2.273 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 238.6528 365.5479 cm 0 0 m -2.273 0 l -2.273 1.698 l -2.51 -1.7 l -2.273 -5.092 l -2.273 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 238.6626 365.5215 cm 0 0 m -2.273 0 l -2.273 1.698 l -2.509 -1.7 l -2.273 -5.096 l -2.273 -3.394 l 0 -3.394 l 0 0 l h S Q q 1 0 0 1 245.3247 365.5479 cm 0 0 m -6.112 0 l -6.112 1.698 l -6.791 -1.7 l -6.112 -5.092 l -6.112 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 245.3247 365.5479 cm 0 0 m -6.112 0 l -6.112 1.698 l -6.791 -1.7 l -6.112 -5.092 l -6.112 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 245.3354 365.5215 cm 0 0 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168.063 344.1934 cm 0 0 m 7.173 0 l 7.173 1.477 l 7.94 -1.475 l 7.173 -4.43 l 7.173 -2.951 l 0 -2.951 l 0 0 l S Q 10 M q 1 0 0 1 168.0674 344.167 cm 0 0 m 7.175 0 l 7.175 1.477 l 7.942 -1.475 l 7.175 -4.428 l 7.175 -2.951 l 0 -2.951 l 0 0 l h S Q q 1 0 0 1 178.0723 344.1934 cm 0 0 m 3.511 0 l 3.511 1.477 l 3.896 -1.475 l 3.511 -4.43 l 3.511 -2.951 l 0 -2.951 l h f* Q 4 M q 1 0 0 1 178.0723 344.1934 cm 0 0 m 3.511 0 l 3.511 1.477 l 3.896 -1.475 l 3.511 -4.43 l 3.511 -2.951 l 0 -2.951 l 0 0 l S Q 10 M q 1 0 0 1 178.0767 344.167 cm 0 0 m 3.513 0 l 3.513 1.477 l 3.897 -1.475 l 3.513 -4.428 l 3.513 -2.951 l 0 -2.951 l 0 0 l h S Q 1 1 1 scn q 1 0 0 1 184.3301 344.1934 cm 0 0 m 8.828 0 l 8.828 1.477 l 9.713 -1.475 l 8.828 -4.43 l 8.828 -2.951 l 0 -2.951 l h f* Q 4 M q 1 0 0 1 184.3301 344.1934 cm 0 0 m 8.828 0 l 8.828 1.477 l 9.713 -1.475 l 8.828 -4.43 l 8.828 -2.951 l 0 -2.951 l 0 0 l S Q 10 M q 1 0 0 1 184.3359 344.167 cm 0 0 m 8.828 0 l 8.828 1.477 l 9.714 -1.475 l 8.828 -4.428 l 8.828 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-3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 256.1597 344.417 cm 0 0 m -13.756 0 l -13.756 1.697 l -14.644 -1.698 l -13.756 -5.094 l -13.756 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 256.1704 344.3887 cm 0 0 m -13.759 0 l -13.759 1.693 l -14.645 -1.696 l -13.759 -5.092 l -13.759 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 272.605 344.417 cm 0 0 m -15.559 0 l -15.559 1.697 l -16.445 -1.698 l -15.559 -5.094 l -15.559 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 272.605 344.417 cm 0 0 m -15.559 0 l -15.559 1.697 l -16.445 -1.698 l -15.559 -5.094 l -15.559 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 272.6157 344.3887 cm 0 0 m -15.558 0 l -15.558 1.693 l -16.445 -1.696 l -15.558 -5.092 l -15.558 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 297.1387 344.417 cm 0 0 m -23.589 0 l -23.589 1.697 l -24.477 -1.698 l -23.589 -5.094 l -23.589 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 297.1387 344.417 cm 0 0 m -23.589 0 l -23.589 1.697 l -24.477 -1.698 l -23.589 -5.094 l -23.589 -3.396 l 0 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-26.57 -5.094 l -26.57 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 359.9219 344.3887 cm 0 0 m -26.572 0 l -26.572 1.693 l -27.459 -1.696 l -26.572 -5.092 l -26.572 -3.396 l 0 -3.396 l 0 0 l h S Q 1 1 1 scn q 1 0 0 1 384.0859 344.417 cm 0 0 m -23.03 0 l -23.03 1.697 l -23.917 -1.698 l -23.03 -5.094 l -23.03 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 384.0859 344.417 cm 0 0 m -23.03 0 l -23.03 1.697 l -23.917 -1.698 l -23.03 -5.094 l -23.03 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 384.1025 344.3887 cm 0 0 m -23.03 0 l -23.03 1.693 l -23.916 -1.696 l -23.03 -5.092 l -23.03 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 414.3154 344.417 cm 0 0 m -26.451 0 l -26.451 1.697 l -27.338 -1.698 l -26.451 -5.094 l -26.451 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 414.3154 344.417 cm 0 0 m -26.451 0 l -26.451 1.697 l -27.338 -1.698 l -26.451 -5.094 l -26.451 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 414.3359 344.3887 cm 0 0 m -26.455 0 l -26.455 1.693 l -27.342 -1.696 l -26.455 -5.092 l -26.455 -3.396 l 0 -3.396 l 0 0 l h S Q 1 1 1 scn q 1 0 0 1 438.4072 344.417 cm 0 0 m -23 0 l -23 1.697 l -23.882 -1.698 l -23 -5.094 l -23 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 438.4072 344.417 cm 0 0 m -23 0 l -23 1.697 l -23.882 -1.698 l -23 -5.094 l -23 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 438.4287 344.3887 cm 0 0 m -23.001 0 l -23.001 1.693 l -23.885 -1.696 l -23.001 -5.092 l -23.001 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 467.6367 344.417 cm 0 0 m -26.277 0 l -26.277 1.697 l -27.164 -1.698 l -26.277 -5.094 l -26.277 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 467.6367 344.417 cm 0 0 m -26.277 0 l -26.277 1.697 l -27.164 -1.698 l -26.277 -5.094 l -26.277 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 467.6582 344.3887 cm 0 0 m -26.278 0 l -26.278 1.693 l -27.163 -1.696 l -26.278 -5.092 l -26.278 -3.396 l 0 -3.396 l 0 0 l h S Q 1 1 1 scn q 1 0 0 1 491.7246 344.417 cm 0 0 m -23.057 0 l -23.057 1.697 l -23.941 -1.698 l -23.057 -5.094 l -23.057 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 491.7246 344.417 cm 0 0 m -23.057 0 l -23.057 1.697 l -23.941 -1.698 l -23.057 -5.094 l -23.057 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 491.752 344.3887 cm 0 0 m -23.06 0 l -23.06 1.693 l -23.945 -1.696 l -23.06 -5.092 l -23.06 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.65 0.316 scn 4 M q 1 0 0 1 511.5361 344.417 cm 0 0 m -16.591 0 l -16.591 1.697 l -17.478 -1.698 l -16.591 -5.094 l -16.591 -3.396 l 0 -3.396 l B* Q 10 M q 1 0 0 1 511.5605 344.3887 cm 0 0 m -16.592 0 l -16.592 1.693 l -17.477 -1.696 l -16.592 -5.092 l -16.592 -3.396 l 0 -3.396 l S Q q 1 0 0 1 94.8164 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 93.9888 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 105.4448 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 104.6187 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 116.0737 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 115.2471 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 126.7017 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 125.876 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 137.333 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 136.5063 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 147.9609 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 147.1333 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 158.5894 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 157.7622 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 169.2192 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 168.3926 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 179.8481 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 179.0215 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 190.4766 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 189.6509 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 201.1055 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 200.2798 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 211.7334 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 210.9067 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 222.3643 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 221.5381 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 232.9932 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 232.167 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 243.6235 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 242.7974 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 254.2515 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 253.4233 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 264.8794 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 264.0532 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 275.5088 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 274.6826 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 286.1387 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 285.3105 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 296.7671 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 295.9404 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 307.3955 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 306.5688 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 318.0234 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 317.1992 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 328.6533 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 327.8281 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 339.2822 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 338.458 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 349.9131 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 349.0869 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 360.542 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 359.7168 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 371.1699 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 370.3418 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 381.7998 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 380.9717 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 392.4277 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 391.6016 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 403.0586 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 402.2305 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 413.6855 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 412.8604 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 424.3164 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 423.4883 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 434.9443 334.5752 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 434.1172 334.5752 cm 0 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0 0 1 398.3438 238.9424 cm 0 0 m -4.546 0 l -4.546 1.695 l -5.05 -1.698 l -4.546 -5.094 l -4.546 -3.398 l 0 -3.398 l h f* Q 4 M q 1 0 0 1 398.3438 238.9424 cm 0 0 m -4.546 0 l -4.546 1.695 l -5.05 -1.698 l -4.546 -5.094 l -4.546 -3.398 l 0 -3.398 l 0 0 l S Q 10 M q 1 0 0 1 398.3623 238.9043 cm 0 0 m -4.547 0 l -4.547 1.695 l -5.047 -1.698 l -4.547 -5.094 l -4.547 -3.395 l 0 -3.395 l 0 0 l h S Q q 1 0 0 1 409.2695 238.9424 cm 0 0 m -9.952 0 l -9.952 1.695 l -10.835 -1.698 l -9.952 -5.094 l -9.952 -3.398 l 0 -3.398 l h f* Q 4 M q 1 0 0 1 409.2695 238.9424 cm 0 0 m -9.952 0 l -9.952 1.695 l -10.835 -1.698 l -9.952 -5.094 l -9.952 -3.398 l 0 -3.398 l 0 0 l S Q 10 M q 1 0 0 1 409.2871 238.9043 cm 0 0 m -9.948 0 l -9.948 1.695 l -10.835 -1.698 l -9.948 -5.094 l -9.948 -3.395 l 0 -3.395 l 0 0 l h S Q 0.501 0.764 0.267 scn q 1 0 0 1 412.4268 238.9424 cm 0 0 m 2.716 0 l 2.716 1.695 l 3.012 -1.698 l 2.716 -5.094 l 2.716 -3.398 l 0 -3.398 l h f* Q 4 M q 1 0 0 1 412.4268 238.9424 cm 0 0 m 2.716 0 l 2.716 1.695 l 3.012 -1.698 l 2.716 -5.094 l 2.716 -3.398 l 0 -3.398 l 0 0 l S Q 10 M q 1 0 0 1 412.4482 238.9043 cm 0 0 m 2.715 0 l 2.715 1.695 l 3.011 -1.698 l 2.715 -5.094 l 2.715 -3.395 l 0 -3.395 l 0 0 l h S Q 0.97 0.579 0.116 scn q 1 0 0 1 415.8223 238.9424 cm 0 0 m 21.581 0 l 21.581 1.695 l 22.466 -1.698 l 21.581 -5.094 l 21.581 -3.398 l 0 -3.398 l h f* Q 4 M q 1 0 0 1 415.8223 238.9424 cm 0 0 m 21.581 0 l 21.581 1.695 l 22.466 -1.698 l 21.581 -5.094 l 21.581 -3.398 l 0 -3.398 l 0 0 l S Q 10 M q 1 0 0 1 415.8428 238.9043 cm 0 0 m 21.584 0 l 21.584 1.695 l 22.469 -1.698 l 21.584 -5.094 l 21.584 -3.395 l 0 -3.395 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 438.4072 238.9424 cm 0 0 m 4.279 0 l 4.279 1.695 l 4.753 -1.698 l 4.279 -5.094 l 4.279 -3.398 l 0 -3.398 l h f* Q 4 M q 1 0 0 1 438.4072 238.9424 cm 0 0 m 4.279 0 l 4.279 1.695 l 4.753 -1.698 l 4.279 -5.094 l 4.279 -3.398 l 0 -3.398 l 0 0 l S Q 10 M q 1 0 0 1 438.4287 238.9043 cm 0 0 m 4.282 0 l 4.282 1.695 l 4.753 -1.698 l 4.282 -5.094 l 4.282 -3.395 l 0 -3.395 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 443.1602 238.9424 cm 0 0 m 4.635 0 l 4.635 1.695 l 5.139 -1.698 l 4.635 -5.094 l 4.635 -3.398 l 0 -3.398 l h f* Q 4 M q 1 0 0 1 443.1602 238.9424 cm 0 0 m 4.635 0 l 4.635 1.695 l 5.139 -1.698 l 4.635 -5.094 l 4.635 -3.398 l 0 -3.398 l 0 0 l S Q 10 M q 1 0 0 1 443.1816 238.9043 cm 0 0 m 4.636 0 l 4.636 1.695 l 5.139 -1.698 l 4.636 -5.094 l 4.636 -3.395 l 0 -3.395 l 0 0 l h S Q q 1 0 0 1 449.5684 238.9424 cm 0 0 m 2.42 0 l 2.42 1.695 l 2.687 -1.698 l 2.42 -5.094 l 2.42 -3.398 l 0 -3.398 l h f* Q 4 M q 1 0 0 1 449.5684 238.9424 cm 0 0 m 2.42 0 l 2.42 1.695 l 2.687 -1.698 l 2.42 -5.094 l 2.42 -3.398 l 0 -3.398 l 0 0 l S Q 10 M q 1 0 0 1 449.5889 238.9043 cm 0 0 m 2.422 0 l 2.422 1.695 l 2.687 -1.698 l 2.422 -5.094 l 2.422 -3.395 l 0 -3.395 l 0 0 l h S Q 0.555 0.846 0.972 scn q 1 0 0 1 452.7861 238.9424 cm 0 0 m 22.881 0 l 22.881 1.695 l 23.764 -1.698 l 22.881 -5.094 l 22.881 -3.398 l 0 -3.398 l h f* Q 4 M q 1 0 0 1 452.7861 238.9424 cm 0 0 m 22.881 0 l 22.881 1.695 l 23.764 -1.698 l 22.881 -5.094 l 22.881 -3.398 l 0 -3.398 l 0 0 l S Q 10 M q 1 0 0 1 452.8057 238.9043 cm 0 0 m 22.883 0 l 22.883 1.695 l 23.77 -1.698 l 22.883 -5.094 l 22.883 -3.395 l 0 -3.395 l 0 0 l h S Q 0.739 0.583 0.77 scn q 1 0 0 1 477.4082 238.9424 cm 0 0 m 5.196 0 l 5.196 1.695 l 5.756 -1.698 l 5.196 -5.094 l 5.196 -3.398 l 0 -3.398 l h f* Q 4 M q 1 0 0 1 477.4082 238.9424 cm 0 0 m 5.196 0 l 5.196 1.695 l 5.756 -1.698 l 5.196 -5.094 l 5.196 -3.398 l 0 -3.398 l 0 0 l S Q 10 M q 1 0 0 1 477.4316 238.9043 cm 0 0 m 5.196 0 l 5.196 1.695 l 5.756 -1.698 l 5.196 -5.094 l 5.196 -3.395 l 0 -3.395 l 0 0 l h S Q q 1 0 0 1 484.6123 238.9424 cm 0 0 m 7.023 0 l 7.023 1.695 l 7.792 -1.698 l 7.023 -5.094 l 7.023 -3.398 l 0 -3.398 l h f* Q 4 M q 1 0 0 1 484.6123 238.9424 cm 0 0 m 7.023 0 l 7.023 1.695 l 7.792 -1.698 l 7.023 -5.094 l 7.023 -3.398 l 0 -3.398 l 0 0 l S Q 10 M q 1 0 0 1 484.6357 238.9043 cm 0 0 m 7.026 0 l 7.026 1.695 l 7.795 -1.698 l 7.026 -5.094 l 7.026 -3.395 l 0 -3.395 l 0 0 l h S Q 0.555 0.846 0.972 scn q 1 0 0 1 493.4102 238.9424 cm 0 0 m 11.069 0 l 11.069 1.695 l 11.956 -1.698 l 11.069 -5.094 l 11.069 -3.398 l 0 -3.398 l h f* Q 4 M q 1 0 0 1 493.4102 238.9424 cm 0 0 m 11.069 0 l 11.069 1.695 l 11.956 -1.698 l 11.069 -5.094 l 11.069 -3.398 l 0 -3.398 l 0 0 l S Q 10 M q 1 0 0 1 493.4346 238.9043 cm 0 0 m 11.072 0 l 11.072 1.695 l 11.957 -1.698 l 11.072 -5.094 l 11.072 -3.395 l 0 -3.395 l 0 0 l h S Q 0.503 0.51 0.52 scn 4 M 506.4 235.544 5.136 3.398 re B* 10 M q 1 0 0 1 511.5605 235.5098 cm 0 0 m -5.138 0 l -5.138 3.395 l 0 3.395 l S Q q 1 0 0 1 86.3999 228.3545 cm 0 0 m 8.268 0 l S Q q 1 0 0 1 94.6675 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 93.811 228.3545 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 93.811 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 105.2969 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 104.4404 228.3545 cm 0 0 m 11.487 0 l S Q q 1 0 0 1 104.4404 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 115.9272 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 115.0693 228.3545 cm 0 0 m 11.485 0 l S Q q 1 0 0 1 115.0693 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 126.5547 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 125.6982 228.3545 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 125.6982 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 137.1846 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 136.3276 228.3545 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 136.3276 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 147.8135 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 146.9565 228.3545 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 146.9565 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 158.4429 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 157.5874 228.3545 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 157.5874 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 169.0718 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 168.2153 228.3545 cm 0 0 m 11.485 0 l S Q q 1 0 0 1 168.2153 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 179.7007 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 178.8442 228.3545 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 178.8442 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 190.3301 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 189.4736 228.3545 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 189.4736 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 200.958 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 200.1025 228.3545 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 200.1025 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 211.5884 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 210.7319 228.3545 cm 0 0 m 11.485 0 l S Q q 1 0 0 1 210.7319 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 222.2173 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 221.3599 228.3545 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 221.3599 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 232.8462 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 231.9897 228.3545 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 231.9897 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 243.4736 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 242.6182 228.3545 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 242.6182 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 254.1045 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 253.2471 228.3545 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 253.2471 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 264.7314 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 263.8774 228.3545 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 263.8774 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 275.3618 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 274.5063 228.3545 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 274.5063 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 285.9907 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 285.1343 228.3545 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 285.1343 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 296.6201 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 295.7646 228.3545 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 295.7646 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 307.249 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 306.3936 228.3545 cm 0 0 m 11.485 0 l S Q q 1 0 0 1 306.3936 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 317.8789 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 317.0244 228.3545 cm 0 0 m 11.482 0 l S Q q 1 0 0 1 317.0244 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 328.5068 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 327.6504 228.3545 cm 0 0 m 11.485 0 l S Q q 1 0 0 1 327.6504 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 339.1357 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 338.2793 228.3545 cm 0 0 m 11.485 0 l S Q q 1 0 0 1 338.2793 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 349.7646 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 348.9063 228.3545 cm 0 0 m 11.488 0 l S Q q 1 0 0 1 348.9063 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 360.3945 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 359.5352 228.3545 cm 0 0 m 11.488 0 l S Q q 1 0 0 1 359.5352 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 371.0234 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 370.167 228.3545 cm 0 0 m 11.483 0 l S Q q 1 0 0 1 370.167 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 381.6504 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 380.7969 228.3545 cm 0 0 m 11.483 0 l S Q q 1 0 0 1 380.7969 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 392.2803 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 391.4238 228.3545 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 391.4238 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 402.9102 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 402.0547 228.3545 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 402.0547 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 413.5391 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 412.6826 228.3545 cm 0 0 m 11.485 0 l S Q q 1 0 0 1 412.6826 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 424.168 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 423.3135 228.3545 cm 0 0 m 11.483 0 l S Q q 1 0 0 1 423.3135 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 434.7969 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 433.9424 228.3545 cm 0 0 m 11.483 0 l S Q q 1 0 0 1 433.9424 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 445.4258 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 444.5713 228.3545 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 444.5713 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 456.0557 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 455.1992 228.3545 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 455.1992 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 466.6836 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 465.8281 228.3545 cm 0 0 m 11.485 0 l S Q q 1 0 0 1 465.8281 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 477.3135 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 476.457 228.3545 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 476.457 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 487.9414 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 487.0859 228.3545 cm 0 0 m 11.483 0 l S Q q 1 0 0 1 487.0859 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 498.5693 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 497.7148 228.3545 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 497.7148 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 509.2012 229.0889 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 508.3438 228.3545 cm 0 0 m 3.217 0 l S Q q 1 0 0 1 508.3438 229.0889 cm 0 0 m 0 -1.475 l S Q BT 0.137 0.123 0.126 scn /TT0 1 Tf 5.2485 0 0 5.2485 515.0791 232.8145 Tm (920 kb )Tj 3.9365 0 0 3.9365 128.1348 239.6475 Tm (0751 )Tj 0 3.9365 -3.9365 0 156.6221 239.2139 Tm (0752 )Tj 0.054 -1.636 Td (0753 )Tj 3.9365 0 0 3.9365 165.626 239.5391 Tm (0754 )Tj 2.697 0.028 Td (0755 )Tj 4.372 0 Td (0756 )Tj 4.57 -0.028 Td (0757 )Tj 3.57 0 Td (0758 )Tj 2.787 -0.028 Td (0759 )Tj 0 3.9365 -3.9365 0 248.332 239.5391 Tm (0760 )Tj 3.9365 0 0 3.9365 259.7314 239.6475 Tm (0761 )Tj 6.179 -0.028 Td (0762 )Tj 0 3.9365 -3.9365 0 303.0615 239.4277 Tm (0763 )Tj 0 -2.316 TD (0764 )Tj 3.9365 0 0 3.9365 317.3467 239.7578 Tm (0765 )Tj 3.347 -0.056 Td (0766 )Tj 0 3.9365 -3.9365 0 344.7002 239.3203 Tm [(0)50(7)50(6)50(7)50( )]TJ 3.9365 0 0 3.9365 345.6553 239.5596 Tm [(0)50(7)50(6)50(8)50( )]TJ 1.916 0.073 Td [(0)50(7)50(6)50(9)50( )]TJ 2.18 -0.106 Td (0770 )Tj 4.286 0.056 Td (0771 )Tj 0 3.9365 -3.9365 0 397.2949 239.3203 Tm (0772 )Tj 3.9365 0 0 3.9365 400.3682 239.5391 Tm (0773 )Tj 0 3.9365 -3.9365 0 414.7979 239.2139 Tm (0774 )Tj 3.9365 0 0 3.9365 422.5469 239.5391 Tm (0775 )Tj 0 3.9365 -3.9365 0 441.7207 239.4277 Tm (0776 )Tj 0.056 -1.298 Td (0777 )Tj 0 -1.179 TD (0778 )Tj 3.9365 0 0 3.9365 459.6279 239.7578 Tm (0779 )Tj 0 3.9365 -3.9365 0 481.4639 239.2139 Tm (0780 )Tj 3.9365 0 0 3.9365 484.501 239.3203 Tm (0781 )Tj 2.77 0.083 Td (0782 )Tj 2.698 0 Td (0783 )Tj -104.342 -2.711 Td (603 )Tj 2.7 0 Td (604 )Tj 2.7 0 Td (605 )Tj 2.7 0 Td (606 )Tj 2.7 0 Td (607 )Tj 2.7 0 Td (608 )Tj 2.7 0 Td (609 )Tj 2.7 0 Td (610 )Tj 2.7 0 Td (611 )Tj 2.7 0 Td (612 )Tj 2.7 0 Td (613 )Tj 2.7 0 Td (614 )Tj 2.7 0 Td (615 )Tj 2.7 0 Td (616 )Tj 2.7 0 Td (617 )Tj 2.7 0 Td (618 )Tj 2.7 0 Td (619 )Tj 2.701 0 Td (620 )Tj 2.7 0 Td (621 )Tj 2.7 0 Td (622 )Tj 2.7 0 Td (623 )Tj 2.7 0 Td (624 )Tj 2.7 0 Td (625 )Tj 2.7 0 Td (626 )Tj 2.7 0 Td (627 )Tj 2.7 0 Td (628 )Tj 2.7 0 Td (629 )Tj 2.7 0 Td (630 )Tj 2.7 0 Td (631 )Tj 2.7 0 Td (632f )Tj 2.7 0 Td (633 )Tj 2.7 0 Td (634 )Tj 2.701 0 Td (635 )Tj 2.699 0 Td (636 )Tj 2.7 0 Td (637 )Tj 2.701 0 Td (638 )Tj 2.699 0 Td (639 )Tj 2.7 0 Td (640 )Tj 2.7 0 Td (641 )Tj 2.7 0 Td (642f )Tj 2.6365 0 0 3.2804 484.7988 236.1396 Tm [(t)-25(n)-25(p)-25(B)-24(_)-25(5)]TJ 1.9184 0 0 3.2804 477.6143 236.1494 Tm (tnpA_5)Tj 2.1784 0 0 2.6243 164.6562 236.2031 Tm [(m)25(m)25(y)25(C)25(I)25(I)25(I)25(M)25(1)25( )]TJ 3.9365 0 0 3.9365 96.5332 239.7578 Tm (0750 )Tj 2.5253 0 0 2.6243 174.4229 236.3145 Tm (mmyCIIIM2 )Tj /TT2 1 Tf 3.2804 0 0 3.2804 190.1689 236.2021 Tm (mmyCIIIR)Tj 1 1 1 scn /TT0 1 Tf 2.304 0 0 2.4698 307.9336 236.4658 Tm (hpt_2 )Tj /TT2 1 Tf 3.2804 0 0 3.2804 317.4453 236.0928 Tm [(p)-25(u)-25(r)-25(B)]TJ 4 0.033 Td [(p)-25(u)-25(r)-25(A)]TJ 0.137 0.123 0.126 scn /TT0 1 Tf 1.1545 0 0 1.3121 345.2207 236.75 Tm [(m)-25(m)-25(y)-26(C)-25(I)-25(V)-25(R)-25( )]TJ 1.8305 0 0 1.9682 352.3291 236.6396 Tm [(m)10(m)10(y)10(C)10(I)10(V)10(M)10( )]TJ ET 0.302 w 4 M 359.716 245.104 -15.419 1.642 re S 1 1 1 scn 358.839 244.285 -13.34 3.281 re f BT 0.137 0.123 0.126 scn /TT0 1 Tf 3.2804 0 0 3.2804 345.2861 246.2109 Tm [(T)25(y)25(p)25(e)25( )25(I)25(I)25( )25(R)26(/)25(M)]TJ 0.609 -0.8 Td [(G)25(A)25(N)25(T)25(C)]TJ 1 1 1 scn 14.2 -2.285 Td [(n)25(r)25(d)25(I)25( )]TJ /TT2 1 Tf -4.69 -0.033 Td [(n)-25(r)-25(d)-25(E)]TJ 6.728 0.066 Td [(n)-25(r)-25(d)-25(F)]TJ /TT0 1 Tf 0 1.6425 -1.9682 0 414.5459 235.5566 Tm [(s)-25(e)-25(c)-25(G)]TJ 2.1861 0 0 2.6243 438.4668 236.3125 Tm [(s)25(m)25(p)25(B)]TJ ET 0.23 w q 1 0 0 1 119.3965 307.8174 cm 0 0 m 1.558 -3.116 l S Q q 0 792 612 -792 re W n 0.137 0.123 0.126 scn q 1 0 0 1 121.2939 304.416 cm 0 0 m -0.05 0.293 -0.063 0.494 -0.083 0.739 c -0.859 0.352 l -0.788 0.296 -0.522 0.058 -0.317 -0.158 c -0.099 -0.39 0.081 -0.609 0.181 -0.759 c 0.121 -0.589 0.054 -0.313 0 0 c f Q Q 0.302 w 406.918 308.447 -33.136 1.638 re S 395.965 307.735 -11.23 3.062 re f BT 0.137 0.123 0.126 scn /TT2 1 Tf 3.2902 0 0 3.2804 385.96 308.1592 Tm (cobalt)Tj ET 0.262 w 10 M q 1 0 0 1 86.3999 295.5664 cm 0 0 m 425.161 0 l S Q 4 M q 1 0 0 1 86.3999 298.3262 cm 0 0 m 9.036 0 l 9.036 3.397 l 0 3.397 l B* Q 10 M q 1 0 0 1 86.3999 298.2959 cm 0 0 m 9.036 0 l 9.036 3.396 l 0 3.396 l S Q 0.503 0.51 0.52 scn q 1 0 0 1 101.6343 301.7236 cm 0 0 m -5.816 0 l -5.816 1.696 l -6.437 -1.699 l -5.816 -5.096 l -5.816 -3.397 l 0 -3.397 l h f* Q 4 M q 1 0 0 1 101.6343 301.7236 cm 0 0 m -5.816 0 l -5.816 1.696 l -6.437 -1.699 l -5.816 -5.096 l -5.816 -3.397 l 0 -3.397 l 0 0 l S Q 10 M q 1 0 0 1 101.6343 301.6914 cm 0 0 m -5.816 0 l -5.816 1.698 l -6.435 -1.697 l -5.816 -5.096 l -5.816 -3.396 l 0 -3.396 l 0 0 l h S Q 1 1 1 scn q 1 0 0 1 102.4316 301.7236 cm 0 0 m 8.059 0 l 8.059 1.696 l 8.945 -1.699 l 8.059 -5.096 l 8.059 -3.397 l 0 -3.397 l h f* Q 4 M q 1 0 0 1 102.4316 301.7236 cm 0 0 m 8.059 0 l 8.059 1.696 l 8.945 -1.699 l 8.059 -5.096 l 8.059 -3.397 l 0 -3.397 l 0 0 l S Q 10 M q 1 0 0 1 102.4341 301.6914 cm 0 0 m 8.059 0 l 8.059 1.698 