Publications
Evolution of allostery in the cyclic nucleotide binding module
Kannan N, Wu J, Anand GS, Yooseph S, Neuwald AF, Venter JC, Taylor SS
PMID:
Abstract
The cyclic nucleotide binding (CNB) domain regulates signaling pathways in both eukaryotes and prokaryotes. In this study, we analyze the evolutionary information embedded in genomic sequences to explore the diversity of signaling through the CNB domain and also how the CNB domain elicits a cellular response upon binding to cAMP.