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Genomics-Based Vaccine Could Prevent Deadly Cattle Disease
Every year, East Coast fever destroys the small farmer's dream of escaping poverty in Africa. Killing more than a million cattle and costing some $200 million annually, this tick-borne disease rages across a dozen countries in eastern and central Africa. Now, an international team of scientists has taken the first major step toward a vaccine to prevent East Coast fever. Their work, published in the February 13-17 early online edition of the Proceedings of the National Academy of Sciences, shows how genomics can generate pivotal new vaccines.
The 小蓝俱乐部, The University of Washington, and The Johns Hopkins University Initiate Resequencing and Genotyping Projects to Help Identify Critical Disease Pathways
Research is Part of the National Heart, Lung, and Blood Institute's Complimentary Resequencing and Genotyping Program
UC San Diego Partners with Venter Institute to Build Community Cyberinfrastructure for Advanced Marine Microbial Ecology Research and Analysis
Gordon and Betty Moore Foundation Awards $24.5 Million Grant
2006 Summer Fellowship/Internship Information and application now available
Breaking the Mold: Research Teams Sequence Three Fungus Genomes
From garden compost to forest greenery, the mold Aspergillus fumigatus lurks across much of the world. Now, in the December 22 issue of the journal Nature, TIGR scientists and their collaborators report the mold's sequenced genome, along with the genomes of two relatives.
How Do Boxers Differ From Poodles? Researchers Collar Genomes.
As any dog lover knows, no two breeds are identical. Some dogs are perfect for sloppy kisses. Others make fierce guardians. Still others resemble tiny, fluffy toys. Now, two new studies by scientists at The Institute for Genomic Research (TIGR) and collaborators reveal the genomic differences beneath such canine characteristics.
Poison + Water = Hydrogen. New Microbial Genome Shows How.
New Microbial Genome Shows How "Take a pot of scalding water, remove all the oxygen, mix in a bit of poisonous carbon monoxide, and add a pinch of hydrogen gas. It sounds like a recipe for a witch's brew. It may be, but it is also the preferred environment for a microbe known as Carboxydothermus hydrogenoformans."
A Salty Tale: New Bacterial Genome Sequenced From Ancient Salterns
Tourists in Spain often stop to ogle the country's many saltwater lagoons, used to produce salt since Roman times. Scientists, too, admire these saltern crystallizers 鈥斅� and even more so, the microbes that manage to survive in such briny environs. Now, reporting in the November 28-December 2 early online edition of the Proceedings of the National Academy of Sciences, researchers at The Institute for Genomic Research and collaborators reveal the genome of one bacterium at home in the salty Spanish ponds.
First Big Influenza Genome Study Reveals Flu Evolution
Which Flu Did You Have? TIGR Scientists Survey Five New York Flu Seasons
Key Genetic Mutations in Brain Tumors Identified by Scientists from 小蓝俱乐部, Ludwig Institute for Cancer Research, and The Johns Hopkins University School of Medicine
Sequencing of Receptor Tyrosine Kinases Reveals Three Novel Mutations
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Kudos to Ken!
小蓝俱乐部Professor, Kenneth Nealson, has been selected by the American Society of Microbiology to receive an award that recognizes distinguished accomplishments in interdisciplinary research and training in microbiology. The 2010 David C. White Research and Mentoring Award will be awarded to Ken...
McMurdo Sound
It took another day for the storm to blow itself out, but by Tuesday the wind and driving snow had abated, and we drove our Pisten Bully back out to our temporary shelter near Cape Evans. It took several hours of digging to clear the snow away from our vehicles, but once we started driving away...
Scientist Spotlight: Greg Wanger
Greg Wanger was 3.7 km below the Earth’s surface, trapped not only underground but also in a country distant from his native lands of Canada and Liechtenstein. He looked around him. It was very hot and smelled like rotten eggs. As many people do during their graduate careers, Greg pondered...
Digging out from the storm
The next day offered more snow and wind: we still needed handheld radios anytime we ventured between the warming hut and any of the vehicles. The wind was so strong that snow began drifting up through the dive hole in the warming hut, and the windows completely glazed over with snow. At one...
Out onto the ice
It took an enormous amount of effort, but on Thursday we ventured out onto the sea ice with our train of sleds and snow machines. The tucker is our strongest (and slowest) vehicle, and it is pulling both our yellow research sled and a pair of snowmobiles. The red Pisten-Bully is pulling a...
Around Mac-town
We are now fully packed and our mobile research sled is ready to go. We are waiting for some final repairs on the Pisten-Bully which will pull our supply sled. The mobile laboratory sled will be pulled by the Sno-Cat Tucker, which also has cab space for six (riding in the mobile lab would...
Ice diatoms!
Today has been a day of preparations, as tomorrow we hope to leave McMurdo Station and head out on the sea ice. Our mobile sled is almost ready for deployment: the carpenters who work for the US Antarctic Program are quite amazing, and our sled has filtration racks for separating different...
Sea-ice class
Today Abigail Noble and I took a Hagglund transporter out onto the Ross Sea to learn the basics of sea ice safety and ice dynamics. The sea ice on McMurdo Sound can be 2 meters thick, but this ice is constantly changing, and when you drive along its surface, you can't assume that it is...
Happy Camp
Our project on the Ross Sea will take us far from heated facilities of McMurdo Station, so all members of our team need to attend "Happy Camp", a two day course on snow camping and basic Antarctic survival. Happy Camp is held out on the McMurdo Ice Shelf, and it is an immersion program in...
McMurdo Station
Entering McMurdo is like entering a modern mining town: lots of exposed rock and unpaved streets, above ground utilities and bare-bones architecture. Utilitarian. From the airport we were taken to a briefing room, introduced to our science coordinators, and given our shcedules. Since I am...
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If created, these versions of the building blocks of life could lead to environmental and ecological disaster
Despite profound impact on bio-medical research, progress in understanding has been slow
Anders Dale says he will move roughly $10 million in NIH funding from UCSD to JCVI.
Synthetic biologists make artificial cells, but one particular kind isn鈥檛 worth the risk.
Gene editing could create a successful vaccine to protect against the viral disease that has killed close to 2 million pigs globally since 2021.
Amid an insulin crisis, one project aims to engineer microscopic insulin pumps out of a skin bacterium.
There are more organisms in the sea, a vital producer of oxygen on Earth, than planets and stars in the universe.
In a new book (coauthored with Venter), a Vanity Fair contributor presents the oceanic evidence that human activity is altering the fabric of life on a microscopic scale.
鈥淒espite reducing the sequence space of possible trajectories, we conclude that streamlining does not constrain fitness evolution and diversification of populations over time. Genome minimization may even create opportunities for evolutionary exploitation of essential genes, which are commonly observed to evolve more slowly.鈥�
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