l 8.944 -1.697 l 8.059 -5.096 l 8.059 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 111.4658 301.7236 cm 0 0 m 8.179 0 l 8.179 1.696 l 9.064 -1.699 l 8.179 -5.096 l 8.179 -3.397 l 0 -3.397 l h f* Q 4 M q 1 0 0 1 111.4658 301.7236 cm 0 0 m 8.179 0 l 8.179 1.696 l 9.064 -1.699 l 8.179 -5.096 l 8.179 -3.397 l 0 -3.397 l 0 0 l S Q 10 M q 1 0 0 1 111.4683 301.6914 cm 0 0 m 8.177 0 l 8.177 1.698 l 9.063 -1.697 l 8.177 -5.096 l 8.177 -3.396 l 0 -3.396 l 0 0 l h S Q 0.967 0.703 0.818 scn q 1 0 0 1 120.9141 300.4749 cm 0 0 m 0.059 -4.183 l 0.059 -2.446 l 0.768 -2.446 l 0.768 1.248 l 0.059 1.248 l 0.059 2.945 l h f Q 4 M q 1 0 0 1 121.6821 301.7236 cm 0 0 m -0.708 0 l -0.708 1.696 l -0.768 -1.249 l -0.708 -5.432 l -0.708 -3.695 l 0 -3.695 l 0 0 l S Q q 1 0 0 1 120.9168 300.429 cm 0 0 m 0.058 -4.175 l 0.058 -2.446 l 0.766 -2.446 l 0.766 1.263 l 0.058 1.263 l 0.058 2.961 l h f Q 10 M q 1 0 0 1 121.6831 301.6914 cm 0 0 m -0.708 0 l -0.708 1.698 l -0.767 -1.263 l -0.708 -5.438 l -0.708 -3.709 l 0 -3.709 l 0 0 l h S Q q 1 0 0 1 122.094 300.4749 cm 0 0 m 0.061 -4.183 l 0.061 -2.446 l 0.798 -2.143 l 0.798 1.248 l 0.061 1.248 l 0.061 2.945 l h f Q 4 M q 1 0 0 1 122.8926 301.7236 cm 0 0 m -0.737 0 l -0.737 1.696 l -0.799 -1.249 l -0.737 -5.432 l -0.737 -3.695 l 0 -3.392 l 0 0 l S Q q 1 0 0 1 122.0976 300.429 cm 0 0 m 0.058 -4.175 l 0.058 -2.446 l 0.742 -2.534 l 0.796 1.263 l 0.058 1.263 l 0.058 2.961 l h f Q 10 M q 1 0 0 1 122.8945 301.6914 cm 0 0 m -0.738 0 l -0.738 1.698 l -0.797 -1.263 l -0.738 -5.438 l -0.738 -3.709 l -0.055 -3.796 l 0 0 l h S Q 0.524 0.135 0.083 scn q 1 0 0 1 128.6484 301.7236 cm 0 0 m -4.487 0 l -4.487 1.696 l -4.959 -1.699 l -4.487 -5.096 l -4.487 -3.397 l 0 -3.397 l h f* Q 4 M q 1 0 0 1 128.6484 301.7236 cm 0 0 m -4.487 0 l -4.487 1.696 l -4.959 -1.699 l -4.487 -5.096 l -4.487 -3.397 l 0 -3.397 l 0 0 l S Q 10 M q 1 0 0 1 128.6504 301.6914 cm 0 0 m -4.487 0 l -4.487 1.698 l -4.959 -1.697 l -4.487 -5.096 l -4.487 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 130.9819 301.7236 cm 0 0 m -2.126 0 l -2.126 1.696 l -2.333 -1.699 l -2.126 -5.096 l -2.126 -3.397 l 0 -3.397 l h f* Q 4 M q 1 0 0 1 130.9819 301.7236 cm 0 0 m -2.126 0 l -2.126 1.696 l -2.333 -1.699 l -2.126 -5.096 l -2.126 -3.397 l 0 -3.397 l 0 0 l S Q 10 M q 1 0 0 1 130.9839 301.6914 cm 0 0 m -2.126 0 l -2.126 1.698 l -2.333 -1.697 l -2.126 -5.096 l -2.126 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 135.0835 301.7236 cm 0 0 m -3.453 0 l -3.453 1.696 l -3.837 -1.699 l -3.453 -5.096 l -3.453 -3.397 l 0 -3.397 l h f* Q 4 M q 1 0 0 1 135.0835 301.7236 cm 0 0 m -3.453 0 l -3.453 1.696 l -3.837 -1.699 l -3.453 -5.096 l -3.453 -3.397 l 0 -3.397 l 0 0 l S Q 10 M q 1 0 0 1 135.0874 301.6914 cm 0 0 m -3.455 0 l -3.455 1.698 l -3.836 -1.697 l -3.455 -5.096 l -3.455 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 146.3325 301.7236 cm 0 0 m -10.48 0 l -10.48 1.696 l -11.365 -1.699 l -10.48 -5.096 l -10.48 -3.397 l 0 -3.397 l h f* Q 4 M q 1 0 0 1 146.3325 301.7236 cm 0 0 m -10.48 0 l -10.48 1.696 l -11.365 -1.699 l -10.48 -5.096 l -10.48 -3.397 l 0 -3.397 l 0 0 l S Q 10 M q 1 0 0 1 146.3364 301.6914 cm 0 0 m -10.482 0 l -10.482 1.698 l -11.365 -1.697 l -10.482 -5.096 l -10.482 -3.396 l 0 -3.396 l 0 0 l h S Q 0.967 0.703 0.818 scn q 1 0 0 1 147.3966 300.024 cm 0 0 m 0.059 -3.396 l 0.059 -1.697 l 0.797 -1.697 l 0.797 1.699 l 0.059 1.699 l 0.059 3.396 l h f Q 4 M q 1 0 0 1 148.1934 301.7236 cm 0 0 m -0.738 0 l -0.738 1.696 l -0.797 -1.699 l -0.738 -5.096 l -0.738 -3.397 l 0 -3.397 l 0 0 l S Q q 1 0 0 1 147.4002 299.9943 cm 0 0 m 0.059 -3.398 l 0.059 -1.698 l 0.798 -1.698 l 0.798 1.697 l 0.059 1.697 l 0.059 3.396 l h f Q 10 M q 1 0 0 1 148.1982 301.6914 cm 0 0 m -0.74 0 l -0.74 1.698 l -0.798 -1.697 l -0.74 -5.096 l -0.74 -3.396 l 0 -3.396 l 0 0 l h S Q 0.503 0.51 0.52 scn q 1 0 0 1 159.3838 301.7236 cm 0 0 m -9.007 0 l -9.007 1.696 l -9.891 -1.699 l -9.007 -5.096 l -9.007 -3.397 l 0 -3.397 l h f* Q 4 M q 1 0 0 1 159.3838 301.7236 cm 0 0 m -9.007 0 l -9.007 1.696 l -9.891 -1.699 l -9.007 -5.096 l -9.007 -3.397 l 0 -3.397 l 0 0 l S Q 10 M q 1 0 0 1 159.3877 301.6914 cm 0 0 m -9.006 0 l -9.006 1.698 l -9.891 -1.697 l -9.006 -5.096 l -9.006 -3.396 l 0 -3.396 l 0 0 l h S Q 0.919 0.152 0.567 scn q 1 0 0 1 172.2544 301.7236 cm 0 0 m -10.746 0 l -10.746 1.696 l -11.632 -1.699 l -10.746 -5.096 l -10.746 -3.397 l 0 -3.397 l h f* Q 4 M q 1 0 0 1 172.2544 301.7236 cm 0 0 m -10.746 0 l -10.746 1.696 l -11.632 -1.699 l -10.746 -5.096 l -10.746 -3.397 l 0 -3.397 l 0 0 l S Q 10 M q 1 0 0 1 172.2603 301.6914 cm 0 0 m -10.748 0 l -10.748 1.698 l -11.632 -1.697 l -10.748 -5.096 l -10.748 -3.396 l 0 -3.396 l 0 0 l h S Q 0.503 0.51 0.52 scn q 1 0 0 1 187.3999 301.7236 cm 0 0 m -14.171 0 l -14.171 1.696 l -15.056 -1.699 l -14.171 -5.096 l -14.171 -3.397 l 0 -3.397 l h f* Q 4 M q 1 0 0 1 187.3999 301.7236 cm 0 0 m -14.171 0 l -14.171 1.696 l -15.056 -1.699 l -14.171 -5.096 l -14.171 -3.397 l 0 -3.397 l 0 0 l S Q 10 M q 1 0 0 1 187.4053 301.6914 cm 0 0 m -14.171 0 l -14.171 1.698 l -15.058 -1.697 l -14.171 -5.096 l -14.171 -3.396 l 0 -3.396 l 0 0 l h S Q 0.92 0.178 0.181 scn q 1 0 0 1 199.3569 301.7236 cm 0 0 m -10.776 0 l -10.776 1.696 l -11.663 -1.699 l -10.776 -5.096 l -10.776 -3.397 l 0 -3.397 l h f* Q 4 M q 1 0 0 1 199.3569 301.7236 cm 0 0 m -10.776 0 l -10.776 1.696 l -11.663 -1.699 l -10.776 -5.096 l -10.776 -3.397 l 0 -3.397 l 0 0 l S Q 10 M q 1 0 0 1 199.3643 301.6914 cm 0 0 m -10.778 0 l -10.778 1.698 l -11.662 -1.697 l -10.778 -5.096 l -10.778 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 206.5015 301.7236 cm 0 0 m -3.63 0 l -3.63 1.696 l -4.015 -1.699 l -3.63 -5.096 l -3.63 -3.397 l 0 -3.397 l h f* Q 4 M q 1 0 0 1 206.5015 301.7236 cm 0 0 m -3.63 0 l -3.63 1.696 l -4.015 -1.699 l -3.63 -5.096 l -3.63 -3.397 l 0 -3.397 l 0 0 l S Q 10 M q 1 0 0 1 206.5083 301.6914 cm 0 0 m -3.631 0 l -3.631 1.698 l -4.014 -1.697 l -3.631 -5.096 l -3.631 -3.396 l 0 -3.396 l 0 0 l h S Q 0.716 0.434 0.681 scn q 1 0 0 1 208.835 301.7236 cm 0 0 m 8.562 0 l 8.562 1.696 l 9.448 -1.699 l 8.562 -5.096 l 8.562 -3.397 l 0 -3.397 l h f* Q 4 M q 1 0 0 1 208.835 301.7236 cm 0 0 m 8.562 0 l 8.562 1.696 l 9.448 -1.699 l 8.562 -5.096 l 8.562 -3.397 l 0 -3.397 l 0 0 l S Q 10 M q 1 0 0 1 208.8433 301.6914 cm 0 0 m 8.562 0 l 8.562 1.698 l 9.446 -1.697 l 8.562 -5.096 l 8.562 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 218.2832 301.7236 cm 0 0 m 7.351 0 l 7.351 1.696 l 8.147 -1.699 l 7.351 -5.096 l 7.351 -3.397 l 0 -3.397 l h f* Q 4 M q 1 0 0 1 218.2832 301.7236 cm 0 0 m 7.351 0 l 7.351 1.696 l 8.147 -1.699 l 7.351 -5.096 l 7.351 -3.397 l 0 -3.397 l 0 0 l S Q 10 M q 1 0 0 1 218.2891 301.6914 cm 0 0 m 7.351 0 l 7.351 1.698 l 8.15 -1.697 l 7.351 -5.096 l 7.351 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 231.8345 301.7236 cm 0 0 m -4.548 0 l -4.548 1.696 l -5.049 -1.699 l -4.548 -5.096 l -4.548 -3.397 l 0 -3.397 l h f* Q 4 M q 1 0 0 1 231.8345 301.7236 cm 0 0 m -4.548 0 l -4.548 1.696 l -5.049 -1.699 l -4.548 -5.096 l -4.548 -3.397 l 0 -3.397 l 0 0 l S Q 10 M q 1 0 0 1 231.8408 301.6914 cm 0 0 m -4.546 0 l -4.546 1.698 l -5.047 -1.697 l -4.546 -5.096 l -4.546 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 249.3696 301.7236 cm 0 0 m -15.677 0 l -15.677 1.696 l -16.563 -1.699 l -15.677 -5.096 l -15.677 -3.397 l 0 -3.397 l h f* Q 4 M q 1 0 0 1 249.3696 301.7236 cm 0 0 m -15.677 0 l -15.677 1.696 l -16.563 -1.699 l -15.677 -5.096 l -15.677 -3.397 l 0 -3.397 l 0 0 l S Q 10 M q 1 0 0 1 249.3794 301.6914 cm 0 0 m -15.676 0 l -15.676 1.698 l -16.563 -1.697 l -15.676 -5.096 l -15.676 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 275.7334 301.7236 cm 0 0 m -24.769 0 l -24.769 1.696 l -25.655 -1.699 l -24.769 -5.096 l -24.769 -3.397 l 0 -3.397 l h f* Q 4 M q 1 0 0 1 275.7334 301.7236 cm 0 0 m -24.769 0 l -24.769 1.696 l -25.655 -1.699 l -24.769 -5.096 l -24.769 -3.397 l 0 -3.397 l 0 0 l S Q 10 M q 1 0 0 1 275.7451 301.6914 cm 0 0 m -24.771 0 l -24.771 1.698 l -25.657 -1.697 l -24.771 -5.096 l -24.771 -3.396 l 0 -3.396 l 0 0 l h S Q 0.969 0.719 0.828 scn q 1 0 0 1 277.2099 300.3678 cm 0 0 m 0.059 -4.076 l 0.059 -2.036 l 0.796 -2.036 l 0.796 1.355 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1 364.6445 301.6914 cm 0 0 m -43.163 0 l -43.163 1.698 l -44.05 -1.697 l -43.163 -5.096 l -43.163 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 373.6611 301.7236 cm 0 0 m -7.233 0 l -7.233 1.696 l -8.03 -1.699 l -7.233 -5.096 l -7.233 -3.397 l 0 -3.397 l h f* Q 4 M q 1 0 0 1 373.6611 301.7236 cm 0 0 m -7.233 0 l -7.233 1.696 l -8.03 -1.699 l -7.233 -5.096 l -7.233 -3.397 l 0 -3.397 l 0 0 l S Q 10 M q 1 0 0 1 373.6797 301.6914 cm 0 0 m -7.232 0 l -7.232 1.698 l -8.03 -1.697 l -7.232 -5.096 l -7.232 -3.396 l 0 -3.396 l 0 0 l h S Q 0.716 0.434 0.681 scn q 1 0 0 1 384.4395 301.7236 cm 0 0 m -9.864 0 l -9.864 1.696 l -10.747 -1.699 l -9.864 -5.096 l -9.864 -3.397 l 0 -3.397 l h f* Q 4 M q 1 0 0 1 384.4395 301.7236 cm 0 0 m -9.864 0 l -9.864 1.696 l -10.747 -1.699 l -9.864 -5.096 l -9.864 -3.397 l 0 -3.397 l 0 0 l S Q 10 M q 1 0 0 1 384.4561 301.6914 cm 0 0 m -9.86 0 l -9.86 1.698 l -10.747 -1.697 l -9.86 -5.096 l -9.86 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 394.2686 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450.5029 301.6914 cm 0 0 m -6.14 0 l -6.14 1.698 l -6.82 -1.697 l -6.14 -5.096 l -6.14 -3.396 l 0 -3.396 l 0 0 l h S Q 0.501 0.764 0.267 scn q 1 0 0 1 467.2217 301.7236 cm 0 0 m -14.498 0 l -14.498 1.696 l -15.382 -1.699 l -14.498 -5.096 l -14.498 -3.397 l 0 -3.397 l h f* Q 4 M q 1 0 0 1 467.2217 301.7236 cm 0 0 m -14.498 0 l -14.498 1.696 l -15.382 -1.699 l -14.498 -5.096 l -14.498 -3.397 l 0 -3.397 l 0 0 l S Q 10 M q 1 0 0 1 467.2441 301.6914 cm 0 0 m -14.494 0 l -14.494 1.698 l -15.383 -1.697 l -14.494 -5.096 l -14.494 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 471.8555 301.7236 cm 0 0 m -4.194 0 l -4.194 1.696 l -4.634 -1.699 l -4.194 -5.096 l -4.194 -3.397 l 0 -3.397 l h f* Q 4 M q 1 0 0 1 471.8555 301.7236 cm 0 0 m -4.194 0 l -4.194 1.696 l -4.634 -1.699 l -4.194 -5.096 l -4.194 -3.397 l 0 -3.397 l 0 0 l S Q 10 M q 1 0 0 1 471.8799 301.6914 cm 0 0 m -4.19 0 l -4.19 1.698 l -4.636 -1.697 l -4.19 -5.096 l -4.19 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 480.1826 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l S Q q 1 0 0 1 327.6504 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 339.1348 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 338.2793 291.1367 cm 0 0 m 11.485 0 l S Q q 1 0 0 1 338.2793 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 349.7646 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 348.9063 291.1367 cm 0 0 m 11.487 0 l S Q q 1 0 0 1 348.9063 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 360.3936 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 359.5352 291.1367 cm 0 0 m 11.488 0 l S Q q 1 0 0 1 359.5352 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 371.0234 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 370.167 291.1367 cm 0 0 m 11.483 0 l S Q q 1 0 0 1 370.167 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 381.6504 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 380.7969 291.1367 cm 0 0 m 11.483 0 l S Q q 1 0 0 1 380.7969 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 392.2803 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 391.4238 291.1367 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 391.4238 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 402.9102 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 402.0527 291.1367 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 402.0527 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 413.5391 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 412.6826 291.1367 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 412.6826 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 424.167 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 423.3115 291.1367 cm 0 0 m 11.482 0 l S Q q 1 0 0 1 423.3115 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 434.7939 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 433.9414 291.1367 cm 0 0 m 11.483 0 l S Q q 1 0 0 1 433.9414 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 445.4248 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 444.5703 291.1367 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 444.5703 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 456.0547 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 455.1992 291.1367 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 455.1992 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 466.6836 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 465.8281 291.1367 cm 0 0 m 11.485 0 l S Q q 1 0 0 1 465.8281 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 477.3135 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 476.457 291.1367 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 476.457 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 487.9414 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 487.0859 291.1367 cm 0 0 m 11.483 0 l S Q q 1 0 0 1 487.0859 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 498.5693 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 497.7148 291.1367 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 497.7148 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 509.2012 291.877 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 508.3438 291.1367 cm 0 0 m 3.217 0 l S Q q 1 0 0 1 508.3438 291.877 cm 0 0 m 0 -1.479 l S Q BT 0.137 0.123 0.126 scn /TT0 1 Tf 5.2485 0 0 5.2485 515.0791 295.5937 Tm (800 kb )Tj 0 3.9365 -3.9365 0 100.5215 302.3184 Tm (0615 )Tj 3.9365 0 0 3.9365 102.5518 302.5391 Tm (0616 )Tj 2.392 -0.014 Td (0617 )Tj 3.2804 0 0 3.2804 109.1084 308.582 Tm (tRNA-trp/sec )Tj 0 3.9365 -3.9365 0 128.0967 302.3184 Tm (0620 )Tj 0.029 -0.859 Td (0621 )Tj 0.028 -0.899 Td (0622 )Tj 3.9365 0 0 3.9365 136.3604 302.4824 Tm (0623 )Tj 2.3196 2.3196 -2.3196 2.3196 147.4684 302.9592 Tm (tRNA-his )Tj 3.9365 0 0 3.9365 151.5049 302.4824 Tm (0625 )Tj 3.039 0 Td (0626 )Tj 3.29 0 Td (0627 )Tj 3.546 0.027 Td (0628 )Tj 0 3.9365 -3.9365 0 206.1484 302.2109 Tm (0629 )Tj 3.9365 0 0 3.9365 209.5596 302.5391 Tm (0630 )Tj 2.224 -0.028 Td (0631 )Tj 0 3.9365 -3.9365 0 230.8936 302.2109 Tm (0632 )Tj 3.9365 0 0 3.9365 237.7412 302.5391 Tm (0633 )Tj 5.223 -0.028 Td (0634 )Tj 2.3196 2.3196 -2.3196 2.3196 276.5189 302.8495 Tm (tRNA-ile )Tj 3.9365 0 0 3.9365 289.5303 302.5391 Tm (0636 )Tj 0 3.9365 -3.9365 0 314.0488 302.4277 Tm (0637 )Tj -0.055 -1.171 Td (0638 )Tj 3.9365 0 0 3.9365 338.7646 302.4307 Tm (0639 )Tj 7.083 -0.001 Td (0640 )Tj 2.393 0 Td (0641 )Tj 2.653 0.001 Td (0642 )Tj 2.735 0.028 Td (0643 )Tj 0 3.9365 -3.9365 0 411.9561 302.1006 Tm (0644 )Tj 3.9365 0 0 3.9365 414.4326 302.4307 Tm (0645 )Tj 0 3.9365 -3.9365 0 426.5439 302.1006 Tm (0646 )Tj 0 3.9364 -3.8526 0 430.1738 302.1006 Tm (0647 )Tj 0 3.9365 -3.9365 0 433.1455 302.1006 Tm (0648 )Tj 0 -0.748 TD (0649 )Tj 0.028 -1.367 Td (0650 )Tj 0 -1.867 TD (0651 )Tj 3.9365 0 0 3.9365 456.2158 302.4307 Tm (0652 )Tj 0 3.9365 -3.9365 0 471.3828 302.2109 Tm (0653 )Tj 0 -1.653 TD (0654 )Tj 0 -1.558 TD (0655 )Tj 0 -1.343 TD (0656 )Tj 0 -1.22 TD (0657 )Tj 0 -0.82 TD (0658 )Tj 0 -1.034 TD (0659 )Tj 0 -1.233 TD (0660 )Tj 0 -0.938 TD (0661 )Tj 0 -1.043 TD (0662 )Tj 3.9365 0 0 3.9365 95.2861 291.7568 Tm (483 )Tj 2.7 0 Td (484 )Tj 2.7 0 Td (485 )Tj 2.7 0 Td (486 )Tj 2.7 0 Td (487 )Tj 2.7 0 Td (488 )Tj 2.7 0 Td (489 )Tj 2.7 0 Td (490 )Tj 2.7 0 Td (491 )Tj 2.7 0 Td (492 )Tj 2.7 0 Td (493 )Tj 2.7 0 Td (494 )Tj 2.7 0 Td (495 )Tj 2.7 0 Td (496 )Tj 2.7 0 Td (497 )Tj 2.7 0 Td (498 )Tj 2.7 0 Td (499 )Tj 2.7 0 Td (500 )Tj 2.7 0 Td (501 )Tj 2.699 0 Td (502 )Tj 2.7 0 Td (503 )Tj 2.7 0 Td (504 )Tj 2.699 0 Td (505 )Tj 2.701 0 Td (506 )Tj 2.7 0 Td (507 )Tj 2.7 0 Td (508 )Tj 2.7 0 Td (509 )Tj 2.7 0 Td (510 )Tj 2.7 0 Td (511 )Tj 2.7 0 Td (512 )Tj 2.7 0 Td (513 )Tj 2.7 0 Td (514 )Tj 2.7 0 Td (515 )Tj 2.7 0 Td (516 )Tj 2.7 0 Td (517 )Tj 2.701 0 Td (518 )Tj 2.699 0 Td (519 )Tj 2.7 0 Td (520 )Tj 2.7 0 Td (521 )Tj 2.699 0 Td (522 )Tj -107.274 2.712 Td (0614 )Tj -0.221 -2.712 Td (482 )Tj 1 1 1 scn /TT2 1 Tf 3.2804 0 0 3.2804 162.9434 298.9863 Tm [(a)-25(g)-25(u)-25(A)]TJ 8.366 -0.034 Td [(a)-25(r)-25(g)-25(F)]TJ 20.967 0 Td [(l)-25(e)-25(u)-25(S)]TJ /TT0 1 Tf 2.8867 0 0 2.8867 310.3408 299.2031 Tm (rpsI )Tj 2.6243 0 0 2.6243 314.9326 299.2031 Tm [(r)25(p)25(l)25(M)]TJ 2.8867 0 0 2.8867 318.8535 299.2031 Tm ( )Tj 3.2804 0 0 3.2804 385.2393 298.875 Tm (cbiO_1)Tj 3.3 0 Td (cbiO_2)Tj 1.9741 0 0 1.9682 408.8594 299.4199 Tm (rplQ)Tj 0.137 0.123 0.126 scn /TT2 1 Tf 3.2902 0 0 3.2804 414.1074 298.9863 Tm [(r)-25(p)-25(o)-25(A)]TJ 1 1 1 scn /TT0 1 Tf 1.9741 0 0 1.9682 422.9619 299.2061 Tm [(r)-25(p)-25(s)-25(K)-25( )-25(r)-25(p)-25(s)-25(M)]TJ 0 1.316 -1.1552 0 432.1836 298.6992 Tm [(r)-25(p)-25(m)-25(J)-25( )]TJ 0 1.9741 -1.9682 0 435.0615 298.4648 Tm [(i)-25(n)-25(f)-25(A)-25( )]TJ 0.137 0.123 0.126 scn /TT2 1 Tf 3.2902 0 0 3.2804 436.5361 299.2852 Tm [(m)-25(a)-25(p)]TJ 1 1 1 scn 2.418 -0.15 Td [(a)-25(d)-25(k)]TJ 0.137 0.123 0.126 scn 3.602 0.05 Td [(s)-25(e)-25(c)-25(Y)]TJ 1 1 1 scn /TT0 1 Tf 2.6321 0 0 2.6243 467.6309 299.0381 Tm (rplO )Tj /TT2 1 Tf 3.2902 0 0 3.2804 472.6641 299.0381 Tm [(r)-25(p)-25(s)-25(E)-25( )]TJ /TT0 1 Tf 1.9741 0 0 2.5536 480.6436 299.2187 Tm [(r)-25(p)-25(l)-25(R)-25( )]TJ 3.2902 0 0 3.2804 484.8535 298.9863 Tm [(r)-25(p)-25(l)-25(F)-25( )]TJ 2.3635 0 0 2.6243 490.4863 299.0381 Tm [(r)25(p)25(s)25(H)26( )]TJ 0 1.9741 -1.9682 0 496.2812 298.3867 Tm [(r)25(p)25(s)25(N)25( )]TJ 3.2902 0 0 3.2804 497.4834 299.0381 Tm (rplE )Tj 2.3031 0 0 2.4639 502.8984 299.1455 Tm [(r)25(p)25(l)25(X)25( )]TJ 2.6321 0 0 2.6243 506.5605 299.1484 Tm [(r)25(p)25(l)25(N)26( )]TJ 3.2804 0 0 3.2804 150.3926 298.8516 Tm [(a)25(r)25(c)25(C)25(_)25(1)]TJ ET q 1 0 0 1 86.772 213.0479 cm 0 0 m 425.161 0 l S Q 0.503 0.51 0.52 scn 4 M q 1 0 0 1 86.772 219.2109 cm 0 0 m 4.605 0 l 4.605 1.698 l 5.107 -1.699 l 4.605 -5.094 l 4.605 -3.396 l 0 -3.396 l B* Q 10 M q 1 0 0 1 86.772 219.1709 cm 0 0 m 4.605 0 l 4.605 1.698 l 5.108 -1.695 l 4.605 -5.092 l 4.605 -3.392 l 0 -3.392 l S Q q 1 0 0 1 102.5078 219.2109 cm 0 0 m -9.005 0 l -9.005 1.698 l -9.89 -1.699 l -9.005 -5.094 l -9.005 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 102.5078 219.2109 cm 0 0 m -9.005 0 l -9.005 1.698 l -9.89 -1.699 l -9.005 -5.094 l -9.005 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 102.5088 219.1709 cm 0 0 m -9.006 0 l -9.006 1.698 l -9.891 -1.695 l -9.006 -5.092 l -9.006 -3.392 l 0 -3.392 l 0 0 l h S Q 0.716 0.434 0.681 scn q 1 0 0 1 118.2139 219.2109 cm 0 0 m -14.674 0 l -14.674 1.698 l -15.558 -1.699 l -14.674 -5.094 l -14.674 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 118.2139 219.2109 cm 0 0 m -14.674 0 l -14.674 1.698 l -15.558 -1.699 l -14.674 -5.094 l -14.674 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 118.2158 219.1709 cm 0 0 m -14.673 0 l -14.673 1.698 l -15.559 -1.695 l -14.673 -5.092 l -14.673 -3.392 l 0 -3.392 l 0 0 l h S Q 0.92 0.178 0.181 scn q 1 0 0 1 129.6089 219.2109 cm 0 0 m -9.682 0 l -9.682 1.698 l -10.568 -1.699 l -9.682 -5.094 l -9.682 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 129.6089 219.2109 cm 0 0 m -9.682 0 l -9.682 1.698 l -10.568 -1.699 l -9.682 -5.094 l -9.682 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 129.6128 219.1709 cm 0 0 m -9.685 0 l -9.685 1.698 l -10.57 -1.695 l -9.685 -5.092 l -9.685 -3.392 l 0 -3.392 l 0 0 l h S Q 0.716 0.434 0.681 scn q 1 0 0 1 162.439 219.2109 cm 0 0 m -29.169 0 l -29.169 1.698 l -30.054 -1.699 l -29.169 -5.094 l -29.169 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 162.439 219.2109 cm 0 0 m -29.169 0 l -29.169 1.698 l -30.054 -1.699 l -29.169 -5.094 l -29.169 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 162.4443 219.1709 cm 0 0 m -29.17 0 l -29.17 1.698 l -30.056 -1.695 l -29.17 -5.092 l -29.17 -3.392 l 0 -3.392 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 166.1304 219.2109 cm 0 0 m 11.75 0 l 11.75 1.698 l 12.636 -1.699 l 11.75 -5.094 l 11.75 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 166.1304 219.2109 cm 0 0 m 11.75 0 l 11.75 1.698 l 12.636 -1.699 l 11.75 -5.094 l 11.75 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 166.1353 219.1709 cm 0 0 m 11.75 0 l 11.75 1.698 l 12.636 -1.695 l 11.75 -5.092 l 11.75 -3.392 l 0 -3.392 l 0 0 l h S Q 0.182 0.19 0.573 scn q 1 0 0 1 182.6929 219.2109 cm 0 0 m -2.864 0 l -2.864 1.698 l -3.159 -1.699 l -2.864 -5.094 l -2.864 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 182.6929 219.2109 cm 0 0 m -2.864 0 l -2.864 1.698 l -3.159 -1.699 l -2.864 -5.094 l -2.864 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 182.6992 219.1709 cm 0 0 m -2.865 0 l -2.865 1.698 l -3.16 -1.695 l -2.865 -5.092 l -2.865 -3.392 l 0 -3.392 l 0 0 l h S Q 0.503 0.51 0.52 scn q 1 0 0 1 197.8662 219.2109 cm 0 0 m -14.287 0 l -14.287 1.698 l -15.173 -1.699 l -14.287 -5.094 l -14.287 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 197.8662 219.2109 cm 0 0 m -14.287 0 l -14.287 1.698 l -15.173 -1.699 l -14.287 -5.094 l -14.287 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 197.875 219.1709 cm 0 0 m -14.29 0 l -14.29 1.698 l -15.176 -1.695 l -14.29 -5.092 l -14.29 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 206.9028 219.2109 cm 0 0 m -8.061 0 l -8.061 1.698 l -8.946 -1.699 l -8.061 -5.094 l -8.061 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 206.9028 219.2109 cm 0 0 m -8.061 0 l -8.061 1.698 l -8.946 -1.699 l -8.061 -5.094 l -8.061 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 206.9097 219.1709 cm 0 0 m -8.059 0 l -8.059 1.698 l -8.947 -1.695 l -8.059 -5.092 l -8.059 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 223.7012 219.2109 cm 0 0 m -15.883 0 l -15.883 1.698 l -16.77 -1.699 l -15.883 -5.094 l -15.883 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 223.7012 219.2109 cm 0 0 m -15.883 0 l -15.883 1.698 l -16.77 -1.699 l -15.883 -5.094 l -15.883 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 223.7095 219.1709 cm 0 0 m -15.885 0 l -15.885 1.698 l -16.769 -1.695 l -15.885 -5.092 l -15.885 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 229.605 219.2109 cm 0 0 m -5.226 0 l -5.226 1.698 l -5.787 -1.699 l -5.226 -5.094 l -5.226 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 229.605 219.2109 cm 0 0 m -5.226 0 l -5.226 1.698 l -5.787 -1.699 l -5.226 -5.094 l -5.226 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 229.6133 219.1709 cm 0 0 m -5.226 0 l -5.226 1.698 l -5.787 -1.695 l -5.226 -5.092 l -5.226 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 235.4219 219.2109 cm 0 0 m -5.227 0 l -5.227 1.698 l -5.788 -1.699 l -5.227 -5.094 l -5.227 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 235.4219 219.2109 cm 0 0 m -5.227 0 l -5.227 1.698 l -5.788 -1.699 l -5.227 -5.094 l -5.227 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 235.4307 219.1709 cm 0 0 m -5.227 0 l -5.227 1.698 l -5.787 -1.695 l -5.227 -5.092 l -5.227 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 238.9648 219.2109 cm 0 0 m -2.924 0 l -2.924 1.698 l -3.218 -1.699 l -2.924 -5.094 l -2.924 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 238.9648 219.2109 cm 0 0 m -2.924 0 l -2.924 1.698 l -3.218 -1.699 l -2.924 -5.094 l -2.924 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 238.9741 219.1709 cm 0 0 m -2.924 0 l -2.924 1.698 l -3.218 -1.695 l -2.924 -5.092 l -2.924 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 248.4712 219.2109 cm 0 0 m -8.296 0 l -8.296 1.698 l -9.181 -1.699 l -8.296 -5.094 l -8.296 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 248.4712 219.2109 cm 0 0 m -8.296 0 l -8.296 1.698 l -9.181 -1.699 l -8.296 -5.094 l -8.296 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 248.4814 219.1709 cm 0 0 m -8.298 0 l -8.298 1.698 l -9.183 -1.695 l -8.298 -5.092 l -8.298 -3.392 l 0 -3.392 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 250.9819 219.2109 cm 0 0 m -2.275 0 l -2.275 1.698 l -2.511 -1.699 l -2.275 -5.094 l -2.275 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 250.9819 219.2109 cm 0 0 m -2.275 0 l -2.275 1.698 l -2.511 -1.699 l -2.275 -5.094 l -2.275 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 250.9907 219.1709 cm 0 0 m -2.273 0 l -2.273 1.698 l -2.509 -1.695 l -2.273 -5.092 l -2.273 -3.392 l 0 -3.392 l 0 0 l h S Q 0.25 0.396 0.688 scn q 1 0 0 1 260.811 219.2109 cm 0 0 m -5.964 0 l -5.964 1.698 l -6.613 -1.699 l -5.964 -5.094 l -5.964 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 260.811 219.2109 cm 0 0 m -5.964 0 l -5.964 1.698 l -6.613 -1.699 l -5.964 -5.094 l -5.964 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 260.8218 219.1709 cm 0 0 m -5.963 0 l -5.963 1.698 l -6.613 -1.695 l -5.963 -5.092 l -5.963 -3.392 l 0 -3.392 l 0 0 l h S Q 0.92 0.178 0.181 scn q 1 0 0 1 275.0698 219.2109 cm 0 0 m -12.31 0 l -12.31 1.698 l -13.195 -1.699 l -12.31 -5.094 l -12.31 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 275.0698 219.2109 cm 0 0 m -12.31 0 l -12.31 1.698 l -13.195 -1.699 l -12.31 -5.094 l -12.31 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 275.083 219.1709 cm 0 0 m -12.312 0 l -12.312 1.698 l -13.199 -1.695 l -12.312 -5.092 l -12.312 -3.392 l 0 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389.2861 219.1709 cm 0 0 m -40.302 0 l -40.302 1.698 l -41.188 -1.695 l -40.302 -5.092 l -40.302 -3.392 l 0 -3.392 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 401.667 219.2109 cm 0 0 m -11.602 0 l -11.602 1.698 l -12.487 -1.699 l -11.602 -5.094 l -11.602 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 401.667 219.2109 cm 0 0 m -11.602 0 l -11.602 1.698 l -12.487 -1.699 l -11.602 -5.094 l -11.602 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 401.6875 219.1709 cm 0 0 m -11.603 0 l -11.603 1.698 l -12.491 -1.695 l -11.603 -5.092 l -11.603 -3.392 l 0 -3.392 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 407.3955 219.2109 cm 0 0 m -3.545 0 l -3.545 1.698 l -3.928 -1.699 l -3.545 -5.094 l -3.545 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 407.3955 219.2109 cm 0 0 m -3.545 0 l -3.545 1.698 l -3.928 -1.699 l -3.545 -5.094 l -3.545 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 407.415 219.1709 cm 0 0 m -3.545 0 l -3.545 1.698 l -3.929 -1.695 l -3.545 -5.092 l -3.545 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 413.3887 219.2109 cm 0 0 m -4.781 0 l -4.781 1.698 l -5.285 -1.699 l -4.781 -5.094 l -4.781 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 413.3887 219.2109 cm 0 0 m -4.781 0 l -4.781 1.698 l -5.285 -1.699 l -4.781 -5.094 l -4.781 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 413.4072 219.1709 cm 0 0 m -4.78 0 l -4.78 1.698 l -5.282 -1.695 l -4.78 -5.092 l -4.78 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 423.042 219.2109 cm 0 0 m -6.524 0 l -6.524 1.698 l -7.233 -1.699 l -6.524 -5.094 l -6.524 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 423.042 219.2109 cm 0 0 m -6.524 0 l -6.524 1.698 l -7.233 -1.699 l -6.524 -5.094 l -6.524 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 423.0615 219.1709 cm 0 0 m -6.523 0 l -6.523 1.698 l -7.232 -1.695 l -6.523 -5.092 l -6.523 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 427.5889 219.2109 cm 0 0 m -4.104 0 l -4.104 1.698 l -4.547 -1.699 l -4.104 -5.094 l -4.104 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 427.5889 219.2109 cm 0 0 m -4.104 0 l -4.104 1.698 l -4.547 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0 l S Q q 1 0 0 1 95.0386 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 94.1816 208.6191 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 94.1816 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 105.668 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 104.8125 208.6191 cm 0 0 m 11.485 0 l S Q q 1 0 0 1 104.8125 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 116.2979 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 115.4414 208.6191 cm 0 0 m 11.485 0 l S Q q 1 0 0 1 115.4414 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 126.9263 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 126.0693 208.6191 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 126.0693 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 137.5552 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 136.6987 208.6191 cm 0 0 m 11.485 0 l S Q q 1 0 0 1 136.6987 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 148.1841 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 147.3267 208.6191 cm 0 0 m 11.488 0 l S Q q 1 0 0 1 147.3267 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 158.8145 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 157.958 208.6191 cm 0 0 m 11.483 0 l S Q q 1 0 0 1 157.958 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 169.4414 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 168.5869 208.6191 cm 0 0 m 11.485 0 l S Q q 1 0 0 1 168.5869 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 180.0718 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 179.2163 208.6191 cm 0 0 m 11.483 0 l S Q q 1 0 0 1 179.2163 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 190.6997 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 189.8433 208.6191 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 189.8433 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 201.3296 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 200.4731 208.6191 cm 0 0 m 11.485 0 l S Q q 1 0 0 1 200.4731 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 211.958 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 211.1025 208.6191 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 211.1025 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 222.5869 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 221.7305 208.6191 cm 0 0 m 11.485 0 l S Q q 1 0 0 1 221.7305 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208.6191 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 499.4434 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 510.8994 209.3574 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 510.0732 208.6191 cm 0 0 m 1.859 0 l S Q q 1 0 0 1 510.0732 209.3574 cm 0 0 m 0 -1.479 l S Q BT 0.137 0.123 0.126 scn /TT0 1 Tf 5.2485 0 0 5.2485 515.4502 213.0869 Tm (960 kb )Tj 3.9365 0 0 3.9365 94.792 219.6992 Tm (0784 )Tj 3.137 0.028 Td (0785 )Tj 3.563 -0.028 Td (0786 )Tj 5.857 0.028 Td (0787 )Tj 6.13 0 Td (0788 )Tj 0 3.9365 -3.9365 0 182.8359 219.6445 Tm (0789 )Tj 3.9365 0 0 3.9365 186.7139 219.7539 Tm (0790 )Tj 3.178 -0.028 Td (0791 )Tj 3.086 0.014 Td (0792 )Tj 0 3.9365 -3.9365 0 228.3701 219.6445 Tm (0793 )Tj 0.014 -1.519 Td (0794 )Tj 0.014 -1.249 Td (0795 )Tj 3.9365 0 0 3.9365 240.749 219.8105 Tm (0796 )Tj 0 3.9365 -3.9365 0 252.0957 219.6992 Tm (0797 )Tj 0 -1.755 TD (0798 )Tj 3.9365 0 0 3.9365 265.3584 219.751 Tm (0799 )Tj 0 3.9365 -3.9365 0 278.835 219.6445 Tm (0800 )Tj 0.014 -1.012 Td (0801 )Tj 3.9365 0 0 3.9365 291.0498 219.6992 Tm (0802 )Tj 8.509 0.013 Td (0803 )Tj 10.064 -0.013 Td (0804 )Tj 7.018 0 Td (0805 )Tj 0 3.9365 -3.9365 0 407.0771 219.5332 Tm (0806 )Tj 0 -1.319 TD (0807 )Tj 0 -2.315 TD (0809 )Tj 0 -1.451 TD (0810 )Tj 3.9365 0 0 3.9365 431.5117 219.6992 Tm (0811 )Tj 4.382 0 Td (0812 )Tj 3.8 0.042 Td (0813 )Tj 3.102 -0.042 Td (0814 )Tj 0 3.9365 -3.9365 0 488.002 219.4805 Tm (0815 )Tj 0.084 -3.658 Td (0816 )Tj 3.9365 0 0 3.9365 505.8506 219.8643 Tm (0817 )Tj -104.203 -2.698 Td (643 )Tj 2.701 0 Td (644 )Tj 2.699 0 Td (645 )Tj 2.7 0 Td (646 )Tj 2.7 0 Td (647 )Tj 2.7 0 Td (648 )Tj 2.7 0 Td (649 )Tj 2.7 0 Td (650 )Tj 2.7 0 Td (651 )Tj 2.7 0 Td (652 )Tj 2.7 0 Td (653 )Tj 2.7 0 Td (654 )Tj 2.7 0 Td (655 )Tj 2.7 0 Td (656 )Tj 2.7 0 Td (657 )Tj 2.7 0 Td (658 )Tj 2.7 0 Td (659 )Tj 2.7 0 Td (660 )Tj 2.7 0 Td (661 )Tj 2.7 0 Td (662 )Tj 2.7 0 Td (663 )Tj 2.7 0 Td (664 )Tj 2.7 0 Td (665 )Tj 2.7 0 Td (666 )Tj 2.701 0 Td (667 )Tj 2.7 0 Td (668 )Tj 2.7 0 Td (669 )Tj 2.7 0 Td (670 )Tj 2.7 0 Td (671 )Tj 2.701 0 Td (672 )Tj 2.7 0 Td (673 )Tj 2.7 0 Td (674 )Tj 2.7 0 Td (675 )Tj 2.7 0 Td (676 )Tj 2.7 0 Td (677 )Tj 2.7 0 Td (678 )Tj 2.7 0 Td (679 )Tj 2.7 0 Td (WM4 )Tj 3.048 0 Td (681 )Tj 0 3.9365 -3.9365 0 90.3369 219.6992 Tm (0783 )Tj 1 1 1 scn 3.2804 0 0 3.2804 93.3574 216.2529 Tm [(a)25(r)25(c)25(C)25(_)25(2)]TJ /TT2 1 Tf 8.464 0.049 Td (arcB)Tj 7.006 0.035 Td [(m)-25(g)-25(t)-25(A)-25( )]TJ /TT0 1 Tf 0 1.7891 -1.9682 0 181.9014 215.8437 Tm [(a)-25(t)-25(p)-25(C)]TJ /TT2 1 Tf 3.2804 0 0 3.2804 187.0083 216.415 Tm [(a)-25(t)-25(p)-25(D)]TJ 3.689 0 Td [(a)-25(t)-25(p)-25(G)]TJ 3.805 0.017 Td [(a)-25(t)-25(p)-25(A)]TJ /TT0 1 Tf 3.0417 0 0 3.2804 224.3184 216.5283 Tm [(a)-25(t)-25(p)-25(H)]TJ 2.9348 0 0 3.2804 230.2056 216.582 Tm [(a)-25(t)-25(p)-25(F)]TJ 0 1.9682 -1.9682 0 238.2148 215.7617 Tm [(a)25(t)25(p)25(E)]TJ /TT2 1 Tf 3.2804 0 0 3.2804 240.7881 216.4717 Tm [(a)-25(t)-25(p)-25(B)]TJ 4.323 0.084 Td [(u)-25(p)-25(p)]TJ 3.216 -0.05 Td [(g)-25(l)-25(y)-25(A)]TJ /TT0 1 Tf 3.1596 0 0 3.2804 275.2563 216.5283 Tm [(r)25(p)25(i)25(B)]TJ 0.137 0.123 0.126 scn /TT2 1 Tf 3.2804 0 0 3.2804 324.4717 216.582 Tm [(r)-25(p)-25(o)-25(C)]TJ 12.128 -0.016 Td [(r)-25(p)-25(o)-25(B)]TJ 1 1 1 scn /TT0 1 Tf 2.6243 0 0 2.6243 403.6924 216.6357 Tm (rplL )Tj /TT2 1 Tf 3.2804 0 0 3.2804 416.5752 216.4717 Tm (rplA )Tj /TT0 1 Tf -2.413 0.001 Td (rplJ )Tj 2.8248 0 0 3.2804 423.5215 216.5283 Tm [(r)25(p)25(l)25(K)25( )]TJ /TT2 1 Tf 3.2804 0 0 3.2804 431.3174 216.5283 Tm (galU )Tj 10.06 0.016 Td (galE )Tj 4.053 -0.049 Td [(g)-25(l)-25(f)-25( )]TJ ET 0.23 w 4 M q 1 0 0 1 218.5977 287.0342 cm 0 0 m 1.806 -2.38 l S Q q 0 792 612 -792 re W n 0.137 0.123 0.126 scn q 1 0 0 1 220.7905 284.4365 cm 0 0 m -0.104 0.279 -0.153 0.475 -0.218 0.712 c -0.91 0.187 l -0.83 0.146 -0.523 -0.039 -0.283 -0.214 c -0.025 -0.401 0.192 -0.583 0.318 -0.713 c 0.228 -0.556 0.111 -0.298 0 0 c f Q Q 0.262 w 10 M q 1 0 0 1 86.3999 275.5176 cm 0 0 m 425.163 0 l S Q 0 0.677 0.647 scn 4 M q 1 0 0 1 86.3999 278.501 cm 0 0 m 1.654 0 l 1.654 2.953 l 0 2.953 l B* Q 10 M q 1 0 0 1 86.3999 278.4727 cm 0 0 m 1.654 0 l 1.654 2.949 l 0 2.949 l S Q q 1 0 0 1 92.4814 281.6748 cm 0 0 m -3.985 0 l -3.985 1.698 l -4.427 -1.695 l -3.985 -5.094 l -3.985 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 92.4814 281.6748 cm 0 0 m -3.985 0 l -3.985 1.698 l -4.427 -1.695 l -3.985 -5.094 l -3.985 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 92.4824 281.6406 cm 0 0 m -3.985 0 l -3.985 1.7 l -4.428 -1.697 l -3.985 -5.094 l -3.985 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 96.8813 281.6748 cm 0 0 m -3.986 0 l -3.986 1.698 l -4.4 -1.695 l -3.986 -5.094 l -3.986 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 96.8813 281.6748 cm 0 0 m -3.986 0 l -3.986 1.698 l -4.4 -1.695 l -3.986 -5.094 l -3.986 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 96.8813 281.6406 cm 0 0 m -3.986 0 l -3.986 1.7 l -4.399 -1.697 l -3.986 -5.094 l -3.986 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 104.3516 281.6748 cm 0 0 m -6.701 0 l -6.701 1.698 l -7.44 -1.695 l -6.701 -5.094 l -6.701 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 104.3516 281.6748 cm 0 0 m -6.701 0 l -6.701 1.698 l -7.44 -1.695 l -6.701 -5.094 l -6.701 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 104.3516 281.6406 cm 0 0 m -6.701 0 l -6.701 1.7 l -7.439 -1.697 l -6.701 -5.094 l -6.701 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 108.1011 281.6748 cm 0 0 m -3.189 0 l -3.189 1.698 l -3.543 -1.695 l -3.189 -5.094 l -3.189 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 108.1011 281.6748 cm 0 0 m -3.189 0 l -3.189 1.698 l -3.543 -1.695 l -3.189 -5.094 l -3.189 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 108.1021 281.6406 cm 0 0 m -3.19 0 l -3.19 1.7 l -3.542 -1.697 l -3.19 -5.094 l -3.19 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 111.2012 281.6748 cm 0 0 m -2.57 0 l -2.57 1.698 l -2.835 -1.695 l -2.57 -5.094 l -2.57 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 111.2012 281.6748 cm 0 0 m -2.57 0 l -2.57 1.698 l -2.835 -1.695 l -2.57 -5.094 l -2.57 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 111.2021 281.6406 cm 0 0 m -2.569 0 l -2.569 1.7 l -2.835 -1.697 l -2.569 -5.094 l -2.569 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 120.4414 281.6748 cm 0 0 m -8.118 0 l -8.118 1.698 l -9.004 -1.695 l -8.118 -5.094 l -8.118 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 120.4414 281.6748 cm 0 0 m -8.118 0 l -8.118 1.698 l -9.004 -1.695 l -8.118 -5.094 l -8.118 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 120.4443 281.6406 cm 0 0 m -8.119 0 l -8.119 1.7 l -9.006 -1.697 l -8.119 -5.094 l -8.119 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 124.0439 281.6748 cm 0 0 m -2.715 0 l -2.715 1.698 l -3.013 -1.695 l -2.715 -5.094 l -2.715 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 124.0439 281.6748 cm 0 0 m -2.715 0 l -2.715 1.698 l -3.013 -1.695 l -2.715 -5.094 l -2.715 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 124.0459 281.6406 cm 0 0 m -2.717 0 l -2.717 1.7 l -3.012 -1.697 l -2.717 -5.094 l -2.717 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 130.686 281.6748 cm 0 0 m -5.993 0 l -5.993 1.698 l -6.642 -1.695 l -5.993 -5.094 l -5.993 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 130.686 281.6748 cm 0 0 m -5.993 0 l -5.993 1.698 l -6.642 -1.695 l -5.993 -5.094 l -5.993 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 130.689 281.6406 cm 0 0 m -5.994 0 l -5.994 1.7 l -6.643 -1.697 l -5.994 -5.094 l -5.994 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 137.9795 281.6748 cm 0 0 m -6.437 0 l -6.437 1.698 l -7.146 -1.695 l -6.437 -5.094 l -6.437 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 137.9795 281.6748 cm 0 0 m -6.437 0 l -6.437 1.698 l -7.146 -1.695 l -6.437 -5.094 l -6.437 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 137.9814 281.6406 cm 0 0 m -6.437 0 l -6.437 1.7 l -7.146 -1.697 l -6.437 -5.094 l -6.437 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 142.0532 281.6748 cm 0 0 m -2.953 0 l -2.953 1.698 l -3.277 -1.695 l -2.953 -5.094 l -2.953 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 142.0532 281.6748 cm 0 0 m -2.953 0 l -2.953 1.698 l -3.277 -1.695 l -2.953 -5.094 l -2.953 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 142.0552 281.6406 cm 0 0 m -2.952 0 l -2.952 1.7 l -3.276 -1.697 l -2.952 -5.094 l -2.952 -3.392 l 0 -3.392 l 0 0 l h S Q 0.524 0.135 0.083 scn q 1 0 0 1 155.3384 281.6748 cm 0 0 m -9.714 0 l -9.714 1.698 l -10.599 -1.695 l -9.714 -5.094 l -9.714 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 155.3384 281.6748 cm 0 0 m -9.714 0 l -9.714 1.698 l -10.599 -1.695 l -9.714 -5.094 l -9.714 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 155.3418 281.6406 cm 0 0 m -9.714 0 l -9.714 1.7 l -10.601 -1.697 l -9.714 -5.094 l -9.714 -3.392 l 0 -3.392 l 0 0 l h S Q 0.503 0.51 0.52 scn q 1 0 0 1 173.7915 281.6748 cm 0 0 m -16.416 0 l -16.416 1.698 l -17.302 -1.695 l -16.416 -5.094 l -16.416 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 173.7915 281.6748 cm 0 0 m -16.416 0 l -16.416 1.698 l -17.302 -1.695 l -16.416 -5.094 l -16.416 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 173.7944 281.6406 cm 0 0 m -16.415 0 l -16.415 1.7 l -17.3 -1.697 l -16.415 -5.094 l -16.415 -3.392 l 0 -3.392 l 0 0 l h S Q 0.716 0.434 0.681 scn q 1 0 0 1 190.3223 281.6748 cm 0 0 m -15.557 0 l -15.557 1.698 l -16.443 -1.695 l -15.557 -5.094 l -15.557 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 190.3223 281.6748 cm 0 0 m -15.557 0 l -15.557 1.698 l -16.443 -1.695 l -15.557 -5.094 l -15.557 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 190.3301 281.6406 cm 0 0 m -15.56 0 l -15.56 1.7 l -16.446 -1.697 l -15.56 -5.094 l -15.56 -3.392 l 0 -3.392 l 0 0 l h S Q 0.524 0.135 0.083 scn q 1 0 0 1 201.4839 281.6748 cm 0 0 m -9.596 0 l -9.596 1.698 l -10.481 -1.695 l -9.596 -5.094 l -9.596 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 201.4839 281.6748 cm 0 0 m -9.596 0 l -9.596 1.698 l -10.481 -1.695 l -9.596 -5.094 l -9.596 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 201.4902 281.6406 cm 0 0 m -9.594 0 l -9.594 1.7 l -10.482 -1.697 l -9.594 -5.094 l -9.594 -3.392 l 0 -3.392 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 207.0635 281.6748 cm 0 0 m 8.797 0 l 8.797 1.698 l 9.683 -1.695 l 8.797 -5.094 l 8.797 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 207.0635 281.6748 cm 0 0 m 8.797 0 l 8.797 1.698 l 9.683 -1.695 l 8.797 -5.094 l 8.797 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 207.0698 281.6406 cm 0 0 m 8.798 0 l 8.798 1.7 l 9.684 -1.697 l 8.798 -5.094 l 8.798 -3.392 l 0 -3.392 l 0 0 l h S Q 0.986 0.823 0.154 scn q 1 0 0 1 219.3147 279.9792 cm 0 0 m 0.059 -3.398 l 0.059 -1.698 l 0.796 -1.698 l 0.796 1.696 l 0.059 1.696 l 0.059 3.394 l h f Q 4 M q 1 0 0 1 220.1113 281.6748 cm 0 0 m -0.737 0 l -0.737 1.698 l -0.796 -1.695 l -0.737 -5.094 l -0.737 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 220.1211 281.6406 cm 0 0 m -0.738 0 l -0.738 1.7 l -0.798 -1.697 l -0.738 -5.094 l -0.738 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 220.2606 279.9792 cm 0 0 m 0.058 -3.398 l 0.058 -1.698 l 0.797 -1.698 l 0.797 1.696 l 0.058 1.696 l 0.058 3.394 l h f Q 4 M q 1 0 0 1 221.0576 281.6748 cm 0 0 m -0.739 0 l -0.739 1.698 l -0.797 -1.695 l -0.739 -5.094 l -0.739 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 221.0659 281.6406 cm 0 0 m -0.739 0 l -0.739 1.7 l -0.799 -1.697 l -0.739 -5.094 l -0.739 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 221.1453 279.9792 cm 0 0 m 0.059 -3.398 l 0.059 -1.698 l 0.797 -1.698 l 0.797 1.696 l 0.059 1.696 l 0.059 3.394 l h f Q 4 M q 1 0 0 1 221.9424 281.6748 cm 0 0 m -0.738 0 l -0.738 1.698 l -0.797 -1.695 l -0.738 -5.094 l -0.738 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 221.9502 281.6406 cm 0 0 m -0.737 0 l -0.737 1.7 l -0.797 -1.697 l -0.737 -5.094 l -0.737 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 222.03 279.9792 cm 0 0 m 0.06 -3.398 l 0.06 -1.698 l 0.797 -1.698 l 0.797 1.696 l 0.06 1.696 l 0.06 3.394 l h f Q 4 M q 1 0 0 1 222.8276 281.6748 cm 0 0 m -0.737 0 l -0.737 1.698 l -0.797 -1.695 l -0.737 -5.094 l -0.737 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 222.8374 281.6406 cm 0 0 m -0.739 0 l -0.739 1.7 l -0.798 -1.697 l -0.739 -5.094 l -0.739 -3.392 l 0 -3.392 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 236.2612 281.6748 cm 0 0 m -11.455 0 l -11.455 1.698 l -12.342 -1.695 l -11.455 -5.094 l -11.455 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 236.2612 281.6748 cm 0 0 m -11.455 0 l -11.455 1.698 l -12.342 -1.695 l -11.455 -5.094 l -11.455 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 236.2695 281.6406 cm 0 0 m -11.455 0 l -11.455 1.7 l -12.34 -1.697 l -11.455 -5.094 l -11.455 -3.392 l 0 -3.392 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 245.5015 281.6748 cm 0 0 m -7.232 0 l -7.232 1.698 l -8.029 -1.695 l -7.232 -5.094 l -7.232 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 245.5015 281.6748 cm 0 0 m -7.232 0 l -7.232 1.698 l -8.029 -1.695 l -7.232 -5.094 l -7.232 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 245.5127 281.6406 cm 0 0 m -7.234 0 l -7.234 1.7 l -8.031 -1.697 l -7.234 -5.094 l -7.234 -3.392 l 0 -3.392 l 0 0 l h S Q 0.137 0.123 0.126 scn q 1 0 0 1 254.5938 281.6748 cm 0 0 m -8.324 0 l -8.324 1.698 l -9.208 -1.695 l -8.324 -5.094 l -8.324 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 254.5938 281.6748 cm 0 0 m -8.324 0 l -8.324 1.698 l -9.208 -1.695 l -8.324 -5.094 l -8.324 -3.394 l 0 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0 0 1 295.8691 281.6748 cm 0 0 m -14.408 0 l -14.408 1.698 l -15.294 -1.695 l -14.408 -5.094 l -14.408 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 295.8691 281.6748 cm 0 0 m -14.408 0 l -14.408 1.698 l -15.294 -1.695 l -14.408 -5.094 l -14.408 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 295.8828 281.6406 cm 0 0 m -14.409 0 l -14.409 1.7 l -15.296 -1.697 l -14.409 -5.094 l -14.409 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 311.3691 281.6748 cm 0 0 m -14.614 0 l -14.614 1.698 l -15.5 -1.695 l -14.614 -5.094 l -14.614 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 311.3691 281.6748 cm 0 0 m -14.614 0 l -14.614 1.698 l -15.5 -1.695 l -14.614 -5.094 l -14.614 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 311.3809 281.6406 cm 0 0 m -14.614 0 l -14.614 1.7 l -15.498 -1.697 l -14.614 -5.094 l -14.614 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 314.5273 281.6748 cm 0 0 m -2.863 0 l -2.863 1.698 l -3.158 -1.695 l -2.863 -5.094 l -2.863 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 314.5273 281.6748 cm 0 0 m 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0 0 1 104.4404 271.0898 cm 0 0 m 11.487 0 l S Q q 1 0 0 1 104.4404 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 115.9272 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 115.0693 271.0898 cm 0 0 m 11.485 0 l S Q q 1 0 0 1 115.0693 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 126.5547 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 125.6982 271.0898 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 125.6982 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 137.1846 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 136.3276 271.0898 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 136.3276 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 147.8135 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 146.9565 271.0898 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 146.9565 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 158.4429 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 157.5874 271.0898 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 157.5874 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 169.0718 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 168.2153 271.0898 cm 0 0 m 11.485 0 l S Q q 1 0 0 1 168.2153 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 179.7007 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 178.8442 271.0898 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 178.8442 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 190.3301 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 189.4736 271.0898 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 189.4736 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 200.958 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 200.1025 271.0898 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 200.1025 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 211.5884 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 210.7319 271.0898 cm 0 0 m 11.485 0 l S Q q 1 0 0 1 210.7319 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 222.2173 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 221.3599 271.0898 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 221.3599 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 232.8462 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 231.9897 271.0898 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 231.9897 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 243.4736 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 242.6182 271.0898 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 242.6182 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 254.1045 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 253.2471 271.0898 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 253.2471 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 264.7314 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 263.8774 271.0898 cm 0 0 m 11.485 0 l S Q q 1 0 0 1 263.8774 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 275.3628 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 274.5063 271.0898 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 274.5063 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 285.9907 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 285.1343 271.0898 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 285.1343 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 296.6201 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 295.7646 271.0898 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 295.7646 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 307.249 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 306.3916 271.0898 cm 0 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S Q q 1 0 0 1 381.6523 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 380.7969 271.0898 cm 0 0 m 11.483 0 l S Q q 1 0 0 1 380.7969 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 392.2803 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 391.4238 271.0898 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 391.4238 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 402.9102 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 402.0537 271.0898 cm 0 0 m 11.486 0 l S Q q 1 0 0 1 402.0537 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 413.54 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 412.6826 271.0898 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 412.6826 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 424.167 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 423.3135 271.0898 cm 0 0 m 11.481 0 l S Q q 1 0 0 1 423.3135 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 434.7949 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 433.9414 271.0898 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 433.9414 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 445.4258 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 444.5703 271.0898 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 444.5703 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 456.0547 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 455.1992 271.0898 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 455.1992 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 466.6836 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 465.8311 271.0898 cm 0 0 m 11.483 0 l S Q q 1 0 0 1 465.8311 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 477.3145 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 476.459 271.0898 cm 0 0 m 11.482 0 l S Q q 1 0 0 1 476.459 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 487.9414 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 487.0869 271.0898 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 487.0869 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 498.5713 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 497.7148 271.0898 cm 0 0 m 11.487 0 l S Q q 1 0 0 1 497.7148 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 509.2021 271.8301 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 508.3447 271.0898 cm 0 0 m 3.218 0 l S Q q 1 0 0 1 508.3447 271.8301 cm 0 0 m 0 -1.479 l S Q BT 0.137 0.123 0.126 scn /TT0 1 Tf 5.2485 0 0 5.2485 515.0791 275.5469 Tm (840 kb )Tj 0 3.9365 -3.9365 0 91.9404 282.1104 Tm (0663 )Tj 0 -1.117 TD (0664 )Tj 0 -1.555 TD (0665 )Tj 0 -1.338 TD (0666 )Tj 0 -0.994 TD (0667 )Tj 3.9365 0 0 3.9365 112.9248 282.2187 Tm (0668 )Tj 0 3.9365 -3.9365 0 124.3896 282.1104 Tm (0669 )Tj 0 -1.174 TD (0670 )Tj 0 -1.726 TD (0671 )Tj 0 -1.642 TD (0672 )Tj 3.9365 0 0 3.9365 146.7832 282.1904 Tm (0673 )Tj 3.776 0.042 Td (0674 )Tj 4.394 -0.042 Td (0675 )Tj 3.575 0.021 Td (0676 )Tj 3.745 -0.021 Td (0677 )Tj 3.2804 0 0 3.2804 213.583 287.5293 Tm (tRNA- thr/val/glu/asn)Tj 3.9365 0 0 3.9365 226.5244 282.1904 Tm (0682 )Tj 3.046 -0.02 Td (0683 )Tj 2.186 0 Td (0684 )Tj 3.349 0 Td (0685 )Tj 2.992 0 Td (0686 )Tj 3.061 0.02 Td (0687 )Tj 4.038 0.021 Td (0688 )Tj 0 3.9365 -3.9365 0 314.7783 282.1943 Tm (0689 )Tj 3.9365 0 0 3.9365 321.5742 282.1104 Tm (0690 )Tj 5.409 0.02 Td (0691 )Tj 4.125 0.021 Td (0692 )Tj 2.613 -0.021 Td (0693 )Tj 0 3.9365 -3.9365 0 381.4365 282.1904 Tm (0694 )Tj 3.9365 0 0 3.9365 389.4775 282.1104 Tm (0695 )Tj 4.166 0 Td (0696 )Tj 2.28 0.02 Td (0697 )Tj 3.331 0.021 Td (0698 )Tj 3.18 -0.041 Td (0699 )Tj 4.261 0.069 Td (0700 )Tj 7.087 -0.049 Td (0701 )Tj 4.374 0.021 Td (0702 )Tj -103.414 -2.683 Td (523 )Tj 2.7 0 Td (524 )Tj 2.7 0 Td (525 )Tj 2.7 0 Td (526 )Tj 2.7 0 Td (527 )Tj 2.7 0 Td (528f )Tj 2.7 0 Td (529f )Tj 2.7 0 Td (530 )Tj 2.7 0 Td (531 )Tj 2.7 0 Td (532 )Tj 2.7 0 Td (533 )Tj 2.7 0 Td (534 )Tj 2.7 0 Td (535 )Tj 2.7 0 Td (536 )Tj 2.7 0 Td (537 )Tj 2.7 0 Td (538 )Tj 2.7 0 Td (539 )Tj 2.7 0 Td (540 )Tj 2.7 0 Td (541 )Tj 2.7 0 Td (542 )Tj 2.7 0 Td (543 )Tj 2.7 0 Td (544 )Tj 2.7 0 Td (545 )Tj 2.7 0 Td (546 )Tj 2.699 0 Td (547 )Tj 2.7 0 Td (548 )Tj 2.7 0 Td (549 )Tj 2.7 0 Td (550 )Tj 2.7 0 Td (551 )Tj 2.7 0 Td (552 )Tj 2.7 0 Td (553 )Tj 2.7 0 Td (554 )Tj 2.7 0 Td (555 )Tj 2.7 0 Td (556 )Tj 2.7 0 Td (557 )Tj 2.701 0 Td (558 )Tj 2.7 0 Td (559 )Tj 2.699 0 Td (560 )Tj 2.701 0 Td (561 )Tj 2.7 0 Td (562 )Tj 1 1 1 scn 0 1.3161 -1.3121 0 87.7129 278.8838 Tm [(r)25(p)25(s)25(Q)25( )]TJ 2.1058 0 0 2.0995 88.1221 279.2109 Tm [(r)25(p)25(m)25(C)]TJ 2.9612 0 0 2.9523 92.7432 278.9951 Tm [(r)25(p)25(l)25(P)25( )]TJ /TT2 1 Tf 3.2902 0 0 3.2804 97.2793 278.8291 Tm (rpsC )Tj /TT0 1 Tf 1.9741 0 0 2.0937 104.8809 279.251 Tm (rplV )Tj 0 1.8311 -1.9682 0 110.293 278.501 Tm (rpsS )Tj /TT2 1 Tf 3.2902 0 0 3.2804 113.0273 278.9941 Tm [(r)-25(p)-25(l)-25(B)-25( )]TJ /TT0 1 Tf 0 1.8823 -1.9682 0 123.4678 278.3379 Tm [(r)25(p)25(l)25(W)25( )]TJ /TT2 1 Tf 3.2902 0 0 3.2804 124.5625 278.9941 Tm [(r)25(p)25(l)25(D)25( )]TJ 2.177 0.016 Td [(r)25(p)25(l)25(C)25( )]TJ /TT0 1 Tf 0 2.0733 -1.9682 0 141.1836 278.4463 Tm [(r)25(p)25(s)25(J)25( )]TJ /TT2 1 Tf 3.2902 0 0 3.2804 146.1572 278.8838 Tm [(d)-25(h)-25(a)-25(K)-25( )]TJ 30.758 -0.034 Td [(f)-25(o)-25(l)-25(D)]TJ 11.316 0.067 Td [(g)-25(a)-25(t)-25(B)]TJ 