小蓝俱乐部

Center for Innovative Recycling and Circular Economy

The Center for Innovative Recycling and Circular Economy (CIRCLE) is one of six . CIRCLE international partnerships include funding agencies in Canada, Republic of Korea, and the United Kingdom, jointly supporting use-inspired research addressing global challenges through the bioeconomy.

CIRCLE will focus on addressing the pressing issues of air pollution reduction, agricultural and food waste treatment, and plastic waste disposal through disruptive solutions鈥攃hallenges that transcend national borders and require a multidisciplinary approach. By addressing these global challenges through international collaboration and innovative research, CIRCLE aims to make a significant impact on human health and the environment.

The team will focus on scalable solutions for 鈥渨aste-stream valorization鈥濃攖he process of taking waste products and giving them renewed economic value through recycling or upcycling. Another aim is to provide sustainable solutions for the commercially viable production of energy, chemicals, and materials.

The scientific aims will focus on developing three core technologies:

  1. Multi-omics-based bioprospecting to discover new enzymes, gene regulators, and organisms for waste valorization
  2. Predictive computational approaches to enable forward engineering of proteins and strains for biomanufacturing, and
  3. Techno-economic analysis (TEA), life cycle analysis (LCA), and risk assessment to develop commercially viable bioprocesses for waste valorization.

These core technologies will be validated for generalizability, scalability, and sustainable bioproduction through three waste streams: mixed plastics, C1 gases (e.g., carbon monoxide and dioxide), and biogenic wastes (e.g., food, agricultural, and paper/cardboard waste).

In addition to scientific output, CIRCLE is committed to training the next generation of scientists and engineers. The Center will offer unique interdisciplinary training opportunities in synthetic biology, systems biology, multi-omics, bioinformatics, computational biology, chemistry, systems engineering, risk assessment, TEA/LCA, and chemical engineering. CIRCLE will also engage the global community through multiple outreach activities, providing free education to ensure the sustainability and broad impact of its innovative approaches.

Funding

This Center is jointly supported by NSF, the Natural Sciences and Engineering Research Council and the Social Sciences and Humanities Research Council of Canada, the National Research Foundation of Korea, and UK Research and Innovation through .

Principal Investigator

Key Staff

Collaborators

Jikai Zhao, PhD
Kansas State University

Reza Zadegan, PhD
North Carolina A&T State University

Sunkyu Park, PhD
NC State University

Kai Lan, PhD
NC State University

Saurav Datta, PhD
Keck Graduate Institute

Gargi Ghosh, PhD
Keck Graduate Institute

Anum Glasgow, PhD
Columbia University

Related

Related Research

Publications

Metabolic engineering. 2025-07-11; 92.22-38.
Establishing Vibrio natriegens as a high-performance host for acetate-based poly-3-hydroxybutyrate production
Politan RJ, Della Valle S, Pineda L, Joshi J, Euler C, Flematti G, Fritz G
PMID: 40653003
Nucleic acids research. 2025-07-08; 53.13:
Expanding genetic engineering capabilities in Vibrio natriegens with the Vnat Collection
Faber A, Politan RJ, Stukenberg D, Morris KM, Kim R, Jeon E, Inckemann R, Becker A, Thuronyi B, Fritz G
PMID: 40650977
Nature communications. 2025-01-16; 16.1: 728.
Developing an alternative medium for in-space biomanufacturing
Lee H, Diao J, Tian Y, Guleria R, Lee E, Smith A, Savage M, Yeh D, Roberson L, Blenner M, Tang YJ, Moon TS
PMID: 39819985
Canadian journal of microbiology. 2025-01-01; 71.1-20.
Harnessing synthetic biology to empower a circular plastics economy
Yip A, Weldon M, Dharmasiddhi I, Zubrzycki B, Euler C, Prince E, Liu Y, Ingalls B, Aucoin MG
PMID: 40638940
Microbial cell factories. 2024-12-30; 23.1: 349.
A single-plasmid-based, easily curable CRISPR/Cas9 system for rapid, iterative genome editing in Pseudomonas putida KT2440
Wen Q, Chen J, Li J, Dharmasiddhi IPW, Yang M, Xing J, Liu Y
PMID: 39734219
Trends in biotechnology. 2024-12-04;
Complex waste stream valorization through combined enzymatic hydrolysis and catabolic assimilation by Pseudomonas putida
Chac贸n M, Alvarez-Gonzalez G, Gosalvitr P, Berepiki A, Fisher K, Cu茅llar-Franca R, Dixon N
PMID: 39638703
Chemical communications (Cambridge, England). 2024-12-03; 60.97: 14360-14375.
Sustainable production of aromatic chemicals from lignin using enzymes and engineered microbes
Sodr茅 V, Bugg TDH
PMID: 39569570
Biotechnology advances. 2024-12-01; 77.108462.
The current progress of tandem chemical and biological plastic upcycling
Hu Y, Tian Y, Zou C, Moon TS
PMID: 39395608
Trends in biotechnology. 2024-11-23;
Producing multiple chemicals through biological upcycling of waste poly(ethylene terephthalate)
Diao J, Tian Y, Hu Y, Moon TS
PMID: 39581772
Green chemistry : an international journal and green chemistry resource : GC. 2023-05-09; 25.9: 3549-3560.
Application of Rhodococcus jostii RHA1 glycolate oxidase as an efficient accessory enzyme for lignin conversion by bacterial Dyp peroxidase enzymes
Alruwaili A, Rashid GMM, Bugg TDH
PMID: 37179958
Microbial cell factories. 2021-01-19; 20.1: 15.
Metabolic engineering of Rhodococcus jostii RHA1 for production of pyridine-dicarboxylic acids from lignin
Spence EM, Calvo-Bado L, Mines P, Bugg TDH
PMID: 33468127
31-Jan-2025
Press Release