4.786 -0.001 Td [(g)-25(a)-25(t)-25(A)]TJ /TT0 1 Tf 0 1.9069 -2.1358 0 313.624 278.3936 Tm [(g)25(a)25(t)25(C)]TJ 0.137 0.123 0.126 scn /TT2 1 Tf 3.2902 0 0 3.2804 322.5322 279.0469 Tm [(l)-25(i)-25(g)-25(A)-25( )]TJ /TT0 1 Tf 3.9365 0 0 3.9365 87.0869 271.71 Tm (522 )Tj 3.2804 0 0 3.2804 438.9629 278.9678 Tm [(m)-25(s)-25(r)-25(A)-25(/)-25(B)]TJ ET q 1 0 0 1 86.4902 191.1543 cm 0 0 m 425.16 0 l S Q 0.73 0.805 0.919 scn 4 M q 1 0 0 1 86.4902 193.9238 cm 0 0 m 2.656 0 l 2.656 3.396 l 0 3.396 l B* Q 10 M q 1 0 0 1 86.4902 193.8818 cm 0 0 m 2.656 0 l 2.656 3.396 l 0 3.396 l S Q 0.501 0.764 0.267 scn q 1 0 0 1 104.5005 197.3193 cm 0 0 m -14.321 0 l -14.321 1.694 l -15.205 -1.699 l -14.321 -5.096 l -14.321 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 104.5005 197.3193 cm 0 0 m -14.321 0 l -14.321 1.694 l -15.205 -1.699 l -14.321 -5.096 l -14.321 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 104.5005 197.2773 cm 0 0 m -14.319 0 l -14.319 1.698 l -15.205 -1.695 l -14.319 -5.094 l -14.319 -3.396 l 0 -3.396 l 0 0 l h S Q 0.503 0.51 0.52 scn q 1 0 0 1 114.4771 197.3193 cm 0 0 m -9.004 0 l -9.004 1.694 l -9.889 -1.699 l -9.004 -5.096 l -9.004 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 114.4771 197.3193 cm 0 0 m -9.004 0 l -9.004 1.694 l -9.889 -1.699 l -9.004 -5.096 l -9.004 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 114.479 197.2773 cm 0 0 m -9.005 0 l -9.005 1.698 l -9.89 -1.695 l -9.005 -5.094 l -9.005 -3.396 l 0 -3.396 l 0 0 l h S Q 0.501 0.764 0.267 scn q 1 0 0 1 131.1279 197.3193 cm 0 0 m -15.912 0 l -15.912 1.694 l -16.798 -1.699 l -15.912 -5.096 l -15.912 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 131.1279 197.3193 cm 0 0 m -15.912 0 l -15.912 1.694 l -16.798 -1.699 l -15.912 -5.096 l -15.912 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 131.1328 197.2773 cm 0 0 m -15.915 0 l -15.915 1.698 l -16.801 -1.695 l -15.915 -5.094 l -15.915 -3.396 l 0 -3.396 l 0 0 l h S Q 0.25 0.396 0.688 scn q 1 0 0 1 141.2251 197.3193 cm 0 0 m -9.121 0 l -9.121 1.694 l -10.008 -1.699 l -9.121 -5.096 l -9.121 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 141.2251 197.3193 cm 0 0 m -9.121 0 l -9.121 1.694 l -10.008 -1.699 l -9.121 -5.096 l -9.121 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 141.2295 197.2773 cm 0 0 m -9.123 0 l -9.123 1.698 l -10.008 -1.695 l -9.123 -5.094 l -9.123 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 149.2866 197.3193 cm 0 0 m -6.467 0 l -6.467 1.694 l -7.175 -1.699 l -6.467 -5.096 l -6.467 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 149.2866 197.3193 cm 0 0 m -6.467 0 l -6.467 1.694 l -7.175 -1.699 l -6.467 -5.096 l -6.467 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 149.291 197.2773 cm 0 0 m -6.466 0 l -6.466 1.698 l -7.174 -1.695 l -6.466 -5.094 l -6.466 -3.396 l 0 -3.396 l 0 0 l h S Q 0.137 0.123 0.126 scn q 1 0 0 1 161.332 197.3193 cm 0 0 m -10.984 0 l -10.984 1.694 l -11.868 -1.699 l -10.984 -5.096 l -10.984 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 161.332 197.3193 cm 0 0 m -10.984 0 l -10.984 1.694 l -11.868 -1.699 l -10.984 -5.096 l -10.984 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 161.3364 197.2773 cm 0 0 m -10.983 0 l -10.983 1.698 l -11.87 -1.695 l -10.983 -5.094 l -10.983 -3.396 l 0 -3.396 l 0 0 l h S Q 0.99 0.914 0.17 scn q 1 0 0 1 191.4448 197.3193 cm 0 0 m -29.315 0 l -29.315 1.694 l -30.202 -1.699 l -29.315 -5.096 l -29.315 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 191.4448 197.3193 cm 0 0 m -29.315 0 l -29.315 1.694 l -30.202 -1.699 l -29.315 -5.096 l -29.315 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 191.4517 197.2773 cm 0 0 m -29.318 0 l -29.318 1.698 l -30.204 -1.695 l -29.318 -5.094 l -29.318 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 212.7607 197.3193 cm 0 0 m -20.342 0 l -20.342 1.694 l -21.226 -1.699 l -20.342 -5.096 l -20.342 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 212.7607 197.3193 cm 0 0 m -20.342 0 l -20.342 1.694 l -21.226 -1.699 l -20.342 -5.096 l -20.342 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 212.77 197.2773 cm 0 0 m -20.344 0 l -20.344 1.698 l -21.23 -1.695 l -20.344 -5.094 l -20.344 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 215.7725 197.3193 cm 0 0 m 9.212 0 l 9.212 1.694 l 10.097 -1.699 l 9.212 -5.096 l 9.212 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 215.7725 197.3193 cm 0 0 m 9.212 0 l 9.212 1.694 l 10.097 -1.699 l 9.212 -5.096 l 9.212 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 215.7813 197.2773 cm 0 0 m 9.212 0 l 9.212 1.698 l 10.097 -1.695 l 9.212 -5.094 l 9.212 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 225.9014 197.3193 cm 0 0 m 14.7 0 l 14.7 1.694 l 15.586 -1.699 l 14.7 -5.096 l 14.7 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 225.9014 197.3193 cm 0 0 m 14.7 0 l 14.7 1.694 l 15.586 -1.699 l 14.7 -5.096 l 14.7 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 225.9063 197.2773 cm 0 0 m 14.705 0 l 14.705 1.698 l 15.59 -1.695 l 14.705 -5.094 l 14.705 -3.396 l 0 -3.396 l 0 0 l h S Q 0.969 0.719 0.828 scn q 1 0 0 1 243.9972 197.6643 cm 0 0 m -0.737 0 l -0.737 -4.076 l 0 -4.076 l 0 -6.113 l 0.058 -2.044 l 0 2.033 l h f Q 4 M q 1 0 0 1 243.2598 197.6641 cm 0 0 m 0.737 0 l 0.737 2.033 l 0.795 -2.044 l 0.737 -6.112 l 0.737 -4.076 l 0 -4.076 l 0 0 l S Q 0.99 0.914 0.17 scn q 1 0 0 1 245.5034 197.3193 cm 0 0 m 7.646 0 l 7.646 1.694 l 8.472 -1.699 l 7.646 -5.096 l 7.646 -3.396 l 0 -3.396 l h f* Q q 1 0 0 1 245.5034 197.3193 cm 0 0 m 7.646 0 l 7.646 1.694 l 8.472 -1.699 l 7.646 -5.096 l 7.646 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 245.5127 197.2773 cm 0 0 m 7.647 0 l 7.647 1.698 l 8.474 -1.695 l 7.647 -5.094 l 7.647 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 254.0044 197.3193 cm 0 0 m 2.481 0 l 2.481 1.694 l 2.746 -1.699 l 2.481 -5.096 l 2.481 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 254.0044 197.3193 cm 0 0 m 2.481 0 l 2.481 1.694 l 2.746 -1.699 l 2.481 -5.096 l 2.481 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 254.0151 197.2773 cm 0 0 m 2.481 0 l 2.481 1.698 l 2.746 -1.695 l 2.481 -5.094 l 2.481 -3.396 l 0 -3.396 l 0 0 l h S Q 0.25 0.396 0.688 scn q 1 0 0 1 258.6704 197.3193 cm 0 0 m 10.097 0 l 10.097 1.694 l 10.982 -1.699 l 10.097 -5.096 l 10.097 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 258.6704 197.3193 cm 0 0 m 10.097 0 l 10.097 1.694 l 10.982 -1.699 l 10.097 -5.096 l 10.097 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 258.6812 197.2773 cm 0 0 m 10.097 0 l 10.097 1.698 l 10.982 -1.695 l 10.097 -5.094 l 10.097 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 274.2002 197.3193 cm 0 0 m 5.344 0 l 5.344 1.694 l 5.934 -1.699 l 5.344 -5.096 l 5.344 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 274.2002 197.3193 cm 0 0 m 5.344 0 l 5.344 1.694 l 5.934 -1.699 l 5.344 -5.096 l 5.344 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 274.2104 197.2773 cm 0 0 m 5.344 0 l 5.344 1.698 l 5.936 -1.695 l 5.344 -5.094 l 5.344 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 281.4326 197.3193 cm 0 0 m 4.251 0 l 4.251 1.694 l 4.693 -1.699 l 4.251 -5.096 l 4.251 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 281.4326 197.3193 cm 0 0 m 4.251 0 l 4.251 1.694 l 4.693 -1.699 l 4.251 -5.096 l 4.251 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 281.4453 197.2773 cm 0 0 m 4.25 0 l 4.25 1.698 l 4.693 -1.695 l 4.25 -5.094 l 4.25 -3.396 l 0 -3.396 l 0 0 l h S Q 0.99 0.914 0.17 scn q 1 0 0 1 286.1875 197.3193 cm 0 0 m 13.077 0 l 13.077 1.694 l 13.962 -1.699 l 13.077 -5.096 l 13.077 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 286.1875 197.3193 cm 0 0 m 13.077 0 l 13.077 1.694 l 13.962 -1.699 l 13.077 -5.096 l 13.077 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 286.1978 197.2773 cm 0 0 m 13.079 0 l 13.079 1.698 l 13.965 -1.695 l 13.079 -5.094 l 13.079 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 300.8584 197.3193 cm 0 0 m 13.021 0 l 13.021 1.694 l 13.904 -1.699 l 13.021 -5.096 l 13.021 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 300.8584 197.3193 cm 0 0 m 13.021 0 l 13.021 1.694 l 13.904 -1.699 l 13.021 -5.096 l 13.021 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 300.8721 197.2773 cm 0 0 m 13.02 0 l 13.02 1.698 l 13.905 -1.695 l 13.02 -5.094 l 13.02 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 316.2686 197.3193 cm 0 0 m 8.947 0 l 8.947 1.694 l 9.835 -1.699 l 8.947 -5.096 l 8.947 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 316.2686 197.3193 cm 0 0 m 8.947 0 l 8.947 1.694 l 9.835 -1.699 l 8.947 -5.096 l 8.947 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 316.2832 197.2773 cm 0 0 m 8.945 0 l 8.945 1.698 l 9.833 -1.695 l 8.945 -5.094 l 8.945 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 326.2188 197.3193 cm 0 0 m 13.196 0 l 13.196 1.694 l 14.085 -1.699 l 13.196 -5.096 l 13.196 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 326.2188 197.3193 cm 0 0 m 13.196 0 l 13.196 1.694 l 14.085 -1.699 l 13.196 -5.096 l 13.196 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 326.2334 197.2773 cm 0 0 m 13.198 0 l 13.198 1.698 l 14.085 -1.695 l 13.198 -5.094 l 13.198 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 340.3037 197.3193 cm 0 0 m 7.053 0 l 7.053 1.694 l 7.82 -1.699 l 7.053 -5.096 l 7.053 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 340.3037 197.3193 cm 0 0 m 7.053 0 l 7.053 1.694 l 7.82 -1.699 l 7.053 -5.096 l 7.053 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 340.3184 197.2773 cm 0 0 m 7.056 0 l 7.056 1.698 l 7.823 -1.695 l 7.056 -5.094 l 7.056 -3.396 l 0 -3.396 l 0 0 l h S Q 0.501 0.764 0.267 scn q 1 0 0 1 350.4863 197.3193 cm 0 0 m 3.102 0 l 3.102 1.694 l 3.425 -1.699 l 3.102 -5.096 l 3.102 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 350.4863 197.3193 cm 0 0 m 3.102 0 l 3.102 1.694 l 3.425 -1.699 l 3.102 -5.096 l 3.102 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 350.5029 197.2773 cm 0 0 m 3.102 0 l 3.102 1.698 l 3.425 -1.695 l 3.102 -5.094 l 3.102 -3.396 l 0 -3.396 l 0 0 l h S Q 0.97 0.579 0.116 scn q 1 0 0 1 354.0898 197.3193 cm 0 0 m 6.14 0 l 6.14 1.694 l 6.817 -1.699 l 6.14 -5.096 l 6.14 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 354.0898 197.3193 cm 0 0 m 6.14 0 l 6.14 1.694 l 6.817 -1.699 l 6.14 -5.096 l 6.14 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 354.1045 197.2773 cm 0 0 m 6.143 0 l 6.143 1.698 l 6.822 -1.695 l 6.143 -5.094 l 6.143 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 365.5752 197.3193 cm 0 0 m 62.055 0 l 62.055 1.694 l 62.941 -1.699 l 62.055 -5.096 l 62.055 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 365.5752 197.3193 cm 0 0 m 62.055 0 l 62.055 1.694 l 62.941 -1.699 l 62.055 -5.096 l 62.055 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 365.5898 197.2773 cm 0 0 m 62.061 0 l 62.061 1.698 l 62.948 -1.695 l 62.061 -5.094 l 62.061 -3.396 l 0 -3.396 l 0 0 l h S Q 0.716 0.434 0.681 scn q 1 0 0 1 428.6055 197.3193 cm 0 0 m 30.559 0 l 30.559 1.694 l 31.443 -1.699 l 30.559 -5.096 l 30.559 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 428.6055 197.3193 cm 0 0 m 30.559 0 l 30.559 1.694 l 31.443 -1.699 l 30.559 -5.096 l 30.559 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 428.626 197.2773 cm 0 0 m 30.561 0 l 30.561 1.698 l 31.446 -1.695 l 30.561 -5.094 l 30.561 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 460.0488 197.3193 cm 0 0 m 10.51 0 l 10.51 1.694 l 11.395 -1.699 l 10.51 -5.096 l 10.51 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 460.0488 197.3193 cm 0 0 m 10.51 0 l 10.51 1.694 l 11.395 -1.699 l 10.51 -5.096 l 10.51 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 460.0723 197.2773 cm 0 0 m 10.508 0 l 10.508 1.698 l 11.396 -1.695 l 10.508 -5.094 l 10.508 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 471.4746 197.3193 cm 0 0 m 9.831 0 l 9.831 1.694 l 10.716 -1.699 l 9.831 -5.096 l 9.831 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 471.4746 197.3193 cm 0 0 m 9.831 0 l 9.831 1.694 l 10.716 -1.699 l 9.831 -5.096 l 9.831 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 471.498 197.2773 cm 0 0 m 9.831 0 l 9.831 1.698 l 10.715 -1.695 l 9.831 -5.094 l 9.831 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 482.2783 197.3193 cm 0 0 m 14.468 0 l 14.468 1.694 l 15.354 -1.699 l 14.468 -5.096 l 14.468 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 482.2783 197.3193 cm 0 0 m 14.468 0 l 14.468 1.694 l 15.354 -1.699 l 14.468 -5.096 l 14.468 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 482.3037 197.2773 cm 0 0 m 14.468 0 l 14.468 1.698 l 15.352 -1.695 l 14.468 -5.094 l 14.468 -3.396 l 0 -3.396 l 0 0 l h S Q 4 M 497.571 193.924 14.055 3.396 re B* 10 M q 1 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223.6343 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 222.8076 186.7256 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 222.8076 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 234.2627 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 233.4365 186.7256 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 233.4365 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 244.8926 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 244.0659 186.7256 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 244.0659 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 255.5205 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 254.6948 186.7256 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 254.6948 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 266.1509 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 265.3242 186.7256 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 265.3242 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 276.7788 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 275.9531 186.7256 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 275.9531 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 287.4097 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 286.5811 186.7256 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 286.5811 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 298.0386 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 297.2104 186.7256 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 297.2104 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 308.666 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 307.8398 186.7256 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 307.8398 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 319.2949 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 318.4697 186.7256 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 318.4697 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 329.9238 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 329.0967 186.7256 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 329.0967 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 340.5527 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 339.7266 186.7256 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 339.7266 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 351.1826 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 350.3574 186.7256 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 350.3574 187.4619 cm 0 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q 1 0 0 1 424.7588 186.7256 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 424.7588 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 436.2129 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 435.3857 186.7256 cm 0 0 m 11.459 0 l S Q q 1 0 0 1 435.3857 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 446.8447 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 446.0176 186.7256 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 446.0176 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 457.4717 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 456.6475 186.7256 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 456.6475 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 468.1025 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 467.2764 186.7256 cm 0 0 m 11.453 0 l S Q q 1 0 0 1 467.2764 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 478.7295 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 477.9053 186.7256 cm 0 0 m 11.452 0 l S Q q 1 0 0 1 477.9053 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 489.3574 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 488.5332 186.7256 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 488.5332 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 499.9912 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 499.1631 186.7256 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 499.1631 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 510.6191 187.4619 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 509.792 186.7256 cm 0 0 m 1.858 0 l S Q q 1 0 0 1 509.792 187.4619 cm 0 0 m 0 -1.477 l S Q BT 0.137 0.123 0.126 scn /TT0 1 Tf 5.2485 0 0 5.2485 515.167 191.1865 Tm (1000 kb )Tj 3.9365 0 0 3.9365 93.5859 197.8311 Tm (0818 )Tj 3.313 -0.02 Td (0819 )Tj 3.168 0 Td (0820 )Tj 3.597 0.02 Td (0821 )Tj 0 3.9365 -3.9365 0 147.3311 197.668 Tm (0822 )Tj 3.9365 0 0 3.9365 152.3643 197.9141 Tm (0823 )Tj 5.326 -0.021 Td (0824 )Tj 6.386 0 Td (0825 )Tj 4.609 -0.02 Td (0826 )Tj 3.228 0 Td (0827 )Tj 2.3196 2.3196 -2.3196 2.3196 242.6751 198.3075 Tm (tRNA-cys )Tj 3.9365 0 0 3.9365 245.5635 197.8086 Tm (0829 )Tj 0 3.9365 -3.9365 0 256.2393 198.1338 Tm (0830 )Tj 3.9365 0 0 3.9365 260.1982 197.9141 Tm (0831 )Tj 0 3.9365 -3.9365 0 277.96 197.9141 Tm (0832 )Tj -0.027 -1.772 Td (0833 )Tj 3.9365 0 0 3.9365 288.9932 198.0225 Tm (0834 )Tj 3.783 0 Td (0835 )Tj 3.296 -0.014 Td (0836 )Tj 3.285 0.042 Td (0837 )Tj 2.587 0 Td (0838 )Tj 0 3.9365 -3.9365 0 353 197.9141 Tm (0839 )Tj -0.027 -1.393 Td (0840 )Tj 3.9365 0 0 3.9365 391.8711 198.0225 Tm (0841 )Tj 12.599 0.007 Td (0842 )Tj 4.922 0 Td (0843 )Tj 2.915 0 Td (0844 )Tj 3.567 0 Td (0845 )Tj 3.638 0 Td (0846 )Tj -102.616 -2.717 Td (683 )Tj 2.7 0 Td (684 )Tj 2.7 0 Td (685 )Tj 2.7 0 Td (686 )Tj 2.7 0 Td (687 )Tj 2.7 0 Td (688 )Tj 2.7 0 Td (689 )Tj 2.7 0 Td (690 )Tj 2.7 0 Td (691 )Tj 2.7 0 Td (692 )Tj 2.7 0 Td (693 )Tj 2.7 0 Td (694 )Tj 2.7 0 Td (695 )Tj 2.7 0 Td (696 )Tj 2.7 0 Td (697 )Tj 2.7 0 Td (698 )Tj 2.7 0 Td (699 )Tj 2.7 0 Td (700 )Tj 2.7 0 Td (701 )Tj 2.7 0 Td (702 )Tj 2.7 0 Td (703 )Tj 2.7 0 Td (704 )Tj 2.7 0 Td (705 )Tj 2.7 0 Td (706 )Tj 2.7 0 Td (707 )Tj 2.7 0 Td (708 )Tj 2.701 0 Td (709 )Tj 2.7 0 Td (710 )Tj 2.7 0 Td (711 )Tj 2.7 0 Td (712 )Tj 2.7 0 Td (713 )Tj 2.7 0 Td (714 )Tj 2.7 0 Td (715 )Tj 2.7 0 Td (716 )Tj 2.699 0 Td (717 )Tj 2.7 0 Td (718 )Tj 2.701 0 Td (719 )Tj 2.699 0 Td (720 )Tj 2.701 0 Td (721 )Tj -105.224 -0.021 Td (682 )Tj 1 1 1 scn /TT2 1 Tf 3.2804 0 0 3.2804 106.7188 194.4697 Tm [(t)-25(r)-25(x)-25(B)-25( )]TJ 8 0.033 Td [(h)-25(p)-25(r)-25(K)]TJ 6.033 -0.067 Td [(f)-25(o)-25(l)-25(C)]TJ 0.137 0.123 0.126 scn 6.167 0.033 Td [(u)-25(v)-25(r)-25(A)]TJ 7.9 0 Td [(u)-25(v)-25(r)-25(B)]TJ 5.667 0 Td [(h)-25(o)-25(l)-25(A)]TJ 1 1 1 scn 13.334 0.067 Td [(p)-25(r)-25(s)]TJ 4.066 -0.067 Td [(p)-25(t)-25(h)-25( )]TJ /TT0 1 Tf 2.167 0 Td [(r)-25(p)-25(l)-25(I)-25( )]TJ 0.137 0.123 0.126 scn /TT2 1 Tf 2.167 0 Td [(d)-25(n)-25(a)-25(B)]TJ 1 1 1 scn 12.433 0.033 Td [(c)-25(y)-25(s)-25(S)]TJ /TT0 1 Tf 0 1.8188 -1.9682 0 352.7451 193.9795 Tm (secE)Tj 0.137 0.123 0.126 scn 3.1967 0 0 3.2804 354.3281 194.4697 Tm (nusG)Tj ET 0.302 w 4 M 511.39 204.369 -83.432 1.644 re S 1 1 1 scn 479.964 203.823 -20.582 3.061 re f BT 0.137 0.123 0.126 scn /TT2 1 Tf 3.2902 0 0 3.2804 460.8008 204.2471 Tm (oligopeptide)Tj ET 0.262 w 10 M q 1 0 0 1 86.4067 170.9336 cm 0 0 m 425.163 0 l S Q 0.739 0.583 0.77 scn q 1 0 0 1 94.5571 177.0996 cm 0 0 m -6.998 0 l -6.998 1.698 l -7.765 -1.697 l -6.998 -5.091 l -6.998 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 94.5571 177.0996 cm 0 0 m -6.998 0 l -6.998 1.698 l -7.765 -1.697 l -6.998 -5.091 l -6.998 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 94.5571 177.0576 cm 0 0 m -6.998 0 l -6.998 1.7 l -7.765 -1.695 l -6.998 -5.094 l -6.998 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 101.7881 177.0996 cm 0 0 m -5.194 0 l -5.194 1.698 l -5.754 -1.697 l -5.194 -5.091 l -5.194 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 101.7881 177.0996 cm 0 0 m -5.194 0 l -5.194 1.698 l -5.754 -1.697 l -5.194 -5.091 l -5.194 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 101.7915 177.0576 cm 0 0 m -5.197 0 l -5.197 1.7 l -5.757 -1.695 l -5.197 -5.094 l -5.197 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 108.0195 177.0996 cm 0 0 m -4.843 0 l 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-1.697 l -1.742 -5.091 l -1.742 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 122.0737 177.0576 cm 0 0 m -1.742 0 l -1.742 1.7 l -1.919 -1.695 l -1.742 -5.094 l -1.742 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 126.2944 177.0996 cm 0 0 m -2.214 0 l -2.214 1.698 l -2.451 -1.697 l -2.214 -5.091 l -2.214 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 126.2944 177.0996 cm 0 0 m -2.214 0 l -2.214 1.698 l -2.451 -1.697 l -2.214 -5.091 l -2.214 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 126.2974 177.0576 cm 0 0 m -2.216 0 l -2.216 1.7 l -2.451 -1.695 l -2.216 -5.094 l -2.216 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 133.8228 177.0996 cm 0 0 m -6.909 0 l -6.909 1.698 l -7.646 -1.697 l -6.909 -5.091 l -6.909 -3.394 l 0 -3.394 l h f* Q 4 M q 1 0 0 1 133.8228 177.0996 cm 0 0 m -6.909 0 l -6.909 1.698 l -7.646 -1.697 l -6.909 -5.091 l -6.909 -3.394 l 0 -3.394 l 0 0 l S Q 10 M q 1 0 0 1 133.8257 177.0576 cm 0 0 m -6.909 0 l -6.909 1.7 l -7.647 -1.695 l -6.909 -5.094 l -6.909 -3.396 l 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287.3271 167.2441 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 286.5 166.5059 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 286.5 167.2441 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 297.957 167.2441 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 297.1289 166.5059 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 297.1289 167.2441 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 308.585 167.2441 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 307.7568 166.5059 cm 0 0 m 11.459 0 l S Q q 1 0 0 1 307.7568 167.2441 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 319.2158 167.2441 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 318.3867 166.5059 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 318.3867 167.2441 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 329.8428 167.2441 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 329.0137 166.5059 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 329.0137 167.2441 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 340.4707 167.2441 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 339.6445 166.5059 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 339.6445 167.2441 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 351.1016 167.2441 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 350.2744 166.5059 cm 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1.7 l -14.261 -1.693 l -13.375 -5.092 l -13.375 -3.392 l 0 -3.392 l 0 0 l h S Q 0.137 0.123 0.126 scn q 1 0 0 1 171.4932 156.8818 cm 0 0 m 4.784 0 l 4.784 1.7 l 5.315 -1.697 l 4.784 -5.091 l 4.784 -3.392 l 0 -3.392 l h f* Q 4 M q 1 0 0 1 171.4932 156.8818 cm 0 0 m 4.784 0 l 4.784 1.7 l 5.315 -1.697 l 4.784 -5.091 l 4.784 -3.392 l 0 -3.392 l 0 0 l S Q 10 M q 1 0 0 1 171.4995 156.8379 cm 0 0 m 4.784 0 l 4.784 1.7 l 5.314 -1.693 l 4.784 -5.092 l 4.784 -3.392 l 0 -3.392 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 184.4849 156.8818 cm 0 0 m -6.495 0 l -6.495 1.7 l -7.203 -1.697 l -6.495 -5.091 l -6.495 -3.392 l 0 -3.392 l h f* Q 4 M q 1 0 0 1 184.4849 156.8818 cm 0 0 m -6.495 0 l -6.495 1.7 l -7.203 -1.697 l -6.495 -5.091 l -6.495 -3.392 l 0 -3.392 l 0 0 l S Q 10 M q 1 0 0 1 184.4902 156.8379 cm 0 0 m -6.495 0 l -6.495 1.7 l -7.204 -1.693 l -6.495 -5.092 l -6.495 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 192.5142 156.8818 cm 0 0 m -5.756 0 l -5.756 1.7 l -6.377 -1.697 l -5.756 -5.091 l 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215.4917 156.8379 cm 0 0 m 12.104 0 l 12.104 1.7 l 12.99 -1.693 l 12.104 -5.092 l 12.104 -3.392 l 0 -3.392 l 0 0 l h S Q q 1 0 0 1 229.8901 156.8818 cm 0 0 m 11.898 0 l 11.898 1.7 l 12.785 -1.697 l 11.898 -5.091 l 11.898 -3.392 l 0 -3.392 l h f* Q 4 M q 1 0 0 1 229.8901 156.8818 cm 0 0 m 11.898 0 l 11.898 1.7 l 12.785 -1.697 l 11.898 -5.091 l 11.898 -3.392 l 0 -3.392 l 0 0 l S Q 10 M q 1 0 0 1 229.8994 156.8379 cm 0 0 m 11.9 0 l 11.9 1.7 l 12.785 -1.693 l 11.9 -5.092 l 11.9 -3.392 l 0 -3.392 l 0 0 l h S Q 1 1 1 scn q 1 0 0 1 267.6221 156.8818 cm 0 0 m -23.176 0 l -23.176 1.7 l -24.062 -1.697 l -23.176 -5.091 l -23.176 -3.392 l 0 -3.392 l h f* Q 4 M q 1 0 0 1 267.6221 156.8818 cm 0 0 m -23.176 0 l -23.176 1.7 l -24.062 -1.697 l -23.176 -5.091 l -23.176 -3.392 l 0 -3.392 l 0 0 l S Q 10 M q 1 0 0 1 267.6328 156.8379 cm 0 0 m -23.176 0 l -23.176 1.7 l -24.063 -1.693 l -23.176 -5.092 l -23.176 -3.392 l 0 -3.392 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 291.7725 156.8818 cm 0 0 m -23.147 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147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 116.5532 146.2881 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 116.5532 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 128.0093 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 127.1836 146.2881 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 127.1836 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 138.6372 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 137.8105 146.2881 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 137.8105 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 149.2666 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 148.4409 146.2881 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 148.4409 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 159.8965 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 159.0708 146.2881 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 159.0708 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 170.5259 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 169.6968 146.2881 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 169.6968 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 181.1538 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 180.3281 146.2881 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 180.3281 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 191.7827 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 190.9561 146.2881 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 190.9561 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 202.4121 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 201.5864 146.2881 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 201.5864 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 213.041 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 212.2144 146.2881 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 212.2144 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 223.6694 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 222.8433 146.2881 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 222.8433 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 234.2998 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 233.4727 146.2881 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 233.4727 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 244.9272 147.0264 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 244.1016 146.2881 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 244.1016 147.0264 cm 0 0 m 0 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2.7 0 Td (797 )Tj 2.701 0 Td (798 )Tj 2.7 0 Td (799a )Tj -99.833 -0.041 Td (762 )Tj 0 3.9365 -3.9365 0 90.6328 157.3721 Tm (0882 )Tj 1 1 1 scn /TT2 1 Tf 3.2804 0 0 3.2804 94.7734 154.0371 Tm [(a)-25(s)-25(n)-25(A)]TJ 8.75 0.025 Td [(g)-25(i)-25(d)-25(A)]TJ 23.975 0.025 Td [(l)-25(p)-25(p)-25(Q)-25( )]TJ 59.375 -0.041 Td [(v)-25(l)-25(c)-25(F)-25( )]TJ /TT0 1 Tf 2.85 -0.009 Td [(v)-25(l)-25(c)-25(G)-25( )]TJ 2.7214 0 0 3.2804 415.5098 154.0352 Tm [(v)-25(l)-25(c)-25(H)-25( )]TJ /TT2 1 Tf 3.2804 0 0 3.2804 426.0068 154.0654 Tm [(v)-25(l)-25(c)-25(I)-25( )]TJ 2.775 0 Td [(v)-25(l)-25(c)-25(J)-25( )]TJ 11.075 0.016 Td [(o)-25(x)-25(a)-25(A)]TJ 0.137 0.123 0.126 scn /TT0 1 Tf 1.6996 0 0 1.9682 481.8555 154.5283 Tm [(r)-25(n)-25(p)-25(A)]TJ 1 1 1 scn /TT2 1 Tf 0 1.1404 -1.3121 0 486.3682 153.7354 Tm [(r)-25(p)-25(m)-25(H)]TJ ET q 1 0 0 1 86.3999 420.3276 cm 0 0 m 425.161 0 l S Q 0.555 0.846 0.972 scn 0.281 w 4 M q 1 0 0 1 86.3999 423.0796 cm 0 0 m 2.834 0 l 2.834 3.395 l 0 3.395 l B* Q 10 M 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-3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 138.689 426.4512 cm 0 0 m -16.563 0 l -16.563 1.698 l -17.447 -1.698 l -16.563 -5.092 l -16.563 -3.394 l 0 -3.394 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 142.2598 426.4746 cm 0 0 m -2.984 0 l -2.984 1.696 l -3.308 -1.697 l -2.984 -5.094 l -2.984 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 142.2598 426.4746 cm 0 0 m -2.984 0 l -2.984 1.696 l -3.308 -1.697 l -2.984 -5.094 l -2.984 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 142.2612 426.4512 cm 0 0 m -2.981 0 l -2.981 1.698 l -3.306 -1.698 l -2.981 -5.092 l -2.981 -3.394 l 0 -3.394 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 144.0601 426.4746 cm 0 0 m 1.889 0 l 1.889 1.696 l 2.096 -1.697 l 1.889 -5.094 l 1.889 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 144.0601 426.4746 cm 0 0 m 1.889 0 l 1.889 1.696 l 2.096 -1.697 l 1.889 -5.094 l 1.889 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 144.063 426.4512 cm 0 0 m 1.892 0 l 1.892 1.698 l 2.097 -1.698 l 1.892 -5.092 l 1.892 -3.394 l 0 -3.394 l 0 0 l h 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cm 0 0 m 11.131 0 l 11.131 1.696 l 12.017 -1.697 l 11.131 -5.094 l 11.131 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 154.251 426.4512 cm 0 0 m 11.129 0 l 11.129 1.698 l 12.015 -1.698 l 11.129 -5.092 l 11.129 -3.394 l 0 -3.394 l 0 0 l h S Q q 1 0 0 1 166.8218 426.4746 cm 0 0 m 21.317 0 l 21.317 1.696 l 22.203 -1.697 l 21.317 -5.094 l 21.317 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 166.8218 426.4746 cm 0 0 m 21.317 0 l 21.317 1.696 l 22.203 -1.697 l 21.317 -5.094 l 21.317 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 166.8286 426.4512 cm 0 0 m 21.316 0 l 21.316 1.698 l 22.202 -1.698 l 21.316 -5.092 l 21.316 -3.394 l 0 -3.394 l 0 0 l h S Q q 1 0 0 1 188.9653 426.4746 cm 0 0 m 7.735 0 l 7.735 1.696 l 8.592 -1.697 l 7.735 -5.094 l 7.735 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 188.9653 426.4746 cm 0 0 m 7.735 0 l 7.735 1.696 l 8.592 -1.697 l 7.735 -5.094 l 7.735 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 188.9707 426.4512 cm 0 0 m 7.735 0 l 7.735 1.698 l 8.593 -1.698 l 7.735 -5.092 l 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232.3735 426.4512 cm 0 0 m 11.484 0 l 11.484 1.698 l 12.372 -1.698 l 11.484 -5.092 l 11.484 -3.394 l 0 -3.394 l 0 0 l h S Q 0.716 0.434 0.681 scn q 1 0 0 1 244.647 426.4746 cm 0 0 m 6.525 0 l 6.525 1.696 l 7.232 -1.697 l 6.525 -5.094 l 6.525 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 244.647 426.4746 cm 0 0 m 6.525 0 l 6.525 1.696 l 7.232 -1.697 l 6.525 -5.094 l 6.525 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 244.6563 426.4512 cm 0 0 m 6.524 0 l 6.524 1.698 l 7.234 -1.698 l 6.524 -5.092 l 6.524 -3.394 l 0 -3.394 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 251.8203 426.4746 cm 0 0 m 13.109 0 l 13.109 1.696 l 13.994 -1.697 l 13.109 -5.094 l 13.109 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 251.8203 426.4746 cm 0 0 m 13.109 0 l 13.109 1.696 l 13.994 -1.697 l 13.109 -5.094 l 13.109 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 251.8286 426.4512 cm 0 0 m 13.111 0 l 13.111 1.698 l 13.997 -1.698 l 13.111 -5.092 l 13.111 -3.394 l 0 -3.394 l 0 0 l h S Q 0.503 0.51 0.52 scn q 1 0 0 1 266.0811 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434.8262 426.4512 cm 0 0 m 5.227 0 l 5.227 1.698 l 5.788 -1.698 l 5.227 -5.092 l 5.227 -3.394 l 0 -3.394 l 0 0 l h S Q q 1 0 0 1 442.0391 426.4746 cm 0 0 m 6.995 0 l 6.995 1.696 l 7.765 -1.697 l 6.995 -5.094 l 6.995 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 442.0391 426.4746 cm 0 0 m 6.995 0 l 6.995 1.696 l 7.765 -1.697 l 6.995 -5.094 l 6.995 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 442.0605 426.4512 cm 0 0 m 6.995 0 l 6.995 1.698 l 7.764 -1.698 l 6.995 -5.092 l 6.995 -3.394 l 0 -3.394 l 0 0 l h S Q 0.503 0.51 0.52 scn q 1 0 0 1 451.5439 426.4746 cm 0 0 m 14.142 0 l 14.142 1.696 l 15.028 -1.697 l 14.142 -5.094 l 14.142 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 451.5439 426.4746 cm 0 0 m 14.142 0 l 14.142 1.696 l 15.028 -1.697 l 14.142 -5.094 l 14.142 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 451.5664 426.4512 cm 0 0 m 14.144 0 l 14.144 1.698 l 15.027 -1.698 l 14.144 -5.092 l 14.144 -3.394 l 0 -3.394 l 0 0 l h S Q 0.99 0.914 0.17 scn q 1 0 0 1 468.5498 426.4746 cm 0 0 m 19.662 0 l 19.662 1.696 l 20.549 -1.697 l 19.662 -5.094 l 19.662 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 468.5498 426.4746 cm 0 0 m 19.662 0 l 19.662 1.696 l 20.549 -1.697 l 19.662 -5.094 l 19.662 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 468.5742 426.4512 cm 0 0 m 19.662 0 l 19.662 1.698 l 20.548 -1.698 l 19.662 -5.092 l 19.662 -3.394 l 0 -3.394 l 0 0 l h S Q 4 M 489.099 423.08 22.438 3.395 re B* 10 M q 1 0 0 1 511.5605 423.0571 cm 0 0 m -22.438 0 l -22.438 3.394 l 0 3.394 l S Q 0.262 w q 1 0 0 1 86.3999 415.8979 cm 0 0 m 6.821 0 l S Q q 1 0 0 1 93.2207 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 92.395 415.8979 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 92.395 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 103.8501 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 103.0239 415.8979 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 103.0239 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 114.479 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 113.6543 415.8979 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 113.6543 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 125.1079 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 124.2813 415.8979 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 124.2813 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 135.7383 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 134.9116 415.8979 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 134.9116 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 146.3662 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 145.5386 415.8979 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 145.5386 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 156.9946 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 156.1685 415.8979 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 156.1685 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 167.6235 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 166.7969 415.8979 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 166.7969 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 178.2534 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 177.4277 415.8979 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 177.4277 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 188.8828 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 188.0562 415.8979 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 188.0562 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 199.5117 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 198.686 415.8979 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 198.686 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 210.1411 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 209.314 415.8979 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 209.314 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 220.769 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 219.9434 415.8979 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 219.9434 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 231.3989 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 230.5723 415.8979 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 230.5723 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 242.0273 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 241.2017 415.8979 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 241.2017 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 252.6567 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 251.8286 415.8979 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 251.8286 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 263.2861 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 262.4585 415.8979 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 262.4585 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 273.915 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 273.0889 415.8979 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 273.0889 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 284.5449 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 283.7178 415.8979 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 283.7178 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 295.1724 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 294.3457 415.8979 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 294.3457 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 305.8032 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 304.9731 415.8979 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 304.9731 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 316.4307 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 315.6035 415.8979 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 315.6035 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 327.0596 416.6367 cm 0 0 m 0 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0 0 1 390.0078 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 401.4639 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 400.6348 415.8979 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 400.6348 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 412.0889 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 411.2646 415.8979 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 411.2646 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 422.7197 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 421.8916 415.8979 cm 0 0 m 11.459 0 l S Q q 1 0 0 1 421.8916 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 433.3506 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 432.5244 415.8979 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 432.5244 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 443.9785 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 443.1514 415.8979 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 443.1514 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 454.6074 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 453.7822 415.8979 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 453.7822 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 465.2363 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 464.4102 415.8979 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 464.4102 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 475.8652 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 475.0371 415.8979 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 475.0371 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 486.4951 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 485.6689 415.8979 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 485.6689 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 497.123 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 496.2969 415.8979 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 496.2969 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 507.7529 416.6367 cm 0 0 m 0 -1.478 l S Q q 1 0 0 1 506.9268 415.8979 cm 0 0 m 4.634 0 l S Q q 1 0 0 1 506.9268 416.6367 cm 0 0 m 0 -1.478 l S Q BT 0.137 0.123 0.126 scn /TT0 1 Tf 5.2485 0 0 5.2485 515.0791 420.3472 Tm (560 kb )Tj 0 3.9365 -3.9365 0 96.2588 426.8257 Tm (0416 )Tj 0.021 -1.114 Td (0417 )Tj 0 -1.949 TD (0418 )Tj 3.9365 0 0 3.9365 112.4072 427.1538 Tm (0419 )Tj 3.603 0 Td (0420 )Tj 0 3.9365 -3.9365 0 142.4746 426.8257 Tm (0421 )Tj -0.041 -0.83 Td (0422 )Tj 2.3196 2.3196 -2.3196 2.3196 146.937 427.7128 Tm (tRNA-leu )Tj 3.9365 0 0 3.9365 156.7383 426.9907 Tm (0425 )Tj 4.358 -0.021 Td (0426 )Tj 3.88 0.021 Td (0427 )Tj 0 3.9365 -3.9365 0 202.208 426.8257 Tm (0428 )Tj 3.9365 0 0 3.9365 208.1377 426.9907 Tm (0429 )Tj 0 3.9365 -3.9365 0 221.3018 426.9077 Tm (0430 )Tj -0.021 -1.503 Td (0431 )Tj 3.9365 0 0 3.9365 234.4756 426.9907 Tm (0432 )Tj 0 3.9365 -3.9365 0 248.9609 426.9067 Tm (0433 )Tj 3.9365 0 0 3.9365 254.6016 427.0718 Tm (0434 )Tj 3.08 -0.021 Td (0435 )Tj 0 3.9365 -3.9365 0 280.332 426.8257 Tm (0436 )Tj 3.9365 0 0 3.9365 284.9473 426.9907 Tm (0437 )Tj 0 3.9365 -3.9365 0 298.1914 426.9897 Tm (0438 )Tj 3.9365 0 0 3.9365 307.2832 426.9907 Tm (0439 )Tj 6.634 -0.042 Td (0440 )Tj 6.122 0.042 Td (0441 )Tj 0 3.9365 -3.9365 0 371.4746 426.9077 Tm (0442 )Tj 0 -1.339 TD (0443 )Tj 3.9365 0 0 3.9365 384.5537 426.9907 Tm (0444 )Tj 5.022 0.041 Td (0445 )Tj 0 3.9365 -3.9365 0 418.6689 426.9077 Tm (0446 )Tj 0 -1.37 TD (0447 )Tj 0 -1.678 TD (0448 )Tj 0.021 -2.11 Td (0449 )Tj 3.9365 0 0 3.9365 441.6562 427.0718 Tm (0450 )Tj 3.366 -0.021 Td (0451 )Tj 5.046 0.021 Td (0452 )Tj 5.315 0 Td (0453 )Tj -102.076 -2.683 Td (238 )Tj 2.7 0 Td (239 )Tj 2.7 0 Td (240 )Tj 2.7 0 Td (241 )Tj 2.7 0 Td (242 )Tj 2.7 0 Td (243 )Tj 2.7 0 Td (244 )Tj 2.7 0 Td (245 )Tj 2.7 0 Td (246 )Tj 2.7 0 Td (247f )Tj 2.7 0 Td (248f )Tj 2.7 0 Td (249 )Tj 2.7 0 Td (250 )Tj 2.7 0 Td (251 )Tj 2.7 0 Td (252 )Tj 2.7 0 Td (253 )Tj 2.7 0 Td (254 )Tj 2.7 0 Td (255 )Tj 2.7 0 Td (256 )Tj 2.7 0 Td (257 )Tj 2.7 0 Td (258 )Tj 2.7 0 Td (259 )Tj 2.7 0 Td (260 )Tj 2.7 0 Td (261 )Tj 2.7 0 Td (262 )Tj 2.7 0 Td (263 )Tj 2.7 0 Td (264 )Tj 2.7 0 Td (265 )Tj 2.7 0 Td (266 )Tj 2.7 0 Td (267 )Tj 2.701 0 Td (268 )Tj 2.7 0 Td (269 )Tj 2.7 0 Td (270 )Tj 2.7 0 Td (271 )Tj 2.7 0 Td (272 )Tj 2.7 0 Td (273 )Tj 2.7 0 Td (274 )Tj 2.7 0 Td (275 )Tj 2.7 0 Td (276 )Tj 2.7 0 Td (277 )Tj /TT2 1 Tf 3.2804 0 0 3.2804 104.2783 423.9556 Tm [(r)-25(n)-25(c)]TJ 1 1 1 scn 2.575 -0.075 Td [(p)-25(l)-25(s)-25(X)]TJ /TT0 1 Tf 0 1.6402 -1.6402 0 145.585 423.1636 Tm [(r)25(p)25(m)25(B)]TJ ET 185.958 431.996 -21.891 3.062 re f BT /TT0 1 Tf 3.2902 0 0 3.2804 197.9326 423.6274 Tm [(p)25(h)25(o)25(U)]TJ /TT2 1 Tf 11.142 0.05 Td [(m)-25(e)-25(t)-25(K)]TJ 5.906 -0.05 Td [(t)-25(r)-25(m)-25(F)-25(O)]TJ 0.137 0.123 0.126 scn 6.805 0.15 Td [(u)-25(n)-25(g)]TJ 1 1 1 scn /TT0 1 Tf 2.6321 0 0 2.6243 373.1035 424.0386 Tm [(m)25(t)25(h)25(f)25(s)]TJ /TT2 1 Tf 3.2902 0 0 3.2804 405.6621 423.7915 Tm [(p)-25(g)-25(i)]TJ 0.137 0.123 0.126 scn 20.962 0 Td [(p)-25(a)-25(r)-25(E)]TJ 6.431 -0.025 Td [(p)-25(a)-25(r)-25(C)]TJ 1 1 1 scn 3.2804 0 0 3.2804 189.5967 423.7368 Tm [(p)-25(t)-25(s)-25(B)]TJ ET 4 M 153.902 430.861 42.725 1.803 re B 183.669 430.719 -16.812 4.921 re f BT 0.137 0.123 0.126 scn /TT2 1 Tf 3.2902 0 0 3.2804 167.5791 430.6548 Tm (phosphate)Tj ET 1 1 1 scn 155.481 430.191 -1.887 3.033 re f BT 0.137 0.123 0.126 scn /TT0 1 Tf 2.7919 2.7919 -2.7835 2.7835 150.6542 426.5686 Tm [(0)25(4)25(2)25(4)]TJ ET 0.23 w q 1 0 0 1 205.3428 391.626 cm 0 0 m 1.886 -2.787 l S Q q 0 792 612 -792 re W n q 1 0 0 1 207.6025 388.6006 cm 0 0 m -0.088 0.284 -0.126 0.482 -0.178 0.723 c -0.898 0.235 l -0.82 0.189 -0.524 -0.011 -0.294 -0.198 c -0.047 -0.399 0.16 -0.593 0.279 -0.729 c 0.197 -0.567 0.095 -0.304 0 0 c f Q Q 0.262 w 10 M q 1 0 0 1 86.5229 379.9893 cm 0 0 m 425.162 0 l S Q 0.25 0.396 0.688 scn 0.281 w 4 M q 1 0 0 1 86.5229 382.7402 cm 0 0 m 4.872 0 l 4.872 3.398 l 0 3.398 l B* Q 10 M q 1 0 0 1 86.5229 382.7148 cm 0 0 m 4.872 0 l 4.872 3.396 l 0 3.396 l S Q 0.73 0.805 0.919 scn q 1 0 0 1 96.3247 386.1387 cm 0 0 m -4.253 0 l -4.253 1.697 l -4.694 -1.699 l -4.253 -5.095 l -4.253 -3.398 l 0 -3.398 l h f* Q 4 M q 1 0 0 1 96.3247 386.1387 cm 0 0 m -4.253 0 l -4.253 1.697 l -4.694 -1.699 l -4.253 -5.095 l -4.253 -3.398 l 0 -3.398 l 0 0 l S Q 10 M q 1 0 0 1 96.3257 386.1104 cm 0 0 m -4.251 0 l -4.251 1.698 l -4.695 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l -9.301 -1.699 l -8.416 -5.095 l -8.416 -3.398 l 0 -3.398 l h f* Q 4 M q 1 0 0 1 130.2476 386.1387 cm 0 0 m -8.416 0 l -8.416 1.697 l -9.301 -1.699 l -8.416 -5.095 l -8.416 -3.398 l 0 -3.398 l 0 0 l S Q 10 M q 1 0 0 1 130.2495 386.1104 cm 0 0 m -8.416 0 l -8.416 1.698 l -9.3 -1.694 l -8.416 -5.093 l -8.416 -3.396 l 0 -3.396 l 0 0 l h S Q 0.503 0.51 0.52 scn q 1 0 0 1 134.9399 386.1387 cm 0 0 m -4.309 0 l -4.309 1.697 l -4.782 -1.699 l -4.309 -5.095 l -4.309 -3.398 l 0 -3.398 l h f* Q 4 M q 1 0 0 1 134.9399 386.1387 cm 0 0 m -4.309 0 l -4.309 1.697 l -4.782 -1.699 l -4.309 -5.095 l -4.309 -3.398 l 0 -3.398 l 0 0 l S Q 10 M q 1 0 0 1 134.9443 386.1104 cm 0 0 m -4.31 0 l -4.31 1.698 l -4.784 -1.694 l -4.31 -5.093 l -4.31 -3.396 l 0 -3.396 l 0 0 l h S Q 0.716 0.434 0.681 scn q 1 0 0 1 153.127 386.1387 cm 0 0 m -17.212 0 l -17.212 1.697 l -18.097 -1.699 l -17.212 -5.095 l -17.212 -3.398 l 0 -3.398 l h f* Q 4 M q 1 0 0 1 153.127 386.1387 cm 0 0 m -17.212 0 l -17.212 1.697 l -18.097 -1.699 l 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-3.396 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 407.0879 386.1387 cm 0 0 m -24.447 0 l -24.447 1.697 l -25.332 -1.699 l -24.447 -5.095 l -24.447 -3.398 l 0 -3.398 l h f* Q 4 M q 1 0 0 1 407.0879 386.1387 cm 0 0 m -24.447 0 l -24.447 1.697 l -25.332 -1.699 l -24.447 -5.095 l -24.447 -3.398 l 0 -3.398 l 0 0 l S Q 10 M q 1 0 0 1 407.1074 386.1104 cm 0 0 m -24.448 0 l -24.448 1.698 l -25.336 -1.694 l -24.448 -5.093 l -24.448 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 418.3643 386.1387 cm 0 0 m -10.304 0 l -10.304 1.697 l -11.189 -1.699 l -10.304 -5.095 l -10.304 -3.398 l 0 -3.398 l h f* Q 4 M q 1 0 0 1 418.3643 386.1387 cm 0 0 m -10.304 0 l -10.304 1.697 l -11.189 -1.699 l -10.304 -5.095 l -10.304 -3.398 l 0 -3.398 l 0 0 l S Q 10 M q 1 0 0 1 418.3857 386.1104 cm 0 0 m -10.305 0 l -10.305 1.698 l -11.19 -1.694 l -10.305 -5.093 l -10.305 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 425.127 386.1387 cm 0 0 m -5.817 0 l -5.817 1.697 l -6.438 -1.699 l -5.817 -5.095 l -5.817 -3.398 l 0 -3.398 l h f* Q 4 M q 1 0 0 1 425.127 386.1387 cm 0 0 m -5.817 0 l -5.817 1.697 l -6.438 -1.699 l -5.817 -5.095 l -5.817 -3.398 l 0 -3.398 l 0 0 l S Q 10 M q 1 0 0 1 425.1445 386.1104 cm 0 0 m -5.814 0 l -5.814 1.698 l -6.435 -1.694 l -5.814 -5.093 l -5.814 -3.396 l 0 -3.396 l 0 0 l h S Q 0.716 0.434 0.681 scn q 1 0 0 1 472.5098 386.1387 cm 0 0 m -46.382 0 l -46.382 1.697 l -47.268 -1.699 l -46.382 -5.095 l -46.382 -3.398 l 0 -3.398 l h f* Q 4 M q 1 0 0 1 472.5098 386.1387 cm 0 0 m -46.382 0 l -46.382 1.697 l -47.268 -1.699 l -46.382 -5.095 l -46.382 -3.398 l 0 -3.398 l 0 0 l S Q 10 M q 1 0 0 1 472.5352 386.1104 cm 0 0 m -46.384 0 l -46.384 1.698 l -47.272 -1.694 l -46.384 -5.093 l -46.384 -3.396 l 0 -3.396 l 0 0 l h S Q 0.986 0.823 0.154 scn q 1 0 0 1 474.8994 386.3955 cm 0 0 m -1.061 0 l -1.061 1.951 l -1.149 -1.954 l -1.061 -5.858 l -1.061 -3.907 l 0 -3.907 l h f* Q 4 M q 1 0 0 1 474.8994 386.3955 cm 0 0 m -1.061 0 l -1.061 1.951 l -1.149 -1.954 l -1.061 -5.858 l -1.061 -3.907 l 0 -3.907 l 0 0 l S Q 0.968 0.71 0.823 scn q 1 0 0 1 474.9258 386.3652 cm 0 0 m -1.063 0 l -1.063 1.95 l -1.15 -1.951 l -1.063 -5.858 l -1.063 -3.905 l 0 -3.905 l h f Q 10 M q 1 0 0 1 474.9258 386.3652 cm 0 0 m -1.063 0 l -1.063 1.95 l -1.15 -1.951 l -1.063 -5.858 l -1.063 -3.905 l 0 -3.905 l 0 0 l h S Q q 1 0 0 1 506.4326 386.3955 cm 0 0 m -29.849 0 l -29.849 1.951 l -30.734 -1.954 l -29.849 -5.858 l -29.849 -3.907 l 0 -3.907 l h f* Q 4 M q 1 0 0 1 506.4326 386.3955 cm 0 0 m -29.849 0 l -29.849 1.951 l -30.734 -1.954 l -29.849 -5.858 l -29.849 -3.907 l 0 -3.907 l 0 0 l S Q 10 M q 1 0 0 1 506.457 386.3652 cm 0 0 m -29.85 0 l -29.85 1.95 l -30.734 -1.951 l -29.85 -5.858 l -29.85 -3.905 l 0 -3.905 l 0 0 l h S Q 4 M q 1 0 0 1 511.6563 386.3955 cm 0 0 m -2.479 0 l -2.479 1.951 l -2.744 -1.954 l -2.479 -5.858 l -2.479 -3.907 l 0 -3.907 l B* Q 10 M q 1 0 0 1 511.6846 386.3652 cm 0 0 m -2.479 0 l -2.479 1.95 l -2.746 -1.951 l -2.479 -5.858 l -2.479 -3.905 l 0 -3.905 l S Q 0.262 w q 1 0 0 1 86.5229 375.5596 cm 0 0 m 8.414 0 l S Q q 1 0 0 1 94.937 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 94.1099 375.5596 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 94.1099 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 105.5684 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 104.7402 375.5596 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 104.7402 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 116.1958 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 115.3682 375.5596 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 115.3682 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 126.8247 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 125.9976 375.5596 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 125.9976 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 137.4526 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 136.6265 375.5596 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 136.6265 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 148.082 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 147.2554 375.5596 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 147.2554 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 158.7119 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 157.8857 375.5596 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 157.8857 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 169.3413 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 168.5146 375.5596 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 168.5146 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 179.9702 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 179.1421 375.5596 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 179.1421 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 190.5991 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 189.772 375.5596 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 189.772 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 201.2295 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 200.4009 375.5596 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 200.4009 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 211.8574 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 211.0303 375.5596 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 211.0303 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 222.4854 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 221.6572 375.5596 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 221.6572 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 233.1138 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 232.2881 375.5596 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 232.2881 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 243.7446 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 242.917 375.5596 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 242.917 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 254.374 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 253.5469 375.5596 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 253.5469 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 265.0029 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 264.1763 375.5596 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 264.1763 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 275.6299 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 274.8032 375.5596 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 274.8032 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 286.2593 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 285.4336 375.5596 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 285.4336 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 296.8892 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 296.0635 375.5596 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 296.0635 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 307.5176 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 306.6914 375.5596 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 306.6914 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 318.1484 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 317.3223 375.5596 cm 0 0 m 11.452 0 l S Q q 1 0 0 1 317.3223 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 328.7744 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 327.9492 375.5596 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 327.9492 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 339.4053 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 338.5771 375.5596 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 338.5771 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 350.0352 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 349.209 375.5596 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 