Revolutionizing plastic waste management through biological upcycling

Innovative research transforms plastic waste into valuable chemicals, paving the way for a circular economy and sustainable space travel

02-Oct-2024
Press Release

小蓝俱乐部 awarded 5-year, $5M grant to lead Center for Innovative Recycling and Circular Economy (CIRCLE)

CIRCLE is one of the six new NSF Global Centers focused on advancing bioeconomy research to solve global challenges

Join us at 小蓝俱乐部for this invitation-only event, bringing together our global team to advance waste valorization and circular economy innovations. This team symposium will feature discussions on core research progress, collaborative strategies, and key technology developments, kicking off project collaboration. With a strong emphasis on sharing scientific knowledge and building collaboration within the consortium team members, the symposium will showcase cutting-edge research, data-driven insights, and innovative approaches shaping the future of sustainable biomanufacturing.

Agenda

See the complete agenda .

Day 1: Check in from 8:15am-8:45, sessions from 8:45am-7pm

Foundational Core Updates

  • Session 1: Discovery/Bioprospecting
  • Session 2: Computation
  • Session 3: Systems Engineering
  • Discussion Session Day 1

Day 2: 9am-7pm

Highlights from Overarching Themes

  • Session 4: Plastic Upcycling
  • Session 5: C1 Waste Conversion
  • Session 6: Biogenic Waste Valorization
  • Discussion Session Day 2

Day 3: 9am-12:30pm

Broader Impacts and Global Insights

  • Session 7: Education, Outreach, Innovation, and Policy
  • Session 8: Each Nation Update

Event Information

May 13-15. May 15 is a half day.

Lunch will be provided Tuesday and Wednesday.

Hotel information

We have reserved a block of rooms at Hotel La Jolla. If you use you will be able to obtain a special rate for the symposium, from May 11 to May 15. The hotel is about 2 miles from JCVI.

Note: if the reduced rate is not showing available at Hotel La Jolla, contact Anna Capria (acapria@jcvi.org) for assistance. The hotel is only releasing rooms at this rate in small blocks.

For information on things to do and explore in San Diego, check out the . Welcome to San Diego! We hope you enjoy your visit to 小蓝俱乐部and the beautiful La Jolla area.

Location

小蓝俱乐部
4120 Capricorn Lane
La Jolla, CA 92037

小蓝俱乐部La Jolla is located approximately 15 miles north of San Diego International Airport (SAN). There are several convenient transportation options available:

Public Transit

Public transportation is available but may require multiple transfers. The MTS Route 992 bus connects the airport to downtown San Diego, where travelers can access additional transit options via trolley or bus. Visit for schedules and route details.

Ride-Sharing & Taxis

Uber and Lyft operate throughout San Diego and provide a direct ride to 小蓝俱乐部La Jolla. Rides can be requested via their respective apps, and pick-up zones are designated at the airport.

Rental Cars

A variety of rental car companies are available at the San Diego International Airport Rental Car Center. Free shuttle service runs between the airport terminals and the rental facility. From Alamo to ZipCar one of the 12 rental car servicers at SAN should meet your needs. there is likely a Here are some of the available rental agencies: For more information, visit the .

Parking

There is limited garage and street parking available. Additional nearby parking will be available at UC San Diego for $4.50/hr. ($36/day). Details will follow. 

Registration & abstract submission

Registration and abstract submission is now closed.