349.209 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 360.6641 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 359.8359 375.5596 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 359.8359 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 371.2939 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 370.4639 375.5596 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 370.4639 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 381.9219 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 381.0938 375.5596 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 381.0938 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 392.5488 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 391.7217 375.5596 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 391.7217 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 403.1787 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 402.3506 375.5596 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 402.3506 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 413.8086 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 412.9814 375.5596 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 412.9814 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 424.4365 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 423.6113 375.5596 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 423.6113 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 435.0664 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 434.2422 375.5596 cm 0 0 m 11.452 0 l S Q q 1 0 0 1 434.2422 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 445.6943 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 444.8711 375.5596 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 444.8711 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 456.3252 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 455.4961 375.5596 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 455.4961 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 466.9531 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 466.1299 375.5596 cm 0 0 m 11.453 0 l S Q q 1 0 0 1 466.1299 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 477.583 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 476.7578 375.5596 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 476.7578 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 488.2119 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 487.3848 375.5596 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 487.3848 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 498.8398 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 498.0137 375.5596 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 498.0137 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 509.4688 376.2988 cm 0 0 m 0 -1.479 l S Q q 1 0 0 1 508.6426 375.5596 cm 0 0 m 3.042 0 l S Q q 1 0 0 1 508.6426 376.2988 cm 0 0 m 0 -1.479 l S Q BT 0.137 0.123 0.126 scn /TT0 1 Tf 5.2485 0 0 5.2485 515.2021 380.0098 Tm (640 kb )Tj 0 3.9365 -3.9365 0 90.9238 386.5713 Tm (0492 )Tj 3.9365 0 0 3.9365 100.3135 386.6543 Tm (0493 )Tj 0 3.9365 -3.9365 0 118.4775 386.6543 Tm (0494 )Tj 3.9365 0 0 3.9365 122.5166 386.7354 Tm (0495 )Tj 0 3.9365 -3.9365 0 134.3203 386.5713 Tm (0496 )Tj 3.9365 0 0 3.9365 140.8486 386.9014 Tm (0497 )Tj 3.526 -0.042 Td (0498 )Tj 0 3.9365 -3.9365 0 167.5107 386.4893 Tm (0499 )Tj 0.021 -0.82 Td (0500 )Tj 0 -0.925 Td (0501 )Tj 0.021 -1.28 Td (0503 )Tj 3.9365 0 0 3.9365 181.6465 386.5713 Tm (0504 )Tj 3.291 0.021 Td (0505 )Tj 3.2804 0 0 3.2804 197.6299 391.9072 Tm (tRNAs- )Tj 3.9365 0 0 3.9365 212.6914 386.7158 Tm [(0)50(5)50(1)50(1)50( )]TJ 2.074 0.005 Td (0512 )Tj 0 3.9365 -3.9365 0 234.3359 386.4902 Tm (0513 )Tj 3.9365 0 0 3.9365 236.9658 386.6543 Tm (0514 )Tj 0 3.9365 -3.9365 0 250.4287 386.5713 Tm (0515 )Tj 3.9365 0 0 3.9365 255.3857 386.7354 Tm (0516 )Tj 3.064 -0.021 Td (0517 )Tj 0 3.9365 -3.9365 0 280.1387 386.5713 Tm (0518 )Tj 3.9365 0 0 3.9365 291.4121 386.7354 Tm (0519 )Tj 7.25 0.021 Td (0520 )Tj 0 3.9365 -3.9365 0 332.3154 386.5713 Tm (0521 )Tj 3.9365 0 0 3.9365 335.9072 386.7354 Tm (0522 )Tj 3.519 0.042 Td (0523 )Tj 2.806 -0.042 Td (0524 )Tj 0 3.9365 -3.9365 0 372.4795 386.7148 Tm (0525 )Tj -0.041 -1 Td (0526 )Tj -0.01 -1.125 Td (0527 )Tj 3.9365 0 0 3.9365 390.249 386.7354 Tm (0528 )Tj 4.91 -0.021 Td (0529 )Tj 0 3.9365 -3.9365 0 423.8184 386.5713 Tm (0530 )Tj 3.9365 0 0 3.9365 443.25 386.6543 Tm (0531 )Tj 2.3196 2.3196 -2.3196 2.3196 474.8379 387.3768 Tm (5SrRNA )Tj 3.423 0 0 3.9365 487.2021 382.9775 Tm (23SrRNA )Tj 3.9365 0 0 3.9365 95.5859 376.1729 Tm (323 )Tj 2.7 0 Td (324 )Tj 2.7 0 Td (325 )Tj 2.7 0 Td (326 )Tj 2.7 0 Td (327 )Tj 2.7 0 Td (328 )Tj 2.7 0 Td (329 )Tj 2.7 0 Td (330 )Tj 2.7 0 Td (331 )Tj 2.7 0 Td (332 )Tj 2.7 0 Td (333 )Tj 2.7 0 Td (334 )Tj 2.7 0 Td (335 )Tj 2.7 0 Td (336 )Tj 2.7 0 Td (337 )Tj 2.7 0 Td (338 )Tj 2.7 0 Td (339 )Tj 2.7 0 Td (340 )Tj 2.7 0 Td (341 )Tj 2.7 0 Td (342f )Tj 2.7 0 Td (343 )Tj 2.7 0 Td (344 )Tj 2.7 0 Td (345 )Tj 2.7 0 Td (346 )Tj 2.7 0 Td (347 )Tj 2.7 0 Td (348 )Tj 2.7 0 Td (349 )Tj 2.7 0 Td (350 )Tj 2.7 0 Td (351 )Tj 2.7 0 Td (352 )Tj 2.7 0 Td (353 )Tj 2.7 0 Td (354 )Tj 2.7 0 Td (355 )Tj 2.7 0 Td (356 )Tj 2.7 0 Td (357 )Tj 2.699 0 Td (358 )Tj 2.701 0 Td (359 )Tj 2.7 0 Td (360 )Tj 2.7 0 Td (361 )Tj 1 1 1 scn -104.922 1.746 Td [(u)25(d)25(k)]TJ 0.137 0.123 0.126 scn 0 3.9365 -3.9365 0 95.8447 386.6543 Tm (0491 )Tj 3.9365 0 0 3.9365 86.4004 376.2549 Tm (322 )Tj 1 1 1 scn /TT2 1 Tf 3.2804 0 0 3.2804 154.0166 383.4551 Tm [(n)-25(a)-25(n)-25(A)]TJ /TT0 1 Tf 0 1.7714 -1.7714 0 166.3984 382.8818 Tm [(r)25(p)25(m)25(A)]TJ 0 1.9682 -1.9682 0 173.124 383.1279 Tm [(r)25(p)25(l)25(U)]TJ /TT2 1 Tf 3.2804 0 0 3.2804 220.9346 383.5381 Tm [(p)25(l)25(s)25(C)]TJ /TT0 1 Tf 1.9682 0 0 1.9682 230.6953 383.8662 Tm [(a)25(c)25(p)25(S)]TJ 3.2804 0 0 3.2804 275.8008 383.375 Tm [(l)25(s)25(p)25(A)]TJ /TT2 1 Tf 5.15 -0.075 Td [(i)-25(l)-25(e)-25(S)]TJ 0.137 0.123 0.126 scn 13.474 0.05 Td [(f)-25(t)-25(s)-25(Z)]TJ 1 1 1 scn 6.9 -0.025 Td (mraW)Tj 0.137 0.123 0.126 scn /TT0 1 Tf 1.9682 0 0 1.9682 369.125 383.7832 Tm (mraZ)Tj 1 1 1 scn 0 1.6402 -1.6402 0 375.7676 382.9658 Tm [(r)25(p)25(m)24(F)]TJ /TT2 1 Tf 3.2804 0 0 3.2804 390.3662 383.4551 Tm [(p)-25(h)-25(e)-25(T)]TJ 5.874 -0.024 Td [(p)-25(h)-25(e)-25(S)]TJ 0.137 0.123 0.126 scn /TT0 1 Tf -61.977 2.634 Td [(l)-25(e)-25(u)-25(/)-25(l)-25(y)-25(s)-25(/)-25(g)-25(l)-25(n)-25(/)-25(t)-25(y)-25(r)-25(/)-25(t)-25(h)-25(r)]TJ ET 0.302 w 4 M 430.442 266.275 -28.432 1.642 re S 1 1 1 scn 422.993 264.607 -21.324 5.249 re f 0.262 w q 1 0 0 1 393.748 265.4443 cm 0 0 m -1.763 -3.422 l S Q q 0 792 612 -792 re W n 0.137 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465.9639 249.542 cm 0 0 m 11.482 0 l S Q q 1 0 0 1 465.9639 250.2783 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 477.4463 250.2783 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 476.5918 249.542 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 476.5918 250.2783 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 488.0762 250.2783 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 487.2217 249.542 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 487.2217 250.2783 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 498.7061 250.2783 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 497.8516 249.542 cm 0 0 m 11.484 0 l S Q q 1 0 0 1 497.8516 250.2783 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 509.3359 250.2783 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 508.4795 249.542 cm 0 0 m 3.218 0 l S Q q 1 0 0 1 508.4795 250.2783 cm 0 0 m 0 -1.475 l S Q BT 0.137 0.123 0.126 scn /TT0 1 Tf 5.2485 0 0 5.2485 515.2139 254.0029 Tm (880 kb )Tj 0 3.9365 -3.9365 0 110.5186 260.4814 Tm (0704 )Tj 3.9365 0 0 3.9365 113.4219 260.5615 Tm (0705 )Tj 4.038 0 Td (0706 )Tj 3.503 0 Td (0707 )Tj 2.813 0 Td (0708 )Tj 3.916 0 Td (0710 )Tj 2.934 0.042 Td (0711 )Tj 0 3.9365 -3.9365 0 194.4629 260.5645 Tm (0712 )Tj 3.9365 0 0 3.9365 199.1182 260.6455 Tm (0713 )Tj 3.715 0 Td (0714 )Tj 3.921 -0.021 Td (0715 )Tj 3.509 0.017 Td (0716 )Tj 3.2804 0 0 3.2804 242.3867 266.2607 Tm (tRNA-arg/pro/ala/met/met/ser/met/asp/phe)Tj 3.9365 0 0 3.9365 265 260.5615 Tm (0726 )Tj 2.312 0 Td (0727 )Tj 2.067 -0.02 Td (0728 )Tj 3.197 0.02 Td (0729 )Tj 0 3.9365 -3.9365 0 313.0811 260.4814 Tm (0730 )Tj 3.9365 0 0 3.9365 316.4541 260.7275 Tm (0731 )Tj 0 3.9365 -3.9365 0 331.9482 260.4814 Tm (0732 )Tj 3.9365 0 0 3.9365 339.1504 260.6455 Tm (0733 )Tj 4.409 -0.021 Td (0734 )Tj 3.165 0.021 Td (0735 )Tj 3.9341 -0.1181 0.1181 3.9341 370.9123 264.0872 Tm (0736 )Tj 3.9365 0 0 3.9365 374.0283 267.2871 Tm (0737 )Tj 2.228 0 Td (0738 )Tj 3.9367 -0.0339 0.0339 3.9367 393.2732 267.1867 Tm (0739 )Tj 3.9365 0 0 3.9365 395.2627 260.5352 Tm (0740 )Tj -0.184 0.853 Td (0741 )Tj 4.798 -0.847 Td (0742 )Tj 6.56 0 Td (0743 )Tj 4.101 0 Td (0744 )Tj 0 3.9365 -3.9365 0 469.0137 260.5615 Tm (0745 )Tj 3.9365 0 0 3.9365 473.4502 260.6455 Tm (0746 )Tj 0 3.9365 -3.9365 0 489.6914 260.5615 Tm (0747 )Tj 0 -1.838 TD (0748 )Tj -0.02 -2.002 Td (0749 )Tj 0.02 -1.904 Td (0750 )Tj 3.9365 0 0 3.9365 95.4209 250.1641 Tm (563 )Tj 2.7 0 Td (564 )Tj 2.701 0 Td (565 )Tj 2.7 0 Td (566 )Tj 2.7 0 Td (567 )Tj 2.7 0 Td (568 )Tj 2.7 0 Td (569 )Tj 2.7 0 Td (570 )Tj 2.701 0 Td (571 )Tj 2.7 0 Td (572 )Tj 2.7 0 Td (573 )Tj 2.7 0 Td (574 )Tj 2.7 0 Td (575 )Tj 2.7 0 Td (576 )Tj 2.7 0 Td (577 )Tj 2.7 0 Td (578f )Tj 2.7 0 Td (579f )Tj 2.7 0 Td (580 )Tj 2.7 0 Td (581 )Tj 2.7 0 Td (582 )Tj 2.7 0 Td (583 )Tj 2.699 0 Td (584 )Tj 2.7 0 Td (585 )Tj 2.7 0 Td (586 )Tj 2.7 0 Td (587 )Tj 2.7 0 Td (588 )Tj 2.7 0 Td (589 )Tj 2.7 0 Td (590 )Tj 2.7 0 Td (591 )Tj 2.7 0 Td (592 )Tj 2.7 0 Td (593 )Tj 2.7 0 Td (594 )Tj 2.7 0 Td (595 )Tj 2.701 0 Td (596 )Tj 2.7 0 Td (597 )Tj 2.699 0 Td (598 )Tj 2.7 0 Td (599 )Tj 2.7 0 Td (600 )Tj 2.7 0 Td (601 )Tj -103.513 2.663 Td (0703 )Tj -1.377 -2.642 Td (562 )Tj ET 0.302 w 4 M 165.46 266.179 -42.1 1.638 re S 1 1 1 scn 1 1 1 SCN 156.629 265.605 -24.438 2.784 re B BT 0.137 0.123 0.126 scn /TT0 1 Tf 3.2804 0 0 3.2804 133.5654 265.8604 Tm (alkylphosphonate )Tj 1 1 1 scn /TT2 1 Tf 40.13 -2.607 Td [(n)25(a)25(g)25(B)]TJ 3 0.025 Td [(t)-25(p)-25(i)-25(A)]TJ 6.025 0.1 Td [(g)-25(p)-25(m)-25(I)]TJ /TT0 1 Tf 9.825 -0.15 Td (deoC)Tj 9.425 0.05 Td [(p)-25(d)-25(p)-25( )]TJ 0.137 0.123 0.126 scn 2.5575 0 0 3.2804 368.7002 257.2725 Tm [(t)-25(n)-25(p)-25(B)-25(_)-25(4)]TJ 1.9646 0 0 3.2804 377.5811 257.3633 Tm (tnpA_4)Tj /TT2 1 Tf 2.4051 0 0 2.6243 393.9062 257.6123 Tm [(m)25(m)25(y)25(C)25(I)25(I)26(R)]TJ 3.2804 0 0 3.2804 409.9775 257.2822 Tm [(m)-25(m)-25(y)-25(C)-25(I)-25(I)-25(M)-25( )]TJ -1.45 3.166 Td (Type II R/M)Tj 0.89 -1 Td (CCTTC)Tj 1 1 1 scn 14.505 -2.133 Td [(p)-25(f)-25(k)-25(B)-25( )]TJ -4.966 -0.067 Td [(f)-25(r)-25(u)-25(A)]TJ ET 0.137 0.123 0.126 SCN 0.23 w q 1 0 0 1 247.7129 265.5791 cm 0 0 m 11.071 -1.044 l S Q q 1 0 0 1 258.7007 264.6074 cm 0 0 m -0.081 -1.638 l S Q q 0 792 612 -792 re W n 0.137 0.123 0.126 scn q 1 0 0 1 258.7759 262.5547 cm 0 0 m 0.1 0.28 0.188 0.461 0.291 0.685 c -0.577 0.728 l -0.542 0.645 -0.426 0.307 -0.354 0.018 c -0.278 -0.291 -0.229 -0.57 -0.215 -0.751 c -0.184 -0.572 -0.107 -0.3 0 0 c f Q Q 0.262 w 10 M q 1 0 0 1 86.5112 588.1001 cm 0 0 m 425.159 0 l S Q 0.73 0.805 0.919 scn q 1 0 0 1 96.106 594.0127 cm 0 0 m 5.785 0 l 5.785 1.477 l 6.406 -1.477 l 5.785 -4.429 l 5.785 -2.953 l 0 -2.953 l h f* Q 4 M q 1 0 0 1 96.106 594.0127 cm 0 0 m 5.785 0 l 5.785 1.477 l 6.406 -1.477 l 5.785 -4.429 l 5.785 -2.953 l 0 -2.953 l 0 0 l S Q 10 M q 1 0 0 1 96.1074 594.0054 cm 0 0 m 5.784 0 l 5.784 1.475 l 6.405 -1.477 l 5.784 -4.429 l 5.784 -2.953 l 0 -2.953 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 111.2529 594.0127 cm 0 0 m -6.378 0 l -6.378 1.477 l -7.059 -1.477 l -6.378 -4.429 l -6.378 -2.953 l 0 -2.953 l h f* Q 4 M q 1 0 0 1 111.2529 594.0127 cm 0 0 m -6.378 0 l -6.378 1.477 l -7.059 -1.477 l -6.378 -4.429 l -6.378 -2.953 l 0 -2.953 l 0 0 l S Q 10 M q 1 0 0 1 111.2529 594.0054 cm 0 0 m -6.377 0 l -6.377 1.475 l -7.057 -1.477 l -6.377 -4.429 l -6.377 -2.953 l 0 -2.953 l 0 0 l h S Q 0.716 0.434 0.681 scn q 1 0 0 1 126.1899 594.0127 cm 0 0 m -14.025 0 l -14.025 1.477 l -14.909 -1.477 l -14.025 -4.429 l -14.025 -2.953 l 0 -2.953 l h f* Q 4 M q 1 0 0 1 126.1899 594.0127 cm 0 0 m -14.025 0 l -14.025 1.477 l -14.909 -1.477 l -14.025 -4.429 l -14.025 -2.953 l 0 -2.953 l 0 0 l S Q 10 M q 1 0 0 1 126.1929 594.0054 cm 0 0 m -14.026 0 l -14.026 1.475 l -14.91 -1.477 l -14.026 -4.429 l -14.026 -2.953 l 0 -2.953 l 0 0 l h S Q 0.969 0.719 0.828 scn 4 M q 1 0 0 1 127.7251 594.2959 cm 0 0 m 3.957 0 l 3.957 1.193 l 4.369 -1.76 l 3.957 -4.712 l 3.957 -3.544 l 0 -3.544 l 0 -0.283 l B* Q 10 M q 1 0 0 1 127.7261 594.2861 cm 0 0 m 3.958 0 l 3.958 1.194 l 4.372 -1.757 l 3.958 -4.71 l 3.958 -3.542 l 0 -3.542 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 133.4233 594.0127 cm 0 0 m 21.729 0 l 21.729 1.477 l 22.615 -1.477 l 21.729 -4.429 l 21.729 -2.953 l 0 -2.953 l h f* Q 4 M q 1 0 0 1 133.4233 594.0127 cm 0 0 m 21.729 0 l 21.729 1.477 l 22.615 -1.477 l 21.729 -4.429 l 21.729 -2.953 l 0 -2.953 l 0 0 l S Q 10 M q 1 0 0 1 133.4263 594.0054 cm 0 0 m 21.732 0 l 21.732 1.475 l 22.615 -1.477 l 21.732 -4.429 l 21.732 -2.953 l 0 -2.953 l 0 0 l h S Q 0.555 0.846 0.972 scn q 1 0 0 1 164.2451 594.0127 cm 0 0 m -7.204 0 l -7.204 1.477 l -7.999 -1.477 l -7.204 -4.429 l -7.204 -2.953 l 0 -2.953 l h f* Q 4 M q 1 0 0 1 164.2451 594.0127 cm 0 0 m -7.204 0 l -7.204 1.477 l -7.999 -1.477 l -7.204 -4.429 l -7.204 -2.953 l 0 -2.953 l 0 0 l S Q 10 M q 1 0 0 1 164.2505 594.0054 cm 0 0 m -7.205 0 l -7.205 1.475 l -8.002 -1.477 l -7.205 -4.429 l -7.205 -2.953 l 0 -2.953 l 0 0 l h S Q q 1 0 0 1 171.5093 594.0127 cm 0 0 m -5.729 0 l -5.729 1.477 l -6.348 -1.477 l -5.729 -4.429 l -5.729 -2.953 l 0 -2.953 l h f* Q 4 M q 1 0 0 1 171.5093 594.0127 cm 0 0 m -5.729 0 l -5.729 1.477 l -6.348 -1.477 l -5.729 -4.429 l -5.729 -2.953 l 0 -2.953 l 0 0 l S Q 10 M q 1 0 0 1 171.5142 594.0054 cm 0 0 m -5.729 0 l -5.729 1.475 l -6.348 -1.477 l -5.729 -4.429 l -5.729 -2.953 l 0 -2.953 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 186.5645 594.0127 cm 0 0 m -11.926 0 l -11.926 1.477 l -12.813 -1.477 l -11.926 -4.429 l -11.926 -2.953 l 0 -2.953 l h f* Q 4 M q 1 0 0 1 186.5645 594.0127 cm 0 0 m -11.926 0 l -11.926 1.477 l -12.813 -1.477 l -11.926 -4.429 l -11.926 -2.953 l 0 -2.953 l 0 0 l S Q 10 M q 1 0 0 1 186.5708 594.0054 cm 0 0 m -11.927 0 l -11.927 1.475 l -12.813 -1.477 l -11.927 -4.429 l -11.927 -2.953 l 0 -2.953 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 216.3535 594.0127 cm 0 0 m -27.691 0 l -27.691 1.477 l -28.579 -1.477 l -27.691 -4.429 l -27.691 -2.953 l 0 -2.953 l h f* Q 4 M q 1 0 0 1 216.3535 594.0127 cm 0 0 m -27.691 0 l -27.691 1.477 l -28.579 -1.477 l -27.691 -4.429 l -27.691 -2.953 l 0 -2.953 l 0 0 l S Q 10 M q 1 0 0 1 216.3633 594.0054 cm 0 0 m -27.696 0 l -27.696 1.475 l -28.582 -1.477 l -27.696 -4.429 l -27.696 -2.953 l 0 -2.953 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 222.4063 594.0127 cm 0 0 m -4.751 0 l -4.751 1.477 l -5.255 -1.477 l -4.751 -4.429 l -4.751 -2.953 l 0 -2.953 l h f* Q 4 M q 1 0 0 1 222.4063 594.0127 cm 0 0 m -4.751 0 l -4.751 1.477 l -5.255 -1.477 l -4.751 -4.429 l -4.751 -2.953 l 0 -2.953 l 0 0 l S Q 10 M q 1 0 0 1 222.4141 594.0054 cm 0 0 m -4.751 0 l -4.751 1.475 l -5.255 -1.477 l -4.751 -4.429 l -4.751 -2.953 l 0 -2.953 l 0 0 l h S Q 0.716 0.434 0.681 scn q 1 0 0 1 224.7095 594.0127 cm 0 0 m 12.34 0 l 12.34 1.477 l 13.227 -1.477 l 12.34 -4.429 l 12.34 -2.953 l 0 -2.953 l h f* Q 4 M q 1 0 0 1 224.7095 594.0127 cm 0 0 m 12.34 0 l 12.34 1.477 l 13.227 -1.477 l 12.34 -4.429 l 12.34 -2.953 l 0 -2.953 l 0 0 l S Q 10 M q 1 0 0 1 224.7183 594.0054 cm 0 0 m 12.341 0 l 12.341 1.475 l 13.227 -1.477 l 12.341 -4.429 l 12.341 -2.953 l 0 -2.953 l 0 0 l h S Q q 1 0 0 1 238.1123 594.2339 cm 0 0 m 9.86 0 l 9.86 1.698 l 10.749 -1.697 l 9.86 -5.092 l 9.86 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 238.1123 594.2339 cm 0 0 m 9.86 0 l 9.86 1.698 l 10.749 -1.697 l 9.86 -5.092 l 9.86 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 238.1221 594.2256 cm 0 0 m 9.862 0 l 9.862 1.697 l 10.75 -1.697 l 9.862 -5.093 l 9.862 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 249.0078 594.2339 cm 0 0 m 17.181 0 l 17.181 1.698 l 18.066 -1.697 l 17.181 -5.092 l 17.181 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 249.0078 594.2339 cm 0 0 m 17.181 0 l 17.181 1.698 l 18.066 -1.697 l 17.181 -5.092 l 17.181 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 249.0171 594.2256 cm 0 0 m 17.184 0 l 17.184 1.697 l 18.067 -1.697 l 17.184 -5.093 l 17.184 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 267.0742 594.2339 cm 0 0 m 18.984 0 l 18.984 1.698 l 19.871 -1.697 l 18.984 -5.092 l 18.984 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 267.0742 594.2339 cm 0 0 m 18.984 0 l 18.984 1.698 l 19.871 -1.697 l 18.984 -5.092 l 18.984 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 267.0845 594.2256 cm 0 0 m 18.986 0 l 18.986 1.697 l 19.873 -1.697 l 18.986 -5.093 l 18.986 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 287.1206 594.2339 cm 0 0 m 32.062 0 l 32.062 1.698 l 32.949 -1.697 l 32.062 -5.092 l 32.062 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 287.1206 594.2339 cm 0 0 m 32.062 0 l 32.062 1.698 l 32.949 -1.697 l 32.062 -5.092 l 32.062 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 287.1348 594.2256 cm 0 0 m 32.062 0 l 32.062 1.697 l 32.949 -1.697 l 32.062 -5.093 l 32.062 -3.396 l 0 -3.396 l 0 0 l h S Q 1 1 1 scn q 1 0 0 1 338.2861 594.2339 cm 0 0 m -12.873 0 l -12.873 1.698 l -13.759 -1.697 l -12.873 -5.092 l -12.873 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 338.2861 594.2339 cm 0 0 m -12.873 0 l -12.873 1.698 l -13.759 -1.697 l -12.873 -5.092 l -12.873 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 338.3008 594.2256 cm 0 0 m -12.873 0 l -12.873 1.697 l -13.759 -1.697 l -12.873 -5.093 l -12.873 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 353.165 594.2339 cm 0 0 m -12.988 0 l -12.988 1.698 l -13.876 -1.697 l -12.988 -5.092 l 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0 0 1 383.3848 594.2256 cm 0 0 m -17.154 0 l -17.154 1.131 l -18.04 -1.697 l -17.154 -5.093 l -17.154 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 385.7012 594.2339 cm 0 0 m 1.385 0 l 1.385 1.131 l 1.536 -1.697 l 1.385 -5.092 l 1.385 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 385.7012 594.2339 cm 0 0 m 1.385 0 l 1.385 1.131 l 1.536 -1.697 l 1.385 -5.092 l 1.385 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 385.7188 594.2256 cm 0 0 m 1.387 0 l 1.387 1.131 l 1.534 -1.697 l 1.387 -5.093 l 1.387 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.65 0.316 scn q 1 0 0 1 405.5107 594.2339 cm 0 0 m -17.008 0 l -17.008 1.131 l -17.892 -1.697 l -17.008 -5.092 l -17.008 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 405.5107 594.2339 cm 0 0 m -17.008 0 l -17.008 1.131 l -17.892 -1.697 l -17.008 -5.092 l -17.008 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 405.5283 594.2256 cm 0 0 m -17.006 0 l -17.006 1.131 l -17.891 -1.697 l -17.006 -5.093 l -17.006 -3.396 l 0 -3.396 l 0 0 l h S Q 0.503 0.51 0.52 scn q 1 0 0 1 413.3623 594.2339 cm 0 0 m -6.022 0 l -6.022 1.131 l -6.672 -1.697 l -6.022 -5.092 l -6.022 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 413.3623 594.2339 cm 0 0 m -6.022 0 l -6.022 1.131 l -6.672 -1.697 l -6.022 -5.092 l -6.022 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 413.3828 594.2256 cm 0 0 m -6.024 0 l -6.024 1.131 l -6.675 -1.697 l -6.024 -5.093 l -6.024 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 432.4932 594.2339 cm 0 0 m -18.245 0 l -18.245 1.131 l -19.131 -1.697 l -18.245 -5.092 l -18.245 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 432.4932 594.2339 cm 0 0 m -18.245 0 l -18.245 1.131 l -19.131 -1.697 l -18.245 -5.092 l -18.245 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 432.5146 594.2256 cm 0 0 m -18.246 0 l -18.246 1.131 l -19.132 -1.697 l -18.246 -5.093 l -18.246 -3.396 l 0 -3.396 l 0 0 l h S Q q 1 0 0 1 452.8369 594.2339 cm 0 0 m -18.218 0 l -18.218 1.131 l -19.104 -1.697 l -18.218 -5.092 l -18.218 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 452.8369 594.2339 cm 0 0 m 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19.015 -1.697 l 18.129 -5.093 l 18.129 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 497.7393 594.2339 cm 0 0 m 4.695 0 l 4.695 1.698 l 5.194 -1.697 l 4.695 -5.092 l 4.695 -3.395 l 0 -3.395 l h f* Q 4 M q 1 0 0 1 497.7393 594.2339 cm 0 0 m 4.695 0 l 4.695 1.698 l 5.194 -1.697 l 4.695 -5.092 l 4.695 -3.395 l 0 -3.395 l 0 0 l S Q 10 M q 1 0 0 1 497.7646 594.2256 cm 0 0 m 4.697 0 l 4.697 1.697 l 5.197 -1.697 l 4.697 -5.093 l 4.697 -3.396 l 0 -3.396 l 0 0 l h S Q 0.716 0.434 0.681 scn 4 M 503.114 590.839 8.529 3.395 re B* 10 M q 1 0 0 1 511.6699 590.8301 cm 0 0 m -8.53 0 l -8.53 3.396 l 0 3.396 l S Q q 1 0 0 1 86.5112 583.6709 cm 0 0 m 10.806 0 l S Q q 1 0 0 1 97.3174 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 96.4907 583.6709 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 96.4907 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 107.9443 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 107.1187 583.6709 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 107.1187 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 118.5747 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 117.748 583.6709 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 117.748 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 129.2036 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 128.377 583.6709 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 128.377 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 139.8335 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 139.0068 583.6709 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 139.0068 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 150.4624 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 149.6353 583.6709 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 149.6353 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 161.0903 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 160.2642 583.6709 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 160.2642 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 171.7197 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 170.8936 583.6709 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 170.8936 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 182.3486 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 181.5225 583.6709 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 181.5225 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 192.979 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 192.1514 583.6709 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 192.1514 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 203.6069 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 202.7798 583.6709 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 202.7798 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 214.2349 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 213.4087 583.6709 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 213.4087 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 224.8662 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 224.0391 583.6709 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 224.0391 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 235.4951 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 234.6694 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 256.7515 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 255.9258 583.6709 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 255.9258 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 267.3804 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 266.5547 583.6709 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 266.5547 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 278.0107 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 277.1836 583.6709 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 277.1836 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 288.6406 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 287.813 583.6709 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 287.813 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 299.269 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 298.4419 583.6709 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 298.4419 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 309.8965 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 309.0693 583.6709 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 309.0693 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 320.5264 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 319.6982 583.6709 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 319.6982 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 331.1563 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 330.3281 583.6709 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 330.3281 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 341.7852 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 340.958 583.6709 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 340.958 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 352.4141 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 351.5859 583.6709 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 351.5859 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 363.042 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 362.2148 583.6709 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 362.2148 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 373.6719 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 372.8428 583.6709 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 372.8428 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 384.3008 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 383.4756 583.6709 cm 0 0 m 11.453 0 l S Q q 1 0 0 1 383.4756 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 394.9287 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 394.1025 583.6709 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 394.1025 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 405.5586 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 404.7314 583.6709 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 404.7314 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 416.1865 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 415.3613 583.6709 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 415.3613 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 426.8154 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 425.9883 583.6709 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 425.9883 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 437.4453 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 436.6182 583.6709 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 436.6182 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 448.0752 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 447.248 583.6709 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 447.248 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 458.7031 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 457.875 583.6709 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 457.875 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 469.333 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 468.5078 583.6709 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 468.5078 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 479.9619 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 479.1328 583.6709 cm 0 0 m 11.459 0 l S Q q 1 0 0 1 479.1328 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 490.5918 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 489.7656 583.6709 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 489.7656 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 501.2207 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 500.3945 583.6709 cm 0 0 m 11.275 0 l S Q q 1 0 0 1 500.3945 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 511.0244 583.6709 cm 0 0 m 0.646 0 l S Q q 1 0 0 1 511.0244 584.4092 cm 0 0 m 0 -1.476 l S Q BT 0.137 0.123 0.126 scn /TT0 1 Tf 5.2485 0 0 5.2485 515.1875 588.1079 Tm (240 kb)Tj 4.4285 0 0 4.4285 528.1113 588.1079 Tm ( )Tj 0 3.9365 -3.9365 0 100.5625 594.7837 Tm (0155 )Tj -0.069 -2.193 Td (0156 )Tj 3.9365 0 0 3.9365 115.5918 594.5122 Tm (0157 )Tj 6.378 -0.021 Td (0159 )Tj 0 3.9365 -3.9365 0 161.7773 594.4302 Tm (0160 )Tj 0.011 -2.127 Td (0161 )Tj 3.9365 0 0 3.9365 176.9395 594.5376 Tm (0162 )Tj 5.545 -0.027 Td (0163 )Tj 0 3.9365 -3.9365 0 221.5254 594.3726 Tm (0164 )Tj 3.9365 0 0 3.9365 227.2852 594.5122 Tm (0165 )Tj 3.086 0.09 Td (0166 )Tj 3.531 0 Td (0167 )Tj 5.403 0 Td (0168 )Tj 6.158 -0.029 Td (0169 )Tj 7.338 -0.012 Td (0170 )Tj 3.958 -0.006 Td (0171 )Tj 3.236 0.02 Td (0172 )Tj 3.932 0 Td (0173 )Tj 0 3.9365 -3.9365 0 387.3721 594.9224 Tm (0174 )Tj 3.9365 0 0 3.9365 393.0537 594.7563 Tm (0175 )Tj 0 3.9365 -3.9365 0 411.8867 594.6763 Tm (0176 )Tj 3.9365 0 0 3.9365 420.2666 594.7563 Tm (0177 )Tj 5.174 0.021 Td (0178 )Tj 5.297 -0.041 Td (0179 )Tj 5.53 0 Td (0180 )Tj 0 3.9365 -3.9365 0 500.9756 594.5132 Tm (0181 )Tj 3.9365 0 0 3.9365 503.9502 594.9214 Tm (0182 )Tj -103.134 -2.706 Td (1018 )Tj 2.7 0 Td (1019 )Tj 2.7 0 Td (1020 )Tj 2.7 0 Td (1021 )Tj 2.7 0 Td (1022 )Tj 2.7 0 Td (1023 )Tj 2.7 0 Td (1024 )Tj 2.7 0 Td (1025 )Tj 2.7 0 Td (1026 )Tj 2.7 0 Td (1027 )Tj 2.7 0 Td (1028f )Tj 2.7 0 Td (1029 )Tj 2.7 0 Td (1030 )Tj 8.1 0 Td (1033 )Tj 2.7 0 Td (1034 )Tj 2.7 0 Td (1035 )Tj 2.7 0 Td (1036 )Tj 2.7 0 Td (1037 )Tj 2.7 0 Td (1038 )Tj 2.7 0 Td (1039 )Tj 2.7 0 Td (1040 )Tj 2.7 0 Td (1041 )Tj 2.7 0 Td (1042 )Tj 2.7 0 Td (1043 )Tj 2.7 0 Td (1044 )Tj 2.7 0 Td (1045 )Tj 2.7 0 Td (1046 )Tj 2.7 0 Td (1047 )Tj 2.701 0 Td (1048 )Tj 2.7 0 Td (1049 )Tj 2.699 0 Td (1050 )Tj 2.701 0 Td (1051 )Tj 2.7 0 Td (1052 )Tj 2.7 0 Td (1053 )Tj 2.7 0 Td (1054 )Tj 2.7 0 Td (1055 )Tj 2.701 0 Td (1056 )Tj 2.2142 0 0 2.2142 516.9004 584.271 Tm ( )Tj 3.9365 0 0 3.9365 86.4004 584.2915 Tm (1017 )Tj 1 1 1 scn /TT2 1 Tf 3.122 0 0 3.2804 104.7705 591.4077 Tm [(t)10(r)10(m)10(B)]TJ 3.2804 0 0 3.2804 115.2129 591.6265 Tm [(m)-10(g)-10(t)-10(E)]TJ 0.137 0.123 0.126 scn /TT0 1 Tf 2.6243 0 0 2.6243 156.873 591.4907 Tm [(A)-10(b)-10(i)-10(G)-10(I)-10(A)]TJ 2.5291 0 0 2.6243 165.5117 591.4907 Tm [(A)50(b)50(i)50(G)50(I)50(B)]TJ 1 1 1 scn /TT2 1 Tf 3.2804 0 0 3.2804 199.5742 591.353 Tm [(a)-10(l)-10(a)-10(S)]TJ ET 0.302 w 4 M 286.23 600.15 -62.109 1.641 re S 265.056 599.439 -19.758 3.063 re f BT 0.137 0.123 0.126 scn /TT2 1 Tf 3.2902 0 0 3.2804 246.3037 599.8647 Tm (oligopeptide)Tj 1 1 1 scn /TT1 1 Tf 3.2804 0 0 3.2804 370.7529 591.436 Tm (LppA)Tj 6.759 -0.009 Td (LppA)Tj /TT0 1 Tf 2.9612 0 0 2.9523 407.2207 591.436 Tm [(p)25(g)25(m)25(B)]TJ 0.137 0.123 0.126 scn 2.3195 2.3195 -2.3196 2.3196 129.0854 594.5707 Tm (tmRNA)Tj ET 0.262 w 10 M q 1 0 0 1 86.3999 565.9712 cm 0 0 m 425.163 0 l S Q 0.716 0.434 0.681 scn 0.281 w 4 M q 1 0 0 1 86.3999 572.1089 cm 0 0 m 16.269 0 l 16.269 1.697 l 17.153 -1.698 l 16.269 -5.094 l 16.269 -3.396 l 0 -3.396 l B* Q 10 M q 1 0 0 1 86.3999 572.0977 cm 0 0 m 16.27 0 l 16.27 1.698 l 17.154 -1.697 l 16.27 -5.092 l 16.27 -3.395 l 0 -3.395 l S Q q 1 0 0 1 103.7021 572.1089 cm 0 0 m 26.127 0 l 26.127 1.697 l 27.014 -1.698 l 26.127 -5.094 l 26.127 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 103.7021 572.1089 cm 0 0 m 26.127 0 l 26.127 1.697 l 27.014 -1.698 l 26.127 -5.094 l 26.127 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 103.7031 572.0977 cm 0 0 m 26.13 0 l 26.13 1.698 l 27.016 -1.697 l 26.13 -5.092 l 26.13 -3.395 l 0 -3.395 l 0 0 l h S Q q 1 0 0 1 130.7163 572.1089 cm 0 0 m 10.656 0 l 10.656 1.697 l 11.543 -1.698 l 10.656 -5.094 l 10.656 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 130.7163 572.1089 cm 0 0 m 10.656 0 l 10.656 1.697 l 11.543 -1.698 l 10.656 -5.094 l 10.656 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 130.7188 572.0977 cm 0 0 m 10.659 0 l 10.659 1.698 l 11.542 -1.697 l 10.659 -5.092 l 10.659 -3.395 l 0 -3.395 l 0 0 l h S Q 0.919 0.152 0.567 scn q 1 0 0 1 143.4111 572.1089 cm 0 0 m 23.529 0 l 23.529 1.697 l 24.416 -1.698 l 23.529 -5.094 l 23.529 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 143.4111 572.1089 cm 0 0 m 23.529 0 l 23.529 1.697 l 24.416 -1.698 l 23.529 -5.094 l 23.529 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 143.4136 572.0977 cm 0 0 m 23.531 0 l 23.531 1.698 l 24.418 -1.697 l 23.531 -5.092 l 23.531 -3.395 l 0 -3.395 l 0 0 l h S Q 0.503 0.51 0.52 scn q 1 0 0 1 167.856 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l -18.156 1.697 l -19.042 -1.698 l -18.156 -5.094 l -18.156 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 212.1479 572.0977 cm 0 0 m -18.158 0 l -18.158 1.698 l -19.043 -1.697 l -18.158 -5.092 l -18.158 -3.395 l 0 -3.395 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 219.4048 572.1089 cm 0 0 m -6.556 0 l -6.556 1.697 l -7.264 -1.698 l -6.556 -5.094 l -6.556 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 219.4048 572.1089 cm 0 0 m -6.556 0 l -6.556 1.697 l -7.264 -1.698 l -6.556 -5.094 l -6.556 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 219.4106 572.0977 cm 0 0 m -6.555 0 l -6.555 1.698 l -7.263 -1.697 l -6.555 -5.092 l -6.555 -3.395 l 0 -3.395 l 0 0 l h S Q 0.501 0.764 0.267 scn q 1 0 0 1 233.9595 572.1089 cm 0 0 m -13.493 0 l -13.493 1.697 l -14.378 -1.698 l -13.493 -5.094 l -13.493 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 233.9595 572.1089 cm 0 0 m -13.493 0 l -13.493 1.697 l -14.378 -1.698 l -13.493 -5.094 l -13.493 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 233.9673 572.0977 cm 0 0 m 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10 M q 1 0 0 1 302.4077 572.0977 cm 0 0 m -32.183 0 l -32.183 1.698 l -33.069 -1.697 l -32.183 -5.092 l -32.183 -3.395 l 0 -3.395 l 0 0 l h S Q q 1 0 0 1 312.7861 572.1089 cm 0 0 m -9.685 0 l -9.685 1.697 l -10.568 -1.698 l -9.685 -5.094 l -9.685 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 312.7861 572.1089 cm 0 0 m -9.685 0 l -9.685 1.697 l -10.568 -1.698 l -9.685 -5.094 l -9.685 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 312.8008 572.0977 cm 0 0 m -9.683 0 l -9.683 1.698 l -10.57 -1.697 l -9.683 -5.092 l -9.683 -3.395 l 0 -3.395 l 0 0 l h S Q q 1 0 0 1 323.9756 572.1089 cm 0 0 m -10.304 0 l -10.304 1.697 l -11.189 -1.698 l -10.304 -5.094 l -10.304 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 323.9756 572.1089 cm 0 0 m -10.304 0 l -10.304 1.697 l -11.189 -1.698 l -10.304 -5.094 l -10.304 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 323.9922 572.0977 cm 0 0 m -10.305 0 l -10.305 1.698 l -11.191 -1.697 l -10.305 -5.092 l -10.305 -3.395 l 0 -3.395 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 331.7695 572.1089 cm 0 0 m -3.454 0 l -3.454 1.697 l -3.808 -1.698 l -3.454 -5.094 l -3.454 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 331.7695 572.1089 cm 0 0 m -3.454 0 l -3.454 1.697 l -3.808 -1.698 l -3.454 -5.094 l -3.454 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 331.7852 572.0977 cm 0 0 m -3.455 0 l -3.455 1.698 l -3.809 -1.697 l -3.455 -5.092 l -3.455 -3.395 l 0 -3.395 l 0 0 l h S Q q 1 0 0 1 334.0117 572.1089 cm 0 0 m -1.858 0 l -1.858 1.697 l -2.034 -1.698 l -1.858 -5.094 l -1.858 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 334.0117 572.1089 cm 0 0 m -1.858 0 l -1.858 1.697 l -2.034 -1.698 l -1.858 -5.094 l -1.858 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 334.0273 572.0977 cm 0 0 m -1.86 0 l -1.86 1.698 l -2.037 -1.697 l -1.86 -5.092 l -1.86 -3.395 l 0 -3.395 l 0 0 l h S Q q 1 0 0 1 340.0664 572.1089 cm 0 0 m -5.227 0 l -5.227 1.697 l -5.788 -1.698 l -5.227 -5.094 l -5.227 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 340.0664 572.1089 cm 0 0 m -5.227 0 l -5.227 1.697 l -5.788 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5.314 -3.395 l 0 -3.395 l 0 0 l h S Q 0.25 0.396 0.688 scn q 1 0 0 1 355.2109 572.1089 cm 0 0 m 8.621 0 l 8.621 1.697 l 9.507 -1.698 l 8.621 -5.094 l 8.621 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 355.2109 572.1089 cm 0 0 m 8.621 0 l 8.621 1.697 l 9.507 -1.698 l 8.621 -5.094 l 8.621 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 355.2275 572.0977 cm 0 0 m 8.621 0 l 8.621 1.698 l 9.509 -1.697 l 8.621 -5.092 l 8.621 -3.395 l 0 -3.395 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 364.5986 572.1089 cm 0 0 m 12.488 0 l 12.488 1.697 l 13.374 -1.698 l 12.488 -5.094 l 12.488 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 364.5986 572.1089 cm 0 0 m 12.488 0 l 12.488 1.697 l 13.374 -1.698 l 12.488 -5.094 l 12.488 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 364.6182 572.0977 cm 0 0 m 12.486 0 l 12.486 1.698 l 13.374 -1.697 l 12.486 -5.092 l 12.486 -3.395 l 0 -3.395 l 0 0 l h S Q 0.524 0.135 0.083 scn q 1 0 0 1 397.46 572.1089 cm 0 0 m -18.541 0 l -18.541 1.697 l -19.428 -1.698 l -18.541 -5.094 l -18.541 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213.3003 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 224.7559 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 223.9292 561.5444 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 223.9292 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 235.3853 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 234.5586 561.5444 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 234.5586 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 246.0132 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 245.1865 561.5444 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 245.1865 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 256.6436 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 255.8154 561.5444 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 255.8154 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 267.2725 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 266.4458 561.5444 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 266.4458 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 277.9004 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 277.0747 561.5444 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 277.0747 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 288.5308 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q 1 0 0 1 426.708 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 425.8799 561.5444 cm 0 0 m 11.459 0 l S Q q 1 0 0 1 425.8799 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 437.3389 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 436.5107 561.5444 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 436.5107 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 447.9658 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 447.1406 561.5444 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 447.1406 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 458.5947 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 457.7695 561.5444 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 457.7695 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 469.2246 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 468.3965 561.5444 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 468.3965 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 479.8525 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 479.0254 561.5444 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 479.0254 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 490.4814 562.2817 cm 0 0 m 0 -1.477 l S Q q 1 0 0 1 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(0198 )Tj 0 -0.828 TD (0199 )Tj -0.042 -1.016 Td (0200 )Tj 0 -2.12 TD (0201 )Tj -0.021 -1.697 Td (0202 )Tj 3.9365 0 0 3.9365 355.9092 572.7075 Tm (0203 )Tj 2.934 -0.035 Td (0204 )Tj 4.236 0.035 Td (0205 )Tj 3.922 0 Td (0206 )Tj 2.449 0 Td (0207 )Tj 2.379 -0.021 Td (0208 )Tj 2.713 0 Td (0209 )Tj 3.337 0 Td (0210 )Tj 3.964 -0.021 Td (0211 )Tj 0 3.9365 -3.9365 0 469.1016 572.3784 Tm (0212 )Tj 3.9365 0 0 3.9365 473.04 572.5435 Tm (0213 )Tj 3.114 0 Td (0214 )Tj 0 3.9365 -3.9365 0 497.1523 572.4604 Tm (0215 )Tj 0.021 -1.36 Td (0216 )Tj 3.9365 0 0 3.9365 505.6895 573.3618 Tm (0217 )Tj -103.604 -2.849 Td (1058 )Tj 2.7 0 Td (1059 )Tj 2.7 0 Td (1060 )Tj 2.7 0 Td (1061 )Tj 2.7 0 Td (1062 )Tj 2.7 0 Td (1063 )Tj 2.7 0 Td (1064 )Tj 2.701 0 Td (1065 )Tj 2.7 0 Td (1066 )Tj 2.7 0 Td (1067 )Tj 2.699 0 Td (1068 )Tj 2.7 0 Td (1069 )Tj 2.7 0 Td (1070 )Tj 2.7 0 Td (1071 )Tj 2.7 0 Td (1072 )Tj 2.7 0 Td (1073 )Tj 2.7 0 Td (1074 )Tj 2.7 0 Td (1075 )Tj 2.7 0 Td (1076 )Tj 2.7 0 Td (1077 )Tj 2.7 0 Td (1078 )Tj 2.7 0 Td (1079 )Tj 2.7 0 Td (1080 )Tj 2.7 0 Td (1081 )Tj 2.701 0 Td (1082 )Tj 2.699 0 Td (1083 )Tj 2.7 0 Td (1084 )Tj 2.7 0 Td (1085 )Tj 2.7 0 Td (1086 )Tj 2.7 0 Td (1087 )Tj 2.7 0 Td (1088 )Tj 2.7 0 Td (1089 )Tj 2.7 0 Td (1090 )Tj 2.7 0 Td (1091 )Tj 2.7 0 Td (1092 )Tj 2.7 0 Td (1093 )Tj 2.7 0 Td (1094 )Tj 2.701 0 Td (1095 )Tj 2.7 0 Td (1096 )Tj -105.342 0.013 Td (1057 )Tj 1.015 2.67 Td (0182 )Tj ET 0.285 w 4 M q 1 0 0 1 141.6558 577.9951 cm 0 0 m -55.11 0.002 l -55.11 1.643 l 0 1.641 l 0 0 l h S Q BT 1 1 1 scn /TT2 1 Tf 3.2902 0 0 3.2804 198.918 569.5083 Tm [(p)-10(e)-10(p)-10(F)]TJ ET 0.197 w 239.18 581.983 14.926 -1.721 re S 1 1 1 SCN 0.656 w 252.344 579.523 -11.4 4.019 re B BT 0.137 0.123 0.126 scn /TT0 1 Tf 3.2804 0 0 3.2804 241.3643 579.9858 Tm [(c)25(h)25(r)25(o)25(m)25(a)25(t)25(e)]TJ 0 3.9365 -3.9365 0 251.3799 572.6255 Tm [(0)50(1)50(9)50(3)50( )]TJ 1 1 1 scn 1.9682 0 0 1.9682 328.5732 569.8364 Tm [(r)-25(p)-25(l)-25(T)]TJ 0 1.7714 -1.7714 0 333.5498 568.9351 Tm [(r)-25(p)-25(m)-25(I)]TJ 3.2804 0 0 3.2804 334.6699 569.2632 Tm [(i)-25(n)-25(f)-25(C)]TJ /TT2 1 Tf 2.483 0 Td [(d)-25(e)-25(f)]TJ 4.151 0.067 Td [(g)-25(m)-25(k)]TJ 3.666 0.016 Td [(s)-25(u)-25(n)]TJ 4.95 -0.016 Td [(t)-25(y)-25(p)-25(A)]TJ 13.35 -0.084 Td [(m)-25(u)-25(r)-25(Q)]TJ 13.734 0.05 Td [(e)-25(n)-25(o)]TJ /TT0 1 Tf 2.6243 0 0 2.6243 498.5791 569.644 Tm [(h)-25(p)-25(t)-25(_)-25(1)]TJ 3.2804 0 0 3.2804 505.959 569.5903 Tm [(g)-25(l)-25(p)-25(F)]TJ 0.137 0.123 0.126 scn 0 3.9365 -3.9365 0 244.3281 572.5435 Tm [(0)50(1)50(9)50(2)50( )]TJ ET 1 1 1 scn 130.303 576.533 -32.722 3.854 re f BT 0.137 0.123 0.126 scn /TT2 1 Tf 3.2803 0 0 3.2804 98.1572 577.8462 Tm (carbohydrate/maltose)Tj ET 0.137 0.123 0.126 SCN 0.262 w 10 M q 1 0 0 1 86.3999 648.1069 cm 0 0 m 425.161 0 l S Q 1 1 1 scn 4 M q 1 0 0 1 86.3999 652.5396 cm 0 0 m 0.472 -3.395 l 0.472 -1.698 l 4.754 -1.698 l 4.754 1.698 l B* Q q 1 0 0 1 91.1543 654.2378 cm 0 0 m -4.282 0 l -4.282 1.696 l -4.754 -1.698 l B* Q 10 M q 1 0 0 1 86.3999 652.5366 cm 0 0 m 0.472 -3.396 l 0.472 -1.698 l 4.755 -1.698 l 4.755 1.697 l 0.472 1.697 l 0.472 3.396 l 0 0 l S Q 0.99 0.914 0.17 scn q 1 0 0 1 107.3931 654.2378 cm 0 0 m -12.815 0 l -12.815 1.696 l -13.699 -1.698 l -12.815 -5.093 l -12.815 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 107.3931 654.2378 cm 0 0 m -12.815 0 l -12.815 1.696 l -13.699 -1.698 l -12.815 -5.093 l -12.815 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 107.3931 654.2334 cm 0 0 m -12.814 0 l -12.814 1.699 l -13.699 -1.697 l -12.814 -5.093 l -12.814 -3.395 l 0 -3.395 l 0 0 l h S Q q 1 0 0 1 116.3379 654.2378 cm 0 0 m -8.031 0 l -8.031 1.696 l -8.915 -1.698 l -8.031 -5.093 l -8.031 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 116.3379 654.2378 cm 0 0 m -8.031 0 l -8.031 1.696 l -8.915 -1.698 l -8.031 -5.093 l -8.031 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 116.3389 654.2334 cm 0 0 m -8.031 0 l -8.031 1.699 l -8.915 -1.697 l -8.031 -5.093 l -8.031 -3.395 l 0 -3.395 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 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m 11.455 0 l S Q q 1 0 0 1 234.5586 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 246.0132 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 245.1865 643.6792 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 245.1865 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 256.6436 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 255.8154 643.6792 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 255.8154 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 267.2725 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 266.4458 643.6792 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 266.4458 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 277.9004 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 277.0747 643.6792 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 277.0747 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 288.5308 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 287.7017 643.6792 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 287.7017 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 299.1597 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 298.332 643.6792 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 298.332 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 309.7881 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 308.9609 643.6792 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 308.9609 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 320.417 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 319.5898 643.6792 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 319.5898 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 331.0459 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 330.2197 643.6792 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 330.2197 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 341.6738 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 340.8486 643.6792 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 340.8486 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 352.3027 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 351.4775 643.6792 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 351.4775 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 362.9336 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 362.1055 643.6792 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 362.1055 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 373.5605 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 372.7354 643.6792 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 372.7354 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 384.1914 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 383.3623 643.6792 cm 0 0 m 11.458 0 l S Q q 1 0 0 1 383.3623 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 394.8203 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 393.9951 643.6792 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 393.9951 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 405.4502 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 404.623 643.6792 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 404.623 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 416.0801 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 415.249 643.6792 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 415.249 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 426.7061 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 425.8799 643.6792 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 425.8799 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 437.3359 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 436.5088 643.6792 cm 0 0 m 11.457 0 l S Q q 1 0 0 1 436.5088 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 447.9658 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 447.1387 643.6792 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 447.1387 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 458.5947 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 457.7686 643.6792 cm 0 0 m 11.454 0 l S Q q 1 0 0 1 457.7686 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 469.2227 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 468.3965 643.6792 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 468.3965 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 479.8516 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 479.0254 643.6792 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 479.0254 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 490.4814 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 489.6543 643.6792 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 489.6543 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 501.1104 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 500.2852 643.6792 cm 0 0 m 11.275 0 l S Q q 1 0 0 1 500.2852 644.4175 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 510.9131 643.6792 cm 0 0 m 0.647 0 l S Q q 1 0 0 1 510.9131 644.4175 cm 0 0 m 0 -1.476 l S Q BT 0.137 0.123 0.126 scn /TT0 1 Tf 5.2485 0 0 5.2485 515.0791 648.1123 Tm (120 kb)Tj 4.4285 0 0 4.4285 528.0029 648.1123 Tm ( )Tj 0 3.9365 -3.9365 0 90.583 654.6846 Tm (0054 )Tj 3.9365 0 0 3.9365 96.9395 654.9253 Tm (0055 )Tj 3.032 0 Td (0056 )Tj 0 3.9365 -3.9365 0 123.5117 654.9253 Tm (0057 )Tj 0 -1.292 Td (0058 )Tj 3.9365 0 0 3.9365 133.7607 654.9253 Tm (0059 )Tj 3.392 0 Td (0060 )Tj 3.093 0 Td (0061 )Tj 0 3.9365 -3.9365 0 173.8115 654.9253 Tm (0062 )Tj 3.9365 0 0 3.9365 175.7783 654.9253 Tm (0063 )Tj 3.263 0 Td (0064 )Tj 0 3.9365 -3.9365 0 205.2148 654.9253 Tm (0065 )Tj 3.9365 0 0 3.9365 206.7139 654.9253 Tm (0066 )Tj 2.3195 2.3195 -2.3195 2.3195 215.6075 654.9132 Tm (5S rRNA )Tj 3.9365 0 0 3.9365 225.4316 651.0093 Tm (23S rRNA )Tj 6.615 0.028 Td (16S rRNA )Tj 2.3195 2.3195 -2.3195 2.3195 268.7328 654.5857 Tm (tRNA-leu)Tj 2.7833 2.7833 -2.7833 2.7833 276.4465 662.2994 Tm ( )Tj 2.3195 2.3195 -2.3195 2.3195 272.5062 654.4189 Tm (tRNA-lys)Tj 2.7833 2.7833 -2.7833 2.7833 280.007 661.9197 Tm ( )Tj 3.9365 0 0 3.9365 279.6543 654.9253 Tm (0072 )Tj 6.899 0 Td (0073 )Tj 4.886 0 Td (0074 )Tj 2.715 0 Td (0075 )Tj 4.485 0 Td (0076 )Tj 3.138 0 Td (0077 )Tj 2.562 0 Td (0078 )Tj 2.924 0 Td (0079 )Tj 0 3.9365 -3.9365 0 401.0703 654.7178 Tm (0080 )Tj 3.9365 0 0 3.9365 405.9062 654.9253 Tm (0081 )Tj 0 3.9365 -3.9365 0 420.3955 654.5723 Tm (0082 )Tj 0.042 -1.507 Td (0083 )Tj 3.9365 0 0 3.9365 436.3271 654.9253 Tm (0084 )Tj 5.367 0 Td (0085 )Tj 4.639 0 Td (0086 )Tj 0 3.9365 -3.9365 0 495.1875 654.5391 Tm (0087 )Tj 3.9365 0 0 3.9365 501.7061 654.8364 Tm (0088 )Tj -102.592 -2.683 Td (894 )Tj 2.7 0 Td (895 )Tj 2.7 0 Td (896 )Tj 2.7 0 Td (897 )Tj 2.7 0 Td (898 )Tj 2.7 0 Td (899 )Tj 2.7 0 Td (900 )Tj 2.701 0 Td (901 )Tj 2.7 0 Td (902 )Tj 2.7 0 Td (903 )Tj 2.699 0 Td (904 )Tj 2.7 0 Td (905 )Tj 2.7 0 Td (906 )Tj 2.7 0 Td (907 )Tj 2.7 0 Td (908 )Tj 2.7 0 Td (909 )Tj 2.7 0 Td (910 )Tj 2.699 0 Td (911 )Tj 2.7 0 Td (912 )Tj 2.7 0 Td (913 )Tj 2.7 0 Td (914 )Tj 2.7 0 Td (915 )Tj 2.7 0 Td (916 )Tj 2.7 0 Td (917 )Tj 2.7 0 Td (918 )Tj 2.7 0 Td (919 )Tj 2.7 0 Td (920 )Tj 2.7 0 Td (921 )Tj 2.7 0 Td (922 )Tj 2.7 0 Td (923 )Tj 2.7 0 Td (924 )Tj 2.7 0 Td (925 )Tj 2.7 0 Td (926 )Tj 2.7 0 Td (927 )Tj 2.7 0 Td (928 )Tj 2.7 0 Td (929 )Tj 2.7 0 Td (930 )Tj 2.7 0 Td (931 )Tj 2.7 0 Td (932 )Tj -105.071 0 Td (893 )Tj 3.2804 0 0 3.2804 94.9287 651.4893 Tm (mmyCVR)Tj 1.9682 0 0 1.9682 108.041 651.8965 Tm [(m)25(m)25(y)25(C)25(5)25(V)25(M)]TJ ET 0.23 w 4 M 117.206 659.371 -24.822 1.421 re S 1 1 1 scn 115.511 658.606 -21.432 2.952 re f BT 0.137 0.123 0.126 scn /TT0 1 Tf 3.2804 0 0 3.2804 94.3877 658.9458 Tm [(T)50(y)50(p)50(e)50( )50(I)50(I)50( )50(R)50(/)50(M)50( )50(-)50( )50(G)50(A)50(T)50(C)]TJ 1 1 1 scn /TT2 1 Tf 12.465 -2.34 Td [(a)-25(l)-25(d)]TJ 7.442 0.051 Td (serS)Tj 4.914 -0.034 Td (dusB)Tj 4.169 0.067 Td (lysS)Tj /TT0 1 Tf 0 1.9682 -1.9682 0 204.1641 651.1611 Tm (trxA)Tj /TT2 1 Tf 3.2804 0 0 3.2804 306.79 651.5698 Tm (phnE)Tj ET q 1 0 0 1 309.3174 662.3184 cm 0 0 m 24.606 0 l 24.606 -3.062 l f Q 347.698 659.798 -52.155 1.641 re S 334.03 658.923 -24.822 3.172 re f BT 0.137 0.123 0.126 scn /TT2 1 Tf 3.2804 0 0 3.2804 312.042 659.5933 Tm (phosphonate)Tj 1 1 1 scn /TT0 1 Tf 4.172 -2.48 Td (phnC)Tj /TT2 1 Tf 8.758 -0.015 Td (asnS)Tj 15.785 0 Td (trmE)Tj /TT0 1 Tf 0 1.9682 -1.9682 0 419.2168 650.9116 Tm (rpsT)Tj ET 0.262 w 10 M q 1 0 0 1 86.3999 644.4463 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 86.3999 669.1895 cm 0 0 m 425.161 0 l S Q 0.716 0.434 0.681 scn 4 M q 1 0 0 1 86.3999 672.144 cm 0 0 m 13.14 0 l 13.14 2.952 l 0 2.952 l B* Q 10 M q 1 0 0 1 86.3999 672.1411 cm 0 0 m 13.141 0 l 13.141 2.952 l 0 2.952 l S Q 1 1 1 scn q 1 0 0 1 117.105 675.3184 cm 0 0 m -13.788 0 l -13.788 1.697 l -14.673 -1.699 l -13.788 -5.093 l -13.788 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 117.105 675.3184 cm 0 0 m -13.788 0 l -13.788 1.697 l -14.673 -1.699 l -13.788 -5.093 l -13.788 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 117.1079 675.3154 cm 0 0 m -13.79 0 l -13.79 1.697 l -14.674 -1.698 l -13.79 -5.093 l -13.79 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 123.689 675.3184 cm 0 0 m -2.155 0 l -2.155 1.697 l -2.39 -1.699 l -2.155 -5.093 l -2.155 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 123.689 675.3184 cm 0 0 m -2.155 0 l -2.155 1.697 l -2.39 -1.699 l -2.155 -5.093 l -2.155 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 123.6909 675.3154 cm 0 0 m -2.156 0 l -2.156 1.697 l -2.391 -1.698 l -2.156 -5.093 l -2.156 -3.396 l 0 -3.396 l 0 0 l h S Q 0.99 0.914 0.17 scn q 1 0 0 1 128.5903 675.3184 cm 0 0 m -4.222 0 l -4.222 1.697 l -4.665 -1.699 l -4.222 -5.093 l -4.222 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 128.5903 675.3184 cm 0 0 m -4.222 0 l -4.222 1.697 l -4.665 -1.699 l -4.222 -5.093 l -4.222 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 128.5913 675.3154 cm 0 0 m -4.221 0 l -4.221 1.697 l -4.664 -1.698 l -4.221 -5.093 l -4.221 -3.396 l 0 -3.396 l 0 0 l h S Q 0 0.677 0.647 scn q 1 0 0 1 133.1064 675.3184 cm 0 0 m -3.986 0 l -3.986 1.697 l -4.397 -1.699 l -3.986 -5.093 l -3.986 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 133.1064 675.3184 cm 0 0 m -3.986 0 l -3.986 1.697 l -4.397 -1.699 l -3.986 -5.093 l -3.986 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 133.1094 675.3154 cm 0 0 m -3.984 0 l -3.984 1.697 l -4.398 -1.698 l -3.984 -5.093 l -3.984 -3.396 l 0 -3.396 l 0 0 l h S Q 0.555 0.846 0.972 scn q 1 0 0 1 137.5054 675.3184 cm 0 0 m -2.007 0 l -2.007 1.697 l -2.213 -1.699 l -2.007 -5.093 l -2.007 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 137.5054 675.3184 cm 0 0 m -2.007 0 l -2.007 1.697 l -2.213 -1.699 l -2.007 -5.093 l -2.007 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 137.5088 675.3154 cm 0 0 m -2.008 0 l -2.008 1.697 l -2.214 -1.698 l -2.008 -5.093 l -2.008 -3.396 l 0 -3.396 l 0 0 l h S Q 0.503 0.51 0.52 scn q 1 0 0 1 139.5137 675.3184 cm 0 0 m 5.727 0 l 5.727 1.697 l 6.348 -1.699 l 5.727 -5.093 l 5.727 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 139.5137 675.3184 cm 0 0 m 5.727 0 l 5.727 1.697 l 6.348 -1.699 l 5.727 -5.093 l 5.727 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 139.5156 675.3154 cm 0 0 m 5.728 0 l 5.728 1.697 l 6.348 -1.698 l 5.728 -5.093 l 5.728 -3.396 l 0 -3.396 l 0 0 l h S Q 0.716 0.434 0.681 scn q 1 0 0 1 157.2573 675.3184 cm 0 0 m -10.098 0 l -10.098 1.697 l -10.984 -1.699 l -10.098 -5.093 l -10.098 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 157.2573 675.3184 cm 0 0 m -10.098 0 l -10.098 1.697 l -10.984 -1.699 l -10.098 -5.093 l -10.098 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 157.2617 675.3154 cm 0 0 m -10.099 0 l -10.099 1.697 l -10.983 -1.698 l -10.099 -5.093 l -10.099 -3.396 l 0 -3.396 l 0 0 l h S Q 0.501 0.764 0.267 scn q 1 0 0 1 166.9697 675.3184 cm 0 0 m -8.324 0 l -8.324 1.697 l -9.209 -1.699 l -8.324 -5.093 l -8.324 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 166.9697 675.3184 cm 0 0 m -8.324 0 l -8.324 1.697 l -9.209 -1.699 l -8.324 -5.093 l -8.324 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 166.9756 675.3154 cm 0 0 m 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q 1 0 0 1 238.1797 675.3184 cm 0 0 m 56.184 0 l 56.184 1.697 l 57.069 -1.699 l 56.184 -5.093 l 56.184 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 238.1797 675.3184 cm 0 0 m 56.184 0 l 56.184 1.697 l 57.069 -1.699 l 56.184 -5.093 l 56.184 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 238.1895 675.3154 cm 0 0 m 56.185 0 l 56.185 1.697 l 57.072 -1.698 l 56.185 -5.093 l 56.185 -3.396 l 0 -3.396 l 0 0 l h S Q 0.73 0.805 0.919 scn q 1 0 0 1 296.5776 675.3184 cm 0 0 m 11.78 0 l 11.78 1.697 l 12.665 -1.699 l 11.78 -5.093 l 11.78 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 296.5776 675.3184 cm 0 0 m 11.78 0 l 11.78 1.697 l 12.665 -1.699 l 11.78 -5.093 l 11.78 -3.396 l 0 -3.396 l 0 0 l S Q 10 M q 1 0 0 1 296.5903 675.3154 cm 0 0 m 11.779 0 l 11.779 1.697 l 12.667 -1.698 l 11.779 -5.093 l 11.779 -3.396 l 0 -3.396 l 0 0 l h S Q 0.503 0.51 0.52 scn q 1 0 0 1 312.5195 675.3184 cm 0 0 m 9.598 0 l 9.598 1.697 l 10.481 -1.699 l 9.598 -5.093 l 9.598 -3.396 l 0 -3.396 l h f* Q 4 M q 1 0 0 1 312.5195 675.3184 cm 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457.7686 665.4985 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 469.2227 665.4985 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 468.3965 664.7603 cm 0 0 m 11.455 0 l S Q q 1 0 0 1 468.3965 665.4985 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 479.8516 665.4985 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 479.0254 664.7603 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 479.0254 665.4985 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 490.4814 665.4985 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 489.6543 664.7603 cm 0 0 m 11.456 0 l S Q q 1 0 0 1 489.6543 665.4985 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 501.1104 665.4985 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 500.2852 664.7603 cm 0 0 m 11.275 0 l S Q q 1 0 0 1 500.2852 665.4985 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 510.9131 664.7603 cm 0 0 m 0.647 0 l S Q q 1 0 0 1 510.9131 665.4985 cm 0 0 m 0 -1.476 l S Q BT 0.137 0.123 0.126 scn /TT0 1 Tf 5.2485 0 0 5.2485 515.0791 669.1924 Tm (80 kb)Tj 4.4285 0 0 4.4285 525.6094 669.1924 Tm ( )Tj 3.9365 0 0 3.9365 106.0967 675.6772 Tm (0024 )Tj 0 3.9365 -3.9365 0 123.7969 676.2456 Tm (0025 )Tj 0 -1.103 TD (0026 )Tj -0.042 -1.195 Td (0027 )Tj 0.042 -1.466 Td (0028 )Tj -0.042 -1.427 Td (0029 )Tj 3.9365 0 0 3.9365 148.6396 675.8662 Tm (0030 )Tj 2.741 0.035 Td (0031 )Tj 5.411 0 Td (0032 )Tj 8.913 0 Td (0033 )Tj 11.257 0 Td (0034 )Tj 9.862 0 Td (0035 )Tj 3.71 0 Td (0036 )Tj 2.992 0 Td (0037 )Tj 4.138 0 Td (0038 )Tj 4.766 0 Td (0039 )Tj 4.092 0 Td (0041 )Tj 3.052 0 Td (0040 )Tj 2.677 0 Td (0042 )Tj 2.307 0 Td (0043 )Tj 0 3.9365 -3.9365 0 420.5283 676.0059 Tm (0044 )Tj 0 -1.816 TD (0045 )Tj 0 -1.677 TD (0046 )Tj 3.9365 0 0 3.9365 442.8301 676.0059 Tm (0047 )Tj 0 3.9365 -3.9365 0 461.4902 676.0068 Tm (0048 )Tj 2.3195 2.3195 -2.3195 2.3195 463.4799 676.8402 Tm (srpRNA )Tj 3.9365 0 0 3.9365 466.1406 676.0059 Tm (0050 )Tj 0 3.9365 -3.9365 0 481.9658 676.0068 Tm (0051 )Tj 0.048 -1.146 Td (0052 )Tj 3.9365 0 0 3.9365 494.9668 676.0059 Tm (0053 )Tj -100.88 -2.706 Td (854 )Tj 2.7 0 Td (855 )Tj 2.7 0 Td (856 )Tj 2.7 0 Td (857 )Tj 2.7 0 Td (858 )Tj 2.7 0 Td (859 )Tj 2.7 0 Td (860 )Tj 2.701 0 Td (861 )Tj 2.7 0 Td (862 )Tj 2.7 0 Td (863 )Tj 2.699 0 Td (864 )Tj 2.7 0 Td (865 )Tj 2.7 0 Td (866 )Tj 2.7 0 Td (867 )Tj 2.7 0 Td (868 )Tj 2.7 0 Td (869 )Tj 2.7 0 Td (870 )Tj 2.699 0 Td (871 )Tj 2.7 0 Td (872 )Tj 2.7 0 Td (873 )Tj 2.7 0 Td (874f )Tj 2.7 0 Td (875 )Tj 2.7 0 Td (876 )Tj 2.7 0 Td (877 )Tj 2.7 0 Td (878 )Tj 2.7 0 Td (879 )Tj 2.7 0 Td (880 )Tj 2.7 0 Td (881 )Tj 2.7 0 Td (882 )Tj 2.7 0 Td (883 )Tj 2.7 0 Td (884 )Tj 2.7 0 Td (885 )Tj 2.7 0 Td (886 )Tj 2.7 0 Td (887 )Tj 2.7 0 Td (888 )Tj 2.7 0 Td (889 )Tj 2.7 0 Td (890 )Tj 2.7 0 Td (891 )Tj 2.7 0 Td (892 )Tj -104.843 2.642 Td (0023)Tj -0.29 -2.683 Td (853 )Tj 1 1 1 scn 0 1.6402 -1.6402 0 122.9766 672.1948 Tm (rpsR)Tj 0.137 0.123 0.126 scn 3.2804 0 0 3.2804 124.2891 672.5537 Tm (ssb)Tj 10.792 -0.067 Td [(h)-10(s)-10(l)-10(O)]TJ /TT2 1 Tf 78.035 0.042 Td (holB)Tj 1 1 1 scn 2.39 0 Td [(t)-25(m)-25(k)]TJ 0.137 0.123 0.126 scn /TT0 1 Tf 1.863 -0.007 Td [(r)22(e)]TJ 0.685 0 Td [(c)35(M)]TJ 3.46 0.016 Td [(d)-25(n)-25(a)-25(X)]TJ 1 1 1 scn 7.05 0.049 Td (guaC)Tj ET q 1 0 0 1 86.3999 665.459 cm 0 0 m 0 -1.477 l S Q 0.791 0.887 0.666 scn 0.262 w 4 M 398.332 558.134 -8.181 2.361 re B 0.797 0.882 0.586 scn 395.702 558.396 0.151 2.011 re f 0.215 w 395.854 558.396 -0.151 2.012 re S 393.923 558.396 0.153 2.011 re f 394.076 558.396 -0.153 2.012 re S 393.034 558.396 0.15 2.011 re f 393.185 558.396 -0.15 2.012 re S 392.145 558.396 0.148 2.011 re f 392.294 558.396 -0.148 2.012 re S 391.254 558.396 0.151 2.011 re f 391.405 558.396 -0.151 2.012 re S 396.59 558.396 0.151 2.011 re f 396.741 558.396 -0.15 2.012 re S 390.368 558.396 0.148 2.011 re f 390.517 558.396 -0.148 2.012 re S 394.817 558.396 0.14 2.011 re f 0.207 w 394.958 558.396 -0.141 2.012 re S 397.485 558.396 0.14 2.011 re f 397.625 558.396 -0.14 2.012 re S 0.268 w [0.659 0.277]0 d q 1 0 0 1 390.4414 558.1934 cm 0 0 m 3.895 -5.74 l S Q 1 1 1 scn 389.837 557.866 0.427 2.788 re f []0 d q 1 0 0 1 300.0664 521.248 cm 0 0 m 16.238 0 l S Q 0.932 0.418 0.31 scn 0.627 w 10 M 135.413 403.21 10.889 4.38 re B BT 1 1 1 scn /TT3 1 Tf 3.9681 0 0 3.2272 135.8193 404.3735 Tm (WM1)Tj ET 0.932 0.418 0.31 scn 0.624 w 136.744 320.276 10.805 4.383 re B BT 1 1 1 scn /TT3 1 Tf 3.1976 0 0 3.2272 137.2646 321.332 Tm (WM2b)Tj ET 0.932 0.418 0.31 scn 0.61 w 390.446 506.1 10.316 4.381 re B BT 1 1 1 scn /TT3 1 Tf 3.7589 0 0 3.2272 391.2227 507.2837 Tm (WM3)Tj ET 0.239 w 4 M q 1 0 0 1 500.1055 220.125 cm 0 0 m -11.682 0 l -11.682 -4.959 l B* Q 0.932 0.418 0.31 scn 0.61 w 10 M 489.106 215.417 10.317 4.38 re B BT 1 1 1 scn /TT3 1 Tf 3.7589 0 0 3.2272 489.4922 216.5771 Tm (WM4)Tj /TT2 1 Tf 3.2804 0 0 3.2804 107.8018 549.5034 Tm [(g)-25(l)-25(p)-25(O)]TJ ET 0.991 0.905 0.368 scn q 1 0 0 1 171.9854 642.6289 cm 0 0 m -0.875 0.458 l -1.75 -0.002 l -1.581 0.973 l -2.29 1.662 l -1.315 1.804 l -0.877 2.691 l -0.437 1.804 l 0.54 1.664 l -0.168 0.974 l h f Q 0.328 w 4 M q 1 0 0 1 171.9854 642.6289 cm 0 0 m -0.875 0.458 l -1.75 -0.002 l -1.581 0.973 l -2.29 1.662 l -1.315 1.804 l -0.877 2.691 l -0.437 1.804 l 0.54 1.664 l -0.168 0.974 l 0 0 l h S Q q 1 0 0 1 489.9844 145.4014 cm 0 0 m -0.875 0.459 l -1.749 0 l -1.582 0.972 l -2.29 1.662 l -1.313 1.805 l -0.876 2.691 l -0.438 1.805 l 0.54 1.662 l -0.167 0.974 l h f Q q 1 0 0 1 489.9844 145.4014 cm 0 0 m -0.875 0.459 l -1.749 0 l -1.582 0.972 l -2.29 1.662 l -1.313 1.805 l -0.876 2.691 l -0.438 1.805 l 0.54 1.662 l -0.167 0.974 l 0 0 l h S Q 0 0.698 0.941 scn q 1 0 0 1 491.1338 664.8032 cm 0 0 m -1.052 -1.578 l -2.104 0 l -1.052 1.578 l h f Q 0.263 w q 1 0 0 1 491.1338 664.8032 cm 0 0 m -1.052 -1.578 l -2.104 0 l -1.052 1.578 l 0 0 l h S Q q 1 0 0 1 384.7305 665.0068 cm 0 0 m -1.054 -1.579 l -2.106 0 l -1.054 1.578 l h f Q q 1 0 0 1 384.7305 665.0068 cm 0 0 m -1.054 -1.579 l -2.106 0 l -1.054 1.578 l 0 0 l h S Q q 1 0 0 1 278.6294 664.8032 cm 0 0 m -1.052 -1.578 l -2.107 0 l -1.052 1.578 l h f Q q 1 0 0 1 278.6294 664.8032 cm 0 0 m -1.052 -1.578 l -2.107 0 l -1.052 1.578 l 0 0 l h S Q q 1 0 0 1 172.125 664.8032 cm 0 0 m -1.054 -1.578 l -2.106 0 l -1.054 1.579 l h f Q q 1 0 0 1 172.125 664.8032 cm 0 0 m -1.054 -1.578 l -2.106 0 l -1.054 1.579 l 0 0 l h S Q q 1 0 0 1 512.375 685.6392 cm 0 0 m -1.054 -1.578 l -2.105 0 l -1.054 1.579 l h f Q q 1 0 0 1 512.375 685.6392 cm 0 0 m -1.054 -1.578 l -2.105 0 l -1.054 1.579 l 0 0 l h S Q q 1 0 0 1 406.5771 685.8418 cm 0 0 m -1.052 -1.578 l -2.104 0 l -1.052 1.579 l h f Q q 1 0 0 1 406.5771 685.8418 cm 0 0 m -1.052 -1.578 l -2.104 0 l -1.052 1.579 l 0 0 l h S Q q 1 0 0 1 300.3755 685.6392 cm 0 0 m -1.053 -1.578 l -2.105 0 l -1.053 1.579 l h f Q q 1 0 0 1 300.3755 685.6392 cm 0 0 m -1.053 -1.578 l -2.105 0 l -1.053 1.579 l 0 0 l h S Q q 1 0 0 1 194.1743 685.5381 cm 0 0 m -1.052 -1.577 l -2.107 0 l -1.052 1.579 l h f Q q 1 0 0 1 194.1743 685.5381 cm 0 0 m -1.052 -1.577 l -2.107 0 l -1.052 1.579 l 0 0 l h S Q 0.797 0.882 0.586 scn q 1 0 0 1 169.8311 670.8853 cm 0 0 m 3.544 0 l 1.772 3.479 l h f Q 0.394 w q 1 0 0 1 169.8311 670.8853 cm 0 0 m 3.544 0 l 1.772 3.479 l 0 0 l h S Q q 1 0 0 1 396.6465 608.9082 cm 0 0 m 3.547 0 l 1.771 3.479 l h f Q q 1 0 0 1 396.6465 608.9082 cm 0 0 m 3.547 0 l 1.771 3.479 l 0 0 l h S Q q 1 0 0 1 380.4131 527.3945 cm 0 0 m 3.548 0 l 1.772 2.61 l h f Q 0.341 w q 1 0 0 1 380.4131 527.3945 cm 0 0 m 3.548 0 l 1.772 2.61 l 0 0 l h S Q q 1 0 0 1 495.6201 360.7764 cm 0 0 m 3.547 0 l 1.771 3.479 l h f Q 0.394 w q 1 0 0 1 495.6201 360.7764 cm 0 0 m 3.547 0 l 1.771 3.479 l 0 0 l h S Q q 1 0 0 1 234.1592 318.9023 cm 0 0 m 3.545 0 l 1.771 3.478 l h f Q q 1 0 0 1 234.1592 318.9023 cm 0 0 m 3.545 0 l 1.771 3.478 l 0 0 l h S Q q 1 0 0 1 277.4487 276.7246 cm 0 0 m 3.545 0 l 1.773 3.476 l h f Q q 1 0 0 1 277.4487 276.7246 cm 0 0 m 3.545 0 l 1.773 3.476 l 0 0 l h S Q q 1 0 0 1 276.6396 276.7246 cm 0 0 m 3.547 0 l 1.772 3.476 l h f Q q 1 0 0 1 276.6396 276.7246 cm 0 0 m 3.547 0 l 1.772 3.476 l 0 0 l h S Q q 1 0 0 1 121.8882 193.584 cm 0 0 m 3.546 0 l 1.772 3.48 l h f Q q 1 0 0 1 121.8882 193.584 cm 0 0 m 3.546 0 l 1.772 3.48 l 0 0 l h S Q 0 0.698 0.941 scn q 1 0 0 1 278.4268 643.6143 cm 0 0 m -1.051 -1.579 l -2.104 0 l -1.051 1.578 l h f Q 0.263 w q 1 0 0 1 278.4268 643.6143 cm 0 0 m -1.051 -1.579 l -2.104 0 l -1.051 1.578 l 0 0 l h S Q q 1 0 0 1 384.7813 643.7661 cm 0 0 m -1.053 -1.579 l -2.104 0 l -1.053 1.578 l h f Q q 1 0 0 1 384.7813 643.7661 cm 0 0 m -1.053 -1.579 l -2.104 0 l -1.053 1.578 l 0 0 l h S Q q 1 0 0 1 490.9824 643.6143 cm 0 0 m -1.054 -1.579 l -2.105 0 l -1.054 1.578 l h f Q q 1 0 0 1 490.9824 643.6143 cm 0 0 m -1.054 -1.579 l -2.105 0 l -1.054 1.578 l 0 0 l h S Q q 1 0 0 1 129.6436 623.0825 cm 0 0 m -1.053 -1.58 l -2.106 0 l -1.053 1.578 l h f Q q 1 0 0 1 129.6436 623.0825 cm 0 0 m -1.053 -1.58 l -2.106 0 l -1.053 1.578 l 0 0 l h S Q q 1 0 0 1 235.8447 623.0825 cm 0 0 m -1.052 -1.58 l -2.105 0 l -1.052 1.578 l h f Q q 1 0 0 1 235.8447 623.0825 cm 0 0 m -1.052 -1.58 l -2.105 0 l -1.052 1.578 l 0 0 l h S Q q 1 0 0 1 342.1982 623.0825 cm 0 0 m -1.053 -1.58 l -2.104 0 l -1.053 1.578 l h f Q q 1 0 0 1 342.1982 623.0825 cm 0 0 m -1.053 -1.58 l -2.104 0 l -1.053 1.578 l 0 0 l h S Q q 1 0 0 1 448.5518 623.0825 cm 0 0 m -1.052 -1.58 l -2.104 0 l -1.052 1.578 l h f Q q 1 0 0 1 448.5518 623.0825 cm 0 0 m -1.052 -1.58 l -2.104 0 l -1.052 1.578 l 0 0 l h S Q q 1 0 0 1 129.6436 603.5107 cm 0 0 m -1.053 -1.579 l -2.106 0 l -1.053 1.577 l h f Q q 1 0 0 1 129.6436 603.5107 cm 0 0 m -1.053 -1.579 l -2.106 0 l -1.053 1.577 l 0 0 l h S Q q 1 0 0 1 235.9971 603.5107 cm 0 0 m -1.052 -1.579 l -2.106 0 l -1.052 1.577 l h f Q q 1 0 0 1 235.9971 603.5107 cm 0 0 m -1.052 -1.579 l -2.106 0 l -1.052 1.577 l 0 0 l h S Q 0.991 0.905 0.368 scn q 1 0 0 1 341.9082 602.5752 cm 0 0 m -0.875 0.458 l -1.748 -0.001 l -1.584 0.973 l -2.292 1.663 l -1.312 1.804 l -0.876 2.691 l -0.438 1.805 l 0.54 1.663 l -0.167 0.973 l h f Q 0.328 w q 1 0 0 1 341.9082 602.5752 cm 0 0 m -0.875 0.458 l -1.748 -0.001 l -1.584 0.973 l -2.292 1.663 l -1.312 1.804 l -0.876 2.691 l -0.438 1.805 l 0.54 1.663 l -0.167 0.973 l 0 0 l h S Q 0 0.698 0.941 scn q 1 0 0 1 448.4014 603.5107 cm 0 0 m -1.054 -1.579 l -2.105 0 l -1.054 1.577 l h f Q 0.263 w q 1 0 0 1 448.4014 603.5107 cm 0 0 m -1.054 -1.579 l -2.105 0 l -1.054 1.577 l 0 0 l h S Q q 1 0 0 1 129.7944 583.6357 cm 0 0 m -1.052 -1.58 l -2.105 0 l -1.052 1.578 l h f Q q 1 0 0 1 129.7944 583.6357 cm 0 0 m -1.052 -1.58 l -2.105 0 l -1.052 1.578 l 0 0 l h S Q q 1 0 0 1 235.9971 583.6357 cm 0 0 m -1.053 -1.58 l -2.106 0 l -1.053 1.578 l h f Q q 1 0 0 1 235.9971 583.6357 cm 0 0 m -1.053 -1.58 l -2.106 0 l -1.053 1.578 l 0 0 l h S Q q 1 0 0 1 342.3506 583.6357 cm 0 0 m -1.054 -1.58 l -2.105 0 l -1.054 1.578 l h f Q q 1 0 0 1 342.3506 583.6357 cm 0 0 m -1.054 -1.58 l -2.105 0 l -1.054 1.578 l 0 0 l h S Q q 1 0 0 1 448.5518 583.6357 cm 0 0 m -1.052 -1.58 l -2.104 0 l -1.052 1.578 l h f Q q 1 0 0 1 448.5518 583.6357 cm 0 0 m -1.052 -1.58 l -2.104 0 l -1.052 1.578 l 0 0 l h S Q q 1 0 0 1 129.6436 561.4844 cm 0 0 m -1.053 -1.578 l -2.106 0 l -1.053 1.579 l h f Q q 1 0 0 1 129.6436 561.4844 cm 0 0 m -1.053 -1.578 l -2.106 0 l -1.053 1.579 l 0 0 l h S Q q 1 0 0 1 235.9971 561.4844 cm 0 0 m -1.053 -1.578 l -2.106 0 l -1.053 1.579 l h f Q q 1 0 0 1 235.9971 561.4844 cm 0 0 m -1.053 -1.578 l -2.106 0 l -1.053 1.579 l 0 0 l h S Q q 1 0 0 1 342.1982 561.4844 cm 0 0 m -1.053 -1.578 l -2.104 0 l -1.053 1.579 l h f Q q 1 0 0 1 342.1982 561.4844 cm 0 0 m -1.053 -1.578 l -2.104 0 l -1.053 1.579 l 0 0 l h S Q q 1 0 0 1 448.5518 561.4844 cm 0 0 m -1.052 -1.578 l -2.104 0 l -1.052 1.579 l h f Q q 1 0 0 1 448.5518 561.4844 cm 0 0 m -1.052 -1.578 l -2.104 0 l -1.052 1.579 l 0 0 l h S Q q 1 0 0 1 129.6602 541.6094 cm 0 0 m -1.053 -1.578 l -2.105 0 l -1.053 1.578 l h f Q q 1 0 0 1 129.6602 541.6094 cm 0 0 m -1.053 -1.578 l -2.105 0 l -1.053 1.578 l 0 0 l h S Q 0.991 0.905 0.368 scn q 1 0 0 1 171.9854 540.6748 cm 0 0 m -0.875 0.459 l -1.75 -0.001 l -1.581 0.972 l -2.29 1.662 l -1.315 1.804 l -0.877 2.691 l -0.437 1.804 l 0.54 1.664 l -0.168 0.973 l h f Q 0.328 w q 1 0 0 1 171.9854 540.6748 cm 0 0 m -0.875 0.459 l -1.75 -0.001 l -1.581 0.972 l -2.29 1.662 l -1.315 1.804 l -0.877 2.691 l -0.437 1.804 l 0.54 1.664 l -0.168 0.973 l 0 0 l h S Q 0 0.698 0.941 scn q 1 0 0 1 267.8574 541.7617 cm 0 0 m -1.053 -1.579 l -2.104 0 l -1.053 1.578 l h f Q 0.263 w q 1 0 0 1 267.8574 541.7617 cm 0 0 m -1.053 -1.579 l -2.104 0 l -1.053 1.578 l 0 0 l h S Q q 1 0 0 1 353.8818 541.6094 cm 0 0 m -1.053 -1.578 l -2.105 0 l -1.053 1.578 l h f Q q 1 0 0 1 353.8818 541.6094 cm 0 0 m -1.053 -1.578 l -2.105 0 l -1.053 1.578 l 0 0 l h S Q q 1 0 0 1 460.2354 541.6094 cm 0 0 m -1.054 -1.578 l -2.105 0 l -1.054 1.578 l h f Q q 1 0 0 1 460.2354 541.6094 cm 0 0 m -1.054 -1.578 l -2.105 0 l -1.054 1.578 l 0 0 l h S Q q 1 0 0 1 141.3267 521.1284 cm 0 0 m -1.053 -1.579 l -2.105 0 l -1.053 1.577 l h f Q q 1 0 0 1 141.3267 521.1284 cm 0 0 m -1.053 -1.579 l -2.105 0 l -1.053 1.577 l 0 0 l h S Q 0.991 0.905 0.368 scn q 1 0 0 1 337.9639 498.6489 cm 0 0 m -0.873 0.459 l -1.75 0 l -1.584 0.973 l -2.29 1.663 l -1.313 1.804 l -0.875 2.691 l -0.438 1.805 l 0.539 1.664 l -0.168 0.973 l h f Q 0.328 w q 1 0 0 1 337.9639 498.6489 cm 0 0 m -0.873 0.459 l -1.75 0 l -1.584 0.973 l -2.29 1.663 l -1.313 1.804 l -0.875 2.691 l -0.438 1.805 l 0.539 1.664 l -0.168 0.973 l 0 0 l h S Q 0 0.698 0.941 scn q 1 0 0 1 247.6792 521.2798 cm 0 0 m -1.051 -1.579 l -2.106 0 l -1.051 1.578 l h f Q 0.263 w q 1 0 0 1 247.6792 521.2798 cm 0 0 m -1.051 -1.579 l -2.106 0 l -1.051 1.578 l 0 0 l h S Q q 1 0 0 1 444.4561 521.2798 cm 0 0 m -1.054 -1.579 l -2.106 0 l -1.054 1.578 l h f Q q 1 0 0 1 444.4561 521.2798 cm 0 0 m -1.054 -1.579 l -2.106 0 l -1.054 1.578 l 0 0 l h S Q q 1 0 0 1 125.3955 499.7358 cm 0 0 m -1.054 -1.578 l -2.105 0 l -1.054 1.578 l h f Q q 1 0 0 1 125.3955 499.7358 cm 0 0 m -1.054 -1.578 l -2.105 0 l -1.054 1.578 l 0 0 l h S Q q 1 0 0 1 231.749 499.5854 cm 0 0 m -1.053 -1.58 l -2.106 0 l -1.053 1.576 l h f Q q 1 0 0 1 231.749 499.5854 cm 0 0 m -1.053 -1.58 l -2.106 0 l -1.053 1.576 l 0 0 l h S Q q 1 0 0 1 444.4561 499.5854 cm 0 0 m -1.054 -1.58 l -2.106 0 l -1.054 1.576 l h f Q q 1 0 0 1 444.4561 499.5854 cm 0 0 m -1.054 -1.58 l -2.106 0 l -1.054 1.576 l 0 0 l h S Q q 1 0 0 1 125.5474 479.71 cm 0 0 m -1.054 -1.58 l -2.105 0 l -1.054 1.578 l h f Q q 1 0 0 1 125.5474 479.71 cm 0 0 m -1.054 -1.58 l -2.105 0 l -1.054 1.578 l 0 0 l h S Q q 1 0 0 1 231.9009 479.71 cm 0 0 m -1.052 -1.58 l -2.105 0 l -1.052 1.578 l h f Q q 1 0 0 1 231.9009 479.71 cm 0 0 m -1.052 -1.58 l -2.105 0 l -1.052 1.578 l 0 0 l h S Q q 1 0 0 1 338.1025 479.71 cm 0 0 m -1.053 -1.58 l -2.105 0 l -1.053 1.578 l h f Q q 1 0 0 1 338.1025 479.71 cm 0 0 m -1.053 -1.58 l -2.105 0 l -1.053 1.578 l 0 0 l h S Q 0.991 0.905 0.368 scn q 1 0 0 1 125.5601 436.4453 cm 0 0 m -0.875 0.458 l -1.751 -0.001 l -1.582 0.973 l -2.292 1.663 l -1.313 1.803 l -0.876 2.69 l -0.437 1.804 l 0.54 1.663 l -0.167 0.974 l h f Q 0.328 w q 1 0 0 1 125.5601 436.4453 cm 0 0 m -0.875 0.458 l -1.751 -0.001 l -1.582 0.973 l -2.292 1.663 l -1.313 1.803 l 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286.5317 395.4805 cm 0 0 m -0.875 0.458 l -1.749 0 l -1.583 0.974 l -2.291 1.663 l -1.313 1.805 l -0.875 2.69 l -0.438 1.806 l 0.541 1.663 l -0.167 0.974 l h f Q 0.328 w q 1 0 0 1 286.5317 395.4805 cm 0 0 m -0.875 0.458 l -1.749 0 l -1.583 0.974 l -2.291 1.663 l -1.313 1.805 l -0.875 2.69 l -0.438 1.806 l 0.541 1.663 l -0.167 0.974 l 0 0 l h S Q 0 0.698 0.941 scn q 1 0 0 1 231.9009 437.229 cm 0 0 m -1.052 -1.58 l -2.105 0 l -1.052 1.578 l h f Q 0.263 w q 1 0 0 1 231.9009 437.229 cm 0 0 m -1.052 -1.58 l -2.105 0 l -1.052 1.578 l 0 0 l h S Q q 1 0 0 1 338.2529 437.3813 cm 0 0 m -1.053 -1.581 l -2.104 0 l -1.053 1.577 l h f Q q 1 0 0 1 338.2529 437.3813 cm 0 0 m -1.053 -1.581 l -2.104 0 l -1.053 1.577 l 0 0 l h S Q q 1 0 0 1 338.2529 415.8359 cm 0 0 m -1.053 -1.578 l -2.104 0 l -1.053 1.579 l h f Q q 1 0 0 1 338.2529 415.8359 cm 0 0 m -1.053 -1.578 l -2.104 0 l -1.053 1.579 l 0 0 l h S Q q 1 0 0 1 444.6084 437.229 cm 0 0 m -1.054 -1.58 l -2.106 0 l -1.054 1.578 l h f Q q 1 0 0 1 444.6084 437.229 cm 0 0 m -1.054 -1.58 l -2.106 0 l -1.054 1.578 l 0 0 l h S Q q 1 0 0 1 444.4561 415.8359 cm 0 0 m -1.054 -1.578 l -2.106 0 l -1.054 1.579 l h f Q q 1 0 0 1 444.4561 415.8359 cm 0 0 m -1.054 -1.578 l -2.106 0 l -1.054 1.579 l 0 0 l h S Q q 1 0 0 1 231.9009 415.8359 cm 0 0 m -1.052 -1.578 l -2.105 0 l -1.052 1.579 l h f Q q 1 0 0 1 231.9009 415.8359 cm 0 0 m -1.052 -1.578 l -2.105 0 l -1.052 1.579 l 0 0 l h S Q q 1 0 0 1 125.6982 415.8359 cm 0 0 m -1.052 -1.578 l -2.104 0 l -1.052 1.579 l h f Q q 1 0 0 1 125.6982 415.8359 cm 0 0 m -1.052 -1.578 l -2.104 0 l -1.052 1.579 l 0 0 l h S Q q 1 0 0 1 125.5474 396.4189 cm 0 0 m -1.054 -1.578 l -2.105 0 l -1.054 1.575 l h f Q q 1 0 0 1 125.5474 396.4189 cm 0 0 m -1.054 -1.578 l -2.105 0 l -1.054 1.575 l 0 0 l h S Q q 1 0 0 1 180.3164 396.4189 cm 0 0 m -1.053 -1.578 l -2.105 0 l -1.053 1.575 l h f Q q 1 0 0 1 180.3164 396.4189 cm 0 0 m -1.053 -1.578 l -2.105 0 l -1.053 1.575 l 0 0 l h S Q 0.991 0.905 0.368 scn q 1 0 0 1 499.126 354.0605 cm 0 0 m -0.875 0.461 l -1.749 0 l -1.582 0.974 l -2.293 1.666 l -1.313 1.807 l -0.877 2.694 l -0.437 1.809 l 0.539 1.668 l -0.168 0.974 l h f Q 0.328 w q 1 0 0 1 499.126 354.0605 cm 0 0 m -0.875 0.461 l -1.749 0 l -1.582 0.974 l -2.293 1.666 l -1.313 1.807 l -0.877 2.694 l -0.437 1.809 l 0.539 1.668 l -0.168 0.974 l 0 0 l h S Q 0 0.698 0.941 scn q 1 0 0 1 393.0234 396.4189 cm 0 0 m -1.053 -1.578 l -2.105 0 l -1.053 1.575 l h f Q 0.263 w q 1 0 0 1 393.0234 396.4189 cm 0 0 m -1.053 -1.578 l -2.105 0 l -1.053 1.575 l 0 0 l h S Q q 1 0 0 1 393.0234 375.4795 cm 0 0 m -1.053 -1.577 l -2.105 0 l -1.053 1.578 l h f Q q 1 0 0 1 393.0234 375.4795 cm 0 0 m -1.053 -1.577 l -2.105 0 l -1.053 1.578 l 0 0 l h S Q q 1 0 0 1 393.0234 354.9961 cm 0 0 m -1.053 -1.577 l -2.105 0 l -1.053 1.579 l h f Q q 1 0 0 1 393.0234 354.9961 cm 0 0 m -1.053 -1.577 l -2.105 0 l -1.053 1.579 l 0 0 l h S Q q 1 0 0 1 286.8208 375.6328 cm 0 0 m -1.052 -1.582 l -2.104 0 l -1.052 1.577 l h f Q q 1 0 0 1 286.8208 375.6328 cm 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1.772 -3.478 l h f Q q 1 0 0 1 310.8818 491.4561 cm 0 0 m 3.545 0 l 1.772 -3.478 l 0 0 l h S Q q 1 0 0 1 366.1055 490.646 cm 0 0 m 3.546 0 l 1.772 -3.478 l h f Q q 1 0 0 1 366.1055 490.646 cm 0 0 m 3.546 0 l 1.772 -3.478 l 0 0 l h S Q q 1 0 0 1 274.4692 408.1123 cm 0 0 m 3.545 0 l 1.773 -3.476 l h f Q q 1 0 0 1 274.4692 408.1123 cm 0 0 m 3.545 0 l 1.773 -3.476 l 0 0 l h S Q q 1 0 0 1 164.4253 324.7686 cm 0 0 m 3.546 0 l 1.771 -3.477 l h f Q q 1 0 0 1 164.4253 324.7686 cm 0 0 m 3.546 0 l 1.771 -3.477 l 0 0 l h S Q q 1 0 0 1 197.3984 240.6162 cm 0 0 m 3.545 0 l 1.771 -3.477 l h f Q q 1 0 0 1 197.3984 240.6162 cm 0 0 m 3.545 0 l 1.771 -3.477 l 0 0 l h S Q q 1 0 0 1 233.6079 178.1074 cm 0 0 m 3.544 0 l 1.773 -3.476 l h f Q q 1 0 0 1 233.6079 178.1074 cm 0 0 m 3.544 0 l 1.773 -3.476 l 0 0 l h S Q q 1 0 0 1 342.0332 158.6904 cm 0 0 m 3.546 0 l 1.773 -3.478 l h f Q q 1 0 0 1 342.0332 158.6904 cm 0 0 m 3.546 0 l 1.773 -3.478 l 0 0 l h S Q q 1 0 0 1 393.0117 158.2842 cm 0 0 m 3.544 0 l 1.771 -3.479 l h f Q q 1 0 0 1 393.0117 158.2842 cm 0 0 m 3.544 0 l 1.771 -3.479 l 0 0 l h S Q q 1 0 0 1 402.1143 158.2842 cm 0 0 m 3.544 0 l 1.773 -3.479 l h f Q q 1 0 0 1 402.1143 158.2842 cm 0 0 m 3.544 0 l 1.773 -3.479 l 0 0 l h S Q q 1 0 0 1 411.6221 158.2842 cm 0 0 m 3.546 0 l 1.773 -3.479 l h f Q q 1 0 0 1 411.6221 158.2842 cm 0 0 m 3.546 0 l 1.773 -3.479 l 0 0 l h S Q q 1 0 0 1 422.5449 158.2842 cm 0 0 m 3.544 0 l 1.773 -3.479 l h f Q q 1 0 0 1 422.5449 158.2842 cm 0 0 m 3.544 0 l 1.773 -3.479 l 0 0 l h S Q 1 1 1 scn 0.182 w [1.092 0.243]0 d 128.618 617.915 -18.511 3.033 re B BT 0.137 0.123 0.126 scn /T1_6 1 Tf 3.0343 0 0 3.0343 110.917 618.3706 Tm (94D - )Tj [(4)75(1)75(3)75(0)]TJ 4.175 0 Td ( bp)Tj ET 1 1 1 scn 110.261 620.722 18.18 0.884 re f 1 1 1 SCN 0.212 w 128.44 620.722 -18.179 0.884 re S 0.137 0.123 0.126 SCN q 1 0 0 1 110.0576 620.9478 cm 0 0 m 8.47 1.543 l S Q q 1 0 0 1 128.5913 620.9478 cm 0 0 m -10.086 1.542 l S Q 0.262 w 10 M []0 d q 1 0 0 1 245.2974 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 246.1235 584.4092 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 234.6694 583.6709 cm 0 0 m 11.454 0 l S Q BT 0.137 0.123 0.126 scn /TT0 1 Tf 3.9365 0 0 3.9365 236.1348 584.271 Tm (1031 )Tj ET q 1 0 0 1 245.2974 583.6709 cm 0 0 m 11.454 0 l S Q BT /TT0 1 Tf 3.9365 0 0 3.9365 246.7627 584.271 Tm (1032 )Tj 1 1 1 scn /TT1 1 Tf 3.0343 0 0 3.0343 197.6494 341.6885 Tm (ICE)Tj -31.068 -0.025 Td (ICE)Tj -4.074 -0.032 Td (ICE)Tj 13.275 0.075 Td (ICE)Tj 12.499 -0.05 Td (ICE)Tj 1.9267 0 0 1.8206 178.2275 342.0937 Tm (ICE)Tj 0.137 0.123 0.126 scn 3.0343 0 0 3.0343 186.6104 341.6494 Tm (ICE)Tj ET q 1 0 0 1 310.8564 522.0552 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 316.3047 521.981 cm 0 0 m 0 -1.475 l S Q q 1 0 0 1 299.4507 522.0552 cm 0 0 m 0 -1.476 l S Q q 1 0 0 1 309.9971 522.0552 cm 0 0 m 0 -1.476 l S Q 0.394 w 4 M 460.115 703.855 -105.443 1.64 re S 1 1 1 scn 426.753 703.144 -38.718 3.063 re f BT 0.137 0.123 0.126 scn /TT2 1 Tf 3.403 0 0 3.2804 390.3682 703.5684 Tm (yeast vector sequence)Tj 1.5815 0 0 2.6243 461.0937 693.729 Tm (tnpA_1)Tj 1.9777 0 0 2.7711 442.3428 423.7534 Tm [(t)-25(n)-25(p)-25(B)-25(_)-25(2)]TJ 1.4889 0 0 2.6243 435.2002 423.811 Tm [(tnp)1(A_2)]TJ ET 393.819 692.382 -4.854 4.021 re f BT 0.983 0.921 0.364 scn /TT2 1 Tf 2.0634 0 0 2.1002 389.1143 694.5488 Tm (CEN)Tj 0 -0.925 TD (ARS)Tj 1 1 1 scn 3.2804 0 0 3.2804 397.917 549.6362 Tm [(c)-25(t)-25(p)-25(A)]TJ -36.692 -6.381 Td [(t)-25(h)-25(i)-25(N)]TJ 2.189 0.124 Td [(r)-25(p)-25(e)]TJ 0.137 0.123 0.126 scn /TT0 1 Tf 6.2327 0 0 6.2327 457.1729 86.6816 Tm (85 bp insertion)Tj ET 0.964 0.553 0.414 scn q 1 0 0 1 277.4414 535.3032 cm 0 0 m 1.859 0 l 0.929 -3.949 l h f Q 0.498 w q 1 0 0 1 277.4414 535.3032 cm 0 0 m 1.859 0 l 0.929 -3.949 l 0 0 l h S Q q 1 0 0 1 446.5488 93.0801 cm 0 0 m 3.72 0 l 1.859 -7.897 l h f Q 0.55 w q 1 0 0 1 446.5488 93.0801 cm 0 0 m 3.72 0 l 1.859 -7.897 l 0 0 l h S Q 0.919 0.254 0.361 scn q 1 0 0 1 136.8887 491.8779 cm 0 0 m 3.544 0 l 1.77 -3.477 l h f Q 0.394 w q 1 0 0 1 136.8887 491.8779 cm 0 0 m 3.544 0 l 1.77 -3.477 l 0 0 l h S Q BT 0.137 0.123 0.126 scn /T1_3 1 Tf 8 0 0 8 64.3345 63.3125 Tm [(Gibson, D)37(. G., J)9(. I. Glass)11(, C. Lar)-23(tigue)14(, )36(V)63(. N. Nosk)7(o)8(v)44(, R.-)56(Y)108(. Chuang)16(, M. A. A)5(lg)4(ir)9(e)14(, G. A. B)-5(enders)11(, M. G. M)-5(on)5(tague)14(, L. M)-4(a, )]TJ -3.864 -1.2 Td [(M. M. M)-5(oodie)14(, C. M)-5(err)-22(yman, S. )36(V)38(ashee)14(, R. K)-5(rishnakumar)59(, N. A)4(ssad-)-13(G)-8(ar)9(cia, C. A)5(ndr)9(ew)12(s-Pfannk)7(och, E)6(. A. Deniso)8(v)6(a, L. )43(Y)94(oung)16(, )]TJ 1.085 -1.2 Td [(Z.-)-13(Q)37(. Qi, )40(T)73(. H. S)-6(egall-Shapir)9(o)30(, C. H. C)9(alv)13(ey)44(, P)142(. P)142(. P)21(armar)59(, C. A. Hut)6(chison III, H. O)37(. Smith, and J)9(. C. )36(V)38(en)5(t)6(er)59(.)]TJ /T1_4 1 Tf [( 2010. Cr)10(ea)4(tion of a )]TJ 9.021 -1.2 Td [(bac)-13(t)6(er)-4(ial c)6(ell c)6(on)4(tr)10(olled b)7(y a chemically syn)4(thesiz)7(ed genome)12(